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1. 发明授权

US5464629A Method of forming hydrogel particles having a controlled size using liposomes 失效
标题翻译：使用脂质体形成具有受控尺寸的水凝胶颗粒的方法
公开(公告)号：US5464629A
公开(公告)日：1995-11-07
申请号：US152366
申请日：1993-11-16
申请人： Mariam Monshipouri , Alan S. Rudolph
发明人： Mariam Monshipouri , Alan S. Rudolph
IPC分类号： A61K9/127 , A61K47/48 , B01J2/00 , B01J2/06 , B01J13/02 , B01J13/04
CPC分类号： A61K47/48784 , A61K47/48876 , A61K47/48923 , A61K9/127 , B01J13/02 , B01J13/04 , B01J2/003 , B01J2/06 , Y10T428/2984
摘要： A method of fabricating hydrogel particles of controlled size within liposomes is provided, which entails encapsulating an effective amount of one or more hydrogel-forming substances in liposomes in a liquid medium, removing any unencapsulated hydrogel-forming substances from the liquid medium, adding initiator to the liquid medium and into the liposomes, thereby initiating reaction of the one or more hydrogel-forming substances, and removing any extra-liposomal initiators from the medium.
摘要翻译：提供了一种在脂质体内制备受控尺寸的水凝胶颗粒的方法，其包括在液体介质中将有效量的一种或多种水凝胶形成物质包封在脂质体中，从液体介质中除去任何未包封的水凝胶形成物质，将引发剂加入到液体介质并进入脂质体，从而引发一种或多种形成水凝胶的物质的反应，并从介质中除去任何超脂质体引发剂。

2. 发明授权

US5051353A Preservation and restoration of hemoglobin in blood substitutes 失效
标题翻译：血液代用品中血红蛋白的保存和恢复
公开(公告)号：US5051353A
公开(公告)日：1991-09-24
申请号：US233303
申请日：1988-08-09
申请人： Lewis P. Stratton , Martha C. Farmer , Alan S. Rudolph
发明人： Lewis P. Stratton , Martha C. Farmer , Alan S. Rudolph
IPC分类号： A61K38/42
CPC分类号： A61K38/42
摘要： A hemoglobin-containing blood substitute preparation is protected from oxtion to methemoglobin. The protected preparation comprises between 10 mM and 60 mM of a compound selected from the group consisting of glutathione (GSH), nicotinamide adenine dinucleotide (NADH), nicotine adenine dinucleotide phosphate (NADPH) and mixtures of these in the aqueous phase of a hemoglobin-containing fluid. Oxidized hemoglobin in a preparation can be restored by adding between 10 mM and 60 mM of a compound selected from the group consisting of glutathione (GSH), nicotinamide adenine dinucleotide (NADH), nicotine adenine dinucleotide phosphate (NADPH) and mixtures of these to a hemoglobin-containing fluid in which the hemoglobin has converted in whole or part to methemoglobin, and storing the fluid at storage temperatures for blood products above the freezing point of the fluid for a time sufficient to convert methemoglobin to hemoglobin.
摘要翻译：含血红蛋白的血液替代物制剂被保护免于氧化成高铁血红蛋白。受保护的制剂包含10mM至60mM的选自谷胱甘肽（GSH），烟酰胺腺嘌呤二核苷酸（NADH），尼古丁腺嘌呤二核苷酸磷酸（NADPH）的化合物及其在血红蛋白 - 含有液体。通过加入10mM至60mM的选自谷胱甘肽（GSH），烟酰胺腺嘌呤二核苷酸（NADH），尼古丁腺嘌呤二核苷酸磷酸（NADPH）和它们的混合物的化合物组合，可以恢复制剂中的氧化血红蛋白其中血红蛋白全部或部分转化为高铁血红蛋白，并将流体存储在高于流体凝固点的血液制品的储存温度上足以将高铁血红蛋白转化成血红蛋白的时间。

3. 发明授权

US09556247B2 Stabilized amyloid-beta oligomers and uses thereof 有权
标题翻译：稳定的淀粉样蛋白-β低聚物及其用途
公开(公告)号：US09556247B2
公开(公告)日：2017-01-31
申请号：US13698857
申请日：2011-05-24
申请人： Roxanne Duan , Jonathan Moll , Alan S. Rudolph
发明人： Roxanne Duan , Jonathan Moll , Alan S. Rudolph
IPC分类号： C07K14/47 , C07K1/14
CPC分类号： C07K14/4711 , C07K1/14
摘要： The present invention pertains to stabilized Aβ oligomer compositions. Methods for generating stabilized Aβ oligomer compounds are also provided herein. Additionally, screening assays employing the Aβ oligomer compounds and methods for generating therapeutics with the Aβ oligomers are also provided. In a particular embodiment, the Aβ oligomer described herein is comprised of Aβ42 peptide.
摘要翻译：本发明涉及稳定的Aβ寡聚体组合物。本文还提供了产生稳定的Aβ寡聚体化合物的方法。此外，还提供了使用Aβ寡聚体化合物的筛选测定法和用Aβ产生治疗剂的方法。在一个具体实施方案中，本文所述的Aβ寡聚体由Aβ42肽组成。

4. 发明授权

US08486617B2 Methods for preparing freeze-dried platelets, compositions comprising freeze-dried platelets, and methods of use 有权
标题翻译：制备冷冻干燥血小板的方法，包含冷冻干燥血小板的组合物和使用方法
公开(公告)号：US08486617B2
公开(公告)日：2013-07-16
申请号：US11659708
申请日：2005-08-12
申请人： David Ho , Cindy S. Orser , Alan S. Rudolph , Keith Moskowitz , Joshua Dee
发明人： David Ho , Cindy S. Orser , Alan S. Rudolph , Keith Moskowitz , Joshua Dee
IPC分类号： A01N1/02 , A01N63/00
CPC分类号： A01N1/0284 , A01N1/02 , G01N33/86
摘要： The present invention provides processes for preparing freeze-dried platelets, freeze-dried platelets made by those processes, platelets reconstituted from those freeze-dried platelets, methods of using the platelets for therapeutic, diagnostic, and research purposes, and kits comprising the freeze-dried platelets.
摘要翻译：本发明提供了制备冻干血小板的方法，由这些方法制备的冷冻干燥血小板，由那些冻干血小板重建的血小板，使用血小板治疗，诊断和研究目的的方法，以及包含冻干血小板的试剂盒，干血小板。

5. 发明授权

US5736313A Method of lyophilizing platelets by incubation with high carbohydrate concentrations and supercooling prior to freezing 失效
标题翻译：通过在高碳水化合物浓度和冷冻前过冷而冻干血小板的方法
公开(公告)号：US5736313A
公开(公告)日：1998-04-07
申请号：US546464
申请日：1995-10-20
申请人： Barry J. Spargo , Alan S. Rudolph , Richard G. Emler , Thomas R. Groel, II
发明人： Barry J. Spargo , Alan S. Rudolph , Richard G. Emler , Thomas R. Groel, II
IPC分类号： A01N1/02 , A01N63/00
CPC分类号： A01N1/02 , A01N1/0221
摘要： A process and medium are disclosed for the lyophilization of platelets. During lyophilization, carbohydrate-load platelets are supercooled while suspended in a buffer solution including a biocompatible polymer that serves to preserve the structure of the platelets. The supercooled platelets are then frozen at a temperature below the glass transition temperature of the suspension. A vacuum is placed on the frozen suspension to remove most of the water therefrom. Then, the temperature of the platelets is increased to the supercooled temperature while the vacuum is maintained. After being sealed under vacuum, the lyophilized platelets may be reconstituted to form viable, transfusable platelets. The reconstituted platelets have a high aggregation index, retain normal agglutination and degranulation capability, and are able to participate in clot formation.
摘要翻译：公开了用于冻干血小板的方法和培养基。在冻干期间，碳水化合物负载血小板被过冷却，同时悬浮在缓冲溶液中，所述缓冲溶液包括用于保持血小板结构的生物相容性聚合物。然后将过冷的血小板在低于悬浮液的玻璃化转变温度的温度下冷冻。在冷冻悬浮液上放置真空以从其中除去大部分水。然后，保持真空时，血小板的温度升高至过冷却温度。在真空下密封后，冻干的血小板可以重构形成活的可输血的血小板。重组的血小板具有高聚集指数，保持正常的凝集和脱颗粒能力，并且能够参与凝块形成。

6. 发明授权

US5721131A Surface modification of polymers with self-assembled monolayers that promote adhesion, outgrowth and differentiation of biological cells 失效
标题翻译：具有自组装单层的聚合物的表面改性，其促进生物细胞的粘附，生长和分化
公开(公告)号：US5721131A
公开(公告)日：1998-02-24
申请号：US234034
申请日：1994-04-28
申请人： Alan S. Rudolph , Chih-Chang Chu , David A. Stenger , Barry J. Spargo , Jacque Georger
发明人： Alan S. Rudolph , Chih-Chang Chu , David A. Stenger , Barry J. Spargo , Jacque Georger
IPC分类号： B05D1/18 , C09D4/00 , C12N5/00 , C23C18/16 , C40B60/14 , G03F7/004 , G06N3/00 , G06N99/00 , H01L21/288 , H05K3/06
CPC分类号： H01L21/2885 , B05D1/185 , B82Y10/00 , B82Y30/00 , B82Y40/00 , B82Y5/00 , C09D4/00 , C12N5/0068 , G03F7/004 , G06N3/002 , G06N99/007 , H01L21/288 , H01L51/0595 , B01J2219/00432 , B01J2219/00603 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00711 , C12N2535/10 , C40B60/14
摘要： A process for forming spatially oriented neo-vascular capillaries comprising: (a) providing a combination ultra-thin film (UTF) pattern of at least one cell adhesion promoter and at least one cell adhesion inhibitor wherein the cell adhesion promoters have a linewidth of between about 50-490 .mu.m; (b) seeding the combination UTF pattern with endothelial cells at an initial seeding cell density; (c) adding a first medium for incubating the seeded endothelial cells until the endothelial cells are grown to confluency; (d) replacing the first medium with a second medium at confluency; and (e) allowing the endothelial cells to differentiate into spatially oriented neo-vascular capillaries.
摘要翻译：一种用于形成空间取向的新血管毛细血管的方法，包括：（a）提供至少一种细胞粘附促进剂和至少一种细胞粘附抑制剂的组合超薄膜（UTF）图案，其中细胞粘附促进剂之间的线宽约50-490亩; （b）以初始播种细胞密度将组合UTF模式与内皮细胞接种; （c）加入用于培养接种的内皮细胞直到内皮细胞生长至融合的第一培养基; （d）用汇合的第二种介质代替第一种介质; 和（e）允许内皮细胞分化成空间取向的新血管毛细血管。

7. 发明授权

US5242792A Method for the preservation of red blood cells by lyophilization using glycerol or inositol with disaccharides 失效
标题翻译：使用甘油或肌醇与二糖冷冻干燥保存红细胞的方法
公开(公告)号：US5242792A
公开(公告)日：1993-09-07
申请号：US659765
申请日：1991-02-25
申请人： Alan S. Rudolph , Joseph P. Larry
发明人： Alan S. Rudolph , Joseph P. Larry
IPC分类号： A01N1/02
CPC分类号： A01N1/02 , A01N1/0221
摘要： The invention is directed to a composition comprising a permeabilizing agent, a preserving agent, and a buffered solvent. This composition is used to prepare the cells for lyophilization cells and to rehydrate the cells to recover them from lyophilization.The process of this invention comprises adding the permeabilizing agent and the preserving agent in a buffered solution to red blood cells, agitating the combination for a period of time sufficient to allow permeation of the preserving agent into the cell, shell freezing the mixture, and lyophilizing the mixture. The dry lyophilized material can then be stored. The cells can be rehydrated using the same composition of permeability agent, preserving agent and buffered solvent.
摘要翻译：本发明涉及包含透化剂，防腐剂和缓冲溶剂的组合物。该组合物用于制备用于冻干细胞的细胞并将细胞再水化以从冷冻干燥中回收它们。本发明的方法包括将缓释溶液中的透化剂和防腐剂加入到红细胞中，搅拌该组合一段足以允许保存剂渗入细胞的时间，壳冷冻该混合物，并冻干混合物。然后可以将干燥的冻干材料储存。可以使用相同组成的渗透剂，防腐剂和缓冲溶剂来再水化细胞。

8. 发明授权

US5143713A .sup.99m Tc labeled liposomes 失效
标题翻译： 99MTC标签脂肪
公开(公告)号：US5143713A
公开(公告)日：1992-09-01
申请号：US610204
申请日：1990-11-05
申请人： William T. Phillips , Robert W. Klipper , James H. Timmons , Alan S. Rudolph
发明人： William T. Phillips , Robert W. Klipper , James H. Timmons , Alan S. Rudolph
IPC分类号： A61K51/12
CPC分类号： A61K51/1234 , A61K2123/00 , Y10T428/2984
摘要： The invention relates to the efficient preparation of radionuclide labeled liposomes and radionuclide-labeled liposome-encapsulated protein. In particular, a .sup.99m Tc carrier is used to label preformed liposomes or liposome-encapsulated hemoglobin. .sup.99m Tc-labeled liposomes and liposome-encapsulated .sup.99m Tc labeled hemoglobin are highly stable in vitro and in vivo and are suitable for a variety of clinical uses, including biodistribution imaging studies. The invention also relates to a method of labeling neutrophils using .sup.99m technetium-labeled liposomes or liposome-encapsulated hemoglobin. A kit method useful for the convenient preparation of .sup.99m Tc-labeled liposomes or liposome-encapsulated hemoglobin for clinical use is also disclosed.
摘要翻译：本发明涉及放射性核素标记的脂质体和放射性核素标记的脂质体包封的蛋白质的有效制备。特别地，99mTc载体用于标记预先形成的脂质体或脂质体包封的血红蛋白。 99mTc标记的脂质体和脂质体包封的99mTc标记的血红蛋白在体外和体内都是高度稳定的，并且适用于各种临床用途，包括生物分布成像研究。本发明还涉及使用99mtechnet标记的脂质体或脂质体包封的血红蛋白标记嗜中性粒细胞的方法。还公开了用于方便地制备用于临床用途的99mTc标记的脂质体或脂质体包封的血红蛋白的试剂盒方法。

9. 发明授权

US6033708A Method for producing sterile filterable liposome dispersion 失效
标题翻译：生产无菌可过滤脂质体分散体的方法
公开(公告)号：US6033708A
公开(公告)日：2000-03-07
申请号：US940739
申请日：1997-09-30
申请人： Victoria Kwasiborski , Richard O. Cliff , Alan S. Rudolph
发明人： Victoria Kwasiborski , Richard O. Cliff , Alan S. Rudolph
IPC分类号： A61K9/127 , A61K9/133 , A61K38/42
CPC分类号： A61K9/1277 , A61K38/42 , A61K9/127
摘要： The present invention relates to a composition and method of producing noggregating, filterable dispersion of liposome encapsulated agent or therapeutic of interest, specifically hemoglobin. A key step in the method of the present invention is the addition of a passivating protein prior to hydration of the liposomes with the agent of interest. The resulting dispersion is composed of unilamellar vesicles having a diameter of less than or equal to 0.2 microns.
摘要翻译：本发明涉及生产脂质体包封剂或感兴趣的治疗剂，特别是血红蛋白的非聚集，可过滤的分散体的组合物和方法。本发明方法的关键步骤是在脂质体与感兴趣的试剂水合之前加入钝化蛋白质。所得分散体由直径小于或等于0.2微米的单层囊泡组成。

10. 发明授权

US5690963A Freeze dried red blood cells 失效
标题翻译：冷冻干红细胞
公开(公告)号：US5690963A
公开(公告)日：1997-11-25
申请号：US497708
申请日：1995-06-30
申请人： Barry J. Spargo , Alan S. Rudolph , Byeong S. Chang , Thomas R. Groel, II
发明人： Barry J. Spargo , Alan S. Rudolph , Byeong S. Chang , Thomas R. Groel, II
IPC分类号： A01N1/02 , A61K35/18
CPC分类号： A61K35/18 , A01N1/02 , A01N1/0226 , A01N1/0289
摘要： A process and medium are disclosed for the lyophilization of cells, specifically red blood cells and platelets, and cell-like matter, which comprises the use of solution including a carbohydrate, and biocompatible polymers to permit reconstitution of transfusably useful cells which are viable by the measure of ATP and 2,3 DPG.
摘要翻译：公开了一种用于冻干细胞，特别是红细胞和血小板以及细胞样物质的方法和培养基，其包括使用包含碳水化合物的溶液和生物相容性聚合物，以允许重构可转移有用的细胞，其可由测量ATP和2,3 DPG。

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