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1. 发明授权

US06280994B1 Zace 1: a human metalloenzyme 失效
标题翻译： Zace 1：人类金属酶
公开(公告)号：US06280994B1
公开(公告)日：2001-08-28
申请号：US09440325
申请日：1999-11-15
申请人： Paul O. Sheppard
发明人： Paul O. Sheppard
IPC分类号： C12N1557
CPC分类号： C12N9/6489 , A61K38/00 , A61K48/00 , C07K2319/00 , C12Y304/15001
摘要： Angiotensin-converting enzyme is a zinc metallopeptidase that plays roles in blood pressure regulation and fertility. The catalytic activities of angiotensin converting enzymes include the production of the potent vasopressor angiotensin II from angiotensin I, and the inactivation of the vasodilatory peptide bradykinin. Zace1 is a new form of human zinc metallopeptidase, which includes one zinc-dependent catalytic domain containing the motif “HEXXH” and one downstream “EX(I/V)X(D/S)” motif.
摘要翻译：血管紧张素转换酶是在血压调节和生育力中发挥作用的锌金属肽酶。血管紧张素转换酶的催化活性包括从血管紧张素I产生有效的血管加压素血管紧张素II，以及血管扩张肽缓激肽的失活。 Zace1是人类锌金属肽酶的新形式，其包括一个含有HEXXH基序和一个下游“EX（I / V）X（D / S）”基序的锌依赖性催化结构域。

2. 发明授权

US06399349B1 Human aminopeptidase P gene 有权
标题翻译：人类氨基肽酶P基因
公开(公告)号：US06399349B1
公开(公告)日：2002-06-04
申请号：US09146053
申请日：1998-09-02
申请人： James W. Ryan , Terry Joe Curtis Sprinkle
发明人： James W. Ryan , Terry Joe Curtis Sprinkle
IPC分类号： C12N1557
CPC分类号： C12N9/48
摘要： Disclosed are the human aminopeptidase P cDNA and genomic DNA. Also disclosed is the human aminopeptidase P protein and antibodies reactive with human aminopeptidase P. These molecules, and derivatives of these molecules, are useful for assay for detecting aminopeptidase polymorphisms, protein variants, and activity, and identifying compounds that inhibit expression of aminopeptidase genes and activity of aminopeptidase protein.
摘要翻译：公开了人类氨基肽酶P cDNA和基因组DNA。还公开了人氨基肽酶P蛋白和与人氨基肽酶P反应的抗体。这些分子和这些分子的衍生物可用于检测氨基肽酶多态性，蛋白质变体和活性的测定，以及鉴定抑制氨基肽酶基因表达的化合物和氨肽酶蛋白的活性。

3. 发明授权

US06344353B1 Isolated human protease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof 失效
公开(公告)号：US06344353B1
公开(公告)日：2002-02-05
申请号：US09740035
申请日：2000-12-20
申请人： Jane Ye , Valentina Di Francesco , Ellen M. Beasley
发明人： Jane Ye , Valentina Di Francesco , Ellen M. Beasley
IPC分类号： C12N1557
CPC分类号： C12N9/6421
摘要： The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the protease peptides, and methods of identifying modulators of the protease peptides.

4. 发明授权

US06319702B1 Nucleic acids encoding mutant human carboxypeptidase A enzymes 失效
标题翻译：编码突变体人羧肽酶A酶的核酸
公开(公告)号：US06319702B1
公开(公告)日：2001-11-20
申请号：US09395936
申请日：1999-09-14
申请人： Gary Keith Smith , Todd Andrew Blumenkopf , Michael Cory
发明人： Gary Keith Smith , Todd Andrew Blumenkopf , Michael Cory
IPC分类号： C12N1557
CPC分类号： B82Y5/00 , A61K38/00 , A61K47/67 , A61K47/6899 , C12N9/48 , C12N9/96
摘要： The present invention relates to nucleic acid molecules encoding mutant human carboxypeptidase A enzymes, and encoding conjugates of targeting molecules and mutant human carboxypeptidase A enzymes. The invention further relates to vectors and cell lines containing such nucleic acid molecules.
摘要翻译：本发明涉及编码突变型人羧肽酶A酶的核酸分子，以及编码靶向分子和突变型人羧肽酶A酶的缀合物。本发明还涉及含有这种核酸分子的载体和细胞系。

5. 发明授权

US06271361B1 Apoptotic protease Mch6, nucleic acids encoding same and methods of use 有权
公开(公告)号：US06271361B1
公开(公告)日：2001-08-07
申请号：US09257218
申请日：1999-02-25
申请人： Emad S. Alnemri , Teresa Fernandes-Alnemri , Gerald Litwack
发明人： Emad S. Alnemri , Teresa Fernandes-Alnemri , Gerald Litwack
IPC分类号： C12N1557
CPC分类号： C12N9/6475 , C07K16/40
摘要： The invention provides an isolated gene encoding Mch6 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch6 or functional fragments thereof. The gene or nucleic acid sequences can be single or double stranded nucleic acids corresponding to coding or non-coding strands of the Mch6 nucleotide sequences. The invention further provides an isolated Mch6 polypeptide and isolated large and small subunits of the Mch6 polypeptide, including functional fragments thereof.

6. 发明授权

US06203979B1 Human protease molecules 失效
标题翻译：人类蛋白酶分子
公开(公告)号：US06203979B1
公开(公告)日：2001-03-20
申请号：US09008271
申请日：1998-01-16
申请人： Olga Bandman , Jennifer L. Hillman , Henry Yue , Karl J. Guegler , Neil C. Corley , Y. Tom Tang , Purvi Shah
发明人： Olga Bandman , Jennifer L. Hillman , Henry Yue , Karl J. Guegler , Neil C. Corley , Y. Tom Tang , Purvi Shah
IPC分类号： C12N1557
CPC分类号： C12N9/6424 , A61K38/00 , C12N9/48 , C12N9/6472 , C12N9/6478
摘要： The invention provides human protease molecules (HUPM) and polynucleotides which identify and encode HUPM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HUPM.
摘要翻译：本发明提供了人类蛋白酶分子（HUPM）和识别和编码HUPM的多核苷酸。本发明还提供了表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供了治疗或预防与HUPM表达相关的病症的方法。

7. 发明授权

US06835821B2 Useful mutations of bacterial alkaline protease 失效
公开(公告)号：US06835821B2
公开(公告)日：2004-12-28
申请号：US10310730
申请日：2002-12-05
申请人： Sven Hastrup , Sven Branner , Fanny Norris , Steffen Bjorn Petersen , Leif Nørskov-Lauridsen , Villy Johannes Jensen , Dorrit Aaslyng
发明人： Sven Hastrup , Sven Branner , Fanny Norris , Steffen Bjorn Petersen , Leif Nørskov-Lauridsen , Villy Johannes Jensen , Dorrit Aaslyng
IPC分类号： C12N1557
CPC分类号： C11D3/386 , C12N9/54
摘要： The present invention relates to mutations of a subtilisin gene which result in changes in the chemical characteristics of subtilisin enzymes. Mutations at specific nucleic acids of the subtilisin gene result in amino acid substitutions and consequently, altered enzyme function. Some of these mutant enzymes exhibit physical properties advantageous to industrial applications, particularly in the detergent industry, providing subtilisin which is more stable to oxidation, possesses greater protease activity, and exhibits improved washability.

8. 发明授权

US06573077B1 Active site of human gamma glutamyl hydrolase 失效
标题翻译：人γ谷氨酰水解酶的活性位点
公开(公告)号：US06573077B1
公开(公告)日：2003-06-03
申请号：US09326157
申请日：1999-06-04
申请人： John H. Galivan , Thomas J. Ryan , Ivan E. Auger
发明人： John H. Galivan , Thomas J. Ryan , Ivan E. Auger
IPC分类号： C12N1557
CPC分类号： C12N9/48 , A61K48/00
摘要： Provided is the active site of human gamma glutamyl hydrolase. The active site resides in amino acid residues 110, 171, 220 and 222 of SEQ ID NO:1. Thus provided is an inactive gamma glutamyl hydrolase protein, as well as a fragment thereof. A method of inactivating a gamma glutamyl hydrolase protein is also provided, as is a molecule capable of binding to one or more of amino acid residues 110, 171, 220 or 222 of SEQ ID NO:1 which can be used in such a method. A method for identifying a molecule that inactivates gamma glutamyl hydrolase is provided, as is a nucleic acid molecule encoding the inactive gamma glutamyl hydrolase.
摘要翻译：提供人γ谷氨酰水解酶的活性位点。活性位点位于SEQ ID NO：1的氨基酸残基110,171,220和222中。因此提供了无活性的γ谷氨酰水解酶蛋白及其片段。还提供灭活γ谷氨酰水解酶蛋白的方法，以及能够结合可以用于该方法的SEQ ID NO：1的氨基酸残基110,171,220或222的一个或多个的分子。提供了用于鉴定灭活γ谷氨酰水解酶的分子的方法，以及编码无活性γ谷氨酰水解酶的核酸分子。

9. 发明授权

US06232456B1 Serine protease reagents and methods useful for detecting and treating diseases of the prostate 失效
标题翻译：丝氨酸蛋白酶试剂和用于检测和治疗前列腺疾病的方法
公开(公告)号：US06232456B1
公开(公告)日：2001-05-15
申请号：US08944483
申请日：1997-10-06
申请人： Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Edward Granados , Michael R. Klass , John C. Russell , Kent D. Stewart , Stephen D. Stroupe
发明人： Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Edward Granados , Michael R. Klass , John C. Russell , Kent D. Stewart , Stephen D. Stroupe
IPC分类号： C12N1557
CPC分类号： C12N9/6424
摘要： A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS133 and transcribed from prostate tissue is described. One polypeptide of the present invention is a member of the human serine protease family. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS133-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS133 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.
摘要翻译：描述了一组连续和部分重叠的RNA序列和由此编码的多肽，命名为PS133并从前列腺组织转录。本发明的一种多肽是人丝氨酸蛋白酶家族的成员。这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对前列腺疾病和病症如前列腺癌的倾向。还提供了特异性结合PS133编码的多肽或蛋白质的抗体，以及预防组织特异性PS133多肽的作用的激动剂或抑制剂，该分子可用于治疗前列腺疾病，肿瘤或转移瘤。

10. 发明授权

US06221657B1 Modified human C3 DNA sequences and vectors 失效
标题翻译：修饰的人C3 DNA序列和载体
公开(公告)号：US06221657B1
公开(公告)日：2001-04-24
申请号：US09132271
申请日：1998-08-11
申请人： Richard Alexander Harrison , Timothy Charles Farries
发明人： Richard Alexander Harrison , Timothy Charles Farries
IPC分类号： C12N1557
CPC分类号： C07K14/472
摘要： This invention is directed to DNA sequences encoding narrative complement pathway proteins modified such that the protein is capable of forming a stable C3 convertase. The modified C3 proteins are useful in therapy.
摘要翻译：本发明涉及编码修饰的叙述性补体途径蛋白质的DNA序列，使得蛋白质能够形成稳定的C3转化酶。经修饰的C3蛋白可用于治疗。

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