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1. 发明授权

US5290221A Systems for eradicating contaminants using photoactive materials in fluids like blood 失效
标题翻译：在血液中使用光敏材料消除污染物的系统
公开(公告)号：US5290221A
公开(公告)日：1994-03-01
申请号：US994094
申请日：1992-12-17
申请人： Ludwig Wolf, Jr. , John T. Foley , William R. Bratten
发明人： Ludwig Wolf, Jr. , John T. Foley , William R. Bratten
IPC分类号： A61K35/14 , A61L2/00 , A61M1/36 , B01J19/12 , C12N7/00
CPC分类号： A61L2/0011 , A61M1/3681 , A61M1/3683 , B01J19/122
摘要： Systems for treating a fluid carrying a contaminant to which a photoactive material has been bound include a treatment device that defines a relatively narrow, arcuately shaped flow path. These systems envelop the path with a radiation chamber that directs radiation from one or more sources into the fluid.
摘要翻译：用于处理携带已经结合有光敏材料的污染物的流体的系统包括限定相对窄的弧形流动路径的处理装置。这些系统用辐射室包围路径，辐射室将来自一个或多个源的辐射引导到流体中。

2. 发明授权

US4583975A Indirect piezoelectric drop counter and method 失效
标题翻译：间接压电滴定计数器及方法
公开(公告)号：US4583975A
公开(公告)日：1986-04-22
申请号：US717487
申请日：1985-03-29
申请人： Michael O. Pekkarinen , Ludwig Wolf, Jr. , Walker Woodworth
发明人： Michael O. Pekkarinen , Ludwig Wolf, Jr. , Walker Woodworth
IPC分类号： A61M5/168 , A61M5/16
CPC分类号： A61M5/1689 , Y10S128/13
摘要： The present invention provides an accurate method and apparatus for monitoring the drop flow rate from a fluid source. The drops are indirectly sensed by piezoelectric means mounted on a drip chamber when the drops impinge on a fluid surface in the chamber. The chamber can include a second differential piezoelectric sensing element, which provides a noise reference signal which can be subtracted from the drop sensing signal. The volume of the fluid drops sensed can be determined. The sensing element can be incorporated in open and closed loop disposable chamber modules which can include both monitoring and occlusion valving functions integral therewith.
摘要翻译：本发明提供了一种用于监测来自流体源的液滴流速的精确方法和装置。当液滴撞击在腔室中的流体表面上时，通过安装在滴水室上的压电装置间接感测液滴。腔室可以包括第二差分压电感测元件，其提供可以从液滴感测信号中减去的噪声参考信号。可以确定感测到的液滴的体积。感测元件可以结合在开放和闭环一次性室模块中，其可以包括与其一体的监测和闭塞阀功能。

3. 发明授权

US4346703A Solution container for continuous ambulatory peritoneal dialysis 失效
标题翻译：用于连续不卧床腹膜透析的溶液容器
公开(公告)号：US4346703A
公开(公告)日：1982-08-31
申请号：US187008
申请日：1980-09-15
申请人： T. Michael Dennehey , Richard J. Greff , Ludwig Wolf, Jr.
发明人： T. Michael Dennehey , Richard J. Greff , Ludwig Wolf, Jr.
IPC分类号： A61J1/00 , A61J1/14 , A61M1/28 , A61M5/14 , A61M39/10 , A61M39/22 , A61J7/00
CPC分类号： A61M39/221 , A61M39/10 , A61M5/14 , A61J1/14 , A61M1/28 , A61M2039/1033 , Y10S604/905
摘要： Equipment for continuous ambulatory peritoneal dialysis in which a solution container is coupled via flexible tubing to a patient's tube that communicates with the patient's peritoneal cavity by means of a catheter, usually a surgically implanted catheter. The equipment includes a flexible, foldable plastic dialysis solution container having a transfer port. A flexible tube having a luer connector at its distal end extends from the transfer port, for connecting to a luer connector carried by the patient's tube. The flexible tube carries a frangible member which normally blocks fluid flow but permits fluid flow after the frangible member is broken. A particulate filter and a manually-operable clamp are in series with the flexible tube.Peritoneal dialysis is accomplished by connecting the luer connector from a fresh dialysis solution bag to the patient's tube luer connector, breaking the frangible member, and opening the clamp on the flexible tubing. After the dialysis solution is introduced into the patient's peritoneal cavity and remains there for a predetermined time, the solution is drained back into the flexible bag, the luer connectors are disconnected and the foregoing steps are repeated. If desired, once the dialysis solution has been introduced into the patient's peritoneal cavity, the luer connections may be disconnected and the patient's tube luer connector may be capped.
摘要翻译：用于连续不卧床腹膜透析的设备，其中溶液容器通过柔性管连接到通过导管（通常是手术植入的导管）与患者的腹膜腔连通的患者管。该设备包括具有转移口的柔性可折叠塑料透析溶液容器。在其远端处具有鲁尔连接器的柔性管从传送端口延伸，用于连接到患者管所承载的鲁尔连接器。柔性管带有易碎构件，其通常阻挡流体流动，但在易碎构件破裂之后允许流体流动。微粒过滤器和可手动操作的夹具与柔性管串联。腹膜透析是通过将鲁尔连接器从新鲜透析溶液袋连接到患者管路鲁尔连接器，破坏易碎构件，以及将柔性管上的夹子打开来实现的。将透析溶液引入患者的腹膜腔内并保持在预定时间之后，将溶液排回到柔性袋中，将鲁尔连接器断开并重复上述步骤。如果需要，一旦透析溶液已经被引入到患者的腹膜腔中，则路厄氏连接可能被断开并且患者的管路鲁尔连接器可能被封盖。

4. 发明授权

US4201406A Spike connector for solution bag 失效
标题翻译：溶液袋用尖头连接器
公开(公告)号：US4201406A
公开(公告)日：1980-05-06
申请号：US960157
申请日：1978-11-13
申请人： T. Michael Dennehey , Ludwig Wolf, Jr.
发明人： T. Michael Dennehey , Ludwig Wolf, Jr.
IPC分类号： A61J1/05 , A61J1/10 , A61M39/14 , A61M5/00 , F16L47/00
CPC分类号： A61M39/14 , A61J1/10 , A61J1/1475 , A61M2039/1027
摘要： A touch-contamination protected spike connector is provided for coupling a plastic fluid conduit to a port extending from a medical solution container. The spike defines a longitudinal bore and has an angled tip, and carries a flange which extends outwardly from the spike. A tube surrounds and is concentric with a major portion of the spike, with the tube having a dimension suited for coupling to the port with a snug pressure fit. A spacer is interposed between the spike and the tube. The flange and surrounding tube cooperate to enable the spike to be connected to the port with the chance of bacterial contamination caused by accidental touching of the spike being minimized.
摘要翻译：提供接触污染保护的尖钉连接器，用于将塑料流体导管连接到从医用溶液容器延伸的端口。尖钉限定纵向孔并且具有倾斜的尖端，并且承载从尖峰向外延伸的凸缘。管围绕并且与钉的主要部分同心，其中管具有适于以贴合压力配合连接到端口的尺寸。间隔件插入在钉和管之间。法兰和周围管配合使得尖峰连接到端口，由于尖峰的意外触摸而导致细菌污染的可能性最小化。

5. 发明授权

US4035305A Support member construction for semipermeable membrane 失效
标题翻译：半透膜支撑构件
公开(公告)号：US4035305A
公开(公告)日：1977-07-12
申请号：US620542
申请日：1975-10-08
申请人： Jimmy L. Miller , William J. Schnell , Ludwig Wolf, Jr.
发明人： Jimmy L. Miller , William J. Schnell , Ludwig Wolf, Jr.
IPC分类号： B01D63/10 , B01D13/00
CPC分类号： B01D61/28 , B01D63/10 , B01D2313/02
摘要： A support member for use in a coil dialyzer to support an elongated, tubularly-shaped, semipermeable membrane is disclosed herein. The member is embossed and has generally angularly extending parallel ribs on both sides of the web. The ribs are arranged so that on each side there are high ribs and low ribs positioned between said high ribs. The ribs on opposite sides overlap in such a manner to form an angle varying between 60.degree. and 140.degree.. Furthermore, the ribs are arranged in a pattern wherein there are four short ribs positioned between adjacent pairs of high ribs.
摘要翻译：本文公开了用于线圈透析器中用于支撑细长的，管状的半透膜的支撑构件。构件被压花并且在幅材的两侧上具有大致角度延伸的平行肋。肋被布置成使得在每一侧上都有高肋和位于所述高肋之间的低肋。相对侧的肋条以这样的方式重叠，形成在60°和140°之间变化的角度。此外，肋以布置在相邻的一对高肋之间的四个短肋的图案布置。

6. 发明授权

US3996027A Swirling flow bubble trap 失效
标题翻译：旋流气泡陷阱
公开(公告)号：US3996027A
公开(公告)日：1976-12-07
申请号：US519731
申请日：1974-10-31
申请人： William J. Schnell , Ludwig Wolf, Jr.
发明人： William J. Schnell , Ludwig Wolf, Jr.
IPC分类号： A61M1/36 , B01D19/00
CPC分类号： A61M1/3627 , B01D19/0057
摘要： A device for separating low density materials such as gas bubbles from a liquid is disclosed which comprises a chamber defined by an inner wall which in turn defines generally circular, transverse cross-sections about a longitudinal axis. The liquid inlet port extends through the inner wall in a position to pass liquid into the chambers circumferentially about the inner wall for swirling flow within the chamber. Accordingly, lower density components of the fluid, such as bubbles, migrate away from the inner wall toward the center of the swirling flow. An outlet port extends through the inner wall, and is spaced from the inlet port, to collect fluid which is free from the low density materials.
摘要翻译：公开了一种用于从液体中分离低密度材料例如气泡的装置，其包括由内壁限定的室，该内壁又围绕纵向轴线限定大致圆形的横截面。液体入口端口延伸穿过内壁，以将液体沿周向环绕内壁传送到腔室中，用于在腔室内旋转流动。因此，诸如气泡的流体的较低密度分量从内壁向旋转流的中心迁移。出口端口延伸穿过内壁，并与入口间隔开，以收集不含低密度材料的流体。

7. 发明授权

US3937064A Membrane leak checking technique 失效
标题翻译：膜泄漏检查技术
公开(公告)号：US3937064A
公开(公告)日：1976-02-10
申请号：US541815
申请日：1975-01-17
申请人： Ludwig Wolf, Jr. , David G. Dominguez
发明人： Ludwig Wolf, Jr. , David G. Dominguez
IPC分类号： G01M3/04
CPC分类号： G01M3/04
摘要： Method and apparatus for testing a membrane strip for leaks due to pin holes are disclosed. A detector fluid is applied to one face of the strip while bringing a detection medium into proximity with the other face thereof, and producing a pressure difference between the opposite faces of the strip in a sense to cause flow of the detector fluid through any open pin holes in the strip, and accordingly into contact with the detection medium. In accordance with this invention, a membrane-compatible liquid is applied to the membrane strip prior to testing for pin holes, so that the liquid is retained in the pin holes by capillary attraction. Accordingly, the flow of detector fluid through pin holes which are less than a predetermined size is prevented. The predetermined size may be controlled by the magnitude of pressure difference between opposite faces and the nature of the membrane-compatible liquid. As a result, the presence only of holes larger than the predetermined size is detected.
摘要翻译：公开了用于测试由于针孔泄漏的膜带的方法和装置。检测器流体被施加到带的一个面上，同时使检测介质与其另一个表面接近，并且在条带的相对面之间产生压力差，以使检测器流体流过任何打开的销并且因此与检测介质接触。根据本发明，在测试针孔之前，将膜兼容液体施加到膜条上，使得液体通过毛细吸引保持在针孔中。因此，防止检测器流体通过小于预定尺寸的销孔的流动。预定尺寸可以由相对面之间的压差的大小和膜相容液体的性质来控制。结果，仅检测到大于预定尺寸的孔的存在。

8. 发明授权

US06800432B1 Apparatus and method for inactivating viral contaminants in body fluids 失效
标题翻译：用于灭活体液中病毒污染物的装置和方法
公开(公告)号：US06800432B1
公开(公告)日：2004-10-05
申请号：US09675511
申请日：2000-09-29
申请人： Ludwig Wolf, Jr. , William Bratten , John Foley
发明人： Ludwig Wolf, Jr. , William Bratten , John Foley
IPC分类号： A01N102
CPC分类号： C12M37/00 , A61L2/0011 , A61L2/0082 , A61L2/08 , C12N7/04
摘要： A method and apparatus for inactivating viruses in a body fluid. A mixture including a therapeutically effective amount of methylene blue and an amount of a body fluid is formed in a container under sterile conditions and then the container is irradiated with a light field of a suitable intensity and wavelength for activating the methylene blue for a time sufficient to inactivate viruses in the mixture. The mixture is maintained in a substantially static state within the container.
摘要翻译：用于灭活体液中的病毒的方法和装置。在无菌条件下在容器中形成包含治疗有效量的亚甲基蓝和体液的混合物，然后用适当强度和波长的光场照射容器以足够的时间活化亚甲基蓝灭活混合物中的病毒。混合物在容器内维持在基本上静止的状态。

9. 发明授权

US06361642B1 Heat and pressure-formed flexible containers 失效
标题翻译：热和压力形成的柔性容器
公开(公告)号：US06361642B1
公开(公告)日：2002-03-26
申请号：US08982758
申请日：1997-12-02
申请人： David Bellamy , Ludwig Wolf, Jr.
发明人： David Bellamy , Ludwig Wolf, Jr.
IPC分类号： B32B3104
CPC分类号： A61J1/05 , A61J1/10 , A61M1/0209 , A61M2207/00 , B29C49/0047 , B29C51/00 , B29C65/18 , B29C66/1122 , B29C66/133 , B29C66/242 , B29C66/53262 , B29C66/63 , B29C66/71 , B29C66/712 , B29C66/81423 , B29C66/81427 , B29C66/81431 , B29C66/81811 , B29C66/8322 , B29C66/843 , B29K2023/083 , B29K2023/086 , B29K2027/06 , B29L2031/7148 , B29C65/00 , B29K2027/12 , B29K2023/12 , B29K2023/06
摘要： A flexible container comprises first and second flexible sheets of plastic material having peripheral edges, which have been sealed together along a plane to create an interior chamber in the container. At least one of the first and second flexible sheets includes a preformed, stress-relieved region, which is extended outside the plane and overlies at least a portion of the interior chamber.
摘要翻译：柔性容器包括具有外围边缘的塑料材料的第一和第二柔性片材，其沿着平面密封在一起以在容器中形成内部腔室。第一和第二柔性片材中的至少一个包括预成型的应力释放区域，其延伸到平面外部并且覆盖在内部室的至少一部分上。

10. 发明授权

US5868695A Systems and methods for eradicating contaminants using photoactive materials in fluids like blood using discrete sources of radiation 失效
标题翻译：使用离散的辐射源，在流体（如血液）中使用光敏材料消除污染物的系统和方法
公开(公告)号：US5868695A
公开(公告)日：1999-02-09
申请号：US174211
申请日：1993-12-28
申请人： Ludwig Wolf, Jr. , John T. Foley , William R. Bratten , Gary Kunz , Michael Stonefield
发明人： Ludwig Wolf, Jr. , John T. Foley , William R. Bratten , Gary Kunz , Michael Stonefield
IPC分类号： A61L2/00 , A61L2/08 , A61L2/10 , A61M1/36 , B01J19/12 , A61M1/00
CPC分类号： A61L2/0011 , A61L2/08 , A61M1/3681 , A61M1/3683 , B01J19/122
摘要： A system and method for treating a fluid carrying a contaminant to which a photoactive material has been bound include a treatment device that defines a flow passage with a gap. The system and method operate to establish a flow of fluid from the inlet end of the gap to the outlet end of the gap. The system and method also channel the flow of fluid in the gap in succession through one or more flow paths. The system and method establish at least two discrete sources of radiation in the flow path at spaced apart locations along the direction of fluid flow. At least one of the radiation sources comprises a photodiode. The system and method further include a control for operating each discrete source of radiation at a selected wavelength within the prescribed range to activate the photoactive material bound to the contaminant. Upon activation, the material eradicates the contaminant. The system and method provide extracorporeal treatment of fluids like blood to quickly and effectively eradicate infection agents at relatively high flow rates.
摘要翻译：用于处理携带已经结合有光敏材料的污染物的流体的系统和方法包括限定具有间隙的流动通道的处理装置。系统和方法操作以建立从间隙的入口端到间隙的出口端的流体流。系统和方法还通过一个或多个流动路径连续地引导间隙中的流体流动。该系统和方法沿着流体流动方向在间隔开的位置处在流动路径中建立至少两个离散的辐射源。辐射源中的至少一个包括光电二极管。该系统和方法还包括用于在规定范围内以选定波长操作每个离散辐射源的控制，以激活与污染物结合的光活性材料。激活后，材料会消除污染物。该系统和方法提供诸如血液之类的流体的体外治疗以在相对高的流速下快速有效地根除感染剂。

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