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1. 发明授权

US09066657B2 Methods and systems of optical imaging for target detection in a scattering medium 有权
标题翻译：散射介质中目标检测的光学成像方法和系统
公开(公告)号：US09066657B2
公开(公告)日：2015-06-30
申请号：US12952359
申请日：2010-11-23
申请人： Siavash Yazdanfar , Floribertus Heukensfeldt Jansen , Stephen Lomnes , Xinghua Wang
发明人： Siavash Yazdanfar , Floribertus Heukensfeldt Jansen , Stephen Lomnes , Xinghua Wang
IPC分类号： G06K9/40 , F21V9/16 , G01J1/58 , G01T1/10 , G21H3/02 , G21K5/00 , H01J65/06 , H01J65/08 , H01L27/00 , G01N21/86 , G01V8/00 , A61B5/00
CPC分类号： A61B5/0059 , A61B5/0064
摘要： A method for enhancing contrast in fluorescence imaging is provided. The method comprises providing a patterned illumination source for illuminating one or more regions corresponding to a scan step, scanning at least a portion of a surface of a subject using a plurality of scan steps, acquiring image frames corresponding to two or more scan steps, deducting a background fluorescence from the image frames corresponding to the two or more scan steps to form one or more processed image frames, and reconstructing an image using one or more of the processed image frames.
摘要翻译：提供了一种增强荧光成像对比度的方法。该方法包括提供用于照亮与扫描步骤相对应的一个或多个区域的图案化照明源，使用多个扫描步骤扫描对象的表面的至少一部分，获取对应于两个或更多个扫描步骤的图像帧，扣除来自对应于两个或更多个扫描步骤的图像帧的背景荧光，以形成一个或多个经处理的图像帧，以及使用一个或多个处理后的图像帧重建图像。

2. 发明申请

US20120128264A1 METHODS AND SYSTEMS OF OPTICAL IMAGING FOR TARGET DETECTION IN A SCATTERING MEDIUM 有权
标题翻译：光学成像技术在散射介质中的目标检测方法与系统
公开(公告)号：US20120128264A1
公开(公告)日：2012-05-24
申请号：US12952359
申请日：2010-11-23
申请人： Siavash Yazdanfar , Floribertus Heukensfeldt Jansen , Stephen Lomnes , Xinghua Wang
发明人： Siavash Yazdanfar , Floribertus Heukensfeldt Jansen , Stephen Lomnes , Xinghua Wang
IPC分类号： G06K9/40 , G01J1/58
CPC分类号： A61B5/0059 , A61B5/0064
摘要： A method for enhancing contrast in fluorescence imaging is provided. The method comprises providing a patterned illumination source for illuminating one or more regions corresponding to a scan step, scanning at least a portion of a surface of a subject using a plurality of scan steps, acquiring image frames corresponding to two or more scan steps, deducting a background fluorescence from the image frames corresponding to the two or more scan steps to form one or more processed image frames, and reconstructing an image using one or more of the processed image frames.
摘要翻译：提供了一种增强荧光成像对比度的方法。该方法包括提供用于照亮与扫描步骤相对应的一个或多个区域的图案化照明源，使用多个扫描步骤扫描对象的表面的至少一部分，获取对应于两个或更多个扫描步骤的图像帧，扣除来自对应于两个或更多个扫描步骤的图像帧的背景荧光，以形成一个或多个经处理的图像帧，以及使用一个或多个处理后的图像帧重建图像。

3. 发明申请

US20060058685A1 System and method for imaging based on ultrasonic tagging of light 有权
标题翻译：基于超声波标记的成像系统和方法
公开(公告)号：US20060058685A1
公开(公告)日：2006-03-16
申请号：US11254266
申请日：2005-10-20
申请人： Pavel Fomitchov , Kajoli Krishnan , Stephen Lomnes , Floribertus Heukensfeldt Jansen
发明人： Pavel Fomitchov , Kajoli Krishnan , Stephen Lomnes , Floribertus Heukensfeldt Jansen
IPC分类号： A61B6/00
CPC分类号： G01N21/6456 , A61B5/0051 , A61B5/0091 , A61B5/4312 , A61K49/0017 , A61K49/0032 , A61K49/0034 , B82Y5/00 , B82Y10/00 , B82Y20/00 , G01N21/1717 , G01N21/4795 , G01N2021/1729 , G01N2021/6439
摘要： A technique is provided for imaging based on localization of fluorescence in a medium. The technique includes illuminating the medium with an excitation light to excite fluorescence, scanning the medium at a plurality of locations via an ultrasonic beam, modulating a portion of the emitted light from the fluorescence via the ultrasonic beam at each of the plurality of locations, differentially detecting the modulated light at a boundary of the medium, and reconstructing an image from the detected signal.
摘要翻译：提供了一种基于荧光在介质中定位的成像技术。该技术包括用激发光照射介质以激发荧光，通过超声波束在多个位置扫描介质，在多个位置的每一个处经由超声波束在荧光上调制一部分发射的光检测介质边界处的调制光，并根据检测到的信号重建图像。

4. 发明申请

US20070025917A1 Optical imaging based on locally activated bioluminescence 审中-公开
标题翻译：基于局部活化生物发光的光学成像
公开(公告)号：US20070025917A1
公开(公告)日：2007-02-01
申请号：US11189892
申请日：2005-07-26
申请人： Peifang Tian , Robert Filkins , Siavash Yazdanfar , Stephen Lomnes , Andrew Healey , Pavel Fomitchov
发明人： Peifang Tian , Robert Filkins , Siavash Yazdanfar , Stephen Lomnes , Andrew Healey , Pavel Fomitchov
IPC分类号： A61K49/00 , A61K38/44
CPC分类号： A61K41/0028 , A61K49/0013 , C12Y113/12007
摘要： Methods and compositions for detecting and localizing light from a subject are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the subject. Also disclosed are methods for locating a target in a subject, such as by detecting light emission from a target site.
摘要翻译：公开了用于检测和定位来自受试者的光的方法和组合物。还公开了用于将光发射定位到选定区域以及用于跟踪受试者内的实体的方法。还公开了用于在对象中定位目标物的方法，例如通过检测来自目标部位的光发射。

5. 发明申请

US20060164084A1 Method and system for enabling adaptive measurement of spin-lattice and spin-spin relaxation times 审中-公开
标题翻译：用于自适应测量自旋 - 晶格和自旋 - 自旋弛豫时间的方法和系统
公开(公告)号：US20060164084A1
公开(公告)日：2006-07-27
申请号：US11038131
申请日：2005-01-21
申请人： Stephen Lomnes
发明人： Stephen Lomnes
IPC分类号： G01V3/00
CPC分类号： G01R33/50
摘要： A method and system for adaptive acquisition of magnetic resonance imaging (MRI) data by initially performing an analysis of a set of samples using a wide range of spin-lattice relaxation time (T1) times, and spin-spin relaxation time (T2) times of the sample under magnetic resonance imaging, and ranking the level of impact each of those T1s and T2s has on inversion times (TIs) and echo times (TEs) respectively. The method and system create a look-up table based on the data generated, and then perform another measurement using a smaller number of T1s and T2s using a small number of TIs and TEs, and compare the results to the data in the look-up table in order to select the closest point in the look-up table.
摘要翻译：通过使用宽范围的自旋 - 晶格弛豫时间（T1）次，以及自旋 - 自旋弛豫时间（T2）时间开始对一组样品的分析进行磁共振成像（MRI）数据的自适应采集的方法和系统的样品在磁共振成像下，并且分别对这些T1和T2中的每一个的影响级别对反转时间（TI）和回波时间（TE）进行排序。该方法和系统基于生成的数据创建查找表，然后使用少量的TI和TE使用较少数量的T1和T2进行另一次测量，并将结果与查找中的数据进行比较表，以便在查找表中选择最近的点。

6. 发明申请

US20050148881A1 High-frequency intensity-modulated incoherent optical source for biomedical optical imaging 审中-公开
标题翻译：高频强度调制非相干光源用于生物医学光学成像
公开(公告)号：US20050148881A1
公开(公告)日：2005-07-07
申请号：US10742410
申请日：2003-12-19
申请人： Ravel Fomitchov , Eugene Olczak , Stephen Lomnes
发明人： Ravel Fomitchov , Eugene Olczak , Stephen Lomnes
IPC分类号： G02B6/42 , G02B27/09 , A61B5/05
CPC分类号： G02B19/0066 , G02B6/4249 , G02B6/4298 , G02B19/0028 , G02B19/0047
摘要： An illumination device comprising: an incoherent light source; a non-imaging light collection system disposed to collect light emitted by the light source; an electro-optic modulator that receives light collected by the light collection system and modulates its intensity; and a light delivery system that receives intensity-modulated light output by the electro-optic modulator and illuminates an area with diverging intensity-modulated light. High-powered incoherent, multi-spectral illumination sources, such as lamps or LED arrays, are used. Non-imaging light collection elements, such as fiber optic bundles, total internal reflection lens arrays or compound parabolic light concentrators, are used to reduce the divergence of the light source for efficient transmission of light through an electro-optic modulator.
摘要翻译：一种照明装置，包括：非相干光源; 设置成收集由所述光源发射的光的非成像光收集系统; 电光调制器，其接收由光采集系统收集的光并调制其强度; 以及光输送系统，其接收由电光调制器输出的强度调制光并照射具有发散强度调制光的区域。使用大功率非相干多光谱照明源，例如灯或LED阵列。使用诸如光纤束，全内反射透镜阵列或复合抛物面聚光器的非成像光收集元件来减少光源的发散，从而有效地透过光电调制器传输光。

7. 发明申请

US20050255044A1 Contrast agent for combined modality imaging and methods and systems thereof 审中-公开
标题翻译：组合形态成像的对比剂及其方法和系统
公开(公告)号：US20050255044A1
公开(公告)日：2005-11-17
申请号：US10846062
申请日：2004-05-14
申请人： Stephen Lomnes , Egidijus Uzgiris , Floribertus Jansen , Pavel Fomitchov , Omayra De Jesus
发明人： Stephen Lomnes , Egidijus Uzgiris , Floribertus Jansen , Pavel Fomitchov , Omayra De Jesus
IPC分类号： A61B10/00 , A61B8/00 , A61K41/00 , A61K49/00 , A61K49/22 , A61K51/00
CPC分类号： A61B5/0059 , A61K41/0028 , A61K49/0089
摘要： In accordance with embodiments of the present technique, a combined modality imaging system includes a first imaging device of a first modality and a second imaging device of a second modality that is different from the first modality. The first and the second imaging devices are both adapted to interact with a contrast agent adapted to be received in a subject. The contrast agent includes an deformable particle that has a geometry that varies in response to an emission from the first imaging device. The deformable particle also includes a fluorescent component adapted to emit electromagnetic radiation that is detectable by the second imaging device and a quenching component separated from the fluorescent component at a distance based on the geometry and that which is adapted to absorb a portion of the electromagnetic radiation from the fluorescent component.
摘要翻译：根据本技术的实施例，组合模态成像系统包括第一模态的第一成像装置和与第一模态不同的第二模态的第二成像装置。第一和第二成像装置都适于与适于被接收在受试者中的造影剂相互作用。造影剂包括可变形颗粒，其具有响应于来自第一成像装置的发射而变化的几何形状。可变形颗粒还包括适于发射可被第二成像装置检测的电磁辐射的荧光组件，以及基于该几何形状在一定距离处从荧光组件分离的淬火组分，以及适于吸收电磁辐射的一部分从荧光成分。

8. 发明申请

US20070148094A1 Polymeric imaging agents and medical imaging methods 审中-公开
标题翻译：聚合成像剂和医学成像方法
公开(公告)号：US20070148094A1
公开(公告)日：2007-06-28
申请号：US11317945
申请日：2005-12-22
申请人： Egidijus Uzgiris , Stephen Lomnes , Anup Sood , Kathleen Bove
发明人： Egidijus Uzgiris , Stephen Lomnes , Anup Sood , Kathleen Bove
IPC分类号： A61K49/10
CPC分类号： A61K49/0002 , A61K49/0032 , A61K49/0056 , A61K49/085 , A61K49/146
摘要： Provided herein are image-enhancing agents that are useful for managing disease by imaging disease tissue using magnetic resonance imaging techniques, optical imaging techniques, and a combination of magnetic resonance imaging techniques and optical imaging techniques. Also provided are methods of imaging disease tissue and managing disease using the image-enhancing agents.
摘要翻译：本文提供的图像增强剂可用于通过使用磁共振成像技术，光学成像技术以及磁共振成像技术和光学成像技术的组合对疾病组织进行成像来治疗疾病。还提供了使用图像增强剂对疾病组织进行成像和管理疾病的方法。

9. 发明申请

US20050107694A1 Method and system for ultrasonic tagging of fluorescence 审中-公开
标题翻译：超声波标记荧光的方法和系统
公开(公告)号：US20050107694A1
公开(公告)日：2005-05-19
申请号：US10714734
申请日：2003-11-17
申请人： Floribertus Jansen , Peter Lorraine , Stephen Lomnes , Pavel Fomitchov
发明人： Floribertus Jansen , Peter Lorraine , Stephen Lomnes , Pavel Fomitchov
IPC分类号： A61B5/00 , G01N21/17 , G01N21/47 , A61B6/00 , A61B8/00
CPC分类号： G01N21/6456 , A61B5/0051 , A61B5/0091 , A61B5/4312 , A61K49/0017 , A61K49/0032 , A61K49/0034 , B82Y5/00 , B82Y10/00 , B82Y20/00 , G01N21/1717 , G01N21/4795 , G01N2021/1729 , G01N2021/6439
摘要： A method and system for localization of fluorescence in a scattering medium such as a biological tissue are provided. In comparison to other optical imaging techniques, this disclosure provides for improved spatial resolution, decreased computational time for reconstructions, and allows anatomical and functional imaging simultaneously. The method including the steps of illuminating the scattering medium with an excitation light to excite the fluorescence; modulating a portion of the emitted light from the fluorescence within the scattering medium using an ultrasonically induced variation of material properties of the scattering medium such as the refractive index; detecting the modulated optical signal at a surface of the scattering medium; and reconstructing a spatial distribution of the fluorescence in the scattering medium from the detected signal.
摘要翻译：提供了用于在诸如生物组织的散射介质中定位荧光的方法和系统。与其他光学成像技术相比，本公开提供了改进的空间分辨率，减少重建的计算时间，并且同时允许解剖和功能成像。该方法包括以激发光照射散射介质以激发荧光的步骤; 使用散射介质的材料性质如折射率的超声波诱导的变化来调制来自散射介质内的荧光的一部分发射光; 检测所述散射介质的表面处的调制光信号; 以及从所检测的信号重构散射介质中的荧光的空间分布。

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