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1. 发明申请

US20100099994A1 IMPLANTABLE HEART ANALYZING DEVICE, SYSTEM AND METHOD 审中-公开
标题翻译：可植入心脏分析装置，系统和方法
公开(公告)号：US20100099994A1
公开(公告)日：2010-04-22
申请号：US12528160
申请日：2007-02-28
申请人： Nils Holmström , Andreas Blomqvist , Berit Larsson , Karin Järverud , Sven-Erik Hedberg
发明人： Nils Holmström , Andreas Blomqvist , Berit Larsson , Karin Järverud , Sven-Erik Hedberg
IPC分类号： A61B5/02
CPC分类号： A61B5/1107 , A61B5/0051 , A61B5/4519 , A61B5/6869 , A61N1/36578
摘要： An implantable heart analyzing device has a housing and a control circuit located within said housing. The control circuit generates an output signal adapted to actuate an activator, which is able to make a wall of the heart deflect or vibrate. The control circuit also communicates with a sensor, which can be identical with the activator, with which the movement of the heart wall can be sensed. The control circuit executes a procedure that involves the generation of an output signal and sensing a corresponding sensor signal, and to be able to derive information concerning the tension of the heart wall. An implantable heart analyzing includes the aforementioned heart analyzing device, as well as the activator and the sensor. The heart analyzing device and the system implement a method that results in generation of the aforementioned information concerning the tension of the heart wall.
摘要翻译：可植入心脏分析装置具有壳体和位于所述壳体内的控制电路。控制电路产生适于致动激活器的输出信号，其能够使心脏的壁发生偏转或振动。控制电路还与传感器通信，传感器可以与激活器相同，通过该传感器可以感测心脏壁的移动。控制电路执行涉及生成输出信号并感测相应的传感器信号的过程，并且能够得出关于心壁的张力的信息。可植入心脏分析包括上述心脏分析装置，以及活化剂和传感器。心脏分析装置和系统实施导致产生上述关于心脏壁张力的信息的方法。

2. 发明申请

US20100041970A1 IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：可植入医疗器械
公开(公告)号：US20100041970A1
公开(公告)日：2010-02-18
申请号：US12532186
申请日：2007-11-27
申请人： Sven-Erik Hedberg , Andreas Blomqvist , Karin Järverud , Karin Ljungström , Leif Lindkvist , Urban Lönn , Nils Holmström
发明人： Sven-Erik Hedberg , Andreas Blomqvist , Karin Järverud , Karin Ljungström , Leif Lindkvist , Urban Lönn , Nils Holmström
IPC分类号： A61B5/1459
CPC分类号： A61N1/3702 , A61B5/14542 , A61B5/1459 , A61N1/056 , A61N1/36557
摘要： An implantable medical device has an oxygen sensor adapted to measure the level of oxygen in oxygenized blood, and to generate an oxygen measurement signal in dependence of the level of oxygen. The oxygen sensor is adapted to perform measurements inside the heart, of blood entering the left atrium of a patient's heart. The obtained oxygen measurement signal is compared to a predetermined threshold level and an indication signal is generated in dependence of the comparison. The, indication signal is indicative of the lung functionality of the patient.
摘要翻译：可植入医疗装置具有适于测量氧合血液中的氧气水平的氧传感器，并且根据氧气水平产生氧测量信号。氧传感器适于在心脏内进行血液进入患者心脏左心房的血液。将获得的氧测量信号与预定阈值电平进行比较，并根据比较产生指示信号。该指示信号表示患者的肺功能。

3. 发明授权

US07228172B2 Bi-ventricular pacer, system and method 有权
标题翻译：双心室起搏器，系统及方法
公开(公告)号：US07228172B2
公开(公告)日：2007-06-05
申请号：US10734767
申请日：2003-12-13
申请人： Karin Järverud , Nils Holmström , Anders Björling , Asa Uhrenius , Sven-Erik Hedberg , Göran Budgifvars , Hans Strandberg
发明人： Karin Järverud , Nils Holmström , Anders Björling , Asa Uhrenius , Sven-Erik Hedberg , Göran Budgifvars , Hans Strandberg
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3684 , A61N1/3712
摘要： An implantable bi-ventricular heart stimulating device and system, suitable for treating congestive heart failure, have a control circuit with first and second pacing circuits and first and second sensing circuits. The device operates with time cycles corresponding to normal heart cycles. The control circuit determines: (a) whether a signal typical of an evoked response to a pacing pulse delivered by the first pacing circuit is sensed within a first time interval and (b) whether a signal typical for an R-wave transferred from the second ventricle, or from some other part of the heart, to the first ventricle is detected within a first time window. The operation of the device depends on whether the conditions (a) and (b) are fulfilled.
摘要翻译：适用于治疗充血性心力衰竭的可植入式双心室心脏刺激装置和系统具有具有第一和第二起搏电路和第一和第二感测电路的控制电路。该装置以对应于正常心脏周期的时间周期运行。控制电路确定：（a）在第一时间间隔内是否感测到由第一起搏电路传送的起搏脉冲的典型诱发响应的信号，以及（b）是否从第二时间间隔传送的R波的典型信号在第一时间窗口内检测到心室或心脏的其他部分到第一脑室。设备的操作取决于条件（a）和（b）是否得到满足。

4. 发明授权

US07089058B2 Multi-chamber pacing system 失效
标题翻译：多室起搏系统
公开(公告)号：US07089058B2
公开(公告)日：2006-08-08
申请号：US10813776
申请日：2004-03-31
申请人： Sven-Erik Hedberg , Anders Björling , Nils Holmström , Karin Järverud
发明人： Sven-Erik Hedberg , Anders Björling , Nils Holmström , Karin Järverud
IPC分类号： A61N1/368
CPC分类号： A61N1/3702 , A61N1/3684
摘要： A multi-chamber pacing system has a pulse generator for successively delivering pacing pulses to chambers of a patient's heart. Evoked response detectors having blanking intervals following the delivery of pacing pulses include sensing elements for sensing IEGM-signals from each of the heart chambers and an integrating unit that integrates the IEGM-signal within evoked response detection time windows after delivery of pacing pulses for detecting evoked response. The evoked response detection time window for a heart chamber contain at least one blanking interval resulting from delivery of a pacing pulse to another chamber and each of the sensed IEGM signals having a generally known morphology. An integral reconstructing unit reconstructs the time integral of the IEGM signal from one of the heart chambers in the blanking interval following delivery of a pacing pulse to another heart chamber.
摘要翻译：多室起搏系统具有脉冲发生器，用于连续地向患者心脏的腔室输送起搏脉冲。在递送起搏脉冲之后具有消隐间隔的诱发响应检测器包括用于感测来自每个心室的IEGM信号的感测元件和在递送用于检测诱发的起搏脉冲之后的诱发响应检测时间窗口内积分IEGM信号的积分单元响应。心室的诱发反应检测时间窗口包含至少一个消隐间隔，其由将起搏脉冲递送到另一个腔室而产生，每个感测的IEGM信号具有通常已知的形态。整体重建单元在将起搏脉冲递送到另一个心室之后的消隐间隔中的一个心室重建IEGM信号的时间积分。

5. 发明授权

US07069076B2 Multi-chamber pacing system 失效
标题翻译：多室起搏系统
公开(公告)号：US07069076B2
公开(公告)日：2006-06-27
申请号：US10761707
申请日：2004-01-21
申请人： Sven Erik Hedberg , Karin Järverud , Nils Holmström , Anders Björling
发明人： Sven Erik Hedberg , Karin Järverud , Nils Holmström , Anders Björling
IPC分类号： A61N1/36
CPC分类号： A61N1/3702 , A61N1/3684
摘要： A multi-chamber pacing system has a pulse generator for successively delivering pacing pulses to chambers of a patient's heart, and IEGM signal detectors, having blanking intervals following the delivery of pacing pulses, including sensing circuits for sensing IEGM-signals from each of the heart chambers. Each of said sensed IEGM signals has a generally known morphology. A signal-reconstructing unit reconstructs the IEGM signal from one of the heart chambers in the blanking interval following delivery of a pacing pulse to another heart chamber.
摘要翻译：多室起搏系统具有脉冲发生器，用于连续地向患者心脏的腔室输送起搏脉冲，以及IEGM信号检测器，其具有递送起搏脉冲之后的消隐间隔，包括用于感测来自每个心脏的IEGM信号的感测电路房间。所述感测的IEGM信号中的每一个具有通常已知的形态。信号重建单元在将起搏脉冲递送到另一个心室之后的消隐间隔中的一个心室重建IEGM信号。

6. 发明授权

US08620432B2 Identification of pacing site 有权
标题翻译：鉴定起搏部位
公开(公告)号：US08620432B2
公开(公告)日：2013-12-31
申请号：US13171952
申请日：2011-06-29
申请人： Sven-Erik Hedberg , Nils Holmström , John Gustafsson , Andreas Blomqvist , Andreas Karlsson
发明人： Sven-Erik Hedberg , Nils Holmström , John Gustafsson , Andreas Blomqvist , Andreas Karlsson
IPC分类号： A61N1/00
CPC分类号： A61N1/3686 , A61N1/36521
摘要： An implantable medical device applies an electric signal over two electrodes and measures the resulting electric signal over a candidate pair of neighboring electrodes on a lead for a first heart ventricle or over a candidate electrode of the lead and a case electrode. An impedance signal is determined for each candidate pair or electrode based on the applied signal and the measured resulting signal. A time difference between start of contraction in a second ventricle and the timing of local myocardial contraction as identified from the impedance signal at the site of the candidate pair or electrode is determined for each candidate pair or electrode. An optimal pacing electrode is selected to correspond to one of the electrodes of the candidate pair having the largest time difference or the candidate electrode having largest time difference.
摘要翻译：可植入医疗装置在两个电极上施加电信号，并且通过在第一心室的引线上或在引线的候选电极和外壳电极上的相邻电极的候选对测量所得到的电信号。基于所施加的信号和测得的结果信号，为每个候选对或电极确定阻抗信号。针对每个候选对或电极确定从候选对或电极的位置处的阻抗信号识别的第二心室的收缩开始与局部心肌收缩的定时之间的时间差。选择最佳起搏电极以对应于具有最大时间差的候选对的电极之一或具有最大时间差的候选电极。

7. 发明申请

US20120004700A1 IDENTIFICATION OF PACING SITE 有权
标题翻译：鉴定场地
公开(公告)号：US20120004700A1
公开(公告)日：2012-01-05
申请号：US13171952
申请日：2011-06-29
申请人： Sven-Erik Hedberg , Nils Holmström , John Gustafsson , Andreas Blomqvist , Andreas Karlsson
发明人： Sven-Erik Hedberg , Nils Holmström , John Gustafsson , Andreas Blomqvist , Andreas Karlsson
IPC分类号： A61N1/368
CPC分类号： A61N1/3686 , A61N1/36521
摘要： An implantable medical device applies an electric signal over two electrodes and measures the resulting electric signal over a candidate pair of neighboring electrodes on a lead for a first heart ventricle or over a candidate electrode of the lead and a case electrode. An impedance signal is determined for each candidate pair or electrode based on the applied signal and the measured resulting signal. A time difference between start of contraction in a second ventricle and the timing of local myocardial contraction as identified from the impedance signal at the site of the candidate pair or electrode is determined for each candidate pair or electrode. An optimal pacing electrode is selected to correspond to one of the electrodes of the candidate pair having the largest time difference or the candidate electrode having largest time difference.
摘要翻译：可植入医疗装置在两个电极上施加电信号，并且通过在第一心室的引线上或在引线的候选电极和外壳电极上的相邻电极的候选对测量所得到的电信号。基于所施加的信号和测得的结果信号，为每个候选对或电极确定阻抗信号。针对每个候选对或电极确定从候选对或电极的位置处的阻抗信号识别的第二心室的收缩开始与局部心肌收缩的定时之间的时间差。选择最佳起搏电极以对应于具有最大时间差的候选对的电极之一或具有最大时间差的候选电极。

8. 发明申请

US20110144508A1 METHOD AND DEVICE FOR MONITORING ACUTE DECOMPENSATED HEART FAILURE 有权
标题翻译：用于监测急性脱发性心脏衰竭的方法和装置
公开(公告)号：US20110144508A1
公开(公告)日：2011-06-16
申请号：US12809255
申请日：2007-12-21
申请人： Andreas Blomqvist , Nils Holmström , Sven-Erik Hedberg , Malin Öhlander
发明人： Andreas Blomqvist , Nils Holmström , Sven-Erik Hedberg , Malin Öhlander
IPC分类号： A61B5/053
CPC分类号： A61B5/053 , A61B5/0245 , A61B5/0452
摘要： An implantable medical device has an impedance determiner for determining a cardiogenic impedance signal based on electric signals sensed by connected electrodes. A parameter calculator processes the impedance signal to calculate an impedance parameter representative of the cardiogenic impedance in connection with the diastolic phase of a heart cycle. This parameter is then employed by the device for monitoring acute decompensated heart failure status of a subject.
摘要翻译：可植入医疗装置具有用于基于由连接电极感测的电信号确定心源阻抗信号的阻抗确定器。参数计算器处理阻抗信号以计算代表与心脏周期的舒张期相关的心源阻抗的阻抗参数。该参数随后被该装置用于监测受试者的急性失代偿性心力衰竭状态。

9. 发明授权

US08321016B2 Implantable medical device and a method comprising means for detecting and classifying ventricular tachyarrhythmias 有权
标题翻译：植入式医疗装置和包括用于检测和分类室性快速性心律失常的装置的方法
公开(公告)号：US08321016B2
公开(公告)日：2012-11-27
申请号：US12602533
申请日：2007-06-13
申请人： Nils Holmström , Andreas Blomqvist , Sven-Erik Hedberg , Malin Öhlander
发明人： Nils Holmström , Andreas Blomqvist , Sven-Erik Hedberg , Malin Öhlander
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/3702 , A61B5/0464 , A61B5/053 , A61B5/7264
摘要： In a method and implantable medical device for ventricular tachyarrhythmia detection and classification, upon detection of a ventricular tachyarrhythmia based on an electrocardiogram signal, cardiogenic impedance data representative of ventricular volume dynamics are collected and used for classifying the detected tachyarrhythmia as stable or unstable. In the latter case but typically not in the former case, defibrillation shocks or other forms of therapy are applied to combat the unstable ventricular tachyarrhythmia.
摘要翻译：在用于室性快速性心律失常检测和分类的方法和可植入医疗装置中，在基于心电图信号检测到心室快速性心律失常时，收集表示心室容积动力学的心源阻抗数据，并用于将检测到的心律失常分类为稳定或不稳定。在后一种情况下，但通常不是在前一种情况下，应用除颤电击或其他形式的治疗来对抗不稳定性室性快速性心律失常。

10. 发明申请

US20100298904A1 IMPLANTABLE HEART STIMULATOR FOR MEASURING DYSSYNCHRONY USING IMPEDANCE 有权
标题翻译：用于测量使用阻抗的DYSSYNCHRONY的可植入心脏刺激仪
公开(公告)号：US20100298904A1
公开(公告)日：2010-11-25
申请号：US12863381
申请日：2008-01-28
申请人： Andreas Blomqvist , Nils Holmström , Malin Öhlander , Sven-Erik Hedberg
发明人： Andreas Blomqvist , Nils Holmström , Malin Öhlander , Sven-Erik Hedberg
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61B5/053 , A61B5/0538 , A61N1/3684
摘要： Implantable heart stimulator connectable to an electrode arrangement has a pulse generator adapted to deliver stimulation pulses to a heart of a subject; an impedance measurement unit adapted monitor at least one heart chamber of the heart of the subject to measure the impedance in the at least one monitored heart chamber for generating an impedance signal corresponding to the measured impedance. The impedance signal is applied to a processor where the signal is processed, according to specified criteria, and a fractionation index value is determined represented by the curve length of the impedance signal during a predetermined measurement period. The fractionation index value is a measure of different degrees of mechanical dyssynchrony of the heart.
摘要翻译：可连接到电极装置的可植入心脏刺激器具有适于将刺激脉冲输送到受试者心脏的脉冲发生器; 阻抗测量单元适于监测所述受试者心脏的至少一个心室，以测量所述至少一个监测的心室中的阻抗，以产生对应于所测量的阻抗的阻抗信号。根据规定的标准，将阻抗信号施加到处理器，信号被处理，并且在预定测量期间由阻抗信号的曲线长度确定分数指数值。分离指数值是心脏不同程度的机械不同步的度量。

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