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1. 发明授权

US5998598A Immunoadhesins and methods of production and use thereof 失效
标题翻译：免疫粘附素及其生产和使用方法
公开(公告)号：US5998598A
公开(公告)日：1999-12-07
申请号：US814567
申请日：1997-03-10
申请人： Karl G. Csaky , Eddy Anglade , Daniel M. Sullivan , William LaRochelle
发明人： Karl G. Csaky , Eddy Anglade , Daniel M. Sullivan , William LaRochelle
IPC分类号： A61K38/00 , A61K47/48 , A61K48/00 , C07K14/495 , C07K14/54 , C07K14/55 , C07K14/705 , C07H21/04 , C12N15/13 , C12N15/62
CPC分类号： A61K47/48415 , C07K14/495 , C07K14/54 , C07K14/5406 , C07K14/5428 , C07K14/5437 , C07K14/55 , C07K14/70525 , A61K38/00 , A61K48/00 , C07K2319/00 , C07K2319/30 , C12N2799/022
摘要： The invention is directed toward a compound comprising a recombinant nucleic acid encoding an immunoadhesin inserted within an adenoviral nucleic acid, wherein the recombinant nucleic acid can be packaged in an adenovirus particle and wherein expression of the recombinant nucleic acid encoding the immunoadhesin results in production of the immunoadhesin protein. The recombinant nucleic acid encoding the immunoadhesin can be within an adenovirus. The invention further provides methods for delivering an immunoadhesin to a cell or a subject comprising administering to the cell or the subject an adenovirus comprising a recombinant nucleic acid encoding an immunoadhesin; producing an immunoadhesin comprising administering to a cell an adenovirus comprising a recombinant nucleic acid encoding an immunoadhesin inserted within an adenoviral nucleic acid, whereby the cell expresses the recombinant nucleic acid encoding the immunoadhesin, thereby producing the immunoadhesin; treating an inflammatory condition in a subject comprising administering to the subject an adenovirus comprising a recombinant nucleic acid encoding an immunoadhesin inserted within an adenoviral nucleic acid or a recombinant nucleic acid encoding an immunoadhesin inserted within an adenoviral nucleic acid, whereby a cell in the subject expresses the recombinant nucleic acid encoding the immunoadhesin and produces the immunoadhesin, thereby treating the inflammatory condition or administering to the subject a recombinant nucleic acid encoding an immunoadhesin, or an immunoadhesin, wherein the immunoadhesin is selected from the group consisting of vIL-10-IgG, IL-13-IgG, LFA-IgG, IL-2ra-IgG, IL-1ra-IgG, mutant IL-4-IgG, VLA4-IgG, IL-2-IgG, TGF-.beta.1-IgG, TGF-.beta.1.sup.223,225 -IgG, and VCAM-IgG; and methods of screening an immunoadhesin for bioactivity.
摘要翻译：本发明涉及包含编码插入在腺病毒核酸内的免疫粘附素的重组核酸的化合物，其中所述重组核酸可以包装在腺病毒颗粒中，并且其中编码免疫粘附素的重组核酸的表达导致产生免疫粘附蛋白。编码免疫粘附素的重组核酸可以在腺病毒内。本发明还提供了将免疫粘附素递送至细胞或受试者的方法，包括向细胞或受试者施用包含编码免疫粘附素的重组核酸的腺病毒; 产生免疫粘附素，其包括向细胞施用包含编码插入在腺病毒核酸内的免疫粘附素的重组核酸的腺病毒，由此所述细胞表达编码免疫粘附素的重组核酸，由此产生免疫粘附素; 治疗受试者中的炎性病症包括向受试者施用包含编码插入腺病毒核酸内的免疫粘附素的重组核酸的腺病毒或编码插入腺病毒核酸内的免疫粘附素的重组核酸，由此受试者中的细胞表达编码免疫粘附素的重组核酸并产生免疫粘附素，从而治疗炎性病症或向受试者施用编码免疫粘附素或免疫粘附素的重组核酸，其中所述免疫粘附素选自vIL-10-IgG， IL-13-IgG，LFA-IgG，IL-2ra-IgG，IL-1ra-IgG，突变型IL-4-IgG，VLA4-IgG，IL-2-IgG，TGF-β1-IgG，TGF-β1223 ，225-IgG和VCAM-IgG; 以及筛选免疫粘附素用于生物活性的方法。

2. 发明申请

US20130156784A1 Compositions Using Antibodies Directed To GPNMB And Uses Thereof 审中-公开
标题翻译：使用针对GPNMB的抗体的组合及其用途
公开(公告)号：US20130156784A1
公开(公告)日：2013-06-20
申请号：US13544526
申请日：2012-07-09
申请人： Michael Jeffers , William LaRochelle
发明人： Michael Jeffers , William LaRochelle
IPC分类号： A61K39/395 , A61K31/426 , A61K31/5025 , A61K31/4439 , A61K33/20 , A61K31/4706 , A61K31/35 , A61K45/06 , A61K31/506
CPC分类号： A61K39/39558 , A61K31/35 , A61K31/426 , A61K31/4439 , A61K31/454 , A61K31/4706 , A61K31/5025 , A61K31/506 , A61K31/52 , A61K31/54 , A61K33/20 , A61K45/06 , A61K47/6803 , A61K47/6851 , C07K16/30 , C07K2317/21 , C07K2317/92 , A61K2300/00
摘要： The present invention relates to antibodies, including fully human monoclonal antibodies, with specificity to GPNMB, and uses of such antibodies. The present invention further provides compositions that increase expression of GPNMB on the surface of tumor cells, and methods of using such compositions to increase the anti-cancer activity or other therapeutic efficacy of the antibodies and immunoconjugates provided herein.
摘要翻译：本发明涉及对GPNMB具有特异性的抗体，包括完全人单克隆抗体，以及此类抗体的用途。本发明还提供增加GPNMB在肿瘤细胞表面的表达的组合物，以及使用这些组合物增加本文提供的抗体和免疫缀合物的抗癌活性或其它治疗功效的方法。

3. 发明申请

US20050208514A1 Novel fibroblast growth factor and nucleic acids encoding dame 审中-公开
标题翻译：新型成纤维细胞生长因子和编码dame的核酸
公开(公告)号：US20050208514A1
公开(公告)日：2005-09-22
申请号：US10980659
申请日：2004-11-03
申请人： John Alsobrook , Ferenc Boldog , Michael Jeffers , William LaRochelle , Denise Lepley , Henri Lichenstein , Richard Shimkets , Meijia Yang , Marie Ruiz-Martinez , Galina Chernaya , Muralidhara Padigaru , Sudhirdas Prayaga , Mei Zhong
发明人： John Alsobrook , Ferenc Boldog , Michael Jeffers , William LaRochelle , Denise Lepley , Henri Lichenstein , Richard Shimkets , Meijia Yang , Marie Ruiz-Martinez , Galina Chernaya , Muralidhara Padigaru , Sudhirdas Prayaga , Mei Zhong
IPC分类号： A61K38/00 , A61K38/18 , C07K14/50 , C12Q1/68
CPC分类号： C07K14/50 , A61K38/00
摘要： The present invention generally relates to nucleic acids, proteins, and antibodies. The invention relates more particularly to nucleic acid molecules, proteins, and antibodies of Fibroblast Growth Factor-20 (FGF-20), or its fragments, derivatives, variants, homologs, analogs, or a combination thereof.
摘要翻译：本发明一般涉及核酸，蛋白质和抗体。本发明更具体涉及成纤维细胞生长因子-20（FGF-20）或其片段，衍生物，变体，同系物，类似物或其组合的核酸分子，蛋白质和抗体。

4. 发明授权

US06368828B1 Attenuated and dominant negative variant cDNAs of Stat6: Stat6b and Stat6c 有权
标题翻译： Stat6：Stat6b和Stat6c的减毒和显性负变异cDNA
公开(公告)号：US06368828B1
公开(公告)日：2002-04-09
申请号：US09511625
申请日：2000-02-23
申请人： William LaRochelle , Bharvin K. R. Patel , Jacalyn H. Pierce
发明人： William LaRochelle , Bharvin K. R. Patel , Jacalyn H. Pierce
IPC分类号： C12P2106
CPC分类号： C07K14/4705
摘要： The present invention provides an isolated nucleic acid encoding the polypeptide Stat6b, having an amino acid sequence of Stat6 wherein a deletion in the nucleic acid is present, encompassing the last base pair of codon 39 of Stat6 and continuing through to and including codon 86 of Stat6 and an isolated polypeptide, Stat6b, having an amino acid sequence of Stat6 wherein amino acids 39-86 are deleted at the amino terminus. Also provided is an isolated nucleic acid encoding the polypeptide Stat6c, having an amino acid sequence of Stat6 wherein amino acids 537-564 are deleted and an isolated polypeptide, Stat6c, having an amino acid sequence of Stat6 wherein amino acids 537-564 are deleted. Methods of producing the polypeptide Stat6b and polypeptide Stat6c are also provided, comprising culturing cells comprising nucleic acid encoding the polypeptide Stat6b or the polypeptide Stat6c under conditions whereby the polypeptide Stat6b or the polypeptide Stat6c is produced.
摘要翻译：本发明提供了编码多肽Stat6b的分离的核酸，其具有Stat6的氨基酸序列，其中存在核酸中的缺失，其包含Stat6的最后一对密码子39，并持续到并包括Stat6的密码子86 和具有Stat6的氨基酸序列的分离的多肽Stat6b，其中在氨基末端缺失氨基酸39-86。还提供了编码多肽Stat6c的分离的核酸，其具有Stat6的氨基酸序列，其中氨基酸537-564缺失，分离的多肽Stat6c具有Stat6的氨基酸序列，其中氨基酸537-564被缺失。还提供了产生多肽Stat6b和多肽Stat6c的方法，包括在产生多肽Stat6b或多肽Stat6c的条件下培养包含编码多肽Stat6b或多肽Stat6c的核酸的细胞。

5. 发明申请

US20070098715A1 Antibodies against the tenascin major antigens 审中-公开
标题翻译：抗腱生蛋白主要抗原的抗体
公开(公告)号：US20070098715A1
公开(公告)日：2007-05-03
申请号：US11391630
申请日：2006-03-27
申请人： Seth Ettenberg , Stephanie Masterman , William LaRochelle , Haihong Zhong
发明人： Seth Ettenberg , Stephanie Masterman , William LaRochelle , Haihong Zhong
IPC分类号： A61K39/395 , G01N33/567 , C07K16/28
CPC分类号： C07K16/30 , A61K47/6825 , A61K47/6851 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/73 , C07K2317/77 , C07K2317/92
摘要： The invention described herein relates to antibodies directed to the antigen Ten-M2 and uses of such antibodies. In particular, there are provided fully human monoclonal antibodies directed to the antigen Ten-M2. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
摘要翻译：本文描述的本发明涉及针对抗原Ten-M2的抗体和这种抗体的用途。特别地，提供针对抗原Ten-M2的完全人单克隆抗体。分离的多核苷酸序列编码和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区（FR）和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是FR1至FR4 或CDR1至CDR3。还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

6. 发明申请

US20060094647A1 Treatment of inflammatory bowel disease using growth factors 审中-公开
标题翻译：用生长因子治疗炎症性肠病
公开(公告)号：US20060094647A1
公开(公告)日：2006-05-04
申请号：US09992840
申请日：2001-11-06
申请人： Michael Jeffers , Richard Shimkets , Sudhirdas Prayaga , Ferenc Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , Beth Rittman , Juliette Shimkets , William LaRochelle , Henri Lichenstein
发明人： Michael Jeffers , Richard Shimkets , Sudhirdas Prayaga , Ferenc Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , Beth Rittman , Juliette Shimkets , William LaRochelle , Henri Lichenstein
IPC分类号： A61K38/17
CPC分类号： A61K38/1825 , C07K14/49 , C07K14/50 , C07K14/51 , C07K14/52
摘要： The present invention is based upon methods of treating inflammatory conditions in the intestinal tract of mammals using growth factor related polypeptides. Methods of using fibroblast growth factor-CX (FGF-CX) polynucleotide sequences and the FGF-CX polypeptides encoded by such nucleic acid sequences, or variants, fragments and homologs thereof, are claimed in the invention. Similarly, methods of using FCTRX polynucleotide sequences and the FCTRX polypeptides encoded by such nucleic acid sequences, or variants, fragments and homologs thereof, alone or in combination, are also claimed in the invention. FCTRX collectively refers to any of six variant FCTRX sequences, variously designated FCTR1, FCTR2, FCTR3, FCTR4, FCTR5 and FCTR6.
摘要翻译：本发明是基于使用生长因子相关多肽治疗哺乳动物肠道炎症状况的方法。在本发明中要求使用成纤维细胞生长因子CX（FGF-CX）多核苷酸序列和由这种核酸序列编码的FGF-CX多肽或其变体，片段和同系物的方法。类似地，在本发明中还要求保护使用FCTRX多核苷酸序列和由此类核酸序列编码的FCTRX多肽，或其变体，片段和同源物单独或组合使用的方法。 FCTRX统称为六种变体FCTRX序列中的任何一种，分别为FCTR1，FCTR2，FCTR3，FCTR4，FCTR5和FCTR6。

7. 发明申请

US20050164929A1 Methods of preventing and treating inflammatory bowel disease 审中-公开
标题翻译：预防和治疗炎症性肠病的方法
公开(公告)号：US20050164929A1
公开(公告)日：2005-07-28
申请号：US10980764
申请日：2004-11-03
申请人： Enrique Alvarez , Jeffrey Peterson , William LaRochelle , Henri Lichenstein , Michael Jeffers
发明人： Enrique Alvarez , Jeffrey Peterson , William LaRochelle , Henri Lichenstein , Michael Jeffers
IPC分类号： A61K38/00 , A61K38/18 , A61K38/19 , C07K14/49 , C07K14/50 , C07K14/51 , C07K14/52 , A61K48/00 , A61K38/17
CPC分类号： C07K14/49 , A61K38/00 , C07K14/50 , C07K14/51 , C07K14/52 , Y02A50/473
摘要： The present invention relates to compositions and methods for preventing and treating an inflammatory disorder of a mucosa, including but is not limited to, inflammatory bowel disease and irritable bowel syndrome. More particularly, the present invention relates to compositions comprising FGF-20, a fragment, a derivative, a variant, a homolog, or an analog thereof, and their uses in preventing and treating an inflammatory disorder of a mucosa, such as inflammatory bowel disease or irritable bowel syndrome.
摘要翻译：本发明涉及用于预防和治疗粘膜炎症性疾病的组合物和方法，包括但不限于炎性肠病和肠易激综合征。更具体地，本发明涉及包含FGF-20，片段，衍生物，变体，同源物或类似物的组合物，以及它们在预防和治疗粘膜炎症性疾病如炎症性肠病中的用途或肠易激综合征。

8. 发明申请

US20060211031A1 Novel proteins and nucleic acids encoding same 审中-公开
公开(公告)号：US20060211031A1
公开(公告)日：2006-09-21
申请号：US11398823
申请日：2006-04-06
申请人： Haihong Zhong , William LaRochelle , Suresh Shenoy , Nikolai Khramtsov
发明人： Haihong Zhong , William LaRochelle , Suresh Shenoy , Nikolai Khramtsov
IPC分类号： C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , C07K14/82 , C07K16/30
CPC分类号： C07K14/705 , A61K38/00 , C07K14/47
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

9. 发明申请

US20050256042A1 Methods of preventing and treating alimentary mucositis 审中-公开
标题翻译：预防和治疗消化性粘膜炎的方法
公开(公告)号：US20050256042A1
公开(公告)日：2005-11-17
申请号：US10980459
申请日：2004-11-03
申请人： Michael Jeffers , Zachary Yim , Pascal Valax , Pradyumna Namdev , Rajeev Chillakuru , William LaRochelle , Henri Lichenstein , Enrique Alvarez , William Hahne
发明人： Michael Jeffers , Zachary Yim , Pascal Valax , Pradyumna Namdev , Rajeev Chillakuru , William LaRochelle , Henri Lichenstein , Enrique Alvarez , William Hahne
IPC分类号： A61K38/00 , A61K38/17 , C07K14/47 , C07K14/50 , C12N1/21 , C12N15/74 , C12P21/06
CPC分类号： C07K14/50 , A61K38/00
摘要： The present invention relates to compositions and methods for preventing and treating alimentary mucositis. More particularly, the present invention provides methods for preventing and/or treating alimetary mucositis by using compositions comprising FGF-20, a fragment, a derivative, a variant, a homolog, or an analog thereof.
摘要翻译：本发明涉及预防和治疗消化性粘膜炎的组合物和方法。更具体地，本发明提供了通过使用包含FGF-20，片段，衍生物，变体，同源物或类似物的组合物来预防和/或治疗哺乳动物粘膜炎的方法。

10. 发明申请

US20130244255A1 ANTIBODIES DIRECTED TO GPNMB AND USES THEREOF 审中-公开
标题翻译：针对GPNMB的抗体及其用途
公开(公告)号：US20130244255A1
公开(公告)日：2013-09-19
申请号：US13368030
申请日：2012-02-07
申请人： Vincent A. Pollack , William LaRochelle
发明人： Haihong Zhong , Vincent A. Pollack , William LaRochelle
IPC分类号： G01N33/68
CPC分类号： G01N33/6869 , G01N33/57407 , G01N33/5743 , G01N2333/5421
摘要： The present invention relates to antibodies with specificity to GPNMB, and uses of such antibodies. In particular, the present invention provides fully human monoclonal antibodies that specifically bind to GPNMB, and uses thereof. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs) are provided. The present invention also provides biomarkers for evaluating the effects of therapeutic methods and uses of the antibodies with specificity to GPNMB.
摘要翻译：本发明涉及对GPNMB具有特异性的抗体，以及这些抗体的用途。特别地，本发明提供了完全与GPNMB结合的人单克隆抗体及其应用。提供了编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列。本发明还提供用于评估治疗方法的效果的生物标志物和对GPNMB具有特异性的抗体的用途。

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