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1. 发明申请

US20110043916A1 OBJECTIVE FOR OPTICAL IMAGING SYSTEMS 有权
标题翻译：光学成像系统的目标
公开(公告)号：US20110043916A1
公开(公告)日：2011-02-24
申请号：US12543785
申请日：2009-08-19
申请人： Xinghua Wang , Mark Marshall Meyers , Siavash Yazdanfar
发明人： Xinghua Wang , Mark Marshall Meyers , Siavash Yazdanfar
IPC分类号： G02B23/24 , G02B27/42
CPC分类号： G02B23/243
摘要： A wide angle hybrid refractive-diffractive endoscope objective is provided. The objective comprises a negative meniscus lens having a first surface and a second surface; a stop adjacent to the negative meniscus lens; a positive lens adjacent to the negative lens and having a first surface and a second surface; and a hybrid refractive-diffractive element adjacent to the positive lens and having a first surface and a second surface, wherein one of the first surface, or the second surface comprises a diffractive surface, wherein the objective has an effective focal length in a range from about 0.8 mm to about 1.6 mm.
摘要翻译：提供广角混合折射衍射内窥镜目的。该目的包括具有第一表面和第二表面的负凹凸透镜; 靠近负弯月透镜的止动件; 与透镜相邻并具有第一表面和第二表面的正透镜; 以及与所述正透镜相邻并且具有第一表面和第二表面的混合折射衍射元件，其中所述第一表面或所述第二表面中的一个包括衍射表面，其中所述物镜具有在以下范围内的有效焦距：约0.8mm至约1.6mm。

2. 发明授权

US07885011B1 Objective for optical imaging systems 有权
标题翻译：光学成像系统的目的
公开(公告)号：US07885011B1
公开(公告)日：2011-02-08
申请号：US12543785
申请日：2009-08-19
申请人： Xinghua Wang , Mark Marshall Meyers , Siavash Yazdanfar
发明人： Xinghua Wang , Mark Marshall Meyers , Siavash Yazdanfar
IPC分类号： G02B21/02 , G02B13/18
CPC分类号： G02B23/243
摘要： A wide angle hybrid refractive-diffractive endoscope objective is provided. The objective comprises a negative meniscus lens having a first surface and a second surface; a stop adjacent to the negative meniscus lens; a positive lens adjacent to the negative lens and having a first surface and a second surface; and a hybrid refractive-diffractive element adjacent to the positive lens and having a first surface and a second surface, wherein one of the first surface, or the second surface comprises a diffractive surface, wherein the objective has an effective focal length in a range from about 0.8 mm to about 1.6 mm.
摘要翻译：提供广角混合折射衍射内窥镜目的。该目的包括具有第一表面和第二表面的负凹凸透镜; 靠近负弯月透镜的止动件; 与透镜相邻并具有第一表面和第二表面的正透镜; 以及与所述正透镜相邻并且具有第一表面和第二表面的混合折射衍射元件，其中所述第一表面或所述第二表面中的一个包括衍射表面，其中所述物镜具有在以下范围内的有效焦距：约0.8mm至约1.6mm。

3. 发明授权

US09066657B2 Methods and systems of optical imaging for target detection in a scattering medium 有权
标题翻译：散射介质中目标检测的光学成像方法和系统
公开(公告)号：US09066657B2
公开(公告)日：2015-06-30
申请号：US12952359
申请日：2010-11-23
申请人： Siavash Yazdanfar , Floribertus Heukensfeldt Jansen , Stephen Lomnes , Xinghua Wang
发明人： Siavash Yazdanfar , Floribertus Heukensfeldt Jansen , Stephen Lomnes , Xinghua Wang
IPC分类号： G06K9/40 , F21V9/16 , G01J1/58 , G01T1/10 , G21H3/02 , G21K5/00 , H01J65/06 , H01J65/08 , H01L27/00 , G01N21/86 , G01V8/00 , A61B5/00
CPC分类号： A61B5/0059 , A61B5/0064
摘要： A method for enhancing contrast in fluorescence imaging is provided. The method comprises providing a patterned illumination source for illuminating one or more regions corresponding to a scan step, scanning at least a portion of a surface of a subject using a plurality of scan steps, acquiring image frames corresponding to two or more scan steps, deducting a background fluorescence from the image frames corresponding to the two or more scan steps to form one or more processed image frames, and reconstructing an image using one or more of the processed image frames.
摘要翻译：提供了一种增强荧光成像对比度的方法。该方法包括提供用于照亮与扫描步骤相对应的一个或多个区域的图案化照明源，使用多个扫描步骤扫描对象的表面的至少一部分，获取对应于两个或更多个扫描步骤的图像帧，扣除来自对应于两个或更多个扫描步骤的图像帧的背景荧光，以形成一个或多个经处理的图像帧，以及使用一个或多个处理后的图像帧重建图像。

4. 发明申请

US20090290236A1 ENDOSCOPE OBJECTIVE LENS WITH LARGE ENTRANCE PUPIL DIAMETER AND HIGH NUMERICAL APERTURE 有权
标题翻译：内窥镜具有大的入口直径和高数值孔径的目镜
公开(公告)号：US20090290236A1
公开(公告)日：2009-11-26
申请号：US12125512
申请日：2008-05-22
申请人： Xinghua Wang , Siavash Yazdanfar
发明人： Xinghua Wang , Siavash Yazdanfar
IPC分类号： G02B13/04
CPC分类号： G02B23/243
摘要： An endoscope objective lens for collecting combined bright field (white light) and fluorescence images includes a negative lens group, a stop, and a positive lens group. The lens has a combination of large entrance pupil diameter (≧0.4 mm) for efficiently collecting weak fluorescence light, large ratio between the entrance pupil diameter and the maximum outside diameter (Dentrance/Dmax larger than 0.2), large field of view (FFOV≧120°) and favorably corrected spherical, lateral chromatic and Petzval field curvature for both visible and near infrared wavelengths.
摘要翻译：用于收集组合亮场（白光）和荧光图像的内窥镜物镜包括负透镜组，光阑和正透镜组。透镜具有大的入射光瞳直径（> = 0.4mm）的组合，用于有效地收集弱荧光，入射光瞳直径与最大外径之比大（Dentrance / Dmax大于0.2），大视野（FFOV > = 120°），并且对于可见光和近红外波长都有良好校正的球面，横向色度和Petzval场曲率。

5. 发明申请

US20120128264A1 METHODS AND SYSTEMS OF OPTICAL IMAGING FOR TARGET DETECTION IN A SCATTERING MEDIUM 有权
标题翻译：光学成像技术在散射介质中的目标检测方法与系统
公开(公告)号：US20120128264A1
公开(公告)日：2012-05-24
申请号：US12952359
申请日：2010-11-23
申请人： Siavash Yazdanfar , Floribertus Heukensfeldt Jansen , Stephen Lomnes , Xinghua Wang
发明人： Siavash Yazdanfar , Floribertus Heukensfeldt Jansen , Stephen Lomnes , Xinghua Wang
IPC分类号： G06K9/40 , G01J1/58
CPC分类号： A61B5/0059 , A61B5/0064
摘要： A method for enhancing contrast in fluorescence imaging is provided. The method comprises providing a patterned illumination source for illuminating one or more regions corresponding to a scan step, scanning at least a portion of a surface of a subject using a plurality of scan steps, acquiring image frames corresponding to two or more scan steps, deducting a background fluorescence from the image frames corresponding to the two or more scan steps to form one or more processed image frames, and reconstructing an image using one or more of the processed image frames.
摘要翻译：提供了一种增强荧光成像对比度的方法。该方法包括提供用于照亮与扫描步骤相对应的一个或多个区域的图案化照明源，使用多个扫描步骤扫描对象的表面的至少一部分，获取对应于两个或更多个扫描步骤的图像帧，扣除来自对应于两个或更多个扫描步骤的图像帧的背景荧光，以形成一个或多个经处理的图像帧，以及使用一个或多个处理后的图像帧重建图像。

6. 发明授权

US07821720B2 Endoscope objective lens with large entrance pupil diameter and high numerical aperture 有权
标题翻译：具有大入口光瞳直径和高数值孔径的内窥镜物镜
公开(公告)号：US07821720B2
公开(公告)日：2010-10-26
申请号：US12125512
申请日：2008-05-22
申请人： Xinghua Wang , Siavash Yazdanfar
发明人： Xinghua Wang , Siavash Yazdanfar
IPC分类号： G02B21/02 , A61B1/00
CPC分类号： G02B23/243
摘要： An endoscope objective lens for collecting combined bright field (white light) and fluorescence images includes a negative lens group, a stop, and a positive lens group. The lens has a combination of large entrance pupil diameter (≧0.4 mm) for efficiently collecting weak fluorescence light, large ratio between the entrance pupil diameter and the maximum outside diameter (Dentrance/Dmax larger than 0.2), large field of view (FFOV≧120°) and favorably corrected spherical, lateral chromatic and Petzval field curvature for both visible and near infrared wavelengths.
摘要翻译：用于收集组合亮场（白光）和荧光图像的内窥镜物镜包括负透镜组，光阑和正透镜组。透镜具有大的入射光瞳直径（≥0.4mm）的组合，用于有效地收集弱荧光，入射光瞳直径和最大外径之间的大比（Dentrance / Dmax大于0.2），大视场（FFOV≥ 120°），并且对于可见光和近红外波长都有良好校正的球面，横向色度和Petzval场曲率。

7. 发明授权

US08169696B2 Systems for intraoperative nerve imaging 有权
标题翻译：术中神经成像系统
公开(公告)号：US08169696B2
公开(公告)日：2012-05-01
申请号：US12821731
申请日：2010-06-23
申请人： Siavash Yazdanfar , Cristina Abucay Tan Hehir , Xinghua Wang
发明人： Siavash Yazdanfar , Cristina Abucay Tan Hehir , Xinghua Wang
IPC分类号： G02B21/06 , G02B27/02 , A61B6/00
CPC分类号： A61K49/0021
摘要： Disclosed are systems for intraoperative nerve imaging using compact high collection power imaging devices for fluorescence and white light imaging of myelin basic protein (MBP) nerve imaging agents during open and minimally invasive surgery.
摘要翻译：公开了使用紧凑型高收集功率成像装置的用于术中神经成像的系统，用于在开放和微创手术期间的髓磷脂碱性蛋白（MBP）神经成像剂的荧光和白光成像。

8. 发明申请

US20100312122A1 SYSTEMS FOR INTRAOPERATIVE NERVE IMAGING 有权
标题翻译：内窥镜成像系统
公开(公告)号：US20100312122A1
公开(公告)日：2010-12-09
申请号：US12821731
申请日：2010-06-23
申请人： Siavash Yazdanfar , Cristina Abucay Tan Hehir , Xinghua Wang
发明人： Siavash Yazdanfar , Cristina Abucay Tan Hehir , Xinghua Wang
IPC分类号： A61B6/00
CPC分类号： A61K49/0021
摘要： Disclosed are systems for intraoperative nerve imaging using compact high collection power imaging devices for fluorescence and white light imaging of myelin basic protein (MBP) nerve imaging agents during open and minimally invasive surgery.
摘要翻译：公开了使用紧凑型高收集功率成像装置的用于术中神经成像的系统，用于在开放和微创手术期间的髓磷脂碱性蛋白（MBP）神经成像剂的荧光和白光成像。

9. 发明申请

US20080088844A1 Method and apparatus for a microscope image selector 有权
公开(公告)号：US20080088844A1
公开(公告)日：2008-04-17
申请号：US11902874
申请日：2007-09-26
申请人： Xinghua Wang , Thomas Voigt , David Tuschel , Chenhui Wang , Patrick Treado
发明人： Xinghua Wang , Thomas Voigt , David Tuschel , Chenhui Wang , Patrick Treado
IPC分类号： G01N21/25
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0291 , G01J3/36 , G01J3/44 , G01N21/359 , G01N21/59 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/656
摘要： The disclosure generally relates to a multimode imaging apparatus for simultaneously obtaining multiple wavelength-discriminative spectral images of a sample. In one embodiment, the apparatus includes an image selector having a rotator assembly, the rotator assembly housing a first plurality of optical components, the image selector adapted to receive a illuminating photons having a first wavelength and direct the illuminating photons to the sample, the image selector adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; a microscope turret housing a second plurality of components, the microscope turret adapted to receive illuminating photons having a second wavelength and direct the photons to the sample; the microscopic turret adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; wherein substantially all of the interacted photons are selectively directed one of a plurality of detection sources to form multiple wavelength discriminative spectral images of the sample simultaneously.

10. 发明申请

US20080007813A1 MULTI-CONJUGATE LIQUID CRYSTAL TUNABLE FILTER 有权
标题翻译：多串联液晶可调滤波器
公开(公告)号：US20080007813A1
公开(公告)日：2008-01-10
申请号：US11112654
申请日：2005-04-22
申请人： Xinghua Wang , Chenhui Wang
发明人： Xinghua Wang , Chenhui Wang
IPC分类号： G02F1/03
CPC分类号： G02B5/28 , G02B27/288 , G02F1/13473 , G02F1/1393 , G02F2202/40 , G02F2203/055
摘要： A hyper-spectral imaging filter has serial stages along an optical signal path with angularly distributed birefringent retarders and polarizers forming interference filters. The retarders can include tunable birefringent elements such as liquid crystals controlled in unison, fixed retarders and/or combined tunable and fixed birefringences. Distinctly different periodic transmission spectra are provided by different filter stages, each having multiple retarders, in particular with some stages having broad bandpass peaks at wide spectral spacing and other stages have very narrow closely spaced peaks. The respective spectra include at least one tunably selectable band at which the transmission spectra of the filter stages coincide, whereby the salutary narrow bandpass and wide spectral spacing ranges of different stages apply together, resulting in a high finesse wavelength filter suitable for spectral imaging.
摘要翻译：超光谱成像滤光器沿着具有角分布的双折射延迟器和形成干涉滤光器的偏振器的光信号路径具有串联级。延迟器可以包括可调谐的双折射元件，例如一致控制的液晶，固定延迟器和/或组合的可调谐和固定的双折射。不同的过滤阶段提供了不同的周期透射光谱，每个滤光片具有多个延迟器，特别是在宽光谱间隔处具有宽带通峰的一些阶段，其他阶段具有非常窄的紧密间隔的峰。各个频谱包括至少一个可调谐可选择的频带，滤波器级的传输频谱在该频带处重合，由此不同阶段的有益窄带通和宽频谱间隔范围一起应用，导致适合于光谱成像的高精细波长滤波器。

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