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1. 发明申请

US20090137561A1 Substituted biphenyl GPR40 modulators 有权
公开(公告)号：US20090137561A1
公开(公告)日：2009-05-28
申请号：US12287036
申请日：2008-10-03
申请人： Sean P. Brown , Qiong Cao , Paul John Dransfield , Xiaohui Du , Jonathan Houze , Xian Yun Jiao , Yong-Jae Kim , Todd J. Kohn , SuJen Lai , An-Rong Li , Daniel Lin , Jian Luo , Julio C. Medina , Jeffrey D. Reagan , Vatee Pattaropong , Margrit Schwarz , Wang Shen , Yongli Su , Gayathri Swaminath , Marc Vimolratana , Xiang Wang , Yumei Xiong , Li Yang , Ming Yu , Jie Zhang , Liusheng Zhu
发明人： Sean P. Brown , Qiong Cao , Paul John Dransfield , Xiaohui Du , Jonathan Houze , Xian Yun Jiao , Yong-Jae Kim , Todd J. Kohn , SuJen Lai , An-Rong Li , Daniel Lin , Jian Luo , Julio C. Medina , Jeffrey D. Reagan , Vatee Pattaropong , Margrit Schwarz , Wang Shen , Yongli Su , Gayathri Swaminath , Marc Vimolratana , Xiang Wang , Yumei Xiong , Li Yang , Ming Yu , Jie Zhang , Liusheng Zhu
IPC分类号： C07C59/48 , A61K31/192 , A61K31/235 , C07C69/76 , C07D309/00 , A61K31/351 , C07D211/20 , A61K31/445 , A61K31/44 , A61K31/55 , C07D223/04 , A61P7/00
CPC分类号： C07C323/62 , C07C59/68 , C07C59/72 , C07C217/54 , C07C217/62 , C07C317/22 , C07C323/19 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D213/64 , C07D309/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

2. 发明授权

US08030354B2 Substituted biphenyl GPR40 modulators 有权
标题翻译：取代的联苯GPR40调节剂
公开(公告)号：US08030354B2
公开(公告)日：2011-10-04
申请号：US12287036
申请日：2008-10-03
申请人： Sean P. Brown , Qiong Cao , Paul John Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , Xian Yun Jiao , Yong-Jae Kim , Todd J. Kohn , SuJen Lai , An-Rong Li , Daniel Lin , Jiwen Liu , Jian Luo , Julio C. Medina , Jeffrey D. Reagan , Vatee Pattaropong , Margrit Schwarz , Wang Shen , Yongli Su , Gayathri Swaminath , Marc Vimolratana , Yingcai Wang , Yumei Xiong , Li Yang , Ming Yu , Jie Zhang , Liusheng Zhu
发明人： Sean P. Brown , Qiong Cao , Paul John Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , Xian Yun Jiao , Yong-Jae Kim , Todd J. Kohn , SuJen Lai , An-Rong Li , Daniel Lin , Jiwen Liu , Jian Luo , Julio C. Medina , Jeffrey D. Reagan , Vatee Pattaropong , Margrit Schwarz , Wang Shen , Yongli Su , Gayathri Swaminath , Marc Vimolratana , Yingcai Wang , Yumei Xiong , Li Yang , Ming Yu , Jie Zhang , Liusheng Zhu
IPC分类号： A61K31/192 , C07C53/134
CPC分类号： C07C323/62 , C07C59/68 , C07C59/72 , C07C217/54 , C07C217/62 , C07C317/22 , C07C323/19 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D213/64 , C07D309/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译：本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。这些化合物具有通式I：其中本文提供变量的定义。本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

3. 发明授权

US07816367B2 Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders 有权
公开(公告)号：US07816367B2
公开(公告)日：2010-10-19
申请号：US10591214
申请日：2005-02-24
申请人： Michelle Akerman , Jonathan Houze , Daniel C. H. Lin , Jiwen Liu , Jian Luo , Julio C. Medina , Wei Qiu , Jeffrey D. Reagan , Rajiv Sharma , Stephen J. Shuttleworth , Ying Sun , Jian Zhang , Liusheng Zhu , Jinqian Liu , Zhihua Ma , Yingcai Wang , Michael J. Schmitt
发明人： Michelle Akerman , Jonathan Houze , Daniel C. H. Lin , Jiwen Liu , Jian Luo , Julio C. Medina , Wei Qiu , Jeffrey D. Reagan , Rajiv Sharma , Stephen J. Shuttleworth , Ying Sun , Jian Zhang , Liusheng Zhu , Jinqian Liu , Zhihua Ma , Yingcai Wang , Michael J. Schmitt
IPC分类号： A61K31/44 , C07D213/02
CPC分类号： C07D277/24 , C07D277/30
摘要： The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formula Q-L1-P-L2-M-X-L3-A wherein the definitions of the variables Q, L1, P, L2, M, X, L3 and A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.

4. 发明授权

US07649110B2 Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders 有权
标题翻译：用于治疗代谢紊乱的化合物，药物组合物和方法
公开(公告)号：US07649110B2
公开(公告)日：2010-01-19
申请号：US11067377
申请日：2005-02-25
申请人： Michelle Akerman , Jonathan Houze , Daniel C. H. Lin , Jinqian Liu , Jiwen Liu , Jian Luo , Zhihua Ma , Julio C. Medina , Wei Qiu , Jeffrey D. Reagan , Rajiv Sharma , Michael J. Schmitt , Stephen J. Shuttleworth , Ying Sun , Yingcai Wang , Jian Zhang , Liusheng Zhu
发明人： Michelle Akerman , Jonathan Houze , Daniel C. H. Lin , Jinqian Liu , Jiwen Liu , Jian Luo , Zhihua Ma , Julio C. Medina , Wei Qiu , Jeffrey D. Reagan , Rajiv Sharma , Michael J. Schmitt , Stephen J. Shuttleworth , Ying Sun , Yingcai Wang , Jian Zhang , Liusheng Zhu
IPC分类号： C07C59/40 , C07C65/03
CPC分类号： C07D277/24 , C07D277/30
摘要： The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formula Q—L1—P—L2—M—X—L3—A wherein the definitions of the variables Q, L1, P, L2, M, X, L3 and A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.
摘要翻译：本发明提供了可用于调节受试者胰岛素水平的化合物，其具有通式Q-L1-P-L2-MX-L3-A，其中变量Q，L1，P，L2， M，X，L3和A。本发明还提供了用于治疗II型糖尿病的化合物的组合物和方法。

5. 发明申请

US20070142384A1 Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders 有权
标题翻译：用于治疗代谢紊乱的化合物，药物组合物和方法
公开(公告)号：US20070142384A1
公开(公告)日：2007-06-21
申请号：US10591214
申请日：2005-02-24
申请人： Michelle Akerman , Jonathan Houze , Daniel Lin , Jinqian Liu , Jiwen Liu , Jian Luo , Zhihua Ma , Julio Medina , Wei Qiu , Jeffrey Reagan , Rajiv Sharma , Michael Schmitt , Stephen Shuttleworth , Ying Sun , Yingcai Wang , Jian Zhang , Liusheng Zhu
发明人： Michelle Akerman , Jonathan Houze , Daniel Lin , Jinqian Liu , Jiwen Liu , Jian Luo , Zhihua Ma , Julio Medina , Wei Qiu , Jeffrey Reagan , Rajiv Sharma , Michael Schmitt , Stephen Shuttleworth , Ying Sun , Yingcai Wang , Jian Zhang , Liusheng Zhu
IPC分类号： A61K31/522 , A61K31/4965 , A61K31/52 , A61K31/4709 , A61K31/498 , A61K31/4439 , A61K31/415
CPC分类号： C07D277/24 , C07D277/30
摘要： The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formula Q-L1-P-L2-M-X-L3-A wherein the definitions of the variables Q, L1, P, L2, M, X, L3 and A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.
摘要翻译：本发明提供了可用于例如用于调节受试者中胰岛素水平的化合物，并且具有通式QL 1 -PL 2 -MXL 3 SUP> -A，其中变量Q，L 1，P，L 2，M，X，L 3和A的定义是本文提供。本发明还提供了用于治疗II型糖尿病的化合物的组合物和方法。

6. 发明申请

US20060004012A1 Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders 有权
标题翻译：用于治疗代谢紊乱的化合物，药物组合物和方法
公开(公告)号：US20060004012A1
公开(公告)日：2006-01-05
申请号：US11067377
申请日：2005-02-25
申请人： Michelle Akerman , Jonathan Houze , Daniel Lin , Jiwen Liu , Jian Luo , Julio Medina , Wei Qiu , Jeffrey Reagan , Rajiv Sharma , Michael Schmitt , Stephen Shuttleworth , Ying Sun , Yingcai Wang , Jian Zhang , Liusheng Zhu
发明人： Michelle Akerman , Jonathan Houze , Daniel Lin , Jiwen Liu , Jian Luo , Julio Medina , Wei Qiu , Jeffrey Reagan , Rajiv Sharma , Michael Schmitt , Stephen Shuttleworth , Ying Sun , Yingcai Wang , Jian Zhang , Liusheng Zhu
IPC分类号： A61K31/498 , C07D43/02
CPC分类号： C07D277/24 , C07D277/30
摘要： The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formula Q-L1-P-L2-M-X-L3-A wherein the definitions of the variables Q, L1, P, L2, M, X, L3 and A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.
摘要翻译：本发明提供了可用于例如调节受试者中的胰岛素水平的化合物，并且具有通式<？in-line-formula description =“In-line formula”end =“lead”→> QL < -PL ^{2 3 -A <？in-line-formula description =“In-line Formulas”end =“tail”？>其中本文提供变量Q，L 1，P，L 2，M，X，L 3和A的定义。本发明还提供了用于治疗II型糖尿病的化合物的组合物和方法。}

7. 发明申请

US20110005349A1 GEARMOTOR ASSEMBLY 审中-公开
标题翻译：齿轮总成
公开(公告)号：US20110005349A1
公开(公告)日：2011-01-13
申请号：US12832595
申请日：2010-07-08
申请人： Jian Luo , Xian Tang , Xuan Li Yang
发明人： Jian Luo , Xian Tang , Xuan Li Yang
IPC分类号： F16H57/02 , F16J15/06
CPC分类号： E05F15/697 , E05Y2900/55 , Y10T74/2186
摘要： A gearmotor assembly has a motor; and a gearbox attached to the motor. The gearbox has: a case having an opening, a cover for closing the opening, and a seal for sealing the cover to the case. The seal is a continuous loop disposed about the opening and having first and second axial end surfaces forming a first seal surface and a second seal surface. Two ridges are formed on each of the two seal surfaces, each of the ridges extending along the seal surface to form a continuous ridge. The two ridges of the first seal surface are spaced from each other and pressed by the case and the two ridges of the second seal surface are spaced from each other and pressed by the cover, whereby the seal is resiliently deformed between the case and the cover.
摘要翻译：减速电机组件具有马达; 以及连接到电动机的变速箱。齿轮箱具有：具有开口的壳体，用于封闭开口的盖，以及用于将盖密封到壳体上的密封件。所述密封件是围绕所述开口设置的连续环，并具有形成第一密封表面和第二密封表面的第一和第二轴向端面。在两个密封表面中的每一个上形成两个脊，每个脊沿着密封表面延伸以形成连续的脊。第一密封表面的两个脊彼此间隔开并被壳体按压，并且第二密封表面的两个脊彼此间隔开并被盖挤压，由此密封件在壳体和盖之间弹性变形。

8. 发明授权

US08336392B2 Integrated micromachining air flow path clog sensor 有权
标题翻译：集成微加工空气流路堵塞传感器
公开(公告)号：US08336392B2
公开(公告)日：2012-12-25
申请号：US12787268
申请日：2010-05-25
申请人： Liji Huang , Jian Luo , Changming Jiang , Yenan Liu , Wenhong Deng , Jialuo Jack Xuan , Chih-Chang Chen
发明人： Liji Huang , Jian Luo , Changming Jiang , Yenan Liu , Wenhong Deng , Jialuo Jack Xuan , Chih-Chang Chen
IPC分类号： G01F1/56
CPC分类号： G01F1/6845
摘要： Nowadays many electronic devices, such as LCD projector, computer servers, and air fresher etc. require reliable air cooling system to reduce the risk of electronics damage caused by overheating. The present invention disclosed an apparatus integrated with air flow sensor as an alarm apparatus for air flow clog detection. The major prior approach for air flow circulation failure detection is based on an indirect measurement method of temperature monitoring on surrounding environments, which method is suffering from the slow response and poor identification of real-time situation. The present invention will demonstrate the advantages by directly monitoring air flow over by indirectly monitoring the surrounding temperature as for the purpose of preventing air flow path clog.
摘要翻译：如今，诸如液晶投影仪，电脑服务器和空气清新器等电子设备需要可靠的空气冷却系统，以减少过热引起的电子设备损坏的风险。本发明公开了一种与空气流量传感器集成的装置，作为气流堵塞检测的报警装置。气流循环故障检测的主要方法是基于对周围环境进行温度监测的间接测量方法，该方法受到响应缓慢和实时状况识别不良。本发明将通过间接地监测周围温度来直接监测气流的优点，以防止气流通道堵塞。

9. 发明授权

US08329749B2 Use of (−) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of hyperuricemia 有权
标题翻译：（ - ）（3-三卤甲基苯氧基）（4-卤代苯基）乙酸衍生物用于治疗高尿酸血症
公开(公告)号：US08329749B2
公开(公告)日：2012-12-11
申请号：US12504061
申请日：2009-07-16
申请人： Kenneth L. Luskey , Jian Luo
发明人： Kenneth L. Luskey , Jian Luo
IPC分类号： A61K31/20
CPC分类号： A61K31/20 , A61K31/215 , A61K31/216 , A61K31/235 , A61K31/24 , A61K31/265 , A61K31/335 , A61K31/40 , A61K31/425 , A61K31/445 , A61K31/455 , A61K31/495 , A61K31/50 , A61K31/535 , A61K31/64 , A61K38/28 , A61K45/06 , C07D205/04 , C07D207/08 , C07D207/34 , C07D213/65 , C07D213/81 , C07D213/82 , C07D295/185 , C07D317/40 , C07D333/40 , A61K2300/00 , A61K31/155
摘要： The present invention provides the use of (−)(3-trihalomethylphenoxy)(4-halophenyl)acetic acid derivatives and compositions in the treatment of insulin resistance, Type 2 diabetes, hyperlipidemia and hyperuricemia.
摘要翻译：本发明提供（ - ）（3-三卤甲基苯氧基）（4-卤代苯基）乙酸衍生物和组合物在治疗胰岛素抵抗，2型糖尿病，高脂血症和高尿酸血症中的用途。

10. 发明申请

US20100093855A1 USE OF (-) (3-TRIHALOMETHYLPHENOXY) (4-HALOPHENYL) ACETIC ACID DERIVATIVES FOR TREATMENT OF INSULIN RESISTANCE, TYPE 2 DIABETES, HYPERLIPIDEMIA AND HYPERURICEMIA 有权
标题翻译：（ - ）（3-三乙氧基苯氧基）（4-乙烯基）乙酸衍生物用于治疗胰岛素抵抗，2型糖尿病，高血脂和高血压的用途
公开(公告)号：US20100093855A1
公开(公告)日：2010-04-15
申请号：US12504061
申请日：2009-07-16
申请人： Kenneth L. Luskey , Jian Luo
发明人： Kenneth L. Luskey , Jian Luo
IPC分类号： A61K31/216 , A61P43/00
CPC分类号： A61K31/20 , A61K31/215 , A61K31/216 , A61K31/235 , A61K31/24 , A61K31/265 , A61K31/335 , A61K31/40 , A61K31/425 , A61K31/445 , A61K31/455 , A61K31/495 , A61K31/50 , A61K31/535 , A61K31/64 , A61K38/28 , A61K45/06 , C07D205/04 , C07D207/08 , C07D207/34 , C07D213/65 , C07D213/81 , C07D213/82 , C07D295/185 , C07D317/40 , C07D333/40 , A61K2300/00 , A61K31/155
摘要： The present invention provides the use of (−)(3-trihalomethylphenoxy)(4-halophenyl)acetic acid derivatives and compositions in the treatment of insulin resistance, Type 2 diabetes, hyperlipidemia and hyperuricemia.
摘要翻译：本发明提供（ - ）（3-三卤甲基苯氧基）（4-卤代苯基）乙酸衍生物和组合物在治疗胰岛素抵抗，2型糖尿病，高脂血症和高尿酸血症中的用途。

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