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1. 发明授权

US08144410B2 Multimodal optical imaging 有权
标题翻译：多模光学成像
公开(公告)号：US08144410B2
公开(公告)日：2012-03-27
申请号：US12263673
申请日：2008-11-03
申请人： Siavash Yazdanfar , Vernon Thomas Jensen , Stephen Johnson Lomnes
发明人： Siavash Yazdanfar , Vernon Thomas Jensen , Stephen Johnson Lomnes
IPC分类号： G02B5/22 , A61B1/06
CPC分类号： G02B5/189 , G02B5/20 , G02B5/201 , G02B7/006 , G02B26/008 , G02B26/0875
摘要： Multimodal optical imaging is disclosed. Possible devices include a filter assembly that is capable of rotary action during real time image acquisition. Systems are disclosed that include such filter assemblies, which are detachable or integrated in the systems. Various techniques for capturing image targets using multiple light sources such as white light and fluorescent light are also disclosed.
摘要翻译：公开了多模光学成像。可能的设备包括在实时图像采集期间能够旋转动作的过滤器组件。公开了包括这样的过滤器组件的系统，其可拆卸或集成在系统中。还公开了使用多个光源（例如白光和荧光）捕获图像目标的各种技术。

2. 发明申请

US20100111353A1 MULTIMODAL OPTICAL IMAGING 有权
标题翻译：多模光学成像
公开(公告)号：US20100111353A1
公开(公告)日：2010-05-06
申请号：US12263677
申请日：2008-11-03
申请人： Siavash Yazdanfar , Vernon Thomas Jensen , Stephen Johnson Lomnes
发明人： Siavash Yazdanfar , Vernon Thomas Jensen , Stephen Johnson Lomnes
IPC分类号： G06K9/00
CPC分类号： G02B26/008 , G02B7/006 , G02B21/16 , G02B21/361 , G02B23/2407
摘要： Provided herein are devices, systems, and methods for multimodal optical imaging. The devices include a filter assembly that is capable of rotary action during real time image acquisition. The systems include such filter assemblies, which are detachable or integrated in the systems. The methods include techniques for capturing image targets using multiple light sources such as white light and fluorescent light.
摘要翻译：本文提供了用于多模光学成像的装置，系统和方法。这些装置包括能够在实时图像采集期间旋转动作的过滤器组件。这些系统包括可拆卸或集成在系统中的过滤组件。这些方法包括使用诸如白光和荧光灯的多个光源捕获图像目标的技术。

3. 发明申请

US20100110572A1 MULTIMODAL OPTICAL IMAGING 有权
公开(公告)号：US20100110572A1
公开(公告)日：2010-05-06
申请号：US12263673
申请日：2008-11-03
申请人： Siavash Yazdanfar , Vernon Thomas Jensen , Stephen Johnson Lomnes
发明人： Siavash Yazdanfar , Vernon Thomas Jensen , Stephen Johnson Lomnes
IPC分类号： G02B5/22
CPC分类号： G02B5/189 , G02B5/20 , G02B5/201 , G02B7/006 , G02B26/008 , G02B26/0875
摘要： Provided herein are devices, systems, and methods for multimodal optical imaging. The devices include a filter assembly that is capable of rotary action during real time image acquisition. The systems include such filter assemblies, which are detachable or integrated in the systems. The methods include techniques for capturing image targets using multiple light sources such as white light and fluorescent light.

4. 发明授权

US08144411B2 Multimodal optical imaging 有权
公开(公告)号：US08144411B2
公开(公告)日：2012-03-27
申请号：US12263677
申请日：2008-11-03
申请人： Siavash Yazdanfar , Vernon Thomas Jensen , Stephen Johnson Lomnes
发明人： Siavash Yazdanfar , Vernon Thomas Jensen , Stephen Johnson Lomnes
IPC分类号： G02B5/22 , A61B1/06
CPC分类号： G02B26/008 , G02B7/006 , G02B21/16 , G02B21/361 , G02B23/2407
摘要： Multimodal optical imaging is disclosed. Possible devices include a filter assembly that is capable of rotary action during real time image acquisition. Systems are disclosed that include such filter assemblies, which are detachable or integrated in the systems. Various techniques for capturing image targets using multiple light sources such as white light and fluorescent light are also disclosed.

5. 发明授权

US07692160B2 Method and system of optical imaging for target detection in a scattering medium 失效
标题翻译：散射介质中目标检测的光学成像方法与系统
公开(公告)号：US07692160B2
公开(公告)日：2010-04-06
申请号：US11756135
申请日：2007-05-31
申请人： Deborah Stutz Lee , Kajoli Banerjee Krishnan , Siavash Yazdanfar , Stephen Johnson Lomnes , Floribertus P. M. Heukensfeldt Jansen , Stephen Andrew Latham
发明人： Deborah Stutz Lee , Kajoli Banerjee Krishnan , Siavash Yazdanfar , Stephen Johnson Lomnes , Floribertus P. M. Heukensfeldt Jansen , Stephen Andrew Latham
IPC分类号： G01J1/58
CPC分类号： A61B5/0059
摘要： A method and system for fluorescence imaging of a target in a subject comprising a scattering medium is provided. The method comprises illuminating one or more points on a surface of the scattering medium using an illumination source, wherein the plurality of points define an illumination region, collecting emitted light from an illumination region and an area away from the illumination region, and generating an image of the scattering medium using the emitted light.
摘要翻译：提供了一种用于包括散射介质的受试者中的靶的荧光成像的方法和系统。该方法包括使用照明源照射散射介质的表面上的一个或多个点，其中多个点限定照明区域，收集来自照明区域的发射光和远离照明区域的区域，以及生成图像的散射介质。

6. 发明申请

US20080296482A1 METHOD AND SYSTEM OF OPTICAL IMAGING FOR TARGET DETECTION IN A SCATTERING MEDIUM 失效
标题翻译：光学成像技术在散射介质中的目标检测方法与系统
公开(公告)号：US20080296482A1
公开(公告)日：2008-12-04
申请号：US11756135
申请日：2007-05-31
申请人： Deborah Stutz Lee , Kajoli Banerjee Krishnan , Siavash Yazdanfar , Stephen Johnson Lomnes , Floribertus P.M. Heukensfeldt Jansen , Stephen Andrew Latham
发明人： Deborah Stutz Lee , Kajoli Banerjee Krishnan , Siavash Yazdanfar , Stephen Johnson Lomnes , Floribertus P.M. Heukensfeldt Jansen , Stephen Andrew Latham
IPC分类号： H01J40/14
CPC分类号： A61B5/0059
摘要： A method and system for fluorescence imaging of a target in a subject comprising a scattering medium is provided. The method comprises illuminating one or more points on a surface of the scattering medium using an illumination source, wherein the plurality of points define an illumination region, collecting emitted light from an illumination region and an area away from the illumination region, and generating an image of the scattering medium using the emitted light.
摘要翻译：提供了一种用于包括散射介质的受试者中的靶的荧光成像的方法和系统。该方法包括使用照明源照射散射介质的表面上的一个或多个点，其中多个点限定照明区域，收集来自照明区域的发射光和远离照明区域的区域，以及生成图像的散射介质。

7. 发明申请

US20090236541A1 System and Methods for Optical Imaging 审中-公开
标题翻译：光学成像系统与方法
公开(公告)号：US20090236541A1
公开(公告)日：2009-09-24
申请号：US12054214
申请日：2008-03-24
申请人： Stephen Johnson Lomnes , Michael Cooper , Anup Sood , Siavash Yazdanfar , Kathleen Bove
发明人： Stephen Johnson Lomnes , Michael Cooper , Anup Sood , Siavash Yazdanfar , Kathleen Bove
IPC分类号： G01T1/00
CPC分类号： A61B1/05 , A61B1/043 , A61B1/0638 , A61B1/0646 , A61B5/0071 , A61B5/0084
摘要： The invention relates to imaging methods and systems. The systems may comprise a white light source configured to generate light in a first wavelength range, an excitation source configured to generate light at one or more wavelengths for exciting a fluorescent substance, a first detector configured to acquire reflectance image data that represents white light reflected from a subject, and a second detector configured to acquire fluorescence image data that represents fluorescence emissions from the subject. At least one of the one or more wavelengths generated by the excitation light source is within the first wavelength range of the white light source. The fluorescent substance may be, for example, a fluorescent dye that is injected into a patient before or during a surgery. The system may also include an image processing engine and a display. The image processing engine may receive the reflectance image data and the fluorescence image data and generate a merged image in which the fluorescence image data is superimposed on the reflectance image data. The display may be used by a surgeon, for example, to more effectively visualize the surgical site during surgery.
摘要翻译：本发明涉及成像方法和系统。所述系统可以包括被配置为产生第一波长范围的光的白光源，被配置为产生用于激发荧光物质的一个或多个波长的光的激发源，被配置为获取表示反射的白光的反射率图像数据的第一检测器以及第二检测器，被配置为获取表示来自所述受试者的荧光发射的荧光图像数据。由激发光源产生的一个或多个波长中的至少一个在白光源的第一波长范围内。荧光物质可以是例如在手术之前或手术期间注射到患者体内的荧光染料。该系统还可以包括图像处理引擎和显示器。图像处理引擎可以接收反射图像数据和荧光图像数据，并生成其中荧光图像数据叠加在反射率图像数据上的合并图像。外科医生可以使用显示器，例如在手术期间更有效地使外科手术部位可视化。

8. 发明申请

US20120128264A1 METHODS AND SYSTEMS OF OPTICAL IMAGING FOR TARGET DETECTION IN A SCATTERING MEDIUM 有权
标题翻译：光学成像技术在散射介质中的目标检测方法与系统
公开(公告)号：US20120128264A1
公开(公告)日：2012-05-24
申请号：US12952359
申请日：2010-11-23
申请人： Siavash Yazdanfar , Floribertus Heukensfeldt Jansen , Stephen Lomnes , Xinghua Wang
发明人： Siavash Yazdanfar , Floribertus Heukensfeldt Jansen , Stephen Lomnes , Xinghua Wang
IPC分类号： G06K9/40 , G01J1/58
CPC分类号： A61B5/0059 , A61B5/0064
摘要： A method for enhancing contrast in fluorescence imaging is provided. The method comprises providing a patterned illumination source for illuminating one or more regions corresponding to a scan step, scanning at least a portion of a surface of a subject using a plurality of scan steps, acquiring image frames corresponding to two or more scan steps, deducting a background fluorescence from the image frames corresponding to the two or more scan steps to form one or more processed image frames, and reconstructing an image using one or more of the processed image frames.
摘要翻译：提供了一种增强荧光成像对比度的方法。该方法包括提供用于照亮与扫描步骤相对应的一个或多个区域的图案化照明源，使用多个扫描步骤扫描对象的表面的至少一部分，获取对应于两个或更多个扫描步骤的图像帧，扣除来自对应于两个或更多个扫描步骤的图像帧的背景荧光，以形成一个或多个经处理的图像帧，以及使用一个或多个处理后的图像帧重建图像。

9. 发明申请

US20110043916A1 OBJECTIVE FOR OPTICAL IMAGING SYSTEMS 有权
标题翻译：光学成像系统的目标
公开(公告)号：US20110043916A1
公开(公告)日：2011-02-24
申请号：US12543785
申请日：2009-08-19
申请人： Xinghua Wang , Mark Marshall Meyers , Siavash Yazdanfar
发明人： Xinghua Wang , Mark Marshall Meyers , Siavash Yazdanfar
IPC分类号： G02B23/24 , G02B27/42
CPC分类号： G02B23/243
摘要： A wide angle hybrid refractive-diffractive endoscope objective is provided. The objective comprises a negative meniscus lens having a first surface and a second surface; a stop adjacent to the negative meniscus lens; a positive lens adjacent to the negative lens and having a first surface and a second surface; and a hybrid refractive-diffractive element adjacent to the positive lens and having a first surface and a second surface, wherein one of the first surface, or the second surface comprises a diffractive surface, wherein the objective has an effective focal length in a range from about 0.8 mm to about 1.6 mm.
摘要翻译：提供广角混合折射衍射内窥镜目的。该目的包括具有第一表面和第二表面的负凹凸透镜; 靠近负弯月透镜的止动件; 与透镜相邻并具有第一表面和第二表面的正透镜; 以及与所述正透镜相邻并且具有第一表面和第二表面的混合折射衍射元件，其中所述第一表面或所述第二表面中的一个包括衍射表面，其中所述物镜具有在以下范围内的有效焦距：约0.8mm至约1.6mm。

10. 发明授权

US07824034B2 Iris imaging system and method for the same 有权
标题翻译：虹膜成像系统和方法相同
公开(公告)号：US07824034B2
公开(公告)日：2010-11-02
申请号：US11857581
申请日：2007-09-19
申请人： Frederick Wilson Wheeler , Siavash Yazdanfar
发明人： Frederick Wilson Wheeler , Siavash Yazdanfar
IPC分类号： A61B3/14 , A61B3/00 , A61B3/10
CPC分类号： A61B3/1216 , A61B3/14
摘要： An iris imaging system is provided. The iris imaging system includes at least one light source configured to illuminate an iris at a spectrum of light. The iris imaging system also includes at least one image capturing device including at least one of an indium-gallium-arsenide, lead sulphide, and lead selenide based detector and configured to capture an image of the iris via light reflected from the iris at the spectrum. The device is further configured to provide a signal representing one or more features of the iris in response to the light reflected from the iris.
摘要翻译：提供虹膜成像系统。虹膜成像系统包括至少一个被配置为以光谱照射虹膜的光源。虹膜成像系统还包括至少一个图像捕获装置，其包括砷化铟镓，硫化铅和基于硒化铅的检测器中的至少一种，并被配置为通过光谱从光谱反射的光线捕获虹膜的图像。该装置还被配置为响应于从虹膜反射的光来提供表示虹膜的一个或多个特征的信号。

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