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1. 发明授权

US06183962B2 Protein kinase molecules and uses therefor 有权
标题翻译：蛋白激酶分子及其用途
公开(公告)号：US06183962B2
公开(公告)日：2001-02-06
申请号：US09163115
申请日：1998-09-29
申请人： Susan Acton
发明人： Susan Acton
IPC分类号： C12N912
CPC分类号： G01N33/5005 , A01K2217/05 , A61N1/3655 , C07K2319/00 , C12N9/1205 , C12Q1/48 , C12Q1/485 , G01N33/5008 , G01N33/5014 , G01N33/502 , G01N33/68 , G01N33/6893 , G01N2500/00 , G01N2800/32
摘要： The invention provides isolated nucleic acid molecules, designated CSAPK-1 nucleic acid molecules, which encode novel cardiovascular system associated protein kinases. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing CSAPK-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for producing CSAPK-1 polypeptides.
摘要翻译：本发明提供编码新的心血管系统相关蛋白激酶的分离的核酸分子，命名为CSAPK-1核酸分子。本发明还提供反义核酸分子，含有CSAPK-1核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及产生CSAPK-1多肽的方法。

2. 发明授权

US06153417A CSAPK-1 protein and uses therefor 有权
标题翻译： CSAPK-1蛋白并用于此
公开(公告)号：US06153417A
公开(公告)日：2000-11-28
申请号：US221416
申请日：1998-12-28
申请人： Susan Acton
发明人： Susan Acton
IPC分类号： G01N33/50 , A61N1/365 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/09 , C12Q1/48 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/68 , C07H21/04 , C07K1/00
CPC分类号： G01N33/5005 , A61N1/3655 , C12N9/1205 , C12Q1/48 , C12Q1/485 , G01N33/5008 , G01N33/5014 , G01N33/502 , G01N33/68 , G01N33/6893 , A01K2217/05 , C07K2319/00 , G01N2500/00 , G01N2800/32
摘要： The present invention provides a novel protein kinase, CSAPK-1, as well as CSAPK-1 fusion proteins, antigenic peptides and anti-CSAPK-1 antibodies.
摘要翻译：本发明提供新型蛋白激酶CSAPK-1以及CSAPK-1融合蛋白，抗原肽和抗CSAPK-1抗体。

3. 发明申请

US20100273989A1 ANGIOTENSIN CONVERTING ENZYME HOMOLOG AND USES THEREFOR 审中-公开
标题翻译： ANGIOTENSIN转化酶同源异构体及其用途
公开(公告)号：US20100273989A1
公开(公告)日：2010-10-28
申请号：US12340815
申请日：2008-12-22
申请人： Susan Acton , Keith E. Robison , Frank Y. Hsieh
发明人： Susan Acton , Keith E. Robison , Frank Y. Hsieh
IPC分类号： C07K16/18
CPC分类号： A61K38/4813 , C12N9/48 , C12Y304/15001
摘要： The present invention relates to the discovery of novel genes encoding an angiotensin converting enzyme, Angiotensin Converting Enzyme-2 (ACE-2). The invention provides therapeutics, prognostic and diagnostic methods for treating blood pressure related disorders as well as various types of allergic conditions, among others. Also disclosed are screening assays for identifying compounds for treating and preventing these conditions.
摘要翻译：本发明涉及编码血管紧张素转换酶血管紧张素转化酶-2（ACE-2）的新基因的发现。本发明提供了用于治疗血压相关疾病以及各种类型的变态反应病症的治疗，预后和诊断方法。还公开了用于鉴定用于治疗和预防这些病症的化合物的筛选测定。

4. 发明授权

US06268135B1 Phospholipase molecule and uses therefor 失效
标题翻译：磷脂酶分子及其用途
公开(公告)号：US06268135B1
公开(公告)日：2001-07-31
申请号：US09163833
申请日：1998-09-30
申请人： Susan Acton
发明人： Susan Acton
IPC分类号： C12Q168
CPC分类号： C12Y301/03048 , C12N9/16
摘要： Novel CSAPL polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length CSAPL proteins, the invention further provides isolated CSAPL fusion proteins, antigenic peptides and anti-CSAPL antibodies. The invention also provides CSAPL nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CSAPL gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：公开了新型CSAPL多肽，蛋白质和核酸分子。除了分离的全长CSAPL蛋白之外，本发明还提供了分离的CSAPL融合蛋白，抗原肽和抗CSAPL抗体。本发明还提供CSAPL核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和其中CSAPL基因被引入或破坏的非人转基因动物。还提供利用本发明组合物的诊断，筛选和治疗方法。

5. 发明授权

US06258582B1 CSAPTP nucleic acid molecules and uses therefor 失效
标题翻译： CSAPTP核酸分子及其用途
公开(公告)号：US06258582B1
公开(公告)日：2001-07-10
申请号：US09164193
申请日：1998-09-30
申请人： Susan Acton
发明人： Susan Acton
IPC分类号： C12N916
CPC分类号： C12Y301/03048 , C12N9/16
摘要： Novel CSAPTP polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length CSAPTP proteins, the invention further provides isolated CSAPTP fusion proteins, antigenic peptides and anti-CSAPTP antibodies. The invention also provides CSAPTP nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CSAPTP gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：公开了新型CSAPTP多肽，蛋白质和核酸分子。除了分离的全长CSAPTP蛋白之外，本发明还提供了分离的CSAPTP融合蛋白，抗原肽和抗CSAPTP抗体。本发明还提供了CSAPTP核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和已引入或破坏了CSAPTP基因的非人转基因动物。还提供利用本发明组合物的诊断，筛选和治疗方法。

6. 发明授权

US6121030A CSAPK-2 protein and uses therefor 有权
标题翻译：新型CSAPK-2蛋白，用于此
公开(公告)号：US6121030A
公开(公告)日：2000-09-19
申请号：US221928
申请日：1998-12-28
申请人： Susan Acton
发明人： Susan Acton
IPC分类号： G01N33/50 , A61N1/365 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/09 , C12Q1/48 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/68 , C07K1/00 , C12N1/20 , C12N15/00
CPC分类号： G01N33/5005 , A61N1/3655 , C12N9/1205 , C12Q1/48 , C12Q1/485 , G01N33/5008 , G01N33/5014 , G01N33/502 , G01N33/68 , G01N33/6893 , A01K2217/05 , C07K2319/00 , G01N2500/00 , G01N2800/32
摘要： The present invention provides a novel protein kinase, CSAPK-2, as well as CSAPK-2 fusion proteins, antigenic peptides and anti-CSAPK-2 antibodies.
摘要翻译：本发明提供新型蛋白激酶CSAPK-2，以及CSAPK-2融合蛋白，抗原肽和抗CSAPK-2抗体。

7. 发明授权

US07482171B2 Angiotensin converting enzyme homolog and uses therefor 失效
标题翻译：血管紧张素转换酶同源物及其用途
公开(公告)号：US07482171B2
公开(公告)日：2009-01-27
申请号：US11059218
申请日：2005-02-16
申请人： Susan Acton , Keith E. Robison , Frank Y. Hsieh
发明人： Susan Acton , Keith E. Robison , Frank Y. Hsieh
IPC分类号： G01N33/566
CPC分类号： A61K38/4813 , C12N9/48 , C12Y304/15001
摘要： The present invention relates to the discovery of novel genes encoding an angiotensin converting enzyme, Angiotensin Converting Enzyme-2 (ACE-2). The invention provides therapeutics, prognostic and diagnostics methods for treating blood pressure related disorders as well as various types of allergic conditions, among others. Also disclosed are screening assays for identifying compounds for treating and preventing these conditions.
摘要翻译：本发明涉及编码血管紧张素转换酶血管紧张素转化酶-2（ACE-2）的新基因的发现。本发明提供了用于治疗血压相关疾病以及各种类型的变态反应病症的治疗，预后和诊断方法。还公开了用于鉴定用于治疗和预防这些病症的化合物的筛选测定。

8. 发明授权

US06884771B1 Angiotensin converting enzyme homolog and uses therefor 有权
标题翻译：血管紧张素转换酶同源物及其用途
公开(公告)号：US06884771B1
公开(公告)日：2005-04-26
申请号：US09635501
申请日：2000-08-09
申请人： Susan Acton , Keith E. Robison , Frank Y. Hsieh
发明人： Susan Acton , Keith E. Robison , Frank Y. Hsieh
IPC分类号： A61K38/00 , A61K38/48 , C12N9/48 , C12N15/12 , A51K38/00
CPC分类号： A61K38/4813 , C12N9/48 , C12Y304/15001
摘要： The present invention relates to the discovery of novel genes encoding an angiotensin converting enzyme, Angiotensin Converting Enzyme-2 (ACE-2). The invention provides therapeutics, prognostic and diagnostics methods for treating blood pressure related disorders as well as various types of allergic conditions, among others. Also disclosed are screening assays for identifying compounds for treating and preventing these conditions.
摘要翻译：本发明涉及编码血管紧张素转换酶血管紧张素转化酶-2（ACE-2）的新基因的发现。本发明提供了用于治疗血压相关疾病以及各种类型的变态反应病症的治疗，预后和诊断方法。还公开了用于鉴定用于治疗和预防这些病症的化合物的筛选测定。

9. 发明申请

US20050037946A1 Methods and compositions for treating cardiovascular disease using 1722, 10280, 59917, 85553, 10653, 9235, 21668, 17794, 2210, 6169, 10102, 21061, 17662, 1468, 12282, 6350, 9035, 1820, 23652, 7301, 8925, 8701, 3533, 9462, 9123, 12788, 17729, 65552, 1261, 21476, 33770, 9380, 2569654, 33556, 53656, 44143, 32612, 10671, 261, 44570, 41922, 2552, 2417, 19319, 43969, 8921, 8993, 955, 32345, 966, 1920, 17318, 1510, 14180, 26005, 554, 16408, 42028, 112091, 13886, 13942, 1673, 54946 or 2419 审中-公开
公开(公告)号：US20050037946A1
公开(公告)日：2005-02-17
申请号：US10753267
申请日：2004-01-08
申请人： Nancy Stagliano , Aileen Healy , Susan Acton , Katherine Galvin , Mary Donoghue , Amelie Rodrigue-Way , James Tomlinson
发明人： Nancy Stagliano , Aileen Healy , Susan Acton , Katherine Galvin , Mary Donoghue , Amelie Rodrigue-Way , James Tomlinson
IPC分类号： C07K14/47 , A61K31/00
CPC分类号： C07K14/47
摘要： The present invention relates to methods for the diagnosis and treatment of cardiovascular disease, including, but not limited to, atherosclerosis, reperfusion injury, hypertension, restenosis, arterial inflammation, thrombosis and endothelial cell disorders. Specifically, the present invention identifies the differential expression of 1722, 10280, 59917, 85553, 10653, 9235, 21668, 17794, 2210, 6169, 10102, 21061, 17662, 1468, 12282, 6350, 9035, 1820, 23652, 7301, 8925, 8701, 3533, 9462, 9123, 12788, 17729, 65552, 1261, 21476, 33770, 9380, 2569654, 33556, 53656, 44143, 32612, 10671, 261, 44570, 41922, 2552, 2417, 19319, 43969, 8921, 8993, 955, 32345, 966, 1920, 17318, 1510, 14180, 26005, 554, 16408, 42028, 112091, 13886, 13942, 1673, 54946 and 2419 genes in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. The present invention describes methods for the diagnostic evaluation and prognosis of various cardiovascular diseases, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating cardiovascular disease. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.

10. 发明申请

US20050027108A1 Novel protein kinase molecules and uses therefor 失效
标题翻译：新型蛋白激酶分子及其用途
公开(公告)号：US20050027108A1
公开(公告)日：2005-02-03
申请号：US10786501
申请日：2004-02-25
申请人： Susan Acton
发明人： Susan Acton
IPC分类号： G01N33/50 , A61N1/365 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/09 , C12Q1/48 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/68 , A01K67/00 , C07H21/04
CPC分类号： G01N33/5005 , A01K2217/05 , A61N1/3655 , C07K2319/00 , C12N9/1205 , C12Q1/48 , C12Q1/485 , G01N33/5008 , G01N33/5014 , G01N33/502 , G01N33/68 , G01N33/6893 , G01N2500/00 , G01N2800/32
摘要： The invention provides isolated nucleic acids molecules, designated CSAPK nucleic acid molecules, which encode novel protein kinases. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing CSAPK nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a CSAPK gene has been introduced or disrupted. The invention still further provides isolated CSAPK proteins, fusion proteins, antigenic peptides and anti-CSAPK antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新型蛋白激酶的分离的核酸分子，命名为CSAPK核酸分子。本发明还提供反义核酸分子，含有CSAPK核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及其中引入或破坏了CSAPK基因的非人类转基因动物。本发明还进一步提供了分离的CSAPK蛋白，融合蛋白，抗原肽和抗CSAPK抗体。还提供了利用本发明组合物的诊断，筛选和治疗方法。

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