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1. 发明申请

US20070175278A1 Automated characterization and classification of microorganisms 失效
标题翻译：微生物的自动表征和分类
公开(公告)号：US20070175278A1
公开(公告)日：2007-08-02
申请号：US10556365
申请日：2004-05-11
申请人： Gerwin Puppels , Tom Bakker Schut , Kornelis Maquelin
发明人： Gerwin Puppels , Tom Bakker Schut , Kornelis Maquelin
IPC分类号： G01H17/00 , C12Q1/10
CPC分类号： G01N33/569 , G01N21/65
摘要： An instrument, method, use and software program to obtain information rapidly about microorganisms that may spread uncontrolled in hospitals, water supply, food or when used in bio terrorism are described. Vibrational spectroscopy provides data to a computer linked to one or more databases. Comparison of the spectral data and information retrieved from the databases is used to identify and classify the microorganisms, applying suitable algorithms, which algorithms are self-generating and self-adapting to new spectroscopic data. The system may alert for the detection of an outbreak or to take disinfection measures. Changes in the traditional taxonomic division of microorganisms have no influence on the instrument. It does not rely on an a priori knowledge about the taxonomic classification of the microbial strain, is straightforward and easily integrated in routine microbial procedures.
摘要翻译：描述了在医疗，供水，食品中或在生物恐怖主义中使用时可能传播不受控制的微生物的快速获取信息的工具，方法，使用和软件程序。振动光谱仪为连接到一个或多个数据库的计算机提供数据。使用从数据库检索的光谱数据和信息的比较来识别和分类微生物，应用合适的算法，哪些算法是自发生的并且适应于新的光谱数据。系统可能会警告爆发的检测或采取消毒措施。微生物传统分类学分类的变化对仪器没有影响。它不依赖于关于微生物菌株的分类学分类的先验知识，是直接和容易地集成在常规微生物程序中。

2. 发明授权

US08688384B2 Automated characterization and classification of microorganisms 失效
标题翻译：微生物的自动表征和分类
公开(公告)号：US08688384B2
公开(公告)日：2014-04-01
申请号：US10556365
申请日：2004-05-11
申请人： Gerwin Jan Puppels , Tom Bakker Schut , Kornelis Maquelin
发明人： Gerwin Jan Puppels , Tom Bakker Schut , Kornelis Maquelin
IPC分类号： G01N33/48 , G01N31/00 , G06G7/48 , G06G7/58
CPC分类号： G01N33/569 , G01N21/65
摘要： An instrument, method, use and software program to obtain information rapidly about microorganisms that may spread uncontrolled in hospitals, water supply, food or when used in bio terrorism are described. Vibrational spectroscopy provides data to a computer linked to one or more databases. Comparison of the spectral data and information retrieved from the databases is used to identify and classify the microorganisms, applying suitable algorithms, which algorithms are self-generating and self-adapting to new spectroscopic data. The system may alert for the detection of an outbreak or to take disinfection measures. Changes in the traditional taxonomic division of microorganisms have no influence on the instrument. It does not rely on an a priori knowledge about the taxonomic classification of the microbial strain, is straightforward and easily integrated in routine microbial procedures.
摘要翻译：描述了在医疗，供水，食品中或在生物恐怖主义中使用时可能传播不受控制的微生物的快速获取信息的工具，方法，使用和软件程序。振动光谱仪为连接到一个或多个数据库的计算机提供数据。使用从数据库检索的光谱数据和信息的比较来识别和分类微生物，应用合适的算法，哪些算法是自发生的并且适应于新的光谱数据。系统可能会警告爆发的检测或采取消毒措施。微生物传统分类学分类的变化对仪器没有影响。它不依赖于关于微生物菌株的分类学分类的先验知识，是直接和容易地集成在常规微生物程序中。

3. 发明申请

US20110143391A1 METHOD FOR TYPING AND IDENTIFICATION OF MICRO-ORGANISMS 有权
标题翻译：微生物分类鉴定方法
公开(公告)号：US20110143391A1
公开(公告)日：2011-06-16
申请号：US12669366
申请日：2008-07-17
申请人： Kornelis Maquelin , Maarten Jan Scholtes , Hendrina Francisca Maria Willemse-Erix , Tom Christian Bakker Schut , Gerwin Jan Puppels
发明人： Kornelis Maquelin , Maarten Jan Scholtes , Hendrina Francisca Maria Willemse-Erix , Tom Christian Bakker Schut , Gerwin Jan Puppels
IPC分类号： C12Q1/04
CPC分类号： G01N21/65 , G01N2021/656
摘要： The invention relates to a method for typing or identification of a micro-organism using vibrational spectroscopy, characterised in that, differences in one or more vibrational spectroscopic signal contributions from one or more bleachable components between different spectra obtained of a sample of said micro-organism, and/or between spectra of different samples of said micro-organism, and/or between spectra of samples of different micro-organisms, are substantially eliminated as a source of signal variance in a dataset of said spectra, said bleachable components being molecules possessing vibrational spectral bands that upon exposure to light show a reduction in signal intensity.
摘要翻译：本发明涉及使用振动光谱法分类或鉴定微生物的方法，其特征在于，从所述微生物样品获得的不同光谱之间的一个或多个可漂白组分的一个或多个振动光谱信号贡献的差异，和/或在所述微生物的不同样品的光谱之间和/或不同微生物样品的光谱之间基本上消除了所述光谱的数据集中的信号方差的来源，所述可漂白组分是具有在暴露于光时的振动光谱带显示信号强度的降低。

4. 发明授权

US09194803B2 Method for typing and identification of micro-organisms 有权
标题翻译：微生物分型和鉴定方法
公开(公告)号：US09194803B2
公开(公告)日：2015-11-24
申请号：US12669366
申请日：2008-07-17
申请人： Kornelis Maquelin , Maarten Jan Scholtes , Hendrina Francisca Maria Willemse-Erix , Tom Christian Bakker Schut , Gerwin Jan Puppels
发明人： Kornelis Maquelin , Maarten Jan Scholtes , Hendrina Francisca Maria Willemse-Erix , Tom Christian Bakker Schut , Gerwin Jan Puppels
IPC分类号： C12Q1/04 , G01N21/65
CPC分类号： G01N21/65 , G01N2021/656
摘要： The invention relates to a method for typing or identification of a micro-organism using vibrational spectroscopy, characterised in that, differences in one or more vibrational spectroscopic signal contributions from one or more bleachable components between different spectra obtained of a sample of said micro-organism, and/or between spectra of different samples of said micro-organism, and/or between spectra of samples of different micro-organisms, are substantially eliminated as a source of signal variance in a dataset of said spectra, said bleachable components being molecules possessing vibrational spectral bands that upon exposure to light show a reduction in signal intensity.
摘要翻译：本发明涉及使用振动光谱法分类或鉴定微生物的方法，其特征在于，从所述微生物样品获得的不同光谱之间的一个或多个可漂白组分的一个或多个振动光谱信号贡献的差异，和/或在所述微生物的不同样品的光谱之间和/或不同微生物样品的光谱之间基本上消除了所述光谱的数据集中的信号方差的来源，所述可漂白组分是具有在暴露于光时的振动光谱带显示信号强度的降低。

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