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1. 发明授权

US07816367B2 Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders 有权
公开(公告)号：US07816367B2
公开(公告)日：2010-10-19
申请号：US10591214
申请日：2005-02-24
申请人： Michelle Akerman , Jonathan Houze , Daniel C. H. Lin , Jiwen Liu , Jian Luo , Julio C. Medina , Wei Qiu , Jeffrey D. Reagan , Rajiv Sharma , Stephen J. Shuttleworth , Ying Sun , Jian Zhang , Liusheng Zhu , Jinqian Liu , Zhihua Ma , Yingcai Wang , Michael J. Schmitt
发明人： Michelle Akerman , Jonathan Houze , Daniel C. H. Lin , Jiwen Liu , Jian Luo , Julio C. Medina , Wei Qiu , Jeffrey D. Reagan , Rajiv Sharma , Stephen J. Shuttleworth , Ying Sun , Jian Zhang , Liusheng Zhu , Jinqian Liu , Zhihua Ma , Yingcai Wang , Michael J. Schmitt
IPC分类号： A61K31/44 , C07D213/02
CPC分类号： C07D277/24 , C07D277/30
摘要： The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formula Q-L1-P-L2-M-X-L3-A wherein the definitions of the variables Q, L1, P, L2, M, X, L3 and A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.

2. 发明授权

US07649110B2 Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders 有权
标题翻译：用于治疗代谢紊乱的化合物，药物组合物和方法
公开(公告)号：US07649110B2
公开(公告)日：2010-01-19
申请号：US11067377
申请日：2005-02-25
申请人： Michelle Akerman , Jonathan Houze , Daniel C. H. Lin , Jinqian Liu , Jiwen Liu , Jian Luo , Zhihua Ma , Julio C. Medina , Wei Qiu , Jeffrey D. Reagan , Rajiv Sharma , Michael J. Schmitt , Stephen J. Shuttleworth , Ying Sun , Yingcai Wang , Jian Zhang , Liusheng Zhu
发明人： Michelle Akerman , Jonathan Houze , Daniel C. H. Lin , Jinqian Liu , Jiwen Liu , Jian Luo , Zhihua Ma , Julio C. Medina , Wei Qiu , Jeffrey D. Reagan , Rajiv Sharma , Michael J. Schmitt , Stephen J. Shuttleworth , Ying Sun , Yingcai Wang , Jian Zhang , Liusheng Zhu
IPC分类号： C07C59/40 , C07C65/03
CPC分类号： C07D277/24 , C07D277/30
摘要： The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formula Q—L1—P—L2—M—X—L3—A wherein the definitions of the variables Q, L1, P, L2, M, X, L3 and A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.
摘要翻译：本发明提供了可用于调节受试者胰岛素水平的化合物，其具有通式Q-L1-P-L2-MX-L3-A，其中变量Q，L1，P，L2， M，X，L3和A。本发明还提供了用于治疗II型糖尿病的化合物的组合物和方法。

3. 发明申请

US20070142384A1 Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders 有权
标题翻译：用于治疗代谢紊乱的化合物，药物组合物和方法
公开(公告)号：US20070142384A1
公开(公告)日：2007-06-21
申请号：US10591214
申请日：2005-02-24
申请人： Michelle Akerman , Jonathan Houze , Daniel Lin , Jinqian Liu , Jiwen Liu , Jian Luo , Zhihua Ma , Julio Medina , Wei Qiu , Jeffrey Reagan , Rajiv Sharma , Michael Schmitt , Stephen Shuttleworth , Ying Sun , Yingcai Wang , Jian Zhang , Liusheng Zhu
发明人： Michelle Akerman , Jonathan Houze , Daniel Lin , Jinqian Liu , Jiwen Liu , Jian Luo , Zhihua Ma , Julio Medina , Wei Qiu , Jeffrey Reagan , Rajiv Sharma , Michael Schmitt , Stephen Shuttleworth , Ying Sun , Yingcai Wang , Jian Zhang , Liusheng Zhu
IPC分类号： A61K31/522 , A61K31/4965 , A61K31/52 , A61K31/4709 , A61K31/498 , A61K31/4439 , A61K31/415
CPC分类号： C07D277/24 , C07D277/30
摘要： The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formula Q-L1-P-L2-M-X-L3-A wherein the definitions of the variables Q, L1, P, L2, M, X, L3 and A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.
摘要翻译：本发明提供了可用于例如用于调节受试者中胰岛素水平的化合物，并且具有通式QL 1 -PL 2 -MXL 3 SUP> -A，其中变量Q，L 1，P，L 2，M，X，L 3和A的定义是本文提供。本发明还提供了用于治疗II型糖尿病的化合物的组合物和方法。

4. 发明申请

US20060004012A1 Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders 有权
标题翻译：用于治疗代谢紊乱的化合物，药物组合物和方法
公开(公告)号：US20060004012A1
公开(公告)日：2006-01-05
申请号：US11067377
申请日：2005-02-25
申请人： Michelle Akerman , Jonathan Houze , Daniel Lin , Jiwen Liu , Jian Luo , Julio Medina , Wei Qiu , Jeffrey Reagan , Rajiv Sharma , Michael Schmitt , Stephen Shuttleworth , Ying Sun , Yingcai Wang , Jian Zhang , Liusheng Zhu
发明人： Michelle Akerman , Jonathan Houze , Daniel Lin , Jiwen Liu , Jian Luo , Julio Medina , Wei Qiu , Jeffrey Reagan , Rajiv Sharma , Michael Schmitt , Stephen Shuttleworth , Ying Sun , Yingcai Wang , Jian Zhang , Liusheng Zhu
IPC分类号： A61K31/498 , C07D43/02
CPC分类号： C07D277/24 , C07D277/30
摘要： The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formula Q-L1-P-L2-M-X-L3-A wherein the definitions of the variables Q, L1, P, L2, M, X, L3 and A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.
摘要翻译：本发明提供了可用于例如调节受试者中的胰岛素水平的化合物，并且具有通式<？in-line-formula description =“In-line formula”end =“lead”→> QL < -PL ^{2 3 -A <？in-line-formula description =“In-line Formulas”end =“tail”？>其中本文提供变量Q，L 1，P，L 2，M，X，L 3和A的定义。本发明还提供了用于治疗II型糖尿病的化合物的组合物和方法。}

5. 发明授权

US07465804B2 Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders 有权
标题翻译：用于治疗代谢紊乱的化合物，药物组合物和方法
公开(公告)号：US07465804B2
公开(公告)日：2008-12-16
申请号：US11436732
申请日：2006-05-17
申请人： Jonathan Houze , Jiwen Liu , Zhihua Ma , Julio C. Medina , Michael J. Schmitt , Rajiv Sharma , Ying Sun , Yingcai Wang , Liusheng Zhu
发明人： Jonathan Houze , Jiwen Liu , Zhihua Ma , Julio C. Medina , Michael J. Schmitt , Rajiv Sharma , Ying Sun , Yingcai Wang , Liusheng Zhu
IPC分类号： C07D263/32 , C07D257/04 , C07D249/04 , C07D249/08 , C07D277/22 , C07D277/24 , C07C59/13
CPC分类号： C07D277/24 , C07B2200/07 , C07C235/34 , C07D233/64 , C07D249/08 , C07D257/04 , C07D263/32 , C07D417/12
摘要： The present invention provides compounds useful, for example, for modulating insulin levels in a subject, having the general formula I: wherein Q is an optionally substituted phenyl; L is a bond or O; P is a benzene or an optionally substituted thiazole ring; and R1 has the values provided herein. The present invention also provides compositions, uses, and methods for use of the compounds, for instance, for treatment of type II diabetes.
摘要翻译：本发明提供了可用于例如用于调节受试者中具有通式I的胰岛素水平的化合物：其中Q是任选取代的苯基; L是一个键或O; P是苯或任选取代的噻唑环; 并且R1具有本文提供的值。本发明还提供了用于治疗II型糖尿病的化合物的组合物，用途和方法。

6. 发明申请

US20070244155A1 Bicyclic carboxylic acid derivatives useful for treating metabolic disorders 审中-公开
标题翻译：用于治疗代谢紊乱的双环羧酸衍生物
公开(公告)号：US20070244155A1
公开(公告)日：2007-10-18
申请号：US11717945
申请日：2007-03-13
申请人： Rajiv Sharma , Michelle Akerman , Mario Cardozo , Jonathan Houze , An-Rong Li , Jinquian Liu , Jiwen Liu , Zhihua Ma , Julio Medina , Michael Schmitt , Ying Sun , Yingcai Wang , Zhongyu Wang , Liusheng Zhu
发明人： Rajiv Sharma , Michelle Akerman , Mario Cardozo , Jonathan Houze , An-Rong Li , Jinquian Liu , Jiwen Liu , Zhihua Ma , Julio Medina , Michael Schmitt , Ying Sun , Yingcai Wang , Zhongyu Wang , Liusheng Zhu
IPC分类号： A61K31/4704 , A61K31/405 , A61K31/366 , A61K31/353 , A61K31/192
CPC分类号： C07C57/62 , C07C59/64 , C07C59/72 , C07D209/08 , C07D209/46 , C07D215/20 , C07D215/227 , C07D277/24 , C07D311/58 , C07D311/74 , C07D311/76 , C07D313/08 , C07D417/12 , C07D498/04
摘要： Compounds having the general formula I and/or the general formula II are useful, for example, for treating metabolic disorders in a subject where the variables are provided herein. Compositions and methods for using the compounds for preparing medicaments and for treating metabolic disorders such as, for instance, type II diabetes are disclosed.
摘要翻译：具有通式I和/或通式II的化合物可用于例如在本文提供变量的受试者中治疗代谢紊乱。公开了用于制备药物和用于治疗代谢性疾病例如II型糖尿病的化合物的组合物和方法。

7. 发明申请

US20060270724A1 Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders 有权
标题翻译：用于治疗代谢紊乱的化合物，药物组合物和方法
公开(公告)号：US20060270724A1
公开(公告)日：2006-11-30
申请号：US11436732
申请日：2006-05-17
申请人： Jonathan Houze , Jiwen Liu , Zhihua Ma , Julio Medina , Michael Schmitt , Rajiv Sharma , Ying Sun , Yingcai Wang , Liusheng Zhu
发明人： Jonathan Houze , Jiwen Liu , Zhihua Ma , Julio Medina , Michael Schmitt , Rajiv Sharma , Ying Sun , Yingcai Wang , Liusheng Zhu
IPC分类号： C07D249/08 , C07D233/61 , A61K31/4196 , A61K31/4172
CPC分类号： C07D277/24 , C07B2200/07 , C07C235/34 , C07D233/64 , C07D249/08 , C07D257/04 , C07D263/32 , C07D417/12
摘要： The present invention provides compounds useful, for example, for modulating insulin levels in a subject, having the general formula I: wherein Q is an optionally substituted phenyl; L is a bond or O; P is a benzene or an optionally substituted thiazole ring; and R1 has the values provided herein. The present invention also provides compositions, uses, and methods for use of the compounds, for instance, for treatment of type II diabetes.
摘要翻译：本发明提供了可用于例如用于调节受试者中具有通式I的胰岛素水平的化合物：其中Q是任选取代的苯基; L是一个键或O; P是苯或任选取代的噻唑环; 且R 1具有本文提供的值。本发明还提供了用于治疗II型糖尿病的化合物的组合物，用途和方法。

8. 发明申请

US20170003079A1 Systems and Methods of Using Phase Change Material in Power Plants 审中-公开
标题翻译：电厂使用相变材料的系统与方法
公开(公告)号：US20170003079A1
公开(公告)日：2017-01-05
申请号：US15266217
申请日：2016-09-15
申请人： Ying Sun , Matthew McCarthy , Young I. Cho , Philipp Boettcher , Han Hu , Baolan Shi , Qinghua Xie , Kent Zammit
发明人： Ying Sun , Matthew McCarthy , Young I. Cho , Philipp Boettcher , Han Hu , Baolan Shi , Qinghua Xie , Kent Zammit
IPC分类号： F28D1/02 , F28B1/02
CPC分类号： F28D1/024 , F28B1/02 , F28B9/06 , F28C1/14 , F28C3/10 , F28D20/021 , F28D20/023 , F28F2245/04 , Y02E60/145
摘要： Phase change material modules for use in a heat exchanger are described. The phase change material module comprises two or more set of a plurality of substantially aligned hollow structures arranged to form a porous structure. A phase change material capable of undergoing a phase change as a result of heat exchange between it and a fluid is housed within the hollow tubes. Also described is a phase change material module with hollow tubes having a cross-sectional area through the phase change material selected from elliptical, rectangular, stadium-shaped, teardrop-shaped, airfoil-shaped, rounded rectangle and ovoid. A heat exchanger comprising a plurality of the phase change material modules, a first fluid inlet and outlet, and a second fluid inlet and outlet, wherein the phase change material modules are repeated circulated from alignment with the first fluid inlet and the second fluid inlet is also described.
摘要翻译：描述了用于热交换器的相变材料模块。相变材料模块包括布置成形成多孔结构的两组或多组多个基本排列的中空结构。能够由于其与流体之间的热交换而发生相变的相变材料容纳在中空管内。还描述了一种相变材料模块，其具有中空管，该中空管具有穿过相变材料的横截面积，该相变材料选自椭圆形，矩形，体育场形，泪滴形，翼型，圆形矩形和卵形。一种热交换器，其包括多个所述相变材料模块，第一流体入口和出口以及第二流体入口和出口，其中所述相变材料模块与所述第一流体入口对准地重复循环，并且所述第二流体入口是也描述。

9. 发明授权

US09332474B2 Signaling support for multi sector deployment in cellular communications 有权
标题翻译：蜂窝通信中多扇区部署的信令支持
公开(公告)号：US09332474B2
公开(公告)日：2016-05-03
申请号：US13545941
申请日：2012-07-10
申请人： Ying Sun , Tao Cui
发明人： Ying Sun , Tao Cui
IPC分类号： H04W4/00 , H04W36/30 , H04W92/20 , H04W36/02
CPC分类号： H04W36/30 , H04B17/318 , H04W36/023 , H04W92/20
摘要： A method in a controller for a first cell in a mobile cellular network for making a decision to handover a user equipment to a second cell of the mobile cellular network is described. The method may include obtaining a first measurement of an uplink signal from a user equipment at the first cell, obtaining a second measurement of an uplink signal from the user equipment at the second cell, and making a decision to handover the user equipment from the first cell to the second cell using the obtained first and second measurements.
摘要翻译：描述了用于移动蜂窝网络中的第一小区的控制器中的用于做出将用户设备切换到移动蜂窝网络的第二小区的决定的方法。该方法可以包括从第一小区的用户设备获得上行链路信号的第一测量值，从第二小区的用户设备获得上行链路信号的第二测量值，以及从第一小区切换用户设备的决定使用获得的第一和第二测量将单元传送到第二单元。

10. 发明授权

US08949293B2 Automatically matching data sets with storage components 有权
标题翻译：自动将数据集与存储组件进行匹配
公开(公告)号：US08949293B2
公开(公告)日：2015-02-03
申请号：US12972137
申请日：2010-12-17
申请人： Magdi A. Morsi , Wai Ho Au , Ying Sun , Sanjeev Katariya , Yang Xu , Nina Sarawgi
发明人： Magdi A. Morsi , Wai Ho Au , Ying Sun , Sanjeev Katariya , Yang Xu , Nina Sarawgi
IPC分类号： G06F17/30 , G06F11/34
CPC分类号： G06F17/30289 , G06F11/3442 , G06F11/3485
摘要： An administrator of an enterprise storage set may be tasked with storing a large number and variety of data sets on a large number and variety of storage components. However, the manual selection of a physical schema by an administrator may be time-consuming, may generate inefficient physical schemata, and may not be easily reevaluated as the data sets and storage set change. Presented herein are techniques for automatically determining a physical schema by comparing the storage factors of each data set (e.g., data size, relationships with other data sets, and usages of the data set by users) with the storage capabilities of the storage components, selecting a suitable storage component, and implementing the storage of the data set on the storage component. An embodiment of these techniques may thereby achieve an automated identification of a physical schema with improved efficiency and flexibility of the physical schema while conserving administrative resources.
摘要翻译：企业存储集的管理员可以负责在大量和多种存储组件上存储大量和多种数据集。然而，由管理员手动选择物理模式可能是耗时的，可能产生低效的物理模式，并且可能不会随数据集和存储集改变而容易地重新评估。这里提出的技术是通过将每个数据集的存储因子（例如，数据大小，与其他数据集的关系以及用户的数据集的使用）与存储组件的存储能力进行比较来自动确定物理模式，选择合适的存储组件，以及在存储组件上实现数据集的存储。因此，这些技术的实施例可以实现物理模式的自动识别，同时节省管理资源，同时提高物理模式的效率和灵活性。

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