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1. 发明授权

US07692160B2 Method and system of optical imaging for target detection in a scattering medium 失效
标题翻译：散射介质中目标检测的光学成像方法与系统
公开(公告)号：US07692160B2
公开(公告)日：2010-04-06
申请号：US11756135
申请日：2007-05-31
申请人： Deborah Stutz Lee , Kajoli Banerjee Krishnan , Siavash Yazdanfar , Stephen Johnson Lomnes , Floribertus P. M. Heukensfeldt Jansen , Stephen Andrew Latham
发明人： Deborah Stutz Lee , Kajoli Banerjee Krishnan , Siavash Yazdanfar , Stephen Johnson Lomnes , Floribertus P. M. Heukensfeldt Jansen , Stephen Andrew Latham
IPC分类号： G01J1/58
CPC分类号： A61B5/0059
摘要： A method and system for fluorescence imaging of a target in a subject comprising a scattering medium is provided. The method comprises illuminating one or more points on a surface of the scattering medium using an illumination source, wherein the plurality of points define an illumination region, collecting emitted light from an illumination region and an area away from the illumination region, and generating an image of the scattering medium using the emitted light.
摘要翻译：提供了一种用于包括散射介质的受试者中的靶的荧光成像的方法和系统。该方法包括使用照明源照射散射介质的表面上的一个或多个点，其中多个点限定照明区域，收集来自照明区域的发射光和远离照明区域的区域，以及生成图像的散射介质。

2. 发明申请

US20080296482A1 METHOD AND SYSTEM OF OPTICAL IMAGING FOR TARGET DETECTION IN A SCATTERING MEDIUM 失效
标题翻译：光学成像技术在散射介质中的目标检测方法与系统
公开(公告)号：US20080296482A1
公开(公告)日：2008-12-04
申请号：US11756135
申请日：2007-05-31
申请人： Deborah Stutz Lee , Kajoli Banerjee Krishnan , Siavash Yazdanfar , Stephen Johnson Lomnes , Floribertus P.M. Heukensfeldt Jansen , Stephen Andrew Latham
发明人： Deborah Stutz Lee , Kajoli Banerjee Krishnan , Siavash Yazdanfar , Stephen Johnson Lomnes , Floribertus P.M. Heukensfeldt Jansen , Stephen Andrew Latham
IPC分类号： H01J40/14
CPC分类号： A61B5/0059
摘要： A method and system for fluorescence imaging of a target in a subject comprising a scattering medium is provided. The method comprises illuminating one or more points on a surface of the scattering medium using an illumination source, wherein the plurality of points define an illumination region, collecting emitted light from an illumination region and an area away from the illumination region, and generating an image of the scattering medium using the emitted light.
摘要翻译：提供了一种用于包括散射介质的受试者中的靶的荧光成像的方法和系统。该方法包括使用照明源照射散射介质的表面上的一个或多个点，其中多个点限定照明区域，收集来自照明区域的发射光和远离照明区域的区域，以及生成图像的散射介质。

3. 发明授权

US08103329B2 System and method for imaging based on ultrasonic tagging of light 有权
标题翻译：基于超声波标记的成像系统和方法
公开(公告)号：US08103329B2
公开(公告)日：2012-01-24
申请号：US11254266
申请日：2005-10-20
申请人： Pavel Alexeyevich Fomitchov , Kajoli Banerjee Krishnan , Stephen Johnson Lomnes , Floribertus P. M. Heukensfeldt Jansen
发明人： Pavel Alexeyevich Fomitchov , Kajoli Banerjee Krishnan , Stephen Johnson Lomnes , Floribertus P. M. Heukensfeldt Jansen
IPC分类号： A61B5/05
CPC分类号： G01N21/6456 , A61B5/0051 , A61B5/0091 , A61B5/4312 , A61K49/0017 , A61K49/0032 , A61K49/0034 , B82Y5/00 , B82Y10/00 , B82Y20/00 , G01N21/1717 , G01N21/4795 , G01N2021/1729 , G01N2021/6439
摘要： A technique is provided for imaging based on localization of fluorescence in a medium. The technique includes illuminating the medium with an excitation light to excite fluorescence, scanning the medium at a plurality of locations via an ultrasonic beam, modulating a portion of the emitted light from the fluorescence via the ultrasonic beam at each of the plurality of locations, differentially detecting the modulated light at a boundary of the medium, and reconstructing an image from the detected signal.
摘要翻译：提供了一种基于荧光在介质中定位的成像技术。该技术包括用激发光照射介质以激发荧光，通过超声波束在多个位置扫描介质，在多个位置的每一个处经由超声波束在荧光上调制一部分发射的光检测介质边界处的调制光，并根据检测到的信号重建图像。

4. 发明申请

US20080004533A1 Optical imaging systems and methods 审中-公开
标题翻译：光学成像系统和方法
公开(公告)号：US20080004533A1
公开(公告)日：2008-01-03
申请号：US11480162
申请日：2006-06-30
申请人： Floribertus P. M. Heukensfeldt Jansen , Stephen Johnson Lomnes
发明人： Floribertus P. M. Heukensfeldt Jansen , Stephen Johnson Lomnes
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/415 , A61B5/418 , A61B6/508 , A61B90/361 , A61B2090/366
摘要： Optical imaging systems and methods are disclosed. The optical imaging system includes an electronic imaging device configured to capture an image of a site and a projector. An optical imaging system includes a projector configured to project a visible representation of the captured image onto the site during surgery. Another optical imaging system includes an optical element capable of aligning an optical axis of the electronic imaging device and the projector on a same optical axis. Also disclosed are methods for displaying an image on to a site. A method includes capturing a fluorescent image of a surgical site; and projecting a visible representation of the captured image onto the surgical site during surgery. Another method includes projecting a visible representation of a captured image of a site onto the site along a same optical axis along which the image is captured.
摘要翻译：公开了光学成像系统和方法。光学成像系统包括被配置为捕获场地和投影仪的图像的电子成像装置。光学成像系统包括投影仪，其被配置为在手术期间将所捕获的图像的可见表示投影到所述部位上。另一种光学成像系统包括能够将电子成像装置的光轴与投影仪对准在同一光轴上的光学元件。还公开了用于将图像显示在站点上的方法。一种方法包括捕获手术部位的荧光图像; 并且在手术期间将所捕获图像的可视表示投影到手术部位上。另一种方法包括将图像的捕获图像的可视表示投影到沿着图像被捕获的同一光轴上的站点上。

5. 发明授权

US08144410B2 Multimodal optical imaging 有权
标题翻译：多模光学成像
公开(公告)号：US08144410B2
公开(公告)日：2012-03-27
申请号：US12263673
申请日：2008-11-03
申请人： Siavash Yazdanfar , Vernon Thomas Jensen , Stephen Johnson Lomnes
发明人： Siavash Yazdanfar , Vernon Thomas Jensen , Stephen Johnson Lomnes
IPC分类号： G02B5/22 , A61B1/06
CPC分类号： G02B5/189 , G02B5/20 , G02B5/201 , G02B7/006 , G02B26/008 , G02B26/0875
摘要： Multimodal optical imaging is disclosed. Possible devices include a filter assembly that is capable of rotary action during real time image acquisition. Systems are disclosed that include such filter assemblies, which are detachable or integrated in the systems. Various techniques for capturing image targets using multiple light sources such as white light and fluorescent light are also disclosed.
摘要翻译：公开了多模光学成像。可能的设备包括在实时图像采集期间能够旋转动作的过滤器组件。公开了包括这样的过滤器组件的系统，其可拆卸或集成在系统中。还公开了使用多个光源（例如白光和荧光）捕获图像目标的各种技术。

6. 发明申请

US20100111353A1 MULTIMODAL OPTICAL IMAGING 有权
标题翻译：多模光学成像
公开(公告)号：US20100111353A1
公开(公告)日：2010-05-06
申请号：US12263677
申请日：2008-11-03
申请人： Siavash Yazdanfar , Vernon Thomas Jensen , Stephen Johnson Lomnes
发明人： Siavash Yazdanfar , Vernon Thomas Jensen , Stephen Johnson Lomnes
IPC分类号： G06K9/00
CPC分类号： G02B26/008 , G02B7/006 , G02B21/16 , G02B21/361 , G02B23/2407
摘要： Provided herein are devices, systems, and methods for multimodal optical imaging. The devices include a filter assembly that is capable of rotary action during real time image acquisition. The systems include such filter assemblies, which are detachable or integrated in the systems. The methods include techniques for capturing image targets using multiple light sources such as white light and fluorescent light.
摘要翻译：本文提供了用于多模光学成像的装置，系统和方法。这些装置包括能够在实时图像采集期间旋转动作的过滤器组件。这些系统包括可拆卸或集成在系统中的过滤组件。这些方法包括使用诸如白光和荧光灯的多个光源捕获图像目标的技术。

7. 发明申请

US20090236541A1 System and Methods for Optical Imaging 审中-公开
标题翻译：光学成像系统与方法
公开(公告)号：US20090236541A1
公开(公告)日：2009-09-24
申请号：US12054214
申请日：2008-03-24
申请人： Stephen Johnson Lomnes , Michael Cooper , Anup Sood , Siavash Yazdanfar , Kathleen Bove
发明人： Stephen Johnson Lomnes , Michael Cooper , Anup Sood , Siavash Yazdanfar , Kathleen Bove
IPC分类号： G01T1/00
CPC分类号： A61B1/05 , A61B1/043 , A61B1/0638 , A61B1/0646 , A61B5/0071 , A61B5/0084
摘要： The invention relates to imaging methods and systems. The systems may comprise a white light source configured to generate light in a first wavelength range, an excitation source configured to generate light at one or more wavelengths for exciting a fluorescent substance, a first detector configured to acquire reflectance image data that represents white light reflected from a subject, and a second detector configured to acquire fluorescence image data that represents fluorescence emissions from the subject. At least one of the one or more wavelengths generated by the excitation light source is within the first wavelength range of the white light source. The fluorescent substance may be, for example, a fluorescent dye that is injected into a patient before or during a surgery. The system may also include an image processing engine and a display. The image processing engine may receive the reflectance image data and the fluorescence image data and generate a merged image in which the fluorescence image data is superimposed on the reflectance image data. The display may be used by a surgeon, for example, to more effectively visualize the surgical site during surgery.
摘要翻译：本发明涉及成像方法和系统。所述系统可以包括被配置为产生第一波长范围的光的白光源，被配置为产生用于激发荧光物质的一个或多个波长的光的激发源，被配置为获取表示反射的白光的反射率图像数据的第一检测器以及第二检测器，被配置为获取表示来自所述受试者的荧光发射的荧光图像数据。由激发光源产生的一个或多个波长中的至少一个在白光源的第一波长范围内。荧光物质可以是例如在手术之前或手术期间注射到患者体内的荧光染料。该系统还可以包括图像处理引擎和显示器。图像处理引擎可以接收反射图像数据和荧光图像数据，并生成其中荧光图像数据叠加在反射率图像数据上的合并图像。外科医生可以使用显示器，例如在手术期间更有效地使外科手术部位可视化。

8. 发明申请

US20100110572A1 MULTIMODAL OPTICAL IMAGING 有权
公开(公告)号：US20100110572A1
公开(公告)日：2010-05-06
申请号：US12263673
申请日：2008-11-03
申请人： Siavash Yazdanfar , Vernon Thomas Jensen , Stephen Johnson Lomnes
发明人： Siavash Yazdanfar , Vernon Thomas Jensen , Stephen Johnson Lomnes
IPC分类号： G02B5/22
CPC分类号： G02B5/189 , G02B5/20 , G02B5/201 , G02B7/006 , G02B26/008 , G02B26/0875
摘要： Provided herein are devices, systems, and methods for multimodal optical imaging. The devices include a filter assembly that is capable of rotary action during real time image acquisition. The systems include such filter assemblies, which are detachable or integrated in the systems. The methods include techniques for capturing image targets using multiple light sources such as white light and fluorescent light.

9. 发明授权

US08144411B2 Multimodal optical imaging 有权
公开(公告)号：US08144411B2
公开(公告)日：2012-03-27
申请号：US12263677
申请日：2008-11-03
申请人： Siavash Yazdanfar , Vernon Thomas Jensen , Stephen Johnson Lomnes
发明人： Siavash Yazdanfar , Vernon Thomas Jensen , Stephen Johnson Lomnes
IPC分类号： G02B5/22 , A61B1/06
CPC分类号： G02B26/008 , G02B7/006 , G02B21/16 , G02B21/361 , G02B23/2407
摘要： Multimodal optical imaging is disclosed. Possible devices include a filter assembly that is capable of rotary action during real time image acquisition. Systems are disclosed that include such filter assemblies, which are detachable or integrated in the systems. Various techniques for capturing image targets using multiple light sources such as white light and fluorescent light are also disclosed.

10. 发明申请

US20080238338A1 Method and system for providing scalable and configurable illumination 审中-公开
标题翻译：用于提供可扩展和可配置照明的方法和系统
公开(公告)号：US20080238338A1
公开(公告)日：2008-10-02
申请号：US11731613
申请日：2007-03-30
申请人： Stephen Andrew Latham , Robert William Tait , Stephen Johnson Lomnes , Duncan Spalding Pratt , Carl Stephen Lester
发明人： Stephen Andrew Latham , Robert William Tait , Stephen Johnson Lomnes , Duncan Spalding Pratt , Carl Stephen Lester
IPC分类号： H05B37/02 , F21V21/00 , F21V9/00
CPC分类号： A61B5/0059 , F21W2131/205 , F21Y2115/10
摘要： A modular, scalable and configurable incoherent light source is provided. The light source includes an array of lighting modules supported on a frame that focuses emitted radiation from the modules at a region of interest. The geometry and physical configuration of the support structures, including the frame, may accommodate various energy intensities at various distances. The modules may be made up of multiple LEDs or other individual light sources, may be of different or the same wavelength, and may be individually controllable for the ultimate lighting application. The light source may be used in medical imaging applications.
摘要翻译：提供了模块化，可扩展和可配置的非相干光源。光源包括支撑在框架上的照明模块阵列，其将来自模块的发射的辐射聚焦在感兴趣的区域。支撑结构（包括框架）的几何形状和物理结构可适应各种距离的各种能量强度。模块可以由多个LED或其他单独的光源组成，可以具有不同或相同的波长，并且可以单独地控制以用于终极照明应用。光源可用于医学成像应用。

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