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1. 发明申请

US20100098713A1 NOVEL 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 AND 65577 MOLECULES AND USES THEREFOR 失效
标题翻译：新颖的27877,18080,14081,32140,50352,16658,14223,16002,50566,655552和65577分子及其用途
公开(公告)号：US20100098713A1
公开(公告)日：2010-04-22
申请号：US12559673
申请日：2009-09-15
申请人： Rachel E. Meyers , Joseph M. Carroll , William James Cook , Rosana Kapeller-Libermann , Nadine S. Welch , Rajasekhar Bandaru
发明人： Rachel E. Meyers , Joseph M. Carroll , William James Cook , Rosana Kapeller-Libermann , Nadine S. Welch , Rajasekhar Bandaru
IPC分类号： A61K39/395 , C07H21/00 , C12N1/00 , C12N5/00 , C07K14/00 , C07K16/00 , C12P21/00 , G01N33/53 , G01N33/48 , G01N33/68 , A61K38/02 , A61K38/16 , A61K31/7052 , A61P35/00 , A61P25/00 , A61P7/00 , A61P19/00 , A61P21/00 , A61P9/00
CPC分类号： A61K38/16 , A01K2217/05 , A61K38/4813 , A61K39/00 , A61K2039/53 , C07K14/47 , C07K2319/00 , C12N9/0008 , C12N9/12 , C12N9/16 , C12N9/20 , C12N9/6416 , C12N9/6424 , C12N9/6491 , C12N9/93 , C12Q1/25 , C12Q1/37 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Y603/02019 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/573 , G01N33/68 , G01N2500/10 , Y10T436/143333 , A61K2300/00
摘要： The invention provides isolated nucleic acids molecules, designated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 gene has been introduced or disrupted. The invention still further provides isolated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 proteins, fusion proteins, antigenic peptides and anti-27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为27877,18080,14081,32140,50352,16658,14223,16002,50566,65552和65577核酸分子。本发明还提供反义核酸分子，含有27877,18080,14081,32140,50502,16658,14223,16002,50566,65552和65577核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及已经引入或破坏了27877,18080,14081,32140,50352,16658,14223,16002,50566,65552或65577基因的非人类转基因动物。本发明还进一步提供分离的27877,18080,14081,32140,50352,16658,14223,16002,50566,65552或65577蛋白，融合蛋白，抗原肽和抗27877,18080,14081,32140,50352,16658,14223 ，16002,50566,65552或65577抗体。还提供了利用本发明组合物的诊断和治疗方法。

2. 发明申请

US20090280482A1 Novel nucleic acid sequences encoding adenylate kinases, alcohol dehydrogenases, ubiquitin proteases, lipases, adenylate cyclases, and GTPase activators 审中-公开
标题翻译：编码腺苷酸激酶，醇脱氢酶，泛素蛋白酶，脂肪酶，腺苷酸环化酶和GTP酶激活剂的新型核酸序列
公开(公告)号：US20090280482A1
公开(公告)日：2009-11-12
申请号：US12001737
申请日：2007-12-12
申请人： Maria Alexandra Glucksmann , Rosana Kapeller-Libermann , Rachel E. Meyers , Miyoung Chun
发明人： Maria Alexandra Glucksmann , Rosana Kapeller-Libermann , Rachel E. Meyers , Miyoung Chun
IPC分类号： C12Q1/68 , C07H21/04 , C12N15/63 , C12N5/00 , C07K14/00 , C07K16/00 , C12P21/06 , G01N33/53
CPC分类号： C12N9/6472
摘要： The invention provides isolated nucleic acids molecules that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a sequence of the invention has been introduced or disrupted. The invention still further provides isolated proteins, fusion proteins, antigenic peptides and antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新多肽的分离的核酸分子。本发明还提供了反义核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及本发明的序列已被引入或破坏的非人类转基因动物。本发明还进一步提供分离的蛋白质，融合蛋白，抗原肽和抗体。还提供了利用本发明组合物的诊断方法。

3. 发明授权

US07351566B2 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552, and 65577 molecules and uses therefor 失效
标题翻译： 27877,18080,14081,32140,50352,16658,14223,16002,50566,655552和65577分子及其用途
公开(公告)号：US07351566B2
公开(公告)日：2008-04-01
申请号：US11429599
申请日：2006-05-05
申请人： Rachel E. Meyers , Joseph M. Carroll , William James Cook , Rosana Kapeller-Libermann , Nadine S. Weich , Rajasekhar Bandaru
发明人： Rachel E. Meyers , Joseph M. Carroll , William James Cook , Rosana Kapeller-Libermann , Nadine S. Weich , Rajasekhar Bandaru
IPC分类号： C12N9/12 , C12N5/00 , C07H21/04
CPC分类号： A61K38/16 , A01K2217/05 , A61K38/4813 , A61K39/00 , A61K2039/53 , C07K14/47 , C07K2319/00 , C12N9/0008 , C12N9/12 , C12N9/16 , C12N9/20 , C12N9/6416 , C12N9/6424 , C12N9/6491 , C12N9/93 , C12Q1/25 , C12Q1/37 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Y603/02019 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/573 , G01N33/68 , G01N2500/10 , Y10T436/143333 , A61K2300/00
摘要： The invention provides isolated nucleic acids molecules, designated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 gene has been introduced or disrupted. The invention still further provides isolated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 proteins, fusion proteins, antigenic peptides and anti-27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为27877,18080,14081,32140,50352,16658,14223,16002,50566,65552和65577核酸分子。本发明还提供反义核酸分子，含有27877,18080,14081,32140,50502,16658,14223,16002,50566,65552和65577核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及已经引入或破坏了27877,18080,14081,32140,50352,16658,14223,16002,50566,65552或65577基因的非人类转基因动物。本发明还进一步提供分离的27877,18080,14081,32140,50352,16658,14223,16002,50566,65552或65577蛋白，融合蛋白，抗原肽和抗27877,18080,14081,32140,50352,16658,14223 ，16002,50566,65552或65577抗体。还提供了利用本发明组合物的诊断和治疗方法。

4. 发明授权

US07282360B2 Human protein kinase, phosphatase, and protease family members and uses thereof 失效
标题翻译：新型人类蛋白激酶，磷酸酶和蛋白酶家族成员及其用途
公开(公告)号：US07282360B2
公开(公告)日：2007-10-16
申请号：US11636948
申请日：2006-12-11
申请人： Rachel E. Meyers , Peter J. Olandt , Rosana Kapeller-Libermann , Rory A. J. Curtis , Mark Williamson , Nadine Weich
发明人： Rachel E. Meyers , Peter J. Olandt , Rosana Kapeller-Libermann , Rory A. J. Curtis , Mark Williamson , Nadine Weich
IPC分类号： C12N9/20 , C12N15/00 , C12N1/20 , C12Q1/68 , C07H21/04
CPC分类号： C12N9/1205 , A61K38/00 , C07K16/40 , C12N9/12 , C12N9/16 , C12N9/48 , C12N9/6424 , C12N9/6427 , C12N9/6472 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156
摘要： The invention provides isolated nucleic acids molecules, designated 53070, 15985, 26583, 21953, m32404, 14089, and 23436 nucleic acid molecules, which encode novel human protein kinase family members, serine/threonine protein kinase family members, serine/threonine phosphatase family members, prolyl oligopeptidase family members, trypsin family members, trypsin serine protease family members, and ubiquitin protease family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 53070, 15985, 26583, 21953, m32404, 14089, or 23436 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 53070, 15985, 26583, 21953, m32404, 14089, or 23436 gene has been introduced or disrupted. The invention still further provides isolated 53070, 15985, 26583, 21953, m32404, 14089, or 23436 proteins, fusion proteins, antigenic peptides and anti-53070, 15985, 26583, 21953, m32404, 14089, or 23436 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为53070,15985,26583,21953，m32404,14089和23436核酸分子，其编码新的人类蛋白激酶家族成员，丝氨酸/苏氨酸蛋白激酶家族成员，丝氨酸/苏氨酸磷酸酶家族成员，脯氨酰寡肽酶家族成员，胰蛋白酶家族成员，胰蛋白酶丝氨酸蛋白酶家族成员和泛素蛋白酶家族成员。本发明还提供反义核酸分子，含有53070,15985,26583,21953，m32404,14089或23436核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中53070 ，15985,26583,21953，m32404,14089或23436基因已被引入或破坏。本发明还进一步提供了分离的53070,15985,26583,21953，m32404,14089或23436蛋白，融合蛋白，抗原肽和抗-53070,15985,26583,21953，m32404,14089或23436抗体。还提供了利用本发明组合物的诊断方法。

5. 发明授权

US07256010B2 Nucleic acid sequences encoding melanoma associated antigen molecules, aminotransferase molecules, ATPase molecules, acyltransferase molecules, pyridoxal-phosphate dependant enzyme molecules and uses therefor 失效
标题翻译：编码黑素瘤相关抗原分子，氨基转移酶分子，ATP酶分子，酰基转移酶分子，吡哆醛 - 磷酸依赖性酶分子的核酸序列及其用途
公开(公告)号：US07256010B2
公开(公告)日：2007-08-14
申请号：US11245400
申请日：2005-10-06
申请人： Rajasekhar Bandaru , Maria Alexandra Glucksmann , Rachel E. Meyers , Laura A. Rudolph-Owen
发明人： Rajasekhar Bandaru , Maria Alexandra Glucksmann , Rachel E. Meyers , Laura A. Rudolph-Owen
IPC分类号： C12Q11/48 , C12N9/10 , C07H21/04 , C07K1/00
CPC分类号： G01N33/5743 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/47 , C07K14/4748 , C07K2319/00 , C12N9/1029 , C12N9/1096 , C12N9/14 , C12N9/90
摘要： The invention provides isolated nucleic acids molecules that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a sequence of the invention has been introduced or disrupted. The invention still further provides isolated proteins, fusion proteins, antigenic peptides and antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新多肽的分离的核酸分子。本发明还提供了反义核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及本发明的序列已被引入或破坏的非人类转基因动物。本发明还进一步提供分离的蛋白质，融合蛋白，抗原肽和抗体。还提供了利用本发明组合物的诊断方法。

6. 发明授权

US06911317B2 2150, human protein kinase family member and uses therefor 失效
标题翻译： 2150，人类蛋白激酶家族成员及其用途
公开(公告)号：US06911317B2
公开(公告)日：2005-06-28
申请号：US10184563
申请日：2002-06-27
申请人： Rachel E. Meyers , Jose M. Lora
发明人： Rachel E. Meyers , Jose M. Lora
IPC分类号： C12N9/12 , C12Q1/48 , C12N1/20 , C12N9/20 , C12N15/00 , C12Q1/68
CPC分类号： C12N9/12 , C07K2319/00 , C12N9/1205
摘要： The invention provides isolated nucleic acids molecules, designated 2150 nucleic acid molecules, which encode novel protein kinase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 2150 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 2150 gene has been introduced or disrupted. The invention still further provides isolated 2150 proteins, fusion proteins, antigenic peptides and anti-2150 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的蛋白激酶家族成员的分离的命名为2150个核酸分子的核酸分子。本发明还提供了反义核酸分子，含有2150个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及2150基因被引入或被破坏的非人类转基因动物。本发明还进一步提供分离的2150蛋白，融合蛋白，抗原肽和抗-2150抗体。还提供了利用本发明组合物的诊断和治疗方法。

7. 发明申请

US20110182879A1 NOVEL HUMAN TRANSFERASE FAMILY MEMBERS AND USES THEREOF 失效
标题翻译：新人类转移家族成员及其用途
公开(公告)号：US20110182879A1
公开(公告)日：2011-07-28
申请号：US12828319
申请日：2010-07-01
申请人： Rachel E. Meyers , Mark Williamson , Kevin R. Leiby , Rosana Kapeller-Libermann , Peter J. Olandt , Kyle J. MacBeth , Laura A. Rudolph-Owen , Fong-Ying Tsai , John J. Hunter
发明人： Rachel E. Meyers , Mark Williamson , Kevin R. Leiby , Rosana Kapeller-Libermann , Peter J. Olandt , Kyle J. MacBeth , Laura A. Rudolph-Owen , Fong-Ying Tsai , John J. Hunter
IPC分类号： A61K39/395 , C07H21/04 , C12N5/10 , C07K14/435 , C07K16/18 , C12P21/02 , G01N33/50 , G01N33/53 , A61K38/02 , A61P43/00
CPC分类号： C12Q1/6883 , A01K2217/05 , A61K38/00 , A61K39/00 , C07K14/47 , C07K16/40 , C07K2319/00 , C12N9/1007 , C12N9/1025 , C12N9/1029 , C12N9/1048 , C12N9/1051 , C12N9/1096 , C12N9/93 , C12Q1/48 , C12Q2600/156 , C12Q2600/158 , C12Y602/01001 , C12Y602/01016
摘要： The invention provides isolated nucleic acids molecules, designated 33877, 47179, 26886, 46743, 27417, 32252, and 53320 nucleic acid molecules, which encode novel human transferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 33877, 47179, 26886, 46743, 27417, 32252, or 53320 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 33877, 47179, 26886, 46743, 27417, 32252, or 53320 gene has been introduced or disrupted. The invention still further provides isolated 33877, 47179, 26886, 46743, 27417, 32252, or 53320 proteins, fusion proteins, antigenic peptides and anti-33877, 47179, 26886, 46743, 27417, 32252, or 53320 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的人转移酶家族成员的分离的核酸分子，命名为33877,47179,26886,4673,27417,32252和53320核酸分子。本发明还提供反义核酸分子，含有33877,47179,26886,4673,27417,32252或53320核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及非人类转基因动物，其中33877 ，47179,26886,46743,27417,32.252或53320基因已被引入或破坏。本发明还进一步提供了分离的33877,47179,26886,46743,27417,32252或53320蛋白，融合蛋白，抗原肽和抗33877,47179,26886,46743,27417,32252或53320抗体。还提供了利用本发明组合物的诊断方法。

8. 发明申请

US20110092388A1 COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF BREAST CANCER 审中-公开
标题翻译：乳腺癌的鉴定，评估，预防和治疗的组合物，试剂盒和方法
公开(公告)号：US20110092388A1
公开(公告)日：2011-04-21
申请号：US12953099
申请日：2010-11-23
申请人： JAMES LILLIE , Manjula Gannavarapu , Karen Glatt , Sebastian Hoersch , Shubhangi Kamatkar , Maureen Mertens Hattersley , John E. Monahan , Vickesh Myer , Youzhen Wang , Yong Yao Xu , Xumei Zhao , Rachel E. Meyers , Robert C. Bast, JR. , Gabriel N. Hortobagyi , Lajos Pusztai
发明人： JAMES LILLIE , Manjula Gannavarapu , Karen Glatt , Sebastian Hoersch , Shubhangi Kamatkar , Maureen Mertens Hattersley , John E. Monahan , Vickesh Myer , Youzhen Wang , Yong Yao Xu , Xumei Zhao , Rachel E. Meyers , Robert C. Bast, JR. , Gabriel N. Hortobagyi , Lajos Pusztai
IPC分类号： C40B30/04 , G01N33/53 , C12Q1/68 , C07H21/00 , C12N15/63 , C12N5/10 , C07K14/47 , C12N9/88 , C12N9/02 , C12N9/90 , C07K16/18 , C07K16/40 , G01N33/566
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： The invention relates to newly discovered nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided.
摘要翻译：本发明涉及新发现的与乳腺癌相关的核酸分子和蛋白质。提供了用于检测，表征，预防和治疗人乳腺癌的组合物，试剂盒和方法。

9. 发明授权

US07879989B2 16836, A human phospholipase C family member, nucleic acids and uses thereof 失效
标题翻译： 16836，人类磷脂酶C家族成员，核酸及其用途
公开(公告)号：US07879989B2
公开(公告)日：2011-02-01
申请号：US11980299
申请日：2007-10-30
申请人： Rachel E. Meyers , John J. Hunter
发明人： Rachel E. Meyers , John J. Hunter
IPC分类号： C07H21/04 , C12N5/00 , C12N15/00
CPC分类号： C12N9/1205 , A01K2217/05 , A61K48/00 , C07K2319/00
摘要： The invention provides isolated nucleic acids molecules, designated 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 and 32252 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 and 32252 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 or 32252 gene has been introduced or disrupted. The invention still further provides isolated 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 or 32252 proteins, fusion proteins, antigenic peptides and anti-13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 or 32252 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为13237,18480,2225,16228,7677,26320,4619,33166,16836,46867,21617,55562,39228,62088,46745,23155,21657,42755,32229,22325,46863 和32252个核酸分子。本发明还提供反义核酸分子，重组表达载体，其含有13237,18480,2245,16228,7677,26320,4619,33166,16836,46867,21617,55562,39228,62088,46745,23155,216575,42755,32229 ，22325,46863和32252核酸分子，其中引入了表达载体的宿主细胞，以及非人类转基因动物，其中13237,18480,2362,46169,3677,26320,46869,38166,16836,46867,21617,26173,26169，已经引入或破坏了55562,39228,62088,4675,23155,21657,42755,32229,22325,46863或32252基因。本发明还进一步提供分离的13237,18480,2225,16228,7677,26320,4619,33166,16836,46867,21617,55562,39228,62088,46745,23155,21657,42755,32229,22325,46863或32252蛋白质，融合蛋白，抗原肽和抗-13237,18480,2225,16228,7677,26320,4619,33166,16836,46867,21617,55562,39228,62088,46745,23155,216547,42755,32229,22325,46863 或32252抗体。还提供了利用本发明组合物的诊断和治疗方法。

10. 发明授权

US07867729B2 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 molecules and uses therefor 失效
标题翻译： 27877,18080,14081,32140,50352,16658,14223,16002,50566,65552和65577分子及其用途
公开(公告)号：US07867729B2
公开(公告)日：2011-01-11
申请号：US12559673
申请日：2009-09-15
申请人： Rachel E. Meyers , William J. Cook
发明人： Rachel E. Meyers , William J. Cook
IPC分类号： C12Q1/32 , C12N9/04
CPC分类号： A61K38/16 , A01K2217/05 , A61K38/4813 , A61K39/00 , A61K2039/53 , C07K14/47 , C07K2319/00 , C12N9/0008 , C12N9/12 , C12N9/16 , C12N9/20 , C12N9/6416 , C12N9/6424 , C12N9/6491 , C12N9/93 , C12Q1/25 , C12Q1/37 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Y603/02019 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/573 , G01N33/68 , G01N2500/10 , Y10T436/143333 , A61K2300/00
摘要： The invention provides isolated nucleic acids molecules, designated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 gene has been introduced or disrupted. The invention still further provides isolated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 proteins, fusion proteins, antigenic peptides and anti-27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为27877,18080,14081,32140,50352,16658,14223,16002,50566,65552和65577核酸分子。本发明还提供反义核酸分子，含有27877,18080,14081,32140,50502,16658,14223,16002,50566,65552和65577核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及已经引入或破坏了27877,18080,14081,32140,50352,16658,14223,16002,50566,65552或65577基因的非人类转基因动物。本发明还进一步提供分离的27877,18080,14081,32140,50352,16658,14223,16002,50566,65552或65577蛋白，融合蛋白，抗原肽和抗27877,18080,14081,32140,50352,16658,14223 ，16002,50566,65552或65577抗体。还提供了利用本发明组合物的诊断和治疗方法。

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