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1. 发明授权

US06491819B2 Method and apparatus for filtering suspension of medical and biological fluids or the like 有权
标题翻译：用于过滤医疗和生物流体等的悬浮液的方法和装置
公开(公告)号：US06491819B2
公开(公告)日：2002-12-10
申请号：US09954734
申请日：2001-09-18
申请人： Paul R. Prince , Michael O. Pekkarinen , David Bellamy, Jr. , Shmuel Sternberg
发明人： Paul R. Prince , Michael O. Pekkarinen , David Bellamy, Jr. , Shmuel Sternberg
IPC分类号： B01D6114
CPC分类号： B01D65/08 , A61M1/262 , A61M1/265 , A61M1/34 , A61M1/3403 , A61M1/341 , A61M2202/0429 , A61M2202/0439 , A61M2205/3334 , B01D39/1692 , B01D61/147 , B01D61/22 , B01D63/16 , B01D69/02 , B01D2321/20 , B01D2321/2025 , B01D2321/2058 , B01D2321/2066 , A61M2202/0042 , A61M2202/0035
摘要： An apparatus is disclosed for separating a suspension comprising at least two types of particles which are differently sized or shaped and in which the first type of particle may be deformable at a relatively lower force or faster rate than the second type of particle. A housing is provided having a generally cylindrical inner surface in which is mounted a rotor having a generally cylindrical outer surface. The outer surface of the rotor is spaced from the inner surface of the housing to define a suspension processing gap. A filter membrane is provided on the surface of the rotor or the housing that has pores with substantially precisely dimensioned shapes and sizes to correspond substantially to the shape of the first type of particle, thus allowing passage of the first type of particle and blocking passage of the second type of particle. A suspension is directed into the processing gap for either a selected residence time in contact with the filter membrane and/or at a selected force.
摘要翻译：公开了一种用于分离包含至少两种不同尺寸或形状的颗粒的悬浮液的装置，其中第一类型的颗粒可以以比第二类型的颗粒更低的力或更快的速率变形。提供具有大致圆柱形内表面的壳体，其中安装有具有大致圆柱形外表面的转子。转子的外表面与壳体的内表面间隔开以限定悬挂处理间隙。在转子或壳体的表面上提供过滤膜，其具有基本上精确尺寸的形状和尺寸的孔，其基本上对应于第一类型的颗粒的形状，从而允许第一类型的颗粒和阻挡通道第二种类型的粒子。将悬浮液引导到处理间隙中以选择与过滤膜接触的停留时间和/或以选定的力。

2. 发明授权

US06497821B1 Method and apparatus for filtering suspensions of medical and biological fluids or the like 有权
公开(公告)号：US06497821B1
公开(公告)日：2002-12-24
申请号：US09312883
申请日：1999-05-17
申请人： David Bellamy, Jr. , Paul R. Prince , Michael O. Pekkarinen , Shmuel Sternberg
发明人： David Bellamy, Jr. , Paul R. Prince , Michael O. Pekkarinen , Shmuel Sternberg
IPC分类号： B01D6100
CPC分类号： B01D65/08 , A61M1/262 , A61M1/265 , A61M1/34 , A61M1/3403 , A61M1/341 , A61M2202/0429 , A61M2202/0439 , A61M2205/3334 , B01D39/1692 , B01D61/147 , B01D61/22 , B01D63/16 , B01D69/02 , B01D2321/20 , B01D2321/2025 , B01D2321/2058 , B01D2321/2066 , A61M2202/0042 , A61M2202/0035
摘要： A method and apparatus for filtering suspensions of medical and biological fluids, one aspect of which is separating a suspension comprising at least two types of particles which are differently sized or shaped and in which the first type of particle may be deformable at a relatively lower force and/or faster rate than the second type of particle. A filter member is provided having substantially precisely dimensioned pore sizes, with the pores being dimensioned to allow passage of the first type of suspended particle without distortion or only minimal distortion and passage of the second type of particle only with substantial distortion. Because the filter membrane has precisely dimensioned pores, with spacing between the pores being maintained despite the smaller interval between the pores, the porosity of the membrane may be much greater than nominal pore size membranes, allowing faster filtration rates and/or smaller membranes for a given filtration rate, while reducing the exposure time of the cells within the shear environment, and consequently reducing particle damage. Various methods for preventing clogging of the membrane are also disclosed.

3. 发明授权

US4526574A Differential occlusion sensing method and apparatus 失效
标题翻译：差分遮挡检测方法及装置
公开(公告)号：US4526574A
公开(公告)日：1985-07-02
申请号：US497369
申请日：1983-05-23
申请人： Michael O. Pekkarinen
发明人： Michael O. Pekkarinen
IPC分类号： A61M5/00 , A61M5/168
CPC分类号： A61M5/16854 , Y10S128/13
摘要： The present invention provides an accurate method and apparatus for sensing and monitoring any buildup in the downline tubing pressure in a fluid infusion system. The initial fluid pressure as indicated by the tubing location is sensed after a delay period and is utilized as a base pressure if it is within allowable limits. The infusion tubing location or pressure is then monitored and compared with the base location or pressure. The system will alarm if a preset differential location or pressure change is exceeded.
摘要翻译：本发明提供了一种用于感测和监测流体输注系统中下行管道压力中的任何累积的精确方法和装置。在延迟时间之后检测由管道位置指示的初始流体压力，并且如果其在允许极限内，则用作基础压力。然后监测输液管的位置或压力，并将其与基部位置或压力进行比较。如果超出预设的差压位置或压力变化，系统将报警。

4. 发明授权

US4133441A Injection site 失效
标题翻译：注射部位
公开(公告)号：US4133441A
公开(公告)日：1979-01-09
申请号：US889207
申请日：1978-03-23
申请人： Herbert Mittleman , Michael O. Pekkarinen
发明人： Herbert Mittleman , Michael O. Pekkarinen
IPC分类号： A61M39/00 , B65D51/00 , B65D47/36
CPC分类号： B65D51/002
摘要： An injection site is provided which is molded inside out with inwardly extending rings. The rings have a smaller internal diameter than the external diameter of the tubular member to which the injection site is to be connected. The injection site has a central portion for receiving a needle therethrough, and a first, cylindrical portion which is extended into the tubular member. After such insertion, the portion with the attached rings is folded back onto the tubular member. The rings become positioned on the outside of the assembly and are in the compressed state squeezing tightly against the tubular member.
摘要翻译：提供注射部位，其内部成型为内向内延伸的环。这些环具有比注射部位要连接的管状构件的外径更小的内径。注射部位具有用于接收针头的中心部分，以及延伸到管状部件中的第一圆柱形部分。在这种插入之后，具有附接环的部分被折回到管状构件上。环变得位于组件的外侧上并处于压缩状态，紧紧地挤压在管状部件上。

5. 发明授权

US4583975A Indirect piezoelectric drop counter and method 失效
标题翻译：间接压电滴定计数器及方法
公开(公告)号：US4583975A
公开(公告)日：1986-04-22
申请号：US717487
申请日：1985-03-29
申请人： Michael O. Pekkarinen , Ludwig Wolf, Jr. , Walker Woodworth
发明人： Michael O. Pekkarinen , Ludwig Wolf, Jr. , Walker Woodworth
IPC分类号： A61M5/168 , A61M5/16
CPC分类号： A61M5/1689 , Y10S128/13
摘要： The present invention provides an accurate method and apparatus for monitoring the drop flow rate from a fluid source. The drops are indirectly sensed by piezoelectric means mounted on a drip chamber when the drops impinge on a fluid surface in the chamber. The chamber can include a second differential piezoelectric sensing element, which provides a noise reference signal which can be subtracted from the drop sensing signal. The volume of the fluid drops sensed can be determined. The sensing element can be incorporated in open and closed loop disposable chamber modules which can include both monitoring and occlusion valving functions integral therewith.
摘要翻译：本发明提供了一种用于监测来自流体源的液滴流速的精确方法和装置。当液滴撞击在腔室中的流体表面上时，通过安装在滴水室上的压电装置间接感测液滴。腔室可以包括第二差分压电感测元件，其提供可以从液滴感测信号中减去的噪声参考信号。可以确定感测到的液滴的体积。感测元件可以结合在开放和闭环一次性室模块中，其可以包括与其一体的监测和闭塞阀功能。

6. 发明授权

US4346705A Metering apparatus having rate compensation circuit 失效
标题翻译：具有速率补偿电路的计量装置
公开(公告)号：US4346705A
公开(公告)日：1982-08-31
申请号：US195432
申请日：1980-10-09
申请人： Michael O. Pekkarinen , Norm Shim
发明人： Michael O. Pekkarinen , Norm Shim
IPC分类号： A61M5/00 , A61M5/172
CPC分类号： A61M5/14232 , A61M5/172
摘要： A system for infusing fluids into the human body includes a peristaltic-type metering apparatus which controls the flow of fluid through a disposable administration set at a preset rate. A compensating circuit within the metering apparatus automatically varies the operating rate of the metering apparatus to compensate for dimensional variations in the apparatus and the tubing.
摘要翻译：用于将流体输入人体的系统包括蠕动型计量装置，其以预设速率控制流体通过一次性给药装置的流动。计量装置内的补偿电路自动改变计量装置的运行速率以补偿装置和管道中的尺寸变化。

7. 发明授权

US4011288A Disposable humidifier assembly 失效
标题翻译：可配置的增湿器总成
公开(公告)号：US4011288A
公开(公告)日：1977-03-08
申请号：US558601
申请日：1975-03-14
申请人： Robert Assenheimer , Michael O. Pekkarinen
发明人： Robert Assenheimer , Michael O. Pekkarinen
IPC分类号： A61M16/16 , A61M15/00
CPC分类号： A61M16/16 , Y10S261/65
摘要： A gas humidifier set is provided which includes a solution bottle containing a sterile water solution, a cap seal providing a sterile seal for the solution bottle, a connector assembly for penetrating the seal at the time of use and coupling the solution bottle to a gas supply and a covering cap for covering the connector assembly and maintaining it in sterile condition prior to use. The connector assembly includes gas inlet and outlet members. To use the device, the covering cap is removed and the connector assembly is turned thereby causing piercing of the cap seal and communication between the sterile water solution and the gas inlet and outlet members.

8. 发明授权

US06520997B1 Porous three dimensional structure 失效
标题翻译：多孔三维结构
公开(公告)号：US06520997B1
公开(公告)日：2003-02-18
申请号：US09731486
申请日：2000-12-07
申请人： Michael O. Pekkarinen , James Brauker
发明人： Michael O. Pekkarinen , James Brauker
IPC分类号： A61F236
CPC分类号： A61F2/02 , A61F2/00 , A61F2/0077 , A61F2/022 , A61F2/06 , A61F2/30767 , A61F2/3094 , A61F2002/30154 , A61F2002/30199 , A61F2002/30263 , A61F2002/30271 , A61F2002/30329 , A61F2002/30677 , A61F2002/307 , A61F2002/30701 , A61F2002/30703 , A61F2220/0025 , A61F2230/0021 , A61F2230/0063 , A61F2230/0082 , A61F2230/0084 , A61F2240/001 , A61F2250/0067 , A61F2250/0081
摘要： A porous three dimensional structure for implantation in a host animal capable of producing an inflammatory foreign body response. The structure includes first and second layers spaced by a plurality of posts having a predetermined length connecting the first and second layers. Each of the layers has a plurality of openings of a predetermined size permitting fluids and inflammatory cells of the animal to pass through the openings and migrate into an interior volume defined by the first and second layers. The size of the openings and length of the posts promote a non-flattened morphology of the cells. The structure promotes vascularization adjacent to the structure when implanted into the animal.
摘要翻译：用于植入能够产生炎症异物反应的宿主动物中的多孔三维结构。该结构包括由具有连接第一和第二层的预定长度的多个柱隔开的第一和第二层。每个层具有预定尺寸的多个开口，允许动物的流体和炎性细胞穿过开口并迁移到由第一和第二层限定的内部空间中。开口的尺寸和柱的长度促进了细胞的非扁平形态。当植入植物时，该结构促进与结构相邻的血管形成。

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