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1. 发明授权

US4414325A Method for measurement of trace enzyme 失效
标题翻译：痕量酶的测定方法
公开(公告)号：US4414325A
公开(公告)日：1983-11-08
申请号：US298814
申请日：1981-09-02
申请人： Nobuhito Masuda , Yuji Mihara , Masaki Okazaki , Hajime Makiuchi
发明人： Nobuhito Masuda , Yuji Mihara , Masaki Okazaki , Hajime Makiuchi
IPC分类号： G01N33/536 , C12Q1/00 , C12Q1/34 , G01N33/53 , G01N33/52 , G01N33/54 , G01N33/58
CPC分类号： C12Q1/34 , C12Q1/00 , C12Q2334/00 , C12Q2337/00 , G01N2333/976 , Y10S435/962 , Y10S436/805
摘要： The amount of enzyme is determined by reacting an enzyme to be measured with a synthetic substrate having at least one structure to be specifically contacted with the enzyme and at least one spectral sensitizer structure, bringing either the reaction product having the spectral sensitizer structure or the unreacted synthetic substrate into contact with a silver halide emulsion layer, exposing the same to light of a spectral sensitizing wavelength region corresponding to the spectral sensitizer structure, developing the silver halide, and then measuring the optical density of developed silver and/or colored dye.
摘要翻译：酶的量通过使待测量的酶与具有至少一种与酶特异性接触的结构的合成底物和至少一种光谱增感剂结构反应，使具有光谱增感剂结构的反应产物或未反应的合成基底与卤化银乳剂层接触，将其暴露于对应于光谱敏化剂结构的光谱增感波长区域的光，显影卤化银，然后测量显影的银和/或着色染料的光密度。

2. 发明授权

US4472498A Analysis film and a method of analysis using the same 失效
标题翻译：分析胶片和使用其的分析方法
公开(公告)号：US4472498A
公开(公告)日：1984-09-18
申请号：US401771
申请日：1982-07-26
申请人： Nobuhito Masuda , Yukio Yasuda , Shigeru Nagatomo , Hajime Makiuchi , Masaki Okazaki
发明人： Nobuhito Masuda , Yukio Yasuda , Shigeru Nagatomo , Hajime Makiuchi , Masaki Okazaki
IPC分类号： G01N33/52 , G01N33/535 , G01N33/542 , G01N33/543 , G01N33/54 , G01N33/78
CPC分类号： G01N33/542 , G01N33/521 , G01N33/535 , G01N33/54386 , Y10S435/805 , Y10S435/97 , Y10S436/81 , Y10S436/815
摘要： An analysis film comprises a reagent layer composed of a porous material which contains an antibody but does not substantially contain a complex of an analyte or a labelled antigen with the antibody. In the analysis film, reagents for enzyme immune reaction of homogenous type are incorporated so that an analyte is analyzed without requiring B/F separation. An analysis method for various analytes using the same provides high sensitivity, high accuracy as well as good reproducibility and is simple and rapid.
摘要翻译：分析膜包括由含有抗体但基本上不含有分析物或标记抗原与抗体的复合物的多孔材料构成的试剂层。在分析膜中，并入用于均匀型酶免疫反应的试剂，从而分析分析物而不需要B / F分离。使用该方法的各种分析物的分析方法提供高灵敏度，高精度以及良好的再现性，并且简单快速。

3. 发明授权

US4587102A Multi-layer analysis element utilizing specific binding reaction 失效
标题翻译：利用特异性结合反应的多层分析元件
公开(公告)号：US4587102A
公开(公告)日：1986-05-06
申请号：US637324
申请日：1984-08-02
申请人： Shigeru Nagatomo , Yukio Yasuda , Nobuhito Masuda , Hajime Makiuchi , Masaki Okazaki
发明人： Shigeru Nagatomo , Yukio Yasuda , Nobuhito Masuda , Hajime Makiuchi , Masaki Okazaki
IPC分类号： G01N33/58 , G01N33/52 , G01N33/543 , G01N21/78 , G01N33/53
CPC分类号： G01N33/54386 , G01N33/525 , Y10S435/805 , Y10S436/81
摘要： A dry type multilayer analysis element for assaying a concentration of a specific component utilizing a competitive immunological reaction comprises a detection element comprising a detection layer which receives a labelled complex formed as a result of the competitive immunological reaction or an optically detectable change formed dependent upon an amount of the labelled complex of the specific component and having further provided thereon the detection layer a reaction layer comprising a fibrous porous medium containing fine particles therein. The multilayer analysis element absorbs an amount of a sample solution necessary for the competitive immunological reaction so that the multilayer analysis element has high sensitivity and high reproducibility.
摘要翻译：用于使用竞争性免疫反应测定特定成分的浓度的干式多层分析元件包括检测元件，其包含检测层，该检测层接受由于竞争性免疫反应而形成的标记复合物，或者由量的特定成分的标记复合物，并且还在其上提供检测层，反应层包含其中含有微粒的纤维状多孔介质。多层分析元件吸收竞争性免疫反应所需的样品溶液的量，使得多层分析元件具有高灵敏度和高再现性。

4. 发明授权

US4429050A Competitive immunochemical measurement of plural trace components involving spectral sensitizing dye labels 失效
标题翻译：涉及光谱增感染料标签的多种微量成分的竞争性免疫化学测定
公开(公告)号：US4429050A
公开(公告)日：1984-01-31
申请号：US298811
申请日：1981-09-02
申请人： Yukio Yasuda , Nobuhito Masuda , Yuji Mihara , Masaki Okazaki , Nobuo Hiratsuka
发明人： Yukio Yasuda , Nobuhito Masuda , Yuji Mihara , Masaki Okazaki , Nobuo Hiratsuka
IPC分类号： G03C5/00 , G01N33/532 , G01N33/536 , G01N33/58 , G03C1/12 , G03C5/04 , G01N33/54 , G01N33/52 , G01N33/74
CPC分类号： G03C5/04 , G01N33/583 , Y10S436/80 , Y10S436/805 , Y10S436/817
摘要： A method for the simultaneous immunochemical assay of trace components in a sample involving competitively reacting the antigens or antibodies in a sample and labeled antigens or labeled antibodies for limited binding sites. The labels are spectral sensitizing dyes. The reaction products are contacted with silver halide and exposed to light having wavelengths corresponding to the absorption spectra of the spectral sensitizing dyes.
摘要翻译：用于同时免疫化学测定样品中痕量组分的方法，其涉及使样品中的抗原或抗体与标记的抗原或标记的抗体竞争性地反应以用于有限的结合位点。标签是光谱增感染料。反应产物与卤化银接触并暴露于具有对应于光谱增感染料的吸收光谱的波长的光。

5. 发明授权

US4473652A Method and immunochemical measurement 失效
标题翻译：方法和免疫化学测量
公开(公告)号：US4473652A
公开(公告)日：1984-09-25
申请号：US506225
申请日：1983-06-22
申请人： Masaki Okazaki , Nobuhito Masuda , Yoshiro Kumano
发明人： Masaki Okazaki , Nobuhito Masuda , Yoshiro Kumano
IPC分类号： G01N33/58 , G01N33/54
CPC分类号： G01N33/583
摘要： A method for immunochemical assay of an antigen or antibody by labelling the antigen or antibody with a specific cyanine or merocyanine dye containing a carboxy group followed by effecting an immune reaction and photochemical processing thereof is provided. The amount of the antigen or antibody is measured in term of optical density of developed silver halide which is brought into contact with either the antigen-antibody reaction product or the unreacted material.This immunochemical assay method gives high detection sensitivity in a simple operation manner.
摘要翻译：提供了通过用含有羧基的特定花青或部花青染料标记抗原或抗体，然后进行免疫反应和其光化学处理来对抗原或抗体进行免疫化学测定的方法。根据与抗原抗体反应产物或未反应物质接触的显影卤化银的光密度来测量抗原或抗体的量。该免疫化学测定方法以简单的操作方式提供高检测灵敏度。

6. 发明授权

US4552837A Silver halide photographic emulsions 失效
标题翻译：卤化银照相乳剂
公开(公告)号：US4552837A
公开(公告)日：1985-11-12
申请号：US598945
申请日：1984-04-11
申请人： Masaki Okazaki , Osami Tanabe , Satoshi Nagaoka , Yuji Mihara , Toshinao Ukai
发明人： Masaki Okazaki , Osami Tanabe , Satoshi Nagaoka , Yuji Mihara , Toshinao Ukai
IPC分类号： G03C1/28 , G03C7/26 , G03C1/02
CPC分类号： G03C1/28
摘要： A silver halide color photographic emulsion is described, containing at least one sensitizing dye represented by formula (I) and at least one compound represented by formula (II). The use of compounds of formula (I) in combination with compounds of formula (II) permits the spectral sensitization of photographic emulsions without extending the wavelength region of spectral sensitivity, enabling the production of a light-sensitive material of high sensitivity and reduced fog. ##STR1## (The symbols V, W.sub.1, W.sub.2, R.sub.1, R.sub.2, R.sub.3, X, n, R.sub.5, Y, X.sub.1, m.sub.1 and m.sub.2 are as defined in the appended claims).
摘要翻译：描述了含有至少一种由式（I）表示的敏化染料和至少一种由式（II）表示的化合物的卤化银彩色照相乳剂。式（I）化合物与式（II）化合物的组合使用可以使照相乳剂的光谱增感不扩大光谱灵敏度的波长范围，从而能够生产高灵敏度和减少雾的感光材料。（图）（II）（符号V，W1，W2，R1，R2，R3，X，n，R5，Y，X1，m1和m2如所附权利要求所限定）。

7. 发明授权

US4362813A Silver halide photographic emulsions 失效
标题翻译：卤化银照相乳剂
公开(公告)号：US4362813A
公开(公告)日：1982-12-07
申请号：US278031
申请日：1981-06-29
申请人： Yuji Mihara , Tadashi Ikeda , Haruo Takei , Masaki Okazaki , Yasuo Aotsuka
发明人： Yuji Mihara , Tadashi Ikeda , Haruo Takei , Masaki Okazaki , Yasuo Aotsuka
IPC分类号： G03C1/28 , G03C1/29 , G03C1/40 , G03C1/18
CPC分类号： G03C1/29
摘要： A light-sensitive silver halide photographic emulsion characterized by containing a combination of at least one sensitizing dye represented by formula (I) and at least one sensitizing dye represented by formula (II). ##STR1## A silver halide color photographic light-sensitive element comprising a support having thereon at least one light-sensitive emulsion layer comprising a sensitizing dye represented by formula (I) and a sensitizing dye represented by formula (II) is also described.
摘要翻译：一种感光卤化银照相乳剂，其特征在于含有至少一种由式（I）表示的敏化染料和至少一种由式（II）表示的增感染料的组合。（I）一种卤化银彩色摄影感光元件，其包括其上具有至少一个感光乳剂层的载体，所述感光乳剂层包含由式（I）表示的敏化染料和由式（I）表示的增感染料，还描述了式（II）。

8. 发明授权

US5229262A Silver halide photographic material and method for processing the same 失效
标题翻译：卤化银照相材料及其加工方法
公开(公告)号：US5229262A
公开(公告)日：1993-07-20
申请号：US807515
申请日：1991-12-16
申请人： Tsutomu Arai , Yuji Mihara , Masaki Okazaki
发明人： Tsutomu Arai , Yuji Mihara , Masaki Okazaki
IPC分类号： C09B23/10 , G03C1/22 , G03C1/34 , G03C1/825 , G03C1/83
CPC分类号： C09B23/102 , G03C1/22 , G03C1/346 , G03C1/832
摘要： A silver halide photographic material comprising a support having thereon at least one silver halide photographic emulsion layer containing at least one sensitizing dye represented by formula (I) and at least one compound represented by formula (II). ##STR1## wherein R.sub.1 and R.sub.2, which may be the same or different, each represent an alkyl group which may be substituted and at least one of R.sub.1 and R.sub.2 is an acetylaminoalkyl group or an N-alkylcarbamoylaminoalkyl group; and V.sub.1 and V.sub.2, which may be the same or different, each represent a hydrogen atom, an alkyl group, an alkoxy group or a trifluoromethyl group. ##STR2## wherein Z represents a non-metallic atomic group required for forming a heterocyclic ring; M represents a hydrogen atom, an --NH.sub.4 group or an alkali metal atom; X represents an >NR group, a sulfur atom or an oxygen atom wherein R represents a hydrogen atom, an alkyl group, an aryl group or an aralkyl group, and a method for processing the silver halide photographic material.
摘要翻译：一种卤化银照相材料，其包括其上具有至少一个含有至少一种由式（I）表示的敏化染料的卤化银照相乳剂层的载体和至少一种由式（II）表示的化合物。（I）其中R 1和R 2可以相同或不同，各自表示可以被取代的烷基，R 1和R 2中的至少一个是乙酰氨基烷基或N-烷基氨基甲酰基氨基烷基; 和可以相同或不同的V1和V2各自表示氢原子，烷基，烷氧基或三氟甲基。（II）其中Z表示形成杂环所需的非金属原子团; M表示氢原子，-NH4基或碱金属原子; X表示NR基，硫原子或氧原子，其中R表示氢原子，烷基，芳基或芳烷基，以及加工卤化银照相材料的方法。

9. 发明授权

US4544628A Silver halide photographic emulsion 失效
标题翻译：卤化银照相乳剂
公开(公告)号：US4544628A
公开(公告)日：1985-10-01
申请号：US576249
申请日：1984-02-02
申请人： Yuji Mihara , Satoshi Nagaoka , Masaki Okazaki
发明人： Yuji Mihara , Satoshi Nagaoka , Masaki Okazaki
IPC分类号： G03C1/28 , G03C1/02
CPC分类号： G03C1/28
摘要： A silver halide photographic emulsion is disclosed which includes a sensitizing dye represented by general formula (I) and a compound represented by general formula (II): ##STR1## The substituents within the general formulae are defined within the specification. The emulsion can be used to prepare a photographic material which has high green-sensitivity which is obtained without expanding the wavelength region of spectral sensitivity in the green sensitive region. Further, the resulting material has these improved results and does not show substantial change of its photographic properties such as sensitivity and amount of fogging during storage.
摘要翻译：公开了一种卤化银照相乳剂，其包含由通式（I）表示的增感染料和由通式（II）表示的化合物：其中通式中的取代基被定义在规范内。乳液可用于制备在绿色敏感区域中不扩大光谱灵敏度的波长区域而获得的具有高绿色感光度的照相材料。此外，所得材料具有这些改进的结果，并且不显示其照相性能的显着变化，例如储存期间的敏感性和雾化量。

10. 发明授权

US4493889A Silver halide photographic light-sensitive materials 失效
标题翻译：卤化银照相感光材料
公开(公告)号：US4493889A
公开(公告)日：1985-01-15
申请号：US573181
申请日：1984-01-23
申请人： Yuji Mihara , Satoshi Nagaoka , Masaki Okazaki
发明人： Yuji Mihara , Satoshi Nagaoka , Masaki Okazaki
IPC分类号： G03C7/20 , C09B23/00 , G03C1/28 , G03C1/02
CPC分类号： G03C1/28
摘要： A silver halide photographic light-sensitive material is disclosed. The material is comprised of a support having thereon a red-sensitive silver halide photographic emulsion layer comprising a tetramethine melocyanine dye represented by the general formula (I) and a compound represented by the general formula (II) ##STR1## the substituents within these structural formulae are defined within the specification. The material gives improved results with respect to preventing diffuse sensitization. The material also provides a red-sensitive silver halide photographic emulsion in which a decline of spectro-sensitivity in the lapse of dissolution is relatively small and which has a small amount of dye fog.
摘要翻译：公开了一种卤化银照相感光材料。该材料包括其上具有红色感光卤化银照相乳剂层的载体，该感光性卤化银照相乳剂层包含由通式（I）表示的四次甲基花环色素染料和由通式（II）表示的化合物。（II）这些结构式中的取代基在本说明书中定义。该材料在防止弥漫性敏化方面提供了改进的结果。该材料还提供红色感光卤化银照相乳剂，其中在溶解过程中光谱灵敏度的下降相对较小并且具有少量的染料雾。

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