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1. 发明申请

US20120193762A1 REVERSAL LITHOGRAPHY APPROACH BY SELECTIVE DEPOSITION OF NANOPARTICLES 有权
标题翻译：通过选择性沉积纳米颗粒的反向光刻方法
公开(公告)号：US20120193762A1
公开(公告)日：2012-08-02
申请号：US13017903
申请日：2011-01-31
申请人： Qin Lin , Daniel M. Sullivan , Hao Xu , Tony D. Flaim
发明人： Qin Lin , Daniel M. Sullivan , Hao Xu , Tony D. Flaim
IPC分类号： H01L29/02 , G03F7/20 , B82Y30/00
CPC分类号： B82Y30/00 , B82Y10/00
摘要： A novel reversal lithography process without etch back is described. The reversal material comprises nanoparticles that are selectively deposited into the gaps between features without overcoating the tops of the features. As a result, a patterned imaging layer can be removed using solvent, blanket exposure followed by developer washing, or dry etching directly, without an etch-back process, and the original bright field lithography pattern can be reversed into dark field features, and transferred into subsequent layers using the nanoparticle reversal material as an etch mask.
摘要翻译：描述了没有回蚀的新型反转光刻工艺。反转材料包括纳米颗粒，其被选择性地沉积到特征之间的间隙中，而不覆盖特征的顶部。结果，可以使用溶剂，毯式曝光，显影剂洗涤或直接干法蚀刻，而不用蚀刻工艺去除图案化成像层，并且原始的明视野光刻图案可以反转成暗场特征，并转移使用纳米颗粒反转材料作为蚀刻掩模进入后续层。

2. 发明授权

US08836082B2 Reversal lithography approach by selective deposition of nanoparticles 有权
标题翻译：通过选择性沉积纳米粒子的反转光刻方法
公开(公告)号：US08836082B2
公开(公告)日：2014-09-16
申请号：US13017903
申请日：2011-01-31
申请人： Qin Lin , Daniel M. Sullivan , Hao Xu , Tony D. Flaim
发明人： Qin Lin , Daniel M. Sullivan , Hao Xu , Tony D. Flaim
IPC分类号： H01L29/02 , B82Y10/00 , B82Y30/00
CPC分类号： B82Y30/00 , B82Y10/00
摘要： A novel reversal lithography process without etch back is described. The reversal material comprises nanoparticles that are selectively deposited into the gaps between features without overcoating the tops of the features. As a result, a patterned imaging layer can be removed using solvent, blanket exposure followed by developer washing, or dry etching directly, without an etch-back process, and the original bright field lithography pattern can be reversed into dark field features, and transferred into subsequent layers using the nanoparticle reversal material as an etch mask.
摘要翻译：描述了没有回蚀的新型反转光刻工艺。反转材料包括纳米颗粒，其被选择性地沉积到特征之间的间隙中，而不覆盖特征的顶部。结果，可以使用溶剂，毯式曝光，显影剂洗涤或直接干法蚀刻，而不用蚀刻工艺去除图案化成像层，并且原始的明视野光刻图案可以反转成暗场特征，并转移使用纳米颗粒反转材料作为蚀刻掩模进入后续层。

3. 发明授权

US5998598A Immunoadhesins and methods of production and use thereof 失效
标题翻译：免疫粘附素及其生产和使用方法
公开(公告)号：US5998598A
公开(公告)日：1999-12-07
申请号：US814567
申请日：1997-03-10
申请人： Karl G. Csaky , Eddy Anglade , Daniel M. Sullivan , William LaRochelle
发明人： Karl G. Csaky , Eddy Anglade , Daniel M. Sullivan , William LaRochelle
IPC分类号： A61K38/00 , A61K47/48 , A61K48/00 , C07K14/495 , C07K14/54 , C07K14/55 , C07K14/705 , C07H21/04 , C12N15/13 , C12N15/62
CPC分类号： A61K47/48415 , C07K14/495 , C07K14/54 , C07K14/5406 , C07K14/5428 , C07K14/5437 , C07K14/55 , C07K14/70525 , A61K38/00 , A61K48/00 , C07K2319/00 , C07K2319/30 , C12N2799/022
摘要： The invention is directed toward a compound comprising a recombinant nucleic acid encoding an immunoadhesin inserted within an adenoviral nucleic acid, wherein the recombinant nucleic acid can be packaged in an adenovirus particle and wherein expression of the recombinant nucleic acid encoding the immunoadhesin results in production of the immunoadhesin protein. The recombinant nucleic acid encoding the immunoadhesin can be within an adenovirus. The invention further provides methods for delivering an immunoadhesin to a cell or a subject comprising administering to the cell or the subject an adenovirus comprising a recombinant nucleic acid encoding an immunoadhesin; producing an immunoadhesin comprising administering to a cell an adenovirus comprising a recombinant nucleic acid encoding an immunoadhesin inserted within an adenoviral nucleic acid, whereby the cell expresses the recombinant nucleic acid encoding the immunoadhesin, thereby producing the immunoadhesin; treating an inflammatory condition in a subject comprising administering to the subject an adenovirus comprising a recombinant nucleic acid encoding an immunoadhesin inserted within an adenoviral nucleic acid or a recombinant nucleic acid encoding an immunoadhesin inserted within an adenoviral nucleic acid, whereby a cell in the subject expresses the recombinant nucleic acid encoding the immunoadhesin and produces the immunoadhesin, thereby treating the inflammatory condition or administering to the subject a recombinant nucleic acid encoding an immunoadhesin, or an immunoadhesin, wherein the immunoadhesin is selected from the group consisting of vIL-10-IgG, IL-13-IgG, LFA-IgG, IL-2ra-IgG, IL-1ra-IgG, mutant IL-4-IgG, VLA4-IgG, IL-2-IgG, TGF-.beta.1-IgG, TGF-.beta.1.sup.223,225 -IgG, and VCAM-IgG; and methods of screening an immunoadhesin for bioactivity.
摘要翻译：本发明涉及包含编码插入在腺病毒核酸内的免疫粘附素的重组核酸的化合物，其中所述重组核酸可以包装在腺病毒颗粒中，并且其中编码免疫粘附素的重组核酸的表达导致产生免疫粘附蛋白。编码免疫粘附素的重组核酸可以在腺病毒内。本发明还提供了将免疫粘附素递送至细胞或受试者的方法，包括向细胞或受试者施用包含编码免疫粘附素的重组核酸的腺病毒; 产生免疫粘附素，其包括向细胞施用包含编码插入在腺病毒核酸内的免疫粘附素的重组核酸的腺病毒，由此所述细胞表达编码免疫粘附素的重组核酸，由此产生免疫粘附素; 治疗受试者中的炎性病症包括向受试者施用包含编码插入腺病毒核酸内的免疫粘附素的重组核酸的腺病毒或编码插入腺病毒核酸内的免疫粘附素的重组核酸，由此受试者中的细胞表达编码免疫粘附素的重组核酸并产生免疫粘附素，从而治疗炎性病症或向受试者施用编码免疫粘附素或免疫粘附素的重组核酸，其中所述免疫粘附素选自vIL-10-IgG， IL-13-IgG，LFA-IgG，IL-2ra-IgG，IL-1ra-IgG，突变型IL-4-IgG，VLA4-IgG，IL-2-IgG，TGF-β1-IgG，TGF-β1223 ，225-IgG和VCAM-IgG; 以及筛选免疫粘附素用于生物活性的方法。

4. 发明授权

US5596088A DNA Encoding the human P.sub.2U receptor and null cells expressing P.sub.2U receptors 失效
标题翻译：编码人P2U受体的DNA和表达P2U受体的无效细胞
公开(公告)号：US5596088A
公开(公告)日：1997-01-21
申请号：US442134
申请日：1995-05-16
申请人： Richard C. Boucher , Gary A. Weisman , John T. Turner , Thomas K. Harden , Claude E. Parr , Daniel M. Sullivan , Laura J. Erb , Kevin D. Lustig
发明人： Richard C. Boucher , Gary A. Weisman , John T. Turner , Thomas K. Harden , Claude E. Parr , Daniel M. Sullivan , Laura J. Erb , Kevin D. Lustig
IPC分类号： A61K38/00 , C07K14/705 , C12N15/12
CPC分类号： C07K14/705 , A61K38/00
摘要： Isolated DNAs encoding the human P.sub.2U receptor are disclosed, along with vectors and host cells containing the same and methods of using the same. Host cells which are essentially free of endogenous P.sub.2U receptor expression, and which express a heterologous P.sub.2U receptor such as a murine P.sub.2U receptor, are also disclosed, along with methods of using the same.
摘要翻译：公开了编码人P2U受体的分离的DNA，以及含有其的载体和宿主细胞以及使用它们的方法。还公开了基本上不含内源性P2U受体表达并且表达异源P2U受体如鼠P2U受体的宿主细胞，以及使用它们的方法。

5. 发明授权

US08647809B2 Metal-oxide films from small molecules for lithographic applications 有权
标题翻译：用于光刻应用的小分子的金属氧化物膜
公开(公告)号：US08647809B2
公开(公告)日：2014-02-11
申请号：US13178301
申请日：2011-07-07
申请人： Daniel M. Sullivan , Charles J. Neef , Yubao Wang , Tantiboro Ouattara
发明人： Daniel M. Sullivan , Charles J. Neef , Yubao Wang , Tantiboro Ouattara
IPC分类号： G03F7/00 , G03F7/004
CPC分类号： H01L21/0276 , C08G77/58 , C09D183/14 , G03F7/0752 , G03F7/09 , G03F7/091 , G03F7/094 , H01L21/0332 , Y10T428/24802
摘要： Metal-oxide films for lithographic applications are provided. The films are formed from compositions comprising metal-oxide precursor compounds including metals and metalloids other than silicon. These films are easily produced and can be modified with a variety of ligands, including alkoxides, phenoxides, carboxylates, beta-diketones, and beta-ketoesters.
摘要翻译：提供了用于光刻应用的金属氧化物膜。该膜由包含金属和氧化物前体化合物的组合物形成，包括除硅以外的金属和准金属。这些膜容易生产，并且可以用各种配体进行改性，包括醇盐，苯氧化物，羧酸盐，β-二酮和β-酮酯。

6. 发明授权

US09482951B2 Non-covalently crosslinkable materials for photolithography processes 有权
标题翻译：用于光刻工艺的非共价交联材料
公开(公告)号：US09482951B2
公开(公告)日：2016-11-01
申请号：US12180832
申请日：2008-07-28
申请人： Daniel M. Sullivan , Runhui Huang , Charles J. Neef , Jinhua Dai , Michael B. Swope
发明人： Daniel M. Sullivan , Runhui Huang , Charles J. Neef , Jinhua Dai , Michael B. Swope
IPC分类号： B32B27/06 , G03F7/09 , C08F212/14 , C08F220/18 , C08F220/34 , C08F226/06 , G03F7/11 , C08F220/14 , C08F220/26 , C08F220/56
CPC分类号： G03F7/091 , C08F212/14 , C08F220/14 , C08F220/18 , C08F220/26 , C08F220/34 , C08F220/56 , C08F226/06 , G03F7/11 , Y10T428/31678 , Y10T428/31855 , Y10T428/31935
摘要： This invention describes compositions and methods of using non-covalently crosslinked resin coatings for lithographic applications. These materials are designed to undergo, after coating, a change that provides solvent resistance and, with some materials, simultaneous aqueous-base solubility. Non-covalent interactions allow for easier removal of these coatings than of covalently crosslinked materials. These types of materials are well-suited for trench and gap fill applications, as well as for anti-reflective coatings, spin-on carbon layers, and etch masks.
摘要翻译：本发明描述了使用非共价交联的树脂涂料用于光刻应用的组合物和方法。这些材料被设计成在涂覆之后进行提供耐溶剂性的改变，并且在一些材料中经历同时的水基溶解度。非共价相互作用允许这些涂层比共价交联的材料更容易去除。这些类型的材料非常适用于沟槽和间隙填充应用，以及抗反射涂层，旋涂碳层和蚀刻掩模。

7. 发明授权

US08623854B2 Nuclear export inhibitors of topoisomerase II alpha 有权
标题翻译：拓扑异构酶IIα的核出口抑制剂
公开(公告)号：US08623854B2
公开(公告)日：2014-01-07
申请号：US13159016
申请日：2011-06-13
申请人： Daniel M. Sullivan , Joel G. Turner , Thomas C. Rowe , David A. Ostrov
发明人： Daniel M. Sullivan , Joel G. Turner , Thomas C. Rowe , David A. Ostrov
IPC分类号： A01N43/00 , A61K31/33 , A01N57/00 , A61K31/66 , A01N43/66 , A61K31/53 , A01N43/50 , A61K31/415
CPC分类号： A61K31/439 , A61K31/122 , A61K31/4164 , A61K31/519 , A61K31/529 , A61K31/53 , A61K31/5395 , A61K45/06 , C07C49/633 , C07D233/24 , C07D471/18 , C07D487/16 , C07D487/22
摘要： A method of treating cancer in a subject comprising the step of administering to the subject in need thereof an effective amount of a combination of a compound that binds a nuclear export signal (NES inhibitor) on topoisomerase IIα and a topoisomerase inhibitor. Twenty small molecule inhibitors (SMI) that bind to the two nuclear export sequences (NES) topo IIα have been identified from the NCI database using computer-generated molecular modeling. These SMI will improve the effectiveness of topo II directed therapeutics, particularly in the treatment of diseases such as multiple myeloma (MM). In vitro apoptosis assays indicate that these drugs may be effective as single agents or in combination with currently used cancer drugs that target topo II.
摘要翻译：一种治疗受试者的癌症的方法，其包括向有需要的受试者施用有效量的与拓扑异构酶IIa上的核出口信号（NES抑制剂）结合的化合物与拓扑异构酶抑制剂的组合的步骤。已经使用计算机生成的分子模拟从NCI数据库中鉴定了结合两个核出口序列（NES）topo IIal的二十个小分子抑制剂（SMI）。这些SMI将提高topo II定向治疗的有效性，特别是治疗多发性骨髓瘤（MM）等疾病。体外细胞凋亡测定表明，这些药物可能作为单一药剂或与目前使用的靶向II的癌症药物联合使用。

8. 发明申请

US20110275581A1 NUCLEAR EXPORT INHIBITORS OF TOPOISOMERASE II ALPHA 有权
标题翻译：出口抑制剂TOPOISOMERASE II ALPHA
公开(公告)号：US20110275581A1
公开(公告)日：2011-11-10
申请号：US13159016
申请日：2011-06-13
申请人： Daniel M. Sullivan , Joel G. Turner , Thomas C. Rowe , David A. Ostrov
发明人： Daniel M. Sullivan , Joel G. Turner , Thomas C. Rowe , David A. Ostrov
IPC分类号： A61K31/7048 , A61K31/53 , A61K31/519 , A61K31/4178 , A61K31/505 , A61P35/02 , A61K31/341 , A61K31/194 , A61K31/192 , A61K31/704 , A61P35/00 , A61K31/395 , A61K31/663
CPC分类号： A61K31/439 , A61K31/122 , A61K31/4164 , A61K31/519 , A61K31/529 , A61K31/53 , A61K31/5395 , A61K45/06 , C07C49/633 , C07D233/24 , C07D471/18 , C07D487/16 , C07D487/22
摘要： A method of treating cancer in a subject comprising the step of administering to the subject in need thereof an effective amount of a combination of a compound that binds a nuclear export signal (NES inhibitor) on topoisomerase IIα and a topoisomerase inhibitor. Twenty small molecule inhibitors (SMI) that bind to the two nuclear export sequences (NES) topo IIα have been identified from the NCI database using computer-generated molecular modeling. These SMI will improve the effectiveness of topo II directed therapeutics, particularly in the treatment of diseases such as multiple myeloma (MM). In vitro apoptosis assays indicate that these drugs may be effective as single agents or in combination with currently used cancer drugs that target topo II.
摘要翻译：一种治疗受试者的癌症的方法，其包括向有需要的受试者施用有效量的结合核出口信号（NES抑制剂）对拓扑异构酶IIα和拓扑异构酶抑制剂的组合的步骤。已经使用计算机生成的分子模拟从NCI数据库中鉴定了与两个核导出序列（NES）topoIIα结合的二十个小分子抑制剂（SMI）。这些SMI将提高topo II定向治疗的有效性，特别是治疗多发性骨髓瘤（MM）等疾病。体外细胞凋亡测定表明，这些药物可能作为单一药剂或与目前使用的靶向II的癌症药物联合使用。

9. 发明授权

US5691156A Method of inhibiting cell growth with the P.sub.2U receptor 失效
标题翻译：用P2U受体抑制细胞生长的方法
公开(公告)号：US5691156A
公开(公告)日：1997-11-25
申请号：US446088
申请日：1995-05-19
申请人： Richard C. Boucher , Gary A. Weisman , John T. Turner , Thomas K. Harden , Claude E. Parr , Daniel M. Sullivan , Laura J. Erb , Kevin D. Lustig
发明人： Richard C. Boucher , Gary A. Weisman , John T. Turner , Thomas K. Harden , Claude E. Parr , Daniel M. Sullivan , Laura J. Erb , Kevin D. Lustig
IPC分类号： A61K38/00 , C07K14/705 , C12Q1/00 , C12N15/12
CPC分类号： C07K14/705 , A61K38/00
摘要： Isolated DNAs encoding the human P.sub.2U receptor are disclosed, along with vectors and host cells containing the same and methods of using the same. Host cells which are essentially free of endogenous P.sub.2U receptor expression, and which express a heterologous P.sub.2U receptor such as a murine P.sub.2U receptor, are also disclosed, along with methods of using the same.
摘要翻译：公开了编码人P2U受体的分离的DNA，以及含有其的载体和宿主细胞以及使用它们的方法。还公开了基本上不含内源性P2U受体表达并且表达异源P2U受体如鼠P2U受体的宿主细胞，以及使用它们的方法。

10. 发明申请

US20130011630A1 METAL-OXIDE FILMS FROM SMALL MOLECULES FOR LITHOGRAPHIC APPLICATIONS 有权
标题翻译：来自小分子的金属氧化物膜用于光刻应用
公开(公告)号：US20130011630A1
公开(公告)日：2013-01-10
申请号：US13178301
申请日：2011-07-07
申请人： Daniel M. Sullivan , Charles J. Neef , Yubao Wang , Tantiboro Ouattara
发明人： Daniel M. Sullivan , Charles J. Neef , Yubao Wang , Tantiboro Ouattara
IPC分类号： B32B3/10 , B05D3/02 , G03F7/004 , C09D183/00 , G03F7/20
CPC分类号： H01L21/0276 , C08G77/58 , C09D183/14 , G03F7/0752 , G03F7/09 , G03F7/091 , G03F7/094 , H01L21/0332 , Y10T428/24802
摘要： Metal-oxide films for lithographic applications are provided. The films are formed from compositions comprising metal-oxide precursor compounds including metals and metalloids other than silicon. These films are easily produced and can be modified with a variety of ligands, including alkoxides, phenoxides, carboxylates, beta-diketones, and beta-ketoesters.
摘要翻译：提供了用于光刻应用的金属氧化物膜。该膜由包含金属和氧化物前体化合物的组合物形成，包括除硅以外的金属和准金属。这些膜容易生产，并且可以用各种配体进行改性，包括醇盐，苯氧化物，羧酸盐，β-二酮和β-酮酯。

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