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1. 发明授权

US5705191A Sustained delivery of active compounds from tubules, with rational control 失效
标题翻译：持续输送活性化合物从小管，合理控制
公开(公告)号：US5705191A
公开(公告)日：1998-01-06
申请号：US523725
申请日：1995-08-18
申请人： Ronald R. Price , Joel M. Schnur , Alan S. Rudolph , Jonathan Selinger , Alok Singh , Bruce P. Gaber
发明人： Ronald R. Price , Joel M. Schnur , Alan S. Rudolph , Jonathan Selinger , Alok Singh , Bruce P. Gaber
IPC分类号： A61K9/00 , A61K9/127 , A61K9/24
CPC分类号： A61K9/0092 , A61K9/1274
摘要： The present invention is a method for releasing an active agent into a use nvironment, by disposing this active agent within the lumen of a population of tubules, and disposing the tubules into a use environment, either directly or in some matrix such as a paint in contact with the use environment. The tubules have a preselected release profile to provide a preselected release rate curve. The preselected release profile may be achieved by controlling the length or length distribution of the tubules, or by placing degradable endcaps over some or all of the tubules in the population, or by combinations of these methods. The invention is also a population of tubules having a preselected release profile to provide a preselected release rate curve.
摘要翻译：本发明是一种将活性剂释放到使用环境中的方法，其通过将该活性剂置于一群小管的内腔内，并将该小管直接或以某种基质如涂料与使用环境接触。小管具有预先选择的释放曲线以提供预选的释放速率曲线。预选释放曲线可以通过控制小管的长度或长度分布，或者通过将可降解端帽置于群体中的一些或全部小管上，或通过这些方法的组合来实现。本发明还是具有预选释放曲线以提供预选释放速率曲线的小管群。

2. 发明授权

US5651976A Controlled release of active agents using inorganic tubules 失效
标题翻译：使用无机小管控制活性剂的释放
公开(公告)号：US5651976A
公开(公告)日：1997-07-29
申请号：US509483
申请日：1995-07-31
申请人： Ronald R. Price , Bruce P. Gaber
发明人： Ronald R. Price , Bruce P. Gaber
IPC分类号： A01N25/08 , A61K9/00 , A01N25/28
CPC分类号： A61K9/0092 , A01N25/08 , B82Y5/00 , Y10S514/963 , Y10T428/2984 , Y10T428/2991
摘要： The present invention is a composition for, and a method of, delivering an active agent at a controlled rate. The composition of the invention is a hollow ceramic or inorganic microtubule, where the active agent is contained within the lumen of the microtubules. Typically, the agent is adsorbed onto an inner surface of the microtubule. The method of the invention is disposing this novel composition in a use environment. In a preferred embodiment of the invention, a microtubule is a tubule having an inner diameter of less than 0.2 .mu.m, and microtubules are tubules having an average inner diameter less than 0.2 .mu.m. In a preferred embodiment, the hollow ceramic or inorganic microtubule is a mineral microtubule, such as halloysite, cylindrite, boulangerite, or imogolite. In a more preferred embodiment of the invention, the mineral microtubule has a biodegradable polymeric carrier disposed in its lumen. In a preferred embodiment of the invention, the inner diameter of the microtubules varies from about 0.20 .mu.m to about 0.35 .mu.m, or averages about 0.40 .mu.m. In another preferred embodiment, of the invention, the inner diameter of the microtubules varies from about 200 .ANG. to about 1000 .ANG..
摘要翻译：本发明是以受控的速率递送活性剂的组合物和方法。本发明的组合物是中空陶瓷或无机微管，其中活性剂包含在微管的内腔内。通常，试剂被吸附到微管的内表面上。本发明的方法是将这种新型组合物置于使用环境中。在本发明的优选实施方案中，微管是内径小于0.2μm的小管，微管是平均内径小于0.2μm的小管。在优选的实施方案中，中空陶瓷或无机微管是矿物微管，例如多水高岭土，圆柱形，boulangerite或imocolite。在本发明的一个更优选的实施方案中，矿物质微管具有设置在其内腔中的可生物降解的聚合物载体。在本发明的优选实施方案中，微管的内径从约0.20μm至约0.35μm变化，或平均约0.40μm。在本发明的另一个优选实施方案中，微管的内径从约200安培至约1000安培度变化。

3. 发明授权

US06401816B1 Efficient method for subsurface treatments, including squeeze treatments 有权
标题翻译：有效的地下处理方法，包括挤压处理
公开(公告)号：US06401816B1
公开(公告)日：2002-06-11
申请号：US09518133
申请日：2000-03-03
申请人： Ronald R. Price , Robert David Eden , Bruce P. Gaber
发明人： Ronald R. Price , Robert David Eden , Bruce P. Gaber
IPC分类号： A01N2508
CPC分类号： C09K8/92 , C09K8/536
摘要： A method for delivering encapsulated materials to a subsurface environment, for the treatment of the subsurface environment, has the steps of: (a) loading the lumen of hollow microtubules with an active agent selected for treating the subsurface environment, where the hollow microtubules are compatible with the subsurface environment; and (b) administering the hollow microtubules to the subsurface environment, permitting the controlled release of the active agent into the subsurface environment. This method may be practiced using a slurry of hollow microtubules, where the lumen of these microtubules is loaded with an agent for the treatment of petroleum well environments, and where these loaded microtubules are dispersed in a liquid phase carrier selected from aqueous carriers, non-aqueous carriers, and emulsions of aqueous and non-aqueous materials. This method may also be practiced using a pill made of a consolidated mass of tubules loaded with one or more active agents, typically bound with a binder.
摘要翻译：将封装的材料递送到地下环境以用于处理地下环境的方法具有以下步骤：（a）用选择用于处理地下环境的活性剂加载中空微管的内腔，其中中空微管是相容的与地下环境; 和（b）将空心微管施用于地下环境，允许活性剂受控释放到地下环境中。该方法可以使用中空微管的浆液来实施，其中这些微管的管腔装载有用于处理石油井环境的试剂，并且其中这些负载的微管分散在选自水性载体，非水溶性载体的液相载体中，含水载体和水性和非水性材料的乳液。也可以使用由装有一种或多种通常与粘合剂结合的活性剂的固体的小管制成的丸来实施该方法。

4. 发明授权

US5948621A Direct molecular patterning using a micro-stamp gel 失效
标题翻译：使用微型凝胶进行直接分子图案化
公开(公告)号：US5948621A
公开(公告)日：1999-09-07
申请号：US940178
申请日：1997-09-30
申请人： David C. Turner , Brett Martin , Bruce P. Gaber
发明人： David C. Turner , Brett Martin , Bruce P. Gaber
IPC分类号： B01J19/00 , B41M3/00 , C12Q1/68 , C40B60/14 , G01N1/30 , B41M3/12 , C12Q1/00 , C12Q1/70
CPC分类号： G01N1/30 , B01J19/0046 , B41M3/006 , C12Q1/68 , C12Q1/6834 , B01J2219/00382 , B01J2219/00527 , B01J2219/00605 , B01J2219/00612 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , C40B60/14 , G01N2650/00 , Y10S977/887
摘要： A stamp for transferring molecules and molecular patterns to a substrate face includes a backing and a polymeric gel bound to the backing and loaded with the a molecular species. Where the molecule to be patterned is a biomolecule, such as a protein or nucleic acid, the polymeric gel is typically a hydrogel. Exemplary hydrogels include sugar-based polyacrylates and polyacrylamides.
摘要翻译：用于将分子和分子图案转移到基底表面的印模包括背衬和与背衬结合并加载分子种类的聚合物凝胶。当待图案化的分子是生物分子，例如蛋白质或核酸时，聚合凝胶通常是水凝胶。示例性水凝胶包括糖基聚丙烯酸酯和聚丙烯酰胺。

5. 发明授权

US06245296B1 Flow immunosensor apparatus 失效
标题翻译：流量免疫传感器
公开(公告)号：US06245296B1
公开(公告)日：2001-06-12
申请号：US07860965
申请日：1992-03-31
申请人： Frances S. Ligler , Bruce P. Gaber , Anne W. Kusterbeck , Gregory A. Wemhoff
发明人： Frances S. Ligler , Bruce P. Gaber , Anne W. Kusterbeck , Gregory A. Wemhoff
IPC分类号： G01N3348
CPC分类号： G01N33/54366 , G01N33/53 , G01N33/54306 , Y10S435/80 , Y10S435/804 , Y10S435/961 , Y10S435/968
摘要： Target moiety is detected by (a) providing an antibody specific to the target, (b) saturating the binding sites of the antibody with a labelled form of the target, (c) flowing a liquid containing the target past the saturated antibody, thereby (d) allowing the target to displace the labelled antigen, and (e) detecting the displaced labelled antigen with a detector for the label. This assay is performed by a flow immunosensor comprising: a liquid flowing through the immunosensor for moving a sample through the immunosensor; a sample receiver for introducing the sample to the liquid stream; a flow controller for moving the liquid stream through the immunosensor; an exchanger connected to the sample receiving area in which the sample is brought in contact with labelled antigens of the target and where any target present is allowed to displace the labelled antigen; a detection apparatus connected to the exchanger for detecting any labelled antigen which is released; and a disposal means connected to the detection apparatus for disposing of or collecting of waste coming from the detection apparatus.
摘要翻译：通过（a）提供对靶特异性的抗体，（b）用靶标的标记形式使抗体的结合位点饱和，（c）使含有靶标的液体流过饱和抗体，从而（ d）允许目标物置换标记的抗原，和（e）用标记的检测器检测置换的标记的抗原。该测定由流动免疫传感器进行，包括：流过免疫传感器的液体，用于使样品移动通过免疫传感器; 用于将样品引入液体流的样品接收器; 用于使液体流通过免疫传感器的流量控制器; 连接到样品接收区域的交换器，其中样品与靶标的标记抗原接触，并且允许存在的任何靶标置换标记的抗原; 连接到交换器的检测装置，用于检测被释放的任何标记的抗原; 以及与检测装置连接的处置装置，用于处置或收集来自检测装置的废物。

6. 发明授权

US5365072A Repositionable substrate for microscopes 失效
标题翻译：显微镜可重定位底物
公开(公告)号：US5365072A
公开(公告)日：1994-11-15
申请号：US113126
申请日：1993-08-30
申请人： David C. Turner , Bruce P. Gaber
发明人： David C. Turner , Bruce P. Gaber
IPC分类号： G01B7/004 , G01N1/28 , H01J37/20
CPC分类号： G01Q40/02 , B82Y35/00 , G01B7/004 , G06K9/3216 , H01J37/20 , G01N2001/2893 , G06K2009/3225 , H01J2237/20292 , H01J2237/30444
摘要： The present invention is a repositionable substrate for microscope applications, having a geometric pattern on its top surface to convey coordinate information. In a preferred embodiment, this geometric pattern is a plurality of geometric shapes having a common axis of symmetry. In a most preferred embodiment, these geometric shapes are concentric, with varying linewidth.
摘要翻译：本发明是用于显微镜应用的可重新定位的基板，其顶表面上具有几何图案以传送坐标信息。在优选实施例中，该几何图案是具有公共对称轴的多个几何形状。在最优选的实施例中，这些几何形状是同心的，具有不同的线宽。

7. 发明授权

US08709740B2 Control of protein activity using a conducting polymer 有权
标题翻译：使用导电聚合物控制蛋白质活性
公开(公告)号：US08709740B2
公开(公告)日：2014-04-29
申请号：US11203575
申请日：2005-08-11
申请人： Brett D. Martin , Luminita M. Velea , Banahalli Ratna , Bruce P. Gaber
发明人： Brett D. Martin , Luminita M. Velea , Banahalli Ratna , Bruce P. Gaber
IPC分类号： C12Q1/34 , C12N13/00 , C12N11/00
CPC分类号： C12Q1/34 , G01N2333/924
摘要： A device having a substrate and an enzyme attached to the substrate. The substrate has a polymeric surface having at least two conductivity states. A minimum voltage that does not cause a redox reaction in the enzyme may be applied to the polymeric surface to change the conductivity state of the surface. A method of controlling enzyme activity by providing the above substrate with polymeric surface, attaching an enzyme to the substrate, and altering the conductivity state of the polymeric surface. Changing the conductivity of the polymer can change the activity of the enzyme.
摘要翻译：具有底物和附着于基底的酶的装置。基底具有至少两个导电状态的聚合物表面。可以在聚合物表面施加不会引起酶的氧化还原反应的最小电压，以改变表面的导电性状态。通过向上述基质提供聚合物表面，将酶连接到基底上并改变聚合物表面的导电性状态来控制酶活性的方法。改变聚合物的电导率可以改变酶的活性。

8. 发明授权

US06713416B2 Molecularly-imprinted material made by template-directed synthesis 失效
标题翻译：通过模板指导合成制备的分子印迹材料
公开(公告)号：US06713416B2
公开(公告)日：2004-03-30
申请号：US10337723
申请日：2003-01-08
申请人： Michael A. Markowitz , Paul E. Schoen , Bruce P. Gaber , Banahalli R. Ratna , Paul R. Kust , David C. Turner , Douglas S. Clark , Jonathan S. Dordick
发明人： Michael A. Markowitz , Paul E. Schoen , Bruce P. Gaber , Banahalli R. Ratna , Paul R. Kust , David C. Turner , Douglas S. Clark , Jonathan S. Dordick
IPC分类号： C03C100
CPC分类号： B82Y30/00 , B01J37/00 , C01B37/02 , C01P2004/52 , C01P2004/62 , C01P2004/64 , C01P2006/16 , C09C1/3081 , Y10T436/10
摘要： A method of making a molecularly imprinted porous structure makes use of a surfactant analog of the molecule to be imprinted that has the imprint molecule portion serving as the surfactant headgroup. The surfactant analog is allowed to self-assemble in a mixture to create at least one supramolecular structure having exposed imprint groups. The imprinted porous structure is formed by adding reactive monomers to the mixture and allowing the monomers to polymerize, with the supramolecular structure serving as a template. The resulting solid structure has a shape that is complementary to the shape of the supramolecular structure and has cavities that are the mirror image of the imprint group. Similarly, molecularly imprinted particles may be made by using the surfactant to create a water-in-oil microemulsion wherein the imprint groups are exposed to the water phase. When reactive monomers are allowed to polymerize in the water phase to form particles, the surface of the particles have cavities that are the mirror image of the imprint group.
摘要翻译：制作分子印迹多孔结构的方法利用具有印迹分子部分作为表面活性剂头基的要印迹的分子的表面活性剂类似物。允许表面活性剂类似物在混合物中自组装以产生具有暴露的印迹基团的至少一个超分子结构。通过将反应性单体加入到混合物中并使单体以超分子结构作为模板聚合而形成印迹多孔结构。所得到的固体结构具有与超分子结构的形状互补的形状，并且具有作为印迹组的镜像的空腔。类似地，分子印迹的颗粒可以通过使用表面活性剂来制备油包水微乳液，其中印迹组暴露于水相。当使反应性单体在水相中聚合以形成颗粒时，颗粒的表面具有作为印迹组的镜像的空腔。

9. 发明授权

US06310110B1 Molecularly-imprinted material made by template-directed synthesis 失效
标题翻译：通过模板指导合成制备的分子印迹材料
公开(公告)号：US06310110B1
公开(公告)日：2001-10-30
申请号：US09363819
申请日：1999-07-30
申请人： Michael A. Markowitz , Paul E. Schoen , Bruce P. Gaber , Banahalli R. Ratna , Paul R. Kust , David C. Turner , Douglas S. Clark , Jonathan S. Dordick
发明人： Michael A. Markowitz , Paul E. Schoen , Bruce P. Gaber , Banahalli R. Ratna , Paul R. Kust , David C. Turner , Douglas S. Clark , Jonathan S. Dordick
IPC分类号： C01B3312
CPC分类号： B82Y30/00 , B01J37/00 , C01B37/02 , C01P2004/52 , C01P2004/62 , C01P2004/64 , C01P2006/16 , C09C1/3081 , Y10T436/10
摘要： A method of making a molecularly imprinted porous structure makes use of a surfactant analog of the molecule to be imprinted that has the imprint molecule portion serving as the surfactant headgroup. The surfactant analog is allowed to self-assemble in a mixture to create at least one supramolecular structure having exposed imprint groups. The imprinted porous structure is formed by adding reactive monomers to the mixture and allowing the monomers to polymerize, with the supramolecular structure serving as a template. The resulting solid structure has a shape that is complementary to the shape of the supramolecular structure and has cavities that are the mirror image of the imprint group. Similarly, molecularly imprinted particles may be made by using the surfactant to create a water-in-oil microemulsion wherein the imprint groups are exposed to the water phase. When reactive monomers are allowed to polymerize in the water phase to form particles, the surface of the particles have cavities that are the mirror image of the imprint group.
摘要翻译：制作分子印迹多孔结构的方法利用具有印迹分子部分作为表面活性剂头基的要印迹的分子的表面活性剂类似物。允许表面活性剂类似物在混合物中自组装以产生具有暴露的印迹基团的至少一个超分子结构。通过将反应性单体加入到混合物中并使单体以超分子结构作为模板聚合而形成印迹多孔结构。所得到的固体结构具有与超分子结构的形状互补的形状，并且具有作为印迹组的镜像的空腔。类似地，分子印迹的颗粒可以通过使用表面活性剂来制备油包水微乳液，其中印迹组暴露于水相。当使反应性单体在水相中聚合以形成颗粒时，颗粒的表面具有作为印迹组的镜像的空腔。

10. 发明授权

US06673246B2 Reusable polysilsesquioxane adsorbents for pollutants 失效
标题翻译：可重复使用的倍半硅氧烷吸附剂用于污染物
公开(公告)号：US06673246B2
公开(公告)日：2004-01-06
申请号：US10084492
申请日：2002-02-28
申请人： Michael A. Markowitz , Mark C. Burleigh , Bruce P. Gaber
发明人： Michael A. Markowitz , Mark C. Burleigh , Bruce P. Gaber
IPC分类号： C02F142
CPC分类号： B01J20/262 , B01D15/00 , B01J20/28016 , B01J20/28042 , B01J20/3425 , B01J20/3475 , B01J20/3483 , C02F1/285 , C02F2101/32 , C02F2101/38
摘要： This invention pertains to adsorption by an adsorbent of an adsorbate and to regeneration of the loaded adsorbent. The adsorption includes contacting an adsorbent selected from arylene-bridged polysilsesquioxanes and derivatives thereof with an adsorbate selected from aromatics and heterocyclics, particularly monocyclic heterocyclics containing carbon and nitrogen atoms in a 6-member non-aromatic ring, for a period of time sufficient to adsorb all or part of the adsorbate by the adsorbent. Regeneration of the loaded adsorbent includes removing all or part of adsorbate from the adsorbent by means of an alcohol wash or by thermal desorption of the adsorbent containing adsorbate.
摘要翻译：本发明涉及吸附剂吸附剂的吸附和负载吸附剂的再生。吸附包括将选自亚芳基桥连的聚倍半硅氧烷及其衍生物的吸附剂与选自芳族化合物和杂环的吸附物接触，特别是含有6个成员非芳族环的碳和氮原子的单环杂环，持续足以吸附的时间吸附剂的全部或部分被吸附物。负载吸附剂的再生包括通过醇洗或通过吸附剂的吸附物的热解吸从所述吸附剂中除去全部或部分吸附物。

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