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1. 发明授权

US07829856B2 Apparatus and methods for determining a system matrix for pinhole collimator imaging systems 有权
标题翻译：用于确定针孔准直仪成像系统的系统矩阵的装置和方法
公开(公告)号：US07829856B2
公开(公告)日：2010-11-09
申请号：US12415630
申请日：2009-03-31
申请人： Floribertus Heukensfeldt Jansen , Girish Bal
发明人： Floribertus Heukensfeldt Jansen , Girish Bal
IPC分类号： G21K1/02
CPC分类号： G06T11/006 , G06T2211/424
摘要： Apparatus and methods for determining a system matrix for pinhole collimator imaging systems are provided. One method includes using a closed form expression to determine a penetration term for a collimator of the medical imaging system and determining a point spread function of the collimator based on the penetration term. The method further includes calculating the system matrix for the medical imaging system based on the determined point spread function.
摘要翻译：提供了用于确定针孔准直器成像系统的系统矩阵的装置和方法。一种方法包括使用闭合形式表达式来确定医学成像系统的准直器的穿透项，并且基于穿透项确定准直仪的点扩散函数。该方法还包括基于确定的点扩散函数来计算医学成像系统的系统矩阵。

2. 发明申请

US20070205368A1 Method and system for calibrating a time of flight positron emission tomography system 失效
标题翻译：校准飞行时间正电子发射断层扫描系统的方法和系统
公开(公告)号：US20070205368A1
公开(公告)日：2007-09-06
申请号：US11786951
申请日：2007-04-13
申请人： Floribertus Heukensfeldt Jansen , Ravindra Manjeshwar
发明人： Floribertus Heukensfeldt Jansen , Ravindra Manjeshwar
IPC分类号： G01T1/161
CPC分类号： G01T1/2985
摘要： A method and system for calibrating a time of flight (TOF) positron emission tomography (PET) scanner are provided. The method stores acquired scan data from detector pairs including data and timing information. The method further calculates an intensity distribution of emission sources based on the scan data and defines a timing pivot point based on a median of an intensity histogram. The method determines a timing correction for each detector based on the location of the timing pivot point. The positron emission tomography (PET) system further provides a plurality of detectors, used in performing imaging scans, and a processor. The processor is configured to determine a timing correction for each detector.
摘要翻译：提供了一种用于校准飞行时间（TOF）正电子发射断层摄影（PET）扫描仪的方法和系统。该方法存储来自检测器对的获取的扫描数据，包括数据和定时信息。该方法还基于扫描数据计算发射源的强度分布，并且基于强度直方图的中值来定义定时枢轴点。该方法基于定时枢轴点的位置确定每个检测器的定时校正。正电子发射断层摄影（PET）系统还提供用于执行成像扫描的多个检测器和处理器。处理器被配置为确定每个检测器的定时校正。

3. 发明授权

US08158951B2 Apparatus and methods for evaluating operation of pixelated detectors 有权
标题翻译：用于评估像素化检测器的操作的装置和方法
公开(公告)号：US08158951B2
公开(公告)日：2012-04-17
申请号：US12365100
申请日：2009-02-03
申请人： Girish Bal , Floribertus Heukensfeldt Jansen , Osnat Zak , Gideon Berlad , Yaron Hefetz , Sergei Dolinsky , Brian D. Yanoff , John Eric Tkaczyk , Yanfeng Du , Ravindra Mohan Manjeshwar , Evren Asma , Qian Hua
发明人： Girish Bal , Floribertus Heukensfeldt Jansen , Osnat Zak , Gideon Berlad , Yaron Hefetz , Sergei Dolinsky , Brian D. Yanoff , John Eric Tkaczyk , Yanfeng Du , Ravindra Mohan Manjeshwar , Evren Asma , Qian Hua
IPC分类号： G01T1/00
CPC分类号： G01T1/249 , G01T1/247
摘要： An apparatus and methods for evaluating the operation of pixelated detectors are provided. The method includes obtaining data values for each of a plurality of pixels of a pixelated detector and determining a data consistency metric for each of the plurality of detector pixels. The method further includes identifying, using the determined data consistency metric, any detector pixels that exceed an acceptance criterion as noisy pixels.
摘要翻译：提供了一种用于评估像素化检测器的操作的装置和方法。该方法包括获得像素化检测器的多个像素中的每一个的数据值，并确定多个检测器像素中的每一个的数据一致性度量。该方法还包括使用所确定的数据一致性度量来识别超过接受标准的任何检测器像素作为噪声像素。

4. 发明授权

US06252232B1 Digital integrator 失效
标题翻译：数字集成商
公开(公告)号：US06252232B1
公开(公告)日：2001-06-26
申请号：US09106588
申请日：1998-06-29
申请人： David L. McDaniel , Floribertus Heukensfeldt Jansen
发明人： David L. McDaniel , Floribertus Heukensfeldt Jansen
IPC分类号： G01T1164
CPC分类号： G01T1/1647 , G01T1/17
摘要： A detector including opposed detector heads having anode signal processors which perform a sliding box car integration of each PMT anode signal, corrects for baseline shifts and pileup from the tails of previous events, vary the length of the box car based on the time between events, and use a peak detection circuit to reduce the dependence of the integrated value on timing differences between the asynchronous events and the synchronous ADC conversion is described. The outputs of anode processors are combined to provide the X and Y coordinates, and the energy E, of an event. The outputs from each head processor are then combined in a coincidence processor to provide the corrected positions and energies of coincidence events. The above described detector heads function at a high count rate with minimum dead time and pileup.
摘要翻译：检测器包括具有阳极信号处理器的相对的检测器头，其执行每个PMT阳极信号的滑动箱车整合，从先前事件的尾部校正基线偏移和堆积，基于事件之间的时间改变箱子的长度，并且使用峰值检测电路来减少积分值对异步事件和同步ADC转换之间的时序差的依赖性。阳极处理器的输出被组合以提供事件的X和Y坐标以及能量E。然后，每个头处理器的输出在重合处理器中组合以提供校正的重合事件的位置和能量。上述检测器头以高计数率起作用，具有最小的死区时间和堆积。

5. 发明授权

US09066657B2 Methods and systems of optical imaging for target detection in a scattering medium 有权
标题翻译：散射介质中目标检测的光学成像方法和系统
公开(公告)号：US09066657B2
公开(公告)日：2015-06-30
申请号：US12952359
申请日：2010-11-23
申请人： Siavash Yazdanfar , Floribertus Heukensfeldt Jansen , Stephen Lomnes , Xinghua Wang
发明人： Siavash Yazdanfar , Floribertus Heukensfeldt Jansen , Stephen Lomnes , Xinghua Wang
IPC分类号： G06K9/40 , F21V9/16 , G01J1/58 , G01T1/10 , G21H3/02 , G21K5/00 , H01J65/06 , H01J65/08 , H01L27/00 , G01N21/86 , G01V8/00 , A61B5/00
CPC分类号： A61B5/0059 , A61B5/0064
摘要： A method for enhancing contrast in fluorescence imaging is provided. The method comprises providing a patterned illumination source for illuminating one or more regions corresponding to a scan step, scanning at least a portion of a surface of a subject using a plurality of scan steps, acquiring image frames corresponding to two or more scan steps, deducting a background fluorescence from the image frames corresponding to the two or more scan steps to form one or more processed image frames, and reconstructing an image using one or more of the processed image frames.
摘要翻译：提供了一种增强荧光成像对比度的方法。该方法包括提供用于照亮与扫描步骤相对应的一个或多个区域的图案化照明源，使用多个扫描步骤扫描对象的表面的至少一部分，获取对应于两个或更多个扫描步骤的图像帧，扣除来自对应于两个或更多个扫描步骤的图像帧的背景荧光，以形成一个或多个经处理的图像帧，以及使用一个或多个处理后的图像帧重建图像。

6. 发明申请

US20110297838A1 CHARGE LOSS CORRECTION 有权
标题翻译：充电损失校正
公开(公告)号：US20110297838A1
公开(公告)日：2011-12-08
申请号：US12794525
申请日：2010-06-04
申请人： Kristen Ann Wangerin , Wen Li , Yanfeng Du , Floribertus Heukensfeldt Jansen
发明人： Kristen Ann Wangerin , Wen Li , Yanfeng Du , Floribertus Heukensfeldt Jansen
IPC分类号： G01T1/24
CPC分类号： G01T1/2928 , A61B6/037
摘要： The present disclosure relates to the correction of charge loss in a radiation detector. In one embodiment, correction factors for charge loss may be determined based on depth of interaction and lateral position within a radiation detector of a charge creating event. The correction factors may be applied to subsequently measured signals to correct for the occurrence of charge loss in the measured signals.
摘要翻译：本公开涉及对辐射检测器中的电荷损失的校正。在一个实施例中，可以基于电荷产生事件的辐射检测器内的相互作用深度和横向位置确定电荷损失的校正因子。校正因子可以应用于随后测量的信号，以校正测量信号中电荷损失的发生。

7. 发明授权

US08010184B2 Method and apparatus for automatically characterizing a malignancy 有权
标题翻译：用于自动表征恶性肿瘤的方法和装置
公开(公告)号：US08010184B2
公开(公告)日：2011-08-30
申请号：US11291830
申请日：2005-11-30
申请人： Ricardo Avila , Floribertus Heukensfeldt Jansen , Dinko Gonzalez Trotter , James Miller , Ravindra Manjeshwar , Thomas Sebastian
发明人： Ricardo Avila , Floribertus Heukensfeldt Jansen , Dinko Gonzalez Trotter , James Miller , Ravindra Manjeshwar , Thomas Sebastian
IPC分类号： A61B5/055
CPC分类号： G01T1/1611 , A61B6/037 , A61B34/10 , G01R33/4808 , G01R33/481 , G01R33/4812 , G01R33/4814
摘要： A region of interest is automatically evaluated. The automatic evaluation is based on assessments of one or more characteristics. The one or more characteristics of the region of interest are assessed in a plurality of image data sets acquired by a respective plurality of imaging modalities. In some embodiments, the evaluation is based on assessments of one or more characteristics for each region of interest derived from a combination of structural and functional image data. In one embodiment, the set of structural image data is a set of CT image data and the set of functional image data is a set of PET image data. The one or more lesions may be detected in the structural and/or functional image data by automated routines or by a visual inspection by a clinician or other reviewer.
摘要翻译：自动评估感兴趣的区域。自动评估是基于一个或多个特征的评估。在由相应的多个成像模式获取的多个图像数据集中评估感兴趣区域的一个或多个特征。在一些实施例中，评估基于从结构和功能图像数据的组合导出的每个感兴趣区域的一个或多个特征的评估。在一个实施例中，该组结构图像数据是一组CT图像数据，并且功能图像数据集合是一组PET图像数据。在结构和/或功能图像数据中可以通过自动程序或临床医生或其他审查者的目视检查来检测一个或多个损伤。

8. 发明申请

US20100243907A1 APPARATUS AND METHODS FOR DETERMINING A SYSTEM MATRIX FOR PINHOLE COLLIMATOR IMAGING SYSTEMS 有权
标题翻译：用于确定针孔夹层成像系统的系统矩阵的装置和方法
公开(公告)号：US20100243907A1
公开(公告)日：2010-09-30
申请号：US12415630
申请日：2009-03-31
申请人： Floribertus Heukensfeldt Jansen , Girish Bal
发明人： Floribertus Heukensfeldt Jansen , Girish Bal
IPC分类号： G01T1/24 , G06F17/10
CPC分类号： G06T11/006 , G06T2211/424
摘要： Apparatus and methods for determining a system matrix for pinhole collimator imaging systems are provided. One method includes using a closed form expression to determine a penetration term for a collimator of the medical imaging system and determining a point spread function of the collimator based on the penetration term. The method further includes calculating the system matrix for the medical imaging system based on the determined point spread function.
摘要翻译：提供了用于确定针孔准直器成像系统的系统矩阵的装置和方法。一种方法包括使用闭合形式表达式来确定医学成像系统的准直器的穿透项，并且基于穿透项确定准直仪的点扩散函数。该方法还包括基于确定的点扩散函数来计算医学成像系统的系统矩阵。

9. 发明申请

US20100193697A1 APPARATUS AND METHODS FOR EVALUATING OPERATION OF PIXELATED DETECTORS 有权
标题翻译：用于评估像素检测器操作的装置和方法
公开(公告)号：US20100193697A1
公开(公告)日：2010-08-05
申请号：US12365100
申请日：2009-02-03
申请人： Girish Bal , Floribertus Heukensfeldt Jansen , Osnat Zak , Gideon Berlad , Yaron Hefetz , Sergei Dolinsky , Brian D. Yanoff , John Eric Tkaczyk , Yanfeng Du , Ravindra Mohan Manjeshwar , Evren Asma , Qian Hua
发明人： Girish Bal , Floribertus Heukensfeldt Jansen , Osnat Zak , Gideon Berlad , Yaron Hefetz , Sergei Dolinsky , Brian D. Yanoff , John Eric Tkaczyk , Yanfeng Du , Ravindra Mohan Manjeshwar , Evren Asma , Qian Hua
IPC分类号： G01T1/00 , G01T1/172
CPC分类号： G01T1/249 , G01T1/247
摘要： An apparatus and methods for evaluating the operation of pixelated detectors are provided. The method includes obtaining data values for each of a plurality of pixels of a pixelated detector and determining a data consistency metric for each of the plurality of detector pixels. The method further includes identifying, using the determined data consistency metric, any detector pixels that exceed an acceptance criterion as noisy pixels.
摘要翻译：提供了一种用于评估像素化检测器的操作的装置和方法。该方法包括获得像素化检测器的多个像素中的每一个的数据值，并确定多个检测器像素中的每一个的数据一致性度量。该方法还包括使用所确定的数据一致性度量来识别超过接受标准的任何检测器像素作为噪声像素。

10. 发明申请

US20090114824A1 MASK FOR CODED APERTURE SYSTEMS 有权
标题翻译：掩蔽编码孔径系统
公开(公告)号：US20090114824A1
公开(公告)日：2009-05-07
申请号：US12122471
申请日：2008-05-16
申请人： Scott Stephen Zelakiewicz , Jeffrey Seymour Gordon , Floribertus Heukensfeldt Jansen
发明人： Scott Stephen Zelakiewicz , Jeffrey Seymour Gordon , Floribertus Heukensfeldt Jansen
IPC分类号： G01T1/161
CPC分类号： G01T1/295
摘要： A detector for identification and localization of radioisotopes, comprising a position sensitive detector configured to observe the location of emitted high energy radiation, wherein the position sensitive detector comprises a surface comprised of a first radiation sensitive material; and an active mask disposed in front of the position sensitive detector positioned such that the emitted high energy radiation is detected by the position sensitive detector after passage through the mask, wherein the mask comprises a second radiation sensitive material.
摘要翻译：一种用于放射性同位素识别和定位的检测器，包括位置敏感检测器，其被配置为观察所发射的高能量辐射的位置，其中所述位置敏感检测器包括由第一辐射敏感材料组成的表面; 以及设置在所述位置敏感检测器前面的有源掩模，其被定位成使得所述发射的高能量辐射在通过所述掩模之后由所述位置敏感检测器检测，其中所述掩模包括第二辐射敏感材料。

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