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1. 发明申请

US20060135861A1 Apparatus and method for blood analysis 审中-公开
标题翻译：血液分析仪器及方法
公开(公告)号：US20060135861A1
公开(公告)日：2006-06-22
申请号：US10544293
申请日：2004-01-19
申请人： Gerhardus Lucassen , Gerwin Puppels , Marjolein Van Der Voort , Rolf Wolthuis
发明人： Gerhardus Lucassen , Gerwin Puppels , Marjolein Van Der Voort , Rolf Wolthuis
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/0066 , G01N21/65 , G01N2021/656
摘要： The present invention relates to an analysis apparatus, in particular a spectroscopic analysis apparatus, for blood analysis on vessels. An excitation system (exs) emits an excitation beam to excite a target region. A detection system (dsy) is provided for detecting and analyzing scattered radiation from the target region. Those areas are selected or predetermined so that only scattered radiation from blood in capillaries having a diameter below a predetermined diameter value and/or including an amount of red blood cells below a predetermined cell amount is analyzed. Thus, in contrast to analysis on whole blood or large amounts of blood cells less reabsorption and scattering of Raman light due to red blood cells is obtained. Further, the possibility to directly measure in the blood plasma without interference of the red blood cells, thereby yielding a higher signal-to-noise ratio, is given.
摘要翻译：本发明涉及用于血管分析的分析装置，特别是光谱分析装置。激发系统（exs）发射激发光束以激发目标区域。提供了一种用于检测和分析来自目标区域的散射辐射的检测系统（dsy）。选择或预定那些区域，以便仅分析具有低于预定直径值的直径的毛细血管和/或包括低于预定细胞量的红细胞量的来自血液的散射辐射。因此，与全血或大量血细胞的分析相反，获得了由于红细胞引起的拉曼光的再吸收和散射较少。此外，给出了在血浆中直接测量而不干扰红细胞，从而产生更高的信噪比的可能性。

2. 发明授权

US07499153B2 Use of high wavenumber Raman spectroscopy for measuring tissue 有权
标题翻译：使用高波数拉曼光谱测量组织
公开(公告)号：US07499153B2
公开(公告)日：2009-03-03
申请号：US10537074
申请日：2003-12-02
申请人： Gerwin Jan Puppels , Rolf Wolthuis , Senada Koljenovic
发明人： Gerwin Jan Puppels , Rolf Wolthuis , Senada Koljenovic
IPC分类号： G01J3/44 , G01N21/64 , G01N21/65
CPC分类号： G01N21/65 , A61B5/0071 , A61B5/0075 , A61B5/0086 , A61B5/441 , A61B5/4848 , G01J3/44 , G01N2021/656
摘要： The invention is related to the instrument for measuring a Raman signal of tissue, the instrument comprising a laser, a signal detection unit for measuring the Raman signal, and a fiber optic probe, wherein the fiber optic probe comprises one or more optical fibers for directing laser light onto the tissue and for collecting light that is scattered by the tissue and guiding the collected light away from the tissue towards the signal detection unit, wherein the fiber or fibers for collecting light have substantially no Raman signal in one or more parts of the 2500-3700 cm−1 spectral region, and wherein the detection unit records the Raman signal scattered by the tissue in said spectral region. The invention enables ex vivo, in vitro and in vivo analysis and diagnosis of atherosclerotic plaque and detection of tumor tissue with great advantages over current state-of-the-art technology.
摘要翻译：本发明涉及用于测量组织的拉曼信号的仪器，仪器包括激光器，用于测量拉曼信号的信号检测单元和光纤探针，其中光纤探针包括一根或多根光纤，用于引导将激光照射到组织上并用于收集由组织散射的光并将收集的光引导离开组织朝向信号检测单元，其中用于收集光的光纤或纤维在一个或多个部分中基本上不具有拉曼信号 2500-3700cm -1光谱区域，并且其中所述检测单元记录由所述光谱区域中的组织散射的拉曼信号。本发明使得动脉粥样硬化斑块的离体，体外和体内分析和诊断和肿瘤组织的检测具有优于现有技术的优点。

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