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1. 发明申请

US20100273989A1 ANGIOTENSIN CONVERTING ENZYME HOMOLOG AND USES THEREFOR 审中-公开
标题翻译： ANGIOTENSIN转化酶同源异构体及其用途
公开(公告)号：US20100273989A1
公开(公告)日：2010-10-28
申请号：US12340815
申请日：2008-12-22
申请人： Susan Acton , Keith E. Robison , Frank Y. Hsieh
发明人： Susan Acton , Keith E. Robison , Frank Y. Hsieh
IPC分类号： C07K16/18
CPC分类号： A61K38/4813 , C12N9/48 , C12Y304/15001
摘要： The present invention relates to the discovery of novel genes encoding an angiotensin converting enzyme, Angiotensin Converting Enzyme-2 (ACE-2). The invention provides therapeutics, prognostic and diagnostic methods for treating blood pressure related disorders as well as various types of allergic conditions, among others. Also disclosed are screening assays for identifying compounds for treating and preventing these conditions.
摘要翻译：本发明涉及编码血管紧张素转换酶血管紧张素转化酶-2（ACE-2）的新基因的发现。本发明提供了用于治疗血压相关疾病以及各种类型的变态反应病症的治疗，预后和诊断方法。还公开了用于鉴定用于治疗和预防这些病症的化合物的筛选测定。

2. 发明授权

US07482171B2 Angiotensin converting enzyme homolog and uses therefor 失效
标题翻译：血管紧张素转换酶同源物及其用途
公开(公告)号：US07482171B2
公开(公告)日：2009-01-27
申请号：US11059218
申请日：2005-02-16
申请人： Susan Acton , Keith E. Robison , Frank Y. Hsieh
发明人： Susan Acton , Keith E. Robison , Frank Y. Hsieh
IPC分类号： G01N33/566
CPC分类号： A61K38/4813 , C12N9/48 , C12Y304/15001
摘要： The present invention relates to the discovery of novel genes encoding an angiotensin converting enzyme, Angiotensin Converting Enzyme-2 (ACE-2). The invention provides therapeutics, prognostic and diagnostics methods for treating blood pressure related disorders as well as various types of allergic conditions, among others. Also disclosed are screening assays for identifying compounds for treating and preventing these conditions.
摘要翻译：本发明涉及编码血管紧张素转换酶血管紧张素转化酶-2（ACE-2）的新基因的发现。本发明提供了用于治疗血压相关疾病以及各种类型的变态反应病症的治疗，预后和诊断方法。还公开了用于鉴定用于治疗和预防这些病症的化合物的筛选测定。

3. 发明授权

US06884771B1 Angiotensin converting enzyme homolog and uses therefor 有权
标题翻译：血管紧张素转换酶同源物及其用途
公开(公告)号：US06884771B1
公开(公告)日：2005-04-26
申请号：US09635501
申请日：2000-08-09
申请人： Susan Acton , Keith E. Robison , Frank Y. Hsieh
发明人： Susan Acton , Keith E. Robison , Frank Y. Hsieh
IPC分类号： A61K38/00 , A61K38/48 , C12N9/48 , C12N15/12 , A51K38/00
CPC分类号： A61K38/4813 , C12N9/48 , C12Y304/15001
摘要： The present invention relates to the discovery of novel genes encoding an angiotensin converting enzyme, Angiotensin Converting Enzyme-2 (ACE-2). The invention provides therapeutics, prognostic and diagnostics methods for treating blood pressure related disorders as well as various types of allergic conditions, among others. Also disclosed are screening assays for identifying compounds for treating and preventing these conditions.
摘要翻译：本发明涉及编码血管紧张素转换酶血管紧张素转化酶-2（ACE-2）的新基因的发现。本发明提供了用于治疗血压相关疾病以及各种类型的变态反应病症的治疗，预后和诊断方法。还公开了用于鉴定用于治疗和预防这些病症的化合物的筛选测定。

4. 发明申请

US20090226450A1 Novel 15571, 2465, 14266, 2882, 52871, 8203 and 16852 molecules and uses therefor 审中-公开
标题翻译：小分子15571,2245,14266,2882,52871,8203和16852分子及其用途
公开(公告)号：US20090226450A1
公开(公告)日：2009-09-10
申请号：US12386856
申请日：2009-04-23
申请人： Martin R. Hodge , Clare M. Lloyd , Nadine S. Weich , Jose M. Lora , David White , Maria A. Glucksmann , Keith E. Robison , Inmaculada Silos-Santiago , Andrew D.J. Goodearl , Rory A.J. Curtis
发明人： Martin R. Hodge , Clare M. Lloyd , Nadine S. Weich , Jose M. Lora , David White , Maria A. Glucksmann , Keith E. Robison , Inmaculada Silos-Santiago , Andrew D.J. Goodearl , Rory A.J. Curtis
IPC分类号： A61K39/395 , C12N15/11 , C12N5/00 , C07K14/00 , C07K16/18 , C12P21/02 , G01N33/566 , G01N33/53 , C12Q1/68 , A61K38/02 , A61K38/16 , A61K31/7088
CPC分类号： C07K14/47 , C07K16/286 , G01N33/6893 , G01N33/74 , G01N2333/726 , G01N2500/04 , G01N2800/122 , G01N2800/24
摘要： The invention provides isolated nucleic acids molecules, designated 15571, 2465, 14266, 2882, 52871, 8203 or 16852 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 15571, 2465, 14266, 2882, 52871, 8203 or 16852 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 15571, 2465, 14266, 2882, 52871, 8203 or 16852 gene has been introduced or disrupted. The invention still further provides isolated 15571, 2465, 14266, 2882, 52871, 8203 or 16852 proteins, fusion proteins, antigenic peptides and anti-15571, 2465, 14266, 2882, 52871, 8203 or 16852 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为15571,2465,14266,2882,52871,8203或16852核酸分子。本发明还提供反义核酸分子，含有15571,2465,14266,2882,52871,8203或16852核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中15571， 2465,14266,2882,52871,8203或16852基因已被引入或破坏。本发明还进一步提供了分离的15571,2465,14266,2882,52871,8203或16852蛋白，融合蛋白，抗原肽和抗15571,2465,14266,2882,52871,8203或16852抗体。还提供了利用本发明组合物的诊断和治疗方法。

5. 发明申请

US20100136010A1 Novel 27875, 22025, 27420, 17906, 16319, 55092 and 10218 molecules and uses therefor 审中-公开
标题翻译：小分子27875,22025,27420,17906,16319,55092和10218分子及其用途
公开(公告)号：US20100136010A1
公开(公告)日：2010-06-03
申请号：US12288465
申请日：2008-10-21
申请人： Rosana Kappeller-Libermann , David White , Keith E. Robison , Kyle J. MacBeth , Joseph M. Carroll , William James Cook , Rachel E. Meyers , Miyoung Chun , Mark J. Williamson
发明人： Rosana Kappeller-Libermann , David White , Keith E. Robison , Kyle J. MacBeth , Joseph M. Carroll , William James Cook , Rachel E. Meyers , Miyoung Chun , Mark J. Williamson
IPC分类号： A61K39/395 , A61K38/45 , A61K38/46 , A61K38/48 , C12Q1/68 , G01N33/53 , C12Q1/34 , C12P21/00 , C12N5/10 , C12N5/00 , A61K38/00 , A61K38/17 , A61K31/713 , A61K31/7088 , C07K14/435 , C07K16/40 , C07H21/04 , A61P31/12 , A61P9/00 , A61P35/00 , A61P19/08 , A61P7/00
CPC分类号： G01N33/5008 , A61K38/00 , C12N9/1007 , C12N9/16 , C12N9/6489 , C12Q1/37 , C12Q1/6883 , C12Q2600/158 , C12Y301/04017 , G01N33/5011 , G01N33/502 , G01N33/56983 , G01N33/56994 , G01N33/57426 , G01N33/5761 , G01N33/5767 , G01N33/68 , G01N2333/916 , G01N2333/96486 , G01N2500/04
摘要： The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27875, 22025, 27420, 16319, 55092 and 10218 gene has been introduced or disrupted. The invention still further provides isolated 27875, 22025, 27420, 17906, 16319, 55092 or 10218 proteins, fusion proteins, antigenic peptides and anti-27875, 22025, 27420, 17906, 16319, 55092 or 10218 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为27875,22025,27420,16319,55092和10218核酸分子。本发明还提供反义核酸分子，含有27875,22025,27420,16319,55092和10218核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中27875,22025， 27420,16319,55092和10218基因已被引入或破坏。本发明还进一步提供了分离的27875,22025,27420,17906,16319,55092或10218蛋白，融合蛋白，抗原肽和抗27875,22025,27420,17906,16319,55092或10218抗体。还提供了利用本发明组合物的诊断和治疗方法。

6. 发明授权

US06395889B1 Nucleic acid molecules encoding human protease homologs 失效
标题翻译：编码人类蛋白酶同系物的核酸分子
公开(公告)号：US06395889B1
公开(公告)日：2002-05-28
申请号：US09392184
申请日：1999-09-09
申请人： Keith E. Robison
发明人： Keith E. Robison
IPC分类号： C12N1557
CPC分类号： C12N9/64
摘要： The invention relates to polynucleotides encoding newly identified protease homologs. The invention also relates to the proteases. The invention further relates to methods using the protease polypeptides and polynucleotides as a target for diagnosis and treatment in protease-mediated disorders. The invention further relates to drug-screening methods using the protease polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the protease polypeptides and polynucleotides. The invention further relates to procedures for producing the protease polypeptides and polynucleotides.
摘要翻译：本发明涉及编码新鉴定的蛋白酶同系物的多核苷酸。本发明还涉及蛋白酶。本发明还涉及使用蛋白酶多肽和多核苷酸作为在蛋白酶介导的病症中进行诊断和治疗的靶标的方法。本发明还涉及使用蛋白酶多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。本发明还包括基于蛋白酶多肽和多核苷酸的激动剂和拮抗剂。本发明还涉及产生蛋白酶多肽和多核苷酸的方法。

7. 发明授权

US08211640B2 Identification of a family of secreted proteins in vascular endothelium 失效
标题翻译：鉴定血管内皮分泌蛋白家族
公开(公告)号：US08211640B2
公开(公告)日：2012-07-03
申请号：US12317046
申请日：2008-12-18
申请人： Ruey-Bing Yang , Chi Kin Domingos Ng , James E. Tomlinson , Laszlo G. Komuves , James N. Topper , Keith E. Robison
发明人： Ruey-Bing Yang , Chi Kin Domingos Ng , James E. Tomlinson , Laszlo G. Komuves , James N. Topper , Keith E. Robison
IPC分类号： C12Q1/68 , C12Q1/02 , C12P21/06 , C12N5/00 , C12N5/02 , C12N1/20 , C12N15/12
CPC分类号： C07K14/47 , G01N2333/485
摘要： The invention relates to SCUBE molecules and generally to gene expression in vascular endothelial cells. The invention specifically relates to the discovery of a novel gene family containing the genes and proteins referred to herein as SCUBE1, SCUBE2 and SCUBE3 which can be expressed in endothelial cells. SCUBE proteins may be involved in the development of cardiovascular disease, hemostasis, thrombosis, inflammatory disease, bone metabolism disorders, urinary bladder disorders and breast disorders.
摘要翻译：本发明涉及SCUBE分子，通常涉及血管内皮细胞中的基因表达。本发明具体涉及含有本文所述的可在内皮细胞中表达的SCUBE1，SCUBE2和SCUBE3的基因和蛋白质的新基因家族的发现。 SCUBE蛋白可能参与心血管疾病，止血，血栓形成，炎性疾病，骨代谢障碍，膀胱疾病和乳腺疾病的发展。

8. 发明授权

US07485431B2 Identification of a family of secreted proteins in vascular endothelium 失效
公开(公告)号：US07485431B2
公开(公告)日：2009-02-03
申请号：US11726543
申请日：2007-03-22
申请人： Ruey-Bing Yang , Chi Kin Domingos Ng , James E. Tomlinson , Laszlo G. Komuves , James N. Topper , Keith E. Robison
发明人： Ruey-Bing Yang , Chi Kin Domingos Ng , James E. Tomlinson , Laszlo G. Komuves , James N. Topper , Keith E. Robison
IPC分类号： G01N33/53 , C07K16/00 , C07K16/18 , C07K16/46
CPC分类号： C07K14/47 , G01N2333/485
摘要： The invention relates to SCUBE molecules and generally to gene expression in vascular endothelial cells. The invention specifically relates to the discovery of a novel gene family containing the genes and proteins referred to herein as SCUBE1, SCUBE2 and SCUBE3 which can be expressed in endothelial cells. SCUBE proteins may be involved in the development of cardiovascular disease, hemostasis, thrombosis, inflammatory disease, bone metabolism disorders, urinary bladder disorders and breast disorders.

9. 发明授权

US06465232B1 Nucleic acid molecules encoding human kinase and phosphatase homologues and uses therefor 失效
标题翻译：编码人类激酶和磷酸酶同系物的核酸分子及其用途
公开(公告)号：US06465232B1
公开(公告)日：2002-10-15
申请号：US09948802
申请日：2001-09-07
申请人： Keith E. Robison
发明人： Keith E. Robison
IPC分类号： C12N912
CPC分类号： G01N33/573 , A61K38/00 , C07K2319/00 , C12N9/12 , C12N9/16 , G01N2333/9121 , G01N2500/00
摘要： The invention provides isolated nucleic acids molecules, designated Kinase and Phosphatase nucleic acid molecules, which encode novel protein kinase and protein phosphatase polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing Kinase and Phosphatase nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a Kinase and Phosphatase gene has been introduced or disrupted. The invention still further provides isolated Kinase and Phosphatase proteins, fusion proteins, antigenic peptides and anti-Kinase and Phosphatase antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的蛋白激酶和蛋白磷酸酶多肽的分离的核酸分子，命名为激酶和磷酸酶核酸分子。本发明还提供反义核酸分子，含有激酶和磷酸酶核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中引入或破坏了激酶和磷酸酶基因的非人类转基因动物。本发明还进一步提供了分离的激酶和磷酸酶蛋白，融合蛋白，抗原肽和抗激酶和磷酸酶抗体。还提供了利用本发明组合物的诊断，筛选和治疗方法。

10. 发明授权

US07083944B1 Molecules of the card-related protein family and uses thereof 失效
标题翻译：卡相关蛋白家族的分子及其用途
公开(公告)号：US07083944B1
公开(公告)日：2006-08-01
申请号：US09697089
申请日：2000-10-26
申请人： John Bertin , Keith E. Robison
发明人： John Bertin , Keith E. Robison
IPC分类号： C07K14/47 , C12N15/12 , C12N15/63 , C12N1/00 , C12N5/10
CPC分类号： C07K14/4702 , A61K38/00
摘要： Novel CARD-12 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-12 proteins, the invention further provides CARD-12, fusion proteins, antigenic peptides and anti-CARD-12 antibodies. The invention also provides CARD-12 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CARD-12 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：公开了新型CARD-12多肽，蛋白质和核酸分子。除了分离的CARD-12蛋白之外，本发明还提供了CARD-12，融合蛋白，抗原肽和抗CARD-12抗体。本发明还提供CARD-12核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和其中引入了CARD-12基因的非人转基因动物，或中断了还提供利用本发明组合物的诊断，筛选和治疗方法。

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