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1. 发明授权

US07499153B2 Use of high wavenumber Raman spectroscopy for measuring tissue 有权
标题翻译：使用高波数拉曼光谱测量组织
公开(公告)号：US07499153B2
公开(公告)日：2009-03-03
申请号：US10537074
申请日：2003-12-02
申请人： Gerwin Jan Puppels , Rolf Wolthuis , Senada Koljenovic
发明人： Gerwin Jan Puppels , Rolf Wolthuis , Senada Koljenovic
IPC分类号： G01J3/44 , G01N21/64 , G01N21/65
CPC分类号： G01N21/65 , A61B5/0071 , A61B5/0075 , A61B5/0086 , A61B5/441 , A61B5/4848 , G01J3/44 , G01N2021/656
摘要： The invention is related to the instrument for measuring a Raman signal of tissue, the instrument comprising a laser, a signal detection unit for measuring the Raman signal, and a fiber optic probe, wherein the fiber optic probe comprises one or more optical fibers for directing laser light onto the tissue and for collecting light that is scattered by the tissue and guiding the collected light away from the tissue towards the signal detection unit, wherein the fiber or fibers for collecting light have substantially no Raman signal in one or more parts of the 2500-3700 cm−1 spectral region, and wherein the detection unit records the Raman signal scattered by the tissue in said spectral region. The invention enables ex vivo, in vitro and in vivo analysis and diagnosis of atherosclerotic plaque and detection of tumor tissue with great advantages over current state-of-the-art technology.
摘要翻译：本发明涉及用于测量组织的拉曼信号的仪器，仪器包括激光器，用于测量拉曼信号的信号检测单元和光纤探针，其中光纤探针包括一根或多根光纤，用于引导将激光照射到组织上并用于收集由组织散射的光并将收集的光引导离开组织朝向信号检测单元，其中用于收集光的光纤或纤维在一个或多个部分中基本上不具有拉曼信号 2500-3700cm -1光谱区域，并且其中所述检测单元记录由所述光谱区域中的组织散射的拉曼信号。本发明使得动脉粥样硬化斑块的离体，体外和体内分析和诊断和肿瘤组织的检测具有优于现有技术的优点。

2. 发明申请

US20060139633A1 Use of high wavenumber raman spectroscopy for measuring tissue 有权
标题翻译：使用高波数拉曼光谱仪测量组织
公开(公告)号：US20060139633A1
公开(公告)日：2006-06-29
申请号：US10537074
申请日：2003-12-02
申请人： Gerwin Puppels , Rolf Wolthus , Senada Koljenovic
发明人： Gerwin Puppels , Rolf Wolthus , Senada Koljenovic
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/65 , A61B5/0071 , A61B5/0075 , A61B5/0086 , A61B5/441 , A61B5/4848 , G01J3/44 , G01N2021/656
摘要： The invention is related to the instrument for measuring a Raman signal of tissue, the instrument comprising a laser, a signal detection unit for measuring the Raman signal, and a fiber optic probe, wherein the fiber optic probe comprises one or more optical fibers for directing laser light onto the tissue and for collecting light that is scattered by the tissue and guiding the collected light away from the tissue towards the signal detection unit, wherein the fiber or fibers for collecting light have substantially no Raman signal in one or more parts of the 2500-3700 cm−1 spectral region, and wherein the detection unit records the Raman signal scattered by the tissue in said spectral region. The invention enables ex vivo, in vitro and in vivo analysis and diagnosis of atherosclerotic plaque and detection of tumor tissue with great advantages over current state-of-the-art technology.
摘要翻译：本发明涉及用于测量组织的拉曼信号的仪器，仪器包括激光器，用于测量拉曼信号的信号检测单元和光纤探针，其中光纤探针包括一根或多根光纤，用于引导将激光照射到组织上并用于收集由组织散射的光并将收集的光引导离开组织朝向信号检测单元，其中用于收集光的光纤或纤维在一个或多个部分中基本上不具有拉曼信号 2500-3700cm -1光谱区域，其中检测单元记录由所述光谱区域中的组织散射的拉曼信号。本发明使得动脉粥样硬化斑块的离体，体外和体内分析和诊断和肿瘤组织的检测具有优于现有技术的优点。

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