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1. 发明授权

US5416015A Isolated genes encoding peptidyl prolyl-cis.trans-isomerase and plasmids comprising said genes 失效
标题翻译：编码肽基脯氨酰基 - 顺反异构酶的分离基因和包含所述基因的质粒
公开(公告)号：US5416015A
公开(公告)日：1995-05-16
申请号：US89850
申请日：1993-07-09
申请人： Toshiya Hayano , Setsuko Katou , Noboru Maki , Nobuhiro Takahashi , Masanori Suzuki
发明人： Toshiya Hayano , Setsuko Katou , Noboru Maki , Nobuhiro Takahashi , Masanori Suzuki
IPC分类号： C12N9/90 , C12N15/61 , C12N15/63 , C12N15/70
CPC分类号： C12N9/90
摘要： A yeast PPIase characterized by possessing following properties: (1) acting on and isomerizing the bond X.sub.aa -Pro (wherein X.sub.aa stands for any amino acid and Pro stands for L-proline), (2) exhibiting a single molecular weight of about 17,000 daltons in the sodium dodecyl sulfate-polyacrylamide concentration gradient gel electrophoresis, (3) exhibiting a single isoelectric point of about 6.2 in the isoelectric focusing, and (4) inhibited by CsA;an E. coli PPIase-.beta. characterized by possessing the following properties: (1) acting on and isomerizing the bond X.sub.aa -Pro (wherein X.sub.aa stands for any amino acid and Pro for L-proline), (2) exhibiting a single molecular weight of about 20,000 daltons in the sodium dodecyl sulfate-polyacrylamide concentration gradient gel electrophoresis, (3) exhibiting a single isoelectric point of about 5.0 in the isoelectric focusing, and (4) no being inhibited by CsA;an E. coli PPIase-.alpha. characterized by possessing the following properties: (1) acting on and isomerizing the bond X.sub.aa -Pro (wherein X.sub.aa stands for any amino acid and Pro for L-proline), (2) exhibiting a single molecular weight of about 22,000 daltons in the sodium dodecyl sulfate-polyacrylamide concentration gradient gel electrophoresis, (3) exhibiting a single isoelectric point of about 9.7 in the isoelectric focusing, and (4) not being inhibited by CsA.
摘要翻译：特征在于具有以下性质的酵母PPI酶：（1）作用于Xaa-Pro键（Xaa代表任何氨基酸，Pro代表L-脯氨酸），（2）表现出约17,000道尔顿单分子量在十二烷基硫酸钠 - 聚丙烯酰胺浓度梯度凝胶电泳中，（3）在等电聚焦中表现出约6.2的单一等电点，（4）被CsA抑制; 特征在于具有以下性质的大肠杆菌PPI酶-β：（1）作用于Xaa-Pro（Xaa代表任何氨基酸，Pro-L-脯氨酸，Xaa代表任意氨基酸，Pro表示单分子量）在十二烷基硫酸钠 - 聚丙烯酰胺浓度梯度凝胶电泳中为约20,000道尔顿，（3）在等电聚焦中呈现约5.0的单等电点，（4）不被CsA抑制; 其特征在于具有以下性质：（1）作用于Xaa-Pro键（Xaa代表任何氨基酸，Pro为L-脯氨酸），（2）表现出单分子量在十二烷基硫酸钠 - 聚丙烯酰胺浓度梯度凝胶电泳中约为22,000道尔顿，（3）在等电聚焦中显示出约9.7的单一等电点，（4）不被CsA抑制。

2. 发明授权

US5284762A Peptidyl prolyl-cis.trans-isomerase 失效
标题翻译：肽基脯氨酰 - 顺反异构酶
公开(公告)号：US5284762A
公开(公告)日：1994-02-08
申请号：US555944
申请日：1990-07-19
申请人： Toshiya Hayano , Setsuko Katou , Noboru Maki , Nobuhiro Takahashi , Masanori Suzuki
发明人： Toshiya Hayano , Setsuko Katou , Noboru Maki , Nobuhiro Takahashi , Masanori Suzuki
IPC分类号： C12N9/90 , C12N15/61 , C12N15/70
CPC分类号： C12N9/90
摘要： A yeast PPIase characterized by possessing the following properties: (1) acting on and isomerizing the bond X.sub.aa -Pro (wherein X.sub.aa stands for any amino acid and Pro stands for L-proline), (2) exhibiting a single molecular weight of about 17,000 daltons in the sodium dodecyl sulfate-polyacrylamide concentration gradient gel electrophoresis, (3) exhibiting a single isoelectric point of about 6.2 in the isoelectric focusing, and (4) inhibited by CsA;an E. coli PPIase-.beta. characterized by possessing the following properties: (1) acting on and isomerizing the bond X.sub.aa -Pro (wherein X.sub.aa stands for any amino acid and Pro for L-proline), (2) exhibiting a single molecular weight of about 20,000 daltons in the sodium dodecyl sulfate-polyacrylamide concentration gradient gel electrophoresis, (3) exhibiting a single isoelectric point of about 5.0 in the isoelectric focusing, and (4) no being inhibited by CsA;an E. coli PPIase-.alpha. characterized by possessing the following properties: (1) acting on and isomerizing the bond X.sub.aa -Pro (wherein X.sub.aa stands for any amino acid and Pro for L-proline), (2) exhibiting a single molecular weight of about 22,000 daltons in the sodium dodecyl sulfate-polyacrylamide concentration gradient gel electrophoresis, (3) exhibiting a single isoelectric point of about 9.7 in the isoelectric focusing, and (4) not being inhibited by CsA.
摘要翻译：特征在于具有以下特性的酵母PPI酶：（1）作用于Xaa-Pro键（Xaa代表任何氨基酸，Pro代表L-脯氨酸），（2）表现出单一分子量约17,000 十二烷基硫酸钠 - 聚丙烯酰胺浓度梯度凝胶电泳中的道尔顿，（3）在等电聚焦中显示约6.2的单一等电点，和（4）被CsA抑制; 特征在于具有以下特性的大肠杆菌PPIase-（β）：（1）作用于Xaa-Pro键（Xaa代表任何氨基酸，Pro代表L-脯氨酸），（2）表现出单一的在十二烷基硫酸钠 - 聚丙烯酰胺浓度梯度凝胶电泳中分子量约20,000道尔顿，（3）在等电聚焦中呈现约5.0的单一等电点，（4）不被CsA抑制; 特征在于具有以下性质的大肠杆菌PPIase-（α）：（1）作用于Xaa-Pro键（Xaa代表任何氨基酸，Pro代表L-脯氨酸），（2）表现出单一的在十二烷基硫酸钠 - 聚丙烯酰胺浓度梯度凝胶电泳中分子量约22,000道尔顿，（3）在等电聚焦中显示约9.7的单一等电点，（4）不被CsA抑制。

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