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1. 发明授权

US5416015A Isolated genes encoding peptidyl prolyl-cis.trans-isomerase and plasmids comprising said genes 失效
标题翻译：编码肽基脯氨酰基 - 顺反异构酶的分离基因和包含所述基因的质粒
公开(公告)号：US5416015A
公开(公告)日：1995-05-16
申请号：US89850
申请日：1993-07-09
申请人： Toshiya Hayano , Setsuko Katou , Noboru Maki , Nobuhiro Takahashi , Masanori Suzuki
发明人： Toshiya Hayano , Setsuko Katou , Noboru Maki , Nobuhiro Takahashi , Masanori Suzuki
IPC分类号： C12N9/90 , C12N15/61 , C12N15/63 , C12N15/70
CPC分类号： C12N9/90
摘要： A yeast PPIase characterized by possessing following properties: (1) acting on and isomerizing the bond X.sub.aa -Pro (wherein X.sub.aa stands for any amino acid and Pro stands for L-proline), (2) exhibiting a single molecular weight of about 17,000 daltons in the sodium dodecyl sulfate-polyacrylamide concentration gradient gel electrophoresis, (3) exhibiting a single isoelectric point of about 6.2 in the isoelectric focusing, and (4) inhibited by CsA;an E. coli PPIase-.beta. characterized by possessing the following properties: (1) acting on and isomerizing the bond X.sub.aa -Pro (wherein X.sub.aa stands for any amino acid and Pro for L-proline), (2) exhibiting a single molecular weight of about 20,000 daltons in the sodium dodecyl sulfate-polyacrylamide concentration gradient gel electrophoresis, (3) exhibiting a single isoelectric point of about 5.0 in the isoelectric focusing, and (4) no being inhibited by CsA;an E. coli PPIase-.alpha. characterized by possessing the following properties: (1) acting on and isomerizing the bond X.sub.aa -Pro (wherein X.sub.aa stands for any amino acid and Pro for L-proline), (2) exhibiting a single molecular weight of about 22,000 daltons in the sodium dodecyl sulfate-polyacrylamide concentration gradient gel electrophoresis, (3) exhibiting a single isoelectric point of about 9.7 in the isoelectric focusing, and (4) not being inhibited by CsA.
摘要翻译：特征在于具有以下性质的酵母PPI酶：（1）作用于Xaa-Pro键（Xaa代表任何氨基酸，Pro代表L-脯氨酸），（2）表现出约17,000道尔顿单分子量在十二烷基硫酸钠 - 聚丙烯酰胺浓度梯度凝胶电泳中，（3）在等电聚焦中表现出约6.2的单一等电点，（4）被CsA抑制; 特征在于具有以下性质的大肠杆菌PPI酶-β：（1）作用于Xaa-Pro（Xaa代表任何氨基酸，Pro-L-脯氨酸，Xaa代表任意氨基酸，Pro表示单分子量）在十二烷基硫酸钠 - 聚丙烯酰胺浓度梯度凝胶电泳中为约20,000道尔顿，（3）在等电聚焦中呈现约5.0的单等电点，（4）不被CsA抑制; 其特征在于具有以下性质：（1）作用于Xaa-Pro键（Xaa代表任何氨基酸，Pro为L-脯氨酸），（2）表现出单分子量在十二烷基硫酸钠 - 聚丙烯酰胺浓度梯度凝胶电泳中约为22,000道尔顿，（3）在等电聚焦中显示出约9.7的单一等电点，（4）不被CsA抑制。

2. 发明授权

US5284762A Peptidyl prolyl-cis.trans-isomerase 失效
标题翻译：肽基脯氨酰 - 顺反异构酶
公开(公告)号：US5284762A
公开(公告)日：1994-02-08
申请号：US555944
申请日：1990-07-19
申请人： Toshiya Hayano , Setsuko Katou , Noboru Maki , Nobuhiro Takahashi , Masanori Suzuki
发明人： Toshiya Hayano , Setsuko Katou , Noboru Maki , Nobuhiro Takahashi , Masanori Suzuki
IPC分类号： C12N9/90 , C12N15/61 , C12N15/70
CPC分类号： C12N9/90
摘要： A yeast PPIase characterized by possessing the following properties: (1) acting on and isomerizing the bond X.sub.aa -Pro (wherein X.sub.aa stands for any amino acid and Pro stands for L-proline), (2) exhibiting a single molecular weight of about 17,000 daltons in the sodium dodecyl sulfate-polyacrylamide concentration gradient gel electrophoresis, (3) exhibiting a single isoelectric point of about 6.2 in the isoelectric focusing, and (4) inhibited by CsA;an E. coli PPIase-.beta. characterized by possessing the following properties: (1) acting on and isomerizing the bond X.sub.aa -Pro (wherein X.sub.aa stands for any amino acid and Pro for L-proline), (2) exhibiting a single molecular weight of about 20,000 daltons in the sodium dodecyl sulfate-polyacrylamide concentration gradient gel electrophoresis, (3) exhibiting a single isoelectric point of about 5.0 in the isoelectric focusing, and (4) no being inhibited by CsA;an E. coli PPIase-.alpha. characterized by possessing the following properties: (1) acting on and isomerizing the bond X.sub.aa -Pro (wherein X.sub.aa stands for any amino acid and Pro for L-proline), (2) exhibiting a single molecular weight of about 22,000 daltons in the sodium dodecyl sulfate-polyacrylamide concentration gradient gel electrophoresis, (3) exhibiting a single isoelectric point of about 9.7 in the isoelectric focusing, and (4) not being inhibited by CsA.
摘要翻译：特征在于具有以下特性的酵母PPI酶：（1）作用于Xaa-Pro键（Xaa代表任何氨基酸，Pro代表L-脯氨酸），（2）表现出单一分子量约17,000 十二烷基硫酸钠 - 聚丙烯酰胺浓度梯度凝胶电泳中的道尔顿，（3）在等电聚焦中显示约6.2的单一等电点，和（4）被CsA抑制; 特征在于具有以下特性的大肠杆菌PPIase-（β）：（1）作用于Xaa-Pro键（Xaa代表任何氨基酸，Pro代表L-脯氨酸），（2）表现出单一的在十二烷基硫酸钠 - 聚丙烯酰胺浓度梯度凝胶电泳中分子量约20,000道尔顿，（3）在等电聚焦中呈现约5.0的单一等电点，（4）不被CsA抑制; 特征在于具有以下性质的大肠杆菌PPIase-（α）：（1）作用于Xaa-Pro键（Xaa代表任何氨基酸，Pro代表L-脯氨酸），（2）表现出单一的在十二烷基硫酸钠 - 聚丙烯酰胺浓度梯度凝胶电泳中分子量约22,000道尔顿，（3）在等电聚焦中显示约9.7的单一等电点，（4）不被CsA抑制。

3. 发明授权

US5578466A Recombinant co-expression system of protein disulfide isomerase gene, yeast receptor protein ERD2 gene and a foreign product polypeptide gene, and a process for producing the foreign polypeptide using such system 失效
标题翻译：蛋白二硫键异构酶基因重组共表达系统，酵母受体蛋白ERD2基因和外来产物多肽基因，以及使用该系统产生外源多肽的方法
公开(公告)号：US5578466A
公开(公告)日：1996-11-26
申请号：US872673
申请日：1992-04-17
申请人： Toshiya Hayano , Setsuko Katoh , Nobuhiro Takahashi , Masanori Suzuki , Keiichi Honma
发明人： Toshiya Hayano , Setsuko Katoh , Nobuhiro Takahashi , Masanori Suzuki , Keiichi Honma
IPC分类号： C07K14/395 , C07K14/765 , C12N9/90 , C12N15/14 , C12N15/61 , C12N15/81 , C12N15/90 , C12N1/19 , C12N15/62
CPC分类号： C07K14/395 , C07K14/765 , C12N15/81 , C12N15/90 , C12N9/90 , C07K2319/00 , C07K2319/02
摘要： The present invention is directed to a transformant comprising the following expression units in a co-expressible state:an expression unit containing a gene coding for a receptor protein ERD2 from yeast or analog thereof which is capable of binding to a protein localizing in endoplasmic reticulum and having a signal for staying therein;an expression unit containing a gene coding for said protein localizing in endoplasmic reticulum; andan expression unit containing a foreign gene coding for a polypeptide which is a subject of function of said protein localizing in endoplasmic reticulum, andto a transformant comprising, in a co-expressible state, a fusion gene which is composed of a DNA fragment coding for a human serum albumin prepro-sequence and a foreign gene coding for a useful polypeptide. The present invention is also directed to a process for producing said polypeptide by co-expressing said genes in said transformant such that the polypeptide is predominantly secreted out of the transformant cell. Consequently, the invention has an advantage of improving the productivity of said polypeptide.
摘要翻译：本发明涉及包含可共表达状态的以下表达单元的转化体：包含编码来自酵母或其类似物的受体蛋白ERD2的基因的表达单元，其能够结合定位在内质网中的蛋白质，以及具有留在其中的信号; 含有编码所述蛋白质定位在内质网中的基因的表达单元; 以及表达单元，其含有编码作为所述蛋白质在内质网中定位的功能的多肽的外源基因，以及含有共可表达状态的转化体，所述融合基因由编码用于人血清白蛋白前原序列和编码有用多肽的外源基因。本发明还涉及通过在所述转化体中共表达所述基因以使多肽主要从转化体细胞中分泌而产生所述多肽的方法。因此，本发明具有提高所述多肽的生产率的优点。

4. 发明申请

US20110161273A1 RIBONUCLEIC ACID IDENTIFICATION APPARATUS, RIBONUCLEIC ACID IDENTIFICATION METHOD, PROGRAM AND RIBONUCLEIC ACID IDENTIFICATION SYSTEM 有权
标题翻译：核糖核酸鉴定装置，核糖核酸鉴定方法，程序和核糖核酸鉴定系统
公开(公告)号：US20110161273A1
公开(公告)日：2011-06-30
申请号：US12988037
申请日：2009-04-17
申请人： Hiroshi Nakayama , Misaki Akiyama , Toshiaki Isobe , Masato Taoka , Yoshio Yamauchi , Nobuhiro Takahashi , Hideaki Ishikawa
发明人： Hiroshi Nakayama , Misaki Akiyama , Toshiaki Isobe , Masato Taoka , Yoshio Yamauchi , Nobuhiro Takahashi , Hideaki Ishikawa
IPC分类号： G06N5/02
CPC分类号： C12Q1/6872 , H01J49/00 , C12Q2521/307
摘要： Disclosed are an apparatus for the identification of a ribonucleic acid, whereby not only the molecular weights of digestion products, from which nothing but the nucleic acid residue composition can be understood, but also nucleic acid residue sequence data is obtained from a product ion mass set and thus the identification reliability for the individual digestion products can be remarkably improved; a method for the identification of a ribonucleic acid; and a program and system for the identification of a ribonucleic acid. The method as described above comprises: searching for nucleic acid sequence database by using a fragment mass set indicating the molecular weights and inner structural data of individual oligonucleotides that are obtained by tandem mass spectrometry on digested oligonucleotides formed by chemically or enzymatically cleaving a ribonucleic acid; scoring candidate sequences; among candidate sequences showing the highest scores, referring those showing scores exceeding the threshold as identified sequences; and using these identified sequences in mapping on nucleic acid sequence database including genomic sequences.
摘要翻译：公开了用于鉴定核糖核酸的装置，其不仅可以理解除了核酸残基组成之外的消化产物的分子量，还可以从核酸残基序列数据获得产物离子质量组从而可以显着提高个体消化产品的鉴定可靠性; 用于鉴定核糖核酸的方法; 以及用于鉴定核糖核酸的程序和系统。如上所述的方法包括：通过使用表示通过串联质谱法获得的各种寡核苷酸的分子量和内部结构数据的片段质谱组来搜索核酸序列数据库对通过化学或酶切割核糖核酸形成的消化的寡核苷酸; 得分候选序列; 在显示最高分数的候选序列中，将显示分数超过阈值的那些指定为鉴定序列; 并使用这些鉴定的序列在包括基因组序列的核酸序列数据库上进行测绘。

5. 发明授权

US06970974B2 Method for managing disk drives of different types in disk array device 失效
标题翻译：用于管理磁盘阵列设备中不同类型的磁盘驱动器的方法
公开(公告)号：US06970974B2
公开(公告)日：2005-11-29
申请号：US10808364
申请日：2004-03-25
申请人： Daisuke Isobe , Azuma Kano , Akihisa Hirasawa , Shingo Itagaki , Kenichi Tateyama , Yoshinori Nagaiwa , Nobuhiro Takahashi
发明人： Daisuke Isobe , Azuma Kano , Akihisa Hirasawa , Shingo Itagaki , Kenichi Tateyama , Yoshinori Nagaiwa , Nobuhiro Takahashi
IPC分类号： G06F3/06 , G06F12/00 , G11B33/12
CPC分类号： G06F3/0661 , G06F3/0607 , G06F3/0658 , G06F3/0689 , G11B33/12
摘要： The present invention manages disk-drive types in a storage device in which a mixture of disk drives of a plurality of types with different interfaces is stored. The storage device enclosure stores a mixture of an FC disk drive 220F with a fiber channel interface and a SATA disk drive with a serial interface. The SATA disk drive is connected to a fiber channel via an FC/SATA interface connection device 233 that performs interface conversion. At startup and so forth, the controller 310 issues an inquiry to the enclosure management unit or to each of the disk drives and, based on the address allocated to each of the disk drives, or similar, automatically confirms the type of each disk drive and manages the confirmation results.
摘要翻译：本发明管理存储装置中的磁盘驱动器类型，其中存储具有不同接口的多种类型的磁盘驱动器的混合。存储设备机柜存储FC磁盘驱动器220F与光纤通道接口和具有串行接口的SATA磁盘驱动器的混合。 SATA磁盘驱动器通过执行接口转换的FC / SATA接口连接设备233连接到光纤通道。在启动等时，控制器310向机箱管理单元或每个磁盘驱动器发出询问，并且基于分配给每个磁盘驱动器等的地址，自动确认每个磁盘驱动器的类型，管理确认结果。

6. 发明授权

US5096338A Throw away insert 失效
标题翻译： THROW AWAY插入
公开(公告)号：US5096338A
公开(公告)日：1992-03-17
申请号：US596085
申请日：1990-10-11
申请人： Nobuhiro Takahashi
发明人： Nobuhiro Takahashi
IPC分类号： B23B27/14 , B23B27/22
CPC分类号： B23B27/141 , B23B2200/085 , B23B2200/204 , B23B2200/323 , Y10T407/235 , Y10T407/245
摘要： A throw-away insert having straight cutting edges defined adjacent the periphery thereof, arcuately curved corner portions extending between adjacent ones of the cutting edges, and a rake face having a center land. In the rake face, chip breaker grooves are formed near the corner portions. Each breaker groove adjoins the center land along a line inclined with respect to one of the adjacent cutting edges and is inclined with respect to the direction of thickness of the insert. An ellipsoidal recess is formed in the bottom surface of each breaker groove across the boundary between the center land and the breaker groove. The ellipsoidal recesses have a major axis extending parallel to the borderline between the center land and the breaker groove.

7. 发明授权

US5088651A Roll crusher and crushing method in use for the roll crusher 失效
标题翻译：滚筒破碎机和破碎方法用于滚筒破碎机
公开(公告)号：US5088651A
公开(公告)日：1992-02-18
申请号：US590562
申请日：1990-09-28
申请人： Nobuhiro Takahashi , Fumio Takagi
发明人： Nobuhiro Takahashi , Fumio Takagi
IPC分类号： G03G5/08 , B02C4/02 , B02C4/28 , B02C4/30 , B02C4/32 , B02C4/42 , G03G5/082 , G03G5/14
CPC分类号： B02C4/30 , B02C4/02 , B02C4/283 , B02C4/32 , B02C4/42
摘要： A roll crusher having a pair of rolls facing each other, in which feed material to be crushed is fed into a space or a crushing chamber formed in between these rolls, and the pair of rolls rolls up the material to compress and crush it. Both ends of one or the other of the rolls are provided with flanges which cover the lower portions of end openings in the crushing chamber. Cheek plates fixedly disposed cover the remaining portions of the end openings of the crushing chamber. This construction helps prevent feed material from flowing out of the crushing chamber. One of the pair of the rolls is driven for rotation by a source of drive power, and the other is rotated freely as well as driven to rotate initially at low speed, which permits coarse materials to be forcibly entrained in between the rolls for crushing. During the process of crushing, the crushing clearance of rolls is set to 0.6 to 2.4 times 80% passing size of feed material, and feed rate is limited so that passing rate of the material ranges 0.5 to 0.8 times the theoretical throughput capacity of the crusher, which remarkably increases the actual throughput of the roll crusher.
摘要翻译：要被粉碎的物体被送入限定在彼此面对的一对辊之间的破碎室中，并在这些辊之间被压缩和压碎。在任一个辊（3）的两端形成凸缘（12），以覆盖破碎室的两个端部开口的下部。破碎室的两端开口的剩余部分被固定地设置的保持构件（11）覆盖。这种结构可以防止物体从破碎室溢出。如果一对辊中的一个被用作驱动辊，另一个辊被允许自由旋转，并且两个辊在初始阶段以低速旋转，则即使粗颗粒也可能被强制地夹带并压碎。辊式破碎机的破碎能力可以通过将辊之间的破碎间隙设定为允许物体的80％通过的粒径的0.6〜2.4倍，并且通过控制进给量使得通过物体的数量在范围是破碎机理论容量的0.5〜0.8倍。

8. 发明授权

US4941780A Indexable cutting insert 失效
标题翻译：可转位切削刀片
公开(公告)号：US4941780A
公开(公告)日：1990-07-17
申请号：US271669
申请日：1988-11-16
申请人： Nobuhiro Takahashi
发明人： Nobuhiro Takahashi
IPC分类号： B23B27/14
CPC分类号： B23B27/143 , Y10T407/235
摘要： An indexable cutting insert of a polygonal shape including a plurality of nose portions formed at vertexes of the polygonal shape, respectively, a cutting edge formed between neighboring ones of the nose portions, a land portion formed inside the cutting edge and a dimple formed, in the vicinity of each of the nose portions and the land portion, inside each of the nose portions, with the cutting edge being inclined upwardly in a direction away from each of the nose portions.

9. 发明授权

US06846212B2 Fuel supply system for engine 有权
标题翻译：发动机燃油供应系统
公开(公告)号：US06846212B2
公开(公告)日：2005-01-25
申请号：US10143819
申请日：2002-05-14
申请人： Tetsu Wada , Tomonori Ikuma , Sadafumi Shidara , Makoto Sakai , Kazuki Ishikawa , Nobuhiro Takahashi
发明人： Tetsu Wada , Tomonori Ikuma , Sadafumi Shidara , Makoto Sakai , Kazuki Ishikawa , Nobuhiro Takahashi
IPC分类号： F02M37/00 , F02B61/04 , F02M37/20
CPC分类号： F02B61/045 , F02M37/20 , F02M55/007
摘要： In fuel supply system for an engine in which a discharge port in a fuel pump driven by the engine to draw up fuel in a fuel tank is connected to an inlet port which is provided in a fuel reservoir and which is controlled in opening and closing by a float valve so that the fuel in the fuel reservoir is supplied to the engine, a second discharge port is provided in the fuel pump, and a second inlet port without a float valve is provided in the fuel reservoir. The second discharge port and the second inlet port are connected to each other through a control valve opened during starting of the engine. Thus, when the engine is started, fuel vapor generated in a pump chamber in the fuel pump can be discharged to the fuel reservoir having an air vent, to normalize the function of the fuel pump, leading to an enhancement in hot startability of the engine.
摘要翻译：在用于发动机的燃料供给系统中，其中由发动机驱动的燃料泵中的排出口在燃料箱中抽取燃料连接到设置在燃料储存器中的入口端口，该入口端口被开启和关闭控制浮子阀，使得燃料储存器中的燃料被供应到发动机，在燃料泵中设置有第二排出口，并且在燃料储存器中设置没有浮阀的第二入口。第二排出口和第二入口通过在发动机起动期间打开的控制阀相互连接。因此，当发动机起动时，在燃料泵中的泵室中产生的燃料蒸汽可以排放到具有排气口的燃料储存器，以使燃料泵的功能正常化，从而提高发动机的热启动性。

10. 发明授权

US06820470B2 Intake manifold leakage detection system of internal combustion engine 失效
标题翻译：内燃机进气歧管泄漏检测系统
公开(公告)号：US06820470B2
公开(公告)日：2004-11-23
申请号：US10267585
申请日：2002-10-10
申请人： Sadafumi Shidara , Nobuhiro Takahashi
发明人： Sadafumi Shidara , Nobuhiro Takahashi
IPC分类号： G01L326
CPC分类号： F02M35/10 , F02B61/045 , F02D11/107 , F02D31/005 , F02D41/062 , F02D2200/0406 , F02D2200/703 , F02M35/167
摘要： A system detecting leakage of an internal combustion engine having a secondary air passage, bypassing a throttle valve, at an air intake pipe connecting to the intake manifold and a secondary air control valve which regulates opening of the secondary air passage. In the system, when the changes in the absolute manifold pressure and the atmospheric pressure before and after the engine starts rotation, are small, it is determined that the intake manifold may possibly leak and should be monitored. Specifically, the opening of the secondary air passage is changed and the changes in the pressure, etc., before and after the opening is changed, are calculated and based thereon, it is determined whether the intake manifold, in fact, leaks. With this, it becomes possible to detect intake manifold leakage accurately with a simple configuration.
摘要翻译：一种检测在连接到进气歧管的进气管处，旁通节流阀的二次空气通道的内燃机的泄漏的系统和调节二次空气通道的开度的二次空气调节阀。在该系统中，当发动机起动旋转之前和之后的绝对歧管压力和大气压力的变化较小时，确定进气歧管可能泄漏并应被监测。具体地说，二次空气通道的打开被改变，并且在打开之前和之后改变压力等的变化，并且基于此，确定进气歧管是否实际上是泄漏的。由此，能够以简单的结构精确地检测进气歧管泄漏。

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