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1. 发明申请

US20110144508A1 METHOD AND DEVICE FOR MONITORING ACUTE DECOMPENSATED HEART FAILURE 有权
标题翻译：用于监测急性脱发性心脏衰竭的方法和装置
公开(公告)号：US20110144508A1
公开(公告)日：2011-06-16
申请号：US12809255
申请日：2007-12-21
申请人： Andreas Blomqvist , Nils Holmström , Sven-Erik Hedberg , Malin Öhlander
发明人： Andreas Blomqvist , Nils Holmström , Sven-Erik Hedberg , Malin Öhlander
IPC分类号： A61B5/053
CPC分类号： A61B5/053 , A61B5/0245 , A61B5/0452
摘要： An implantable medical device has an impedance determiner for determining a cardiogenic impedance signal based on electric signals sensed by connected electrodes. A parameter calculator processes the impedance signal to calculate an impedance parameter representative of the cardiogenic impedance in connection with the diastolic phase of a heart cycle. This parameter is then employed by the device for monitoring acute decompensated heart failure status of a subject.
摘要翻译：可植入医疗装置具有用于基于由连接电极感测的电信号确定心源阻抗信号的阻抗确定器。参数计算器处理阻抗信号以计算代表与心脏周期的舒张期相关的心源阻抗的阻抗参数。该参数随后被该装置用于监测受试者的急性失代偿性心力衰竭状态。

2. 发明授权

US08321016B2 Implantable medical device and a method comprising means for detecting and classifying ventricular tachyarrhythmias 有权
标题翻译：植入式医疗装置和包括用于检测和分类室性快速性心律失常的装置的方法
公开(公告)号：US08321016B2
公开(公告)日：2012-11-27
申请号：US12602533
申请日：2007-06-13
申请人： Nils Holmström , Andreas Blomqvist , Sven-Erik Hedberg , Malin Öhlander
发明人： Nils Holmström , Andreas Blomqvist , Sven-Erik Hedberg , Malin Öhlander
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/3702 , A61B5/0464 , A61B5/053 , A61B5/7264
摘要： In a method and implantable medical device for ventricular tachyarrhythmia detection and classification, upon detection of a ventricular tachyarrhythmia based on an electrocardiogram signal, cardiogenic impedance data representative of ventricular volume dynamics are collected and used for classifying the detected tachyarrhythmia as stable or unstable. In the latter case but typically not in the former case, defibrillation shocks or other forms of therapy are applied to combat the unstable ventricular tachyarrhythmia.
摘要翻译：在用于室性快速性心律失常检测和分类的方法和可植入医疗装置中，在基于心电图信号检测到心室快速性心律失常时，收集表示心室容积动力学的心源阻抗数据，并用于将检测到的心律失常分类为稳定或不稳定。在后一种情况下，但通常不是在前一种情况下，应用除颤电击或其他形式的治疗来对抗不稳定性室性快速性心律失常。

3. 发明申请

US20100298904A1 IMPLANTABLE HEART STIMULATOR FOR MEASURING DYSSYNCHRONY USING IMPEDANCE 有权
标题翻译：用于测量使用阻抗的DYSSYNCHRONY的可植入心脏刺激仪
公开(公告)号：US20100298904A1
公开(公告)日：2010-11-25
申请号：US12863381
申请日：2008-01-28
申请人： Andreas Blomqvist , Nils Holmström , Malin Öhlander , Sven-Erik Hedberg
发明人： Andreas Blomqvist , Nils Holmström , Malin Öhlander , Sven-Erik Hedberg
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61B5/053 , A61B5/0538 , A61N1/3684
摘要： Implantable heart stimulator connectable to an electrode arrangement has a pulse generator adapted to deliver stimulation pulses to a heart of a subject; an impedance measurement unit adapted monitor at least one heart chamber of the heart of the subject to measure the impedance in the at least one monitored heart chamber for generating an impedance signal corresponding to the measured impedance. The impedance signal is applied to a processor where the signal is processed, according to specified criteria, and a fractionation index value is determined represented by the curve length of the impedance signal during a predetermined measurement period. The fractionation index value is a measure of different degrees of mechanical dyssynchrony of the heart.
摘要翻译：可连接到电极装置的可植入心脏刺激器具有适于将刺激脉冲输送到受试者心脏的脉冲发生器; 阻抗测量单元适于监测所述受试者心脏的至少一个心室，以测量所述至少一个监测的心室中的阻抗，以产生对应于所测量的阻抗的阻抗信号。根据规定的标准，将阻抗信号施加到处理器，信号被处理，并且在预定测量期间由阻抗信号的曲线长度确定分数指数值。分离指数值是心脏不同程度的机械不同步的度量。

4. 发明授权

US08565866B2 Method and device for monitoring acute decompensated heart failure 有权
标题翻译：监测急性失代偿性心力衰竭的方法和装置
公开(公告)号：US08565866B2
公开(公告)日：2013-10-22
申请号：US12809255
申请日：2007-12-21
申请人： Andreas Blomqvist , Nils Holmström , Sven-Erik Hedberg , Malin Öhlander
发明人： Andreas Blomqvist , Nils Holmström , Sven-Erik Hedberg , Malin Öhlander
IPC分类号： A61B5/0295
CPC分类号： A61B5/053 , A61B5/0245 , A61B5/0452
摘要： An implantable medical device has an impedance determiner for determining a cardiogenic impedance signal based on electric signals sensed by connected electrodes. A parameter calculator processes the impedance signal to calculate an impedance parameter representative of the cardiogenic impedance in connection with the diastolic phase of a heart cycle. This parameter is then employed by the device for monitoring acute decompensated heart failure status of a subject.
摘要翻译：可植入医疗装置具有用于基于由连接电极感测的电信号确定心源阻抗信号的阻抗确定器。参数计算器处理阻抗信号以计算代表与心脏周期的舒张期相关的心源阻抗的阻抗参数。该参数随后被该装置用于监测受试者的急性失代偿性心力衰竭状态。

5. 发明授权

US08355782B2 Implantable heart stimulator for measuring dyssynchrony using impedance 有权
标题翻译：用于测量使用阻抗的不同步的可植入心脏刺激器
公开(公告)号：US08355782B2
公开(公告)日：2013-01-15
申请号：US12863381
申请日：2008-01-28
申请人： Andreas Blomqvist , Nils Holmström , Malin Öhlander , Sven-Erik Hedberg
发明人： Andreas Blomqvist , Nils Holmström , Malin Öhlander , Sven-Erik Hedberg
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61B5/053 , A61B5/0538 , A61N1/3684
摘要： Implantable heart stimulator connectable to an electrode arrangement has a pulse generator adapted to deliver stimulation pulses to a heart of a subject; an impedance measurement unit adapted monitor at least one heart chamber of the heart of the subject to measure the impedance in the at least one monitored heart chamber for generating an impedance signal corresponding to the measured impedance. The impedance signal is applied to a processor where the signal is processed, according to specified criteria, and a fractionation index value is determined represented by the curve length of the impedance signal during a predetermined measurement period. The fractionation index value is a measure of different degrees of mechanical dyssynchrony of the heart.
摘要翻译：可连接到电极装置的可植入心脏刺激器具有适于将刺激脉冲输送到受试者心脏的脉冲发生器; 阻抗测量单元适于监测所述受试者心脏的至少一个心室，以测量所述至少一个监测的心室中的阻抗，以产生对应于所测量的阻抗的阻抗信号。根据规定的标准，将阻抗信号施加到处理器，信号被处理，并且在预定测量期间由阻抗信号的曲线长度确定分数指数值。分离指数值是心脏不同程度的机械不同步的度量。

6. 发明申请

US20100179411A1 IMPLANTABLE MEDICAL DEVICE AND A METHOD COMPRISING MEANS FOR DETECTING AND CLASSIFYING VENTRICULAR TACHYARRHYTMIAS (As Amended) 有权
标题翻译：可植入医疗装置和包含用于检测和分类静脉滴管的手段的方法（如修改）
公开(公告)号：US20100179411A1
公开(公告)日：2010-07-15
申请号：US12602533
申请日：2007-06-13
申请人： Nils Holmström , Andreas Blomqvist , Sven-Erik Hedberg , Malin Öhlander
发明人： Nils Holmström , Andreas Blomqvist , Sven-Erik Hedberg , Malin Öhlander
IPC分类号： A61B5/04
CPC分类号： A61N1/3702 , A61B5/0464 , A61B5/053 , A61B5/7264
摘要： In a method and implantable medical device for ventricular tachyarrhythmia detection and classification, upon detection of a ventricular tachyarrhythmia based on an electrocardiogram signal, cardiogenic impedance data representative of ventricular volume dynamics are collected and used for classifying the detected tachyarrhythmia as stable or unstable. In the latter case but typically not in the former case, defibrillation shocks or other forms of therapy are applied to combat the unstable ventricular tachyarrhythmia.
摘要翻译：在用于室性快速性心律失常检测和分类的方法和可植入医疗装置中，在基于心电图信号检测到心室快速性心律失常时，收集表示心室容积动力学的心源阻抗数据，并用于将检测到的心律失常分类为稳定或不稳定。在后一种情况下，但通常不是在前一种情况下，应用除颤电击或其他形式的治疗来对抗不稳定性室性快速性心律失常。

7. 发明授权

US08630700B2 Implantable heart monitoring device, system and method 有权
标题翻译：可植入心脏监测装置，系统及方法
公开(公告)号：US08630700B2
公开(公告)日：2014-01-14
申请号：US12808041
申请日：2007-12-19
申请人： Andreas Blomqvist , Nils Holmstöm , Sven-Erik Hedberg , Malin Öhlander
发明人： Andreas Blomqvist , Nils Holmstöm , Sven-Erik Hedberg , Malin Öhlander
IPC分类号： A61B5/053
CPC分类号： A61N1/36521 , A61B5/0456 , A61B5/053 , A61B5/0538 , A61N1/3622 , A61N1/3684
摘要： In an implantable heart monitoring device and a monitoring method, an impedance is measured across at least part of an atrium, such that variation of the impedance is related to the volume change of the atrium. Values are stored at different occasions that indicate the rate of change of the measured impedance. The stored values are determined such that, when the device is used in a living being, the variation of the stored values will be related to the variation of the speed with which the atrium is filled with blood during the atrial diastole.
摘要翻译：在可植入心脏监测装置和监测方法中，跨越心房的至少一部分测量阻抗，使得阻抗的变化与心房的体积变化相关。值存储在指示测量阻抗的变化率的不同场合。确定所存储的值，使得当在生物体中使用该装置时，存储值的变化将与在心房舒张期期间心房充满血液的速度的变化相关。

8. 发明申请

US20100268102A1 IMPLANTABLE HEART MONITORING DEVICE, SYSTEM AND METHOD 有权
标题翻译：可植入心脏监测装置，系统和方法
公开(公告)号：US20100268102A1
公开(公告)日：2010-10-21
申请号：US12808041
申请日：2007-12-19
申请人： Andreas Blomqvist , Nils Holmstöm , Sven-Erik Hedberg , Malin Öhlander
发明人： Andreas Blomqvist , Nils Holmstöm , Sven-Erik Hedberg , Malin Öhlander
IPC分类号： A61B5/0472
CPC分类号： A61N1/36521 , A61B5/0456 , A61B5/053 , A61B5/0538 , A61N1/3622 , A61N1/3684
摘要： In an implantable heart monitoring device and a monitoring method, an impedance is measured across at least part of an atrium, such that variation of the impedance is related to the volume change of the atrium. Values are stored at different occasions that indicate the rate of change of the measured impedance. The stored values are determined such that, when the device is used in a living being, the variation of the stored values will be related to the variation of the speed with which the atrium is filled with blood during the atrial diastole.
摘要翻译：在可植入心脏监测装置和监测方法中，跨越心房的至少一部分测量阻抗，使得阻抗的变化与心房的体积变化相关。值存储在指示测量阻抗的变化率的不同场合。确定所存储的值，使得当在生物体中使用该装置时，存储值的变化将与在心房舒张期期间心房充满血液的速度的变化相关。

9. 发明申请

US20100121400A1 IMPLANTABLE CARDIAC DEVICE AND METHOD FOR MONITORING THE STATUS OF A CARDIOVASCULAR DISEASE 有权
标题翻译：可注射的心脏装置和监测心血管疾病状态的方法
公开(公告)号：US20100121400A1
公开(公告)日：2010-05-13
申请号：US12528653
申请日：2007-03-23
申请人： Nils Holmström , Malin Öhlander , Kjell Norén , Andreas Blomqvist , Karin Ljungström
发明人： Nils Holmström , Malin Öhlander , Kjell Norén , Andreas Blomqvist , Karin Ljungström
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61B5/0215 , A61B5/02405 , A61B5/053 , A61B5/4035 , A61B5/4836 , A61B5/7257 , A61N1/36564 , A61N1/36578 , A61N1/36592 , A61N1/3702
摘要： An implantable cardiac device has a heart stimulator for electrically stimulating the heart of a patient, detector that measures a physiologic parameter that is affected by the status of a cardiovascular disease associated with sympathetic activation, a signal processor that determines at least one of a low frequency, LF, and a very low frequency, VLF, Mayer wave component in the measured parameter, and analyzer that automatically analyzes the determined Mayer wave component in relation to a predetermined reference value to determine the status of the cardiovascular disease. The detector is a cardio-mechanical parameter detector that measures, as said physiologic parameter, a mechanical change in at least one of the four chambers of the heart. In a corresponding method for monitoring the status of a cardiovascular disease associated with sympathetic activation of a patient having an implantable electric heart stimulator a physiologic parameter affected by the cardiac disease is measured. At least one of a low frequency, LF, and a very low frequency, VLF, Mayer wave component in the parameter is determined, and the wave component is analyzed in relation to a predetermined reference value to determine the status of the cardiovascular disease. A mechanical change in at least one of the four chambers of the heart is measured as the physiologic parameter.
摘要翻译：可植入心脏装置具有用于电刺激患者心脏的心脏刺激器，所述心脏刺激器测量受到与交感神经激活相关的心血管疾病状态影响的生理参数的检测器，信号处理器确定低频 LF，以及在测量参数中的非常低频VLF，Mayer波分量，以及分析仪，其自动分析与预定参考值相关的确定的Mayer波分量，以确定心血管疾病的状态。检测器是心机械参数检测器，其作为所述生理参数测量心脏的四个腔室中的至少一个中的机械变化。在用于监测与具有可植入电心脏刺激器的患者的交感神经激活相关的心血管疾病的状态的相应方法中，测量受心脏病影响的生理参数。确定参数中的低频，低频和极低频VLF，迈耶波分量中的至少一个，并且相对于预定参考值分析波分量以确定心血管疾病的状态。心脏的四个腔室中的至少一个的机械变化被测量为生理参数。

10. 发明授权

US08308649B2 Implantable cardiac device and method for monitoring the status of a cardiovascular disease 有权
标题翻译：可植入的心脏装置和监测心血管疾病状态的方法
公开(公告)号：US08308649B2
公开(公告)日：2012-11-13
申请号：US12528653
申请日：2007-03-23
申请人： Nils Holmström , Malin Öhlander , Kjell Norén , Andreas Blomqvist , Karin Ljungström
发明人： Nils Holmström , Malin Öhlander , Kjell Norén , Andreas Blomqvist , Karin Ljungström
IPC分类号： A61B5/02
CPC分类号： A61N1/36521 , A61B5/0215 , A61B5/02405 , A61B5/053 , A61B5/4035 , A61B5/4836 , A61B5/7257 , A61N1/36564 , A61N1/36578 , A61N1/36592 , A61N1/3702
摘要： An implantable cardiac device has a heart stimulator for electrically stimulating the heart of a patient, detector that measures a physiologic parameter that is affected by the status of a cardiovascular disease associated with sympathetic activation, a signal processor that determines at least one of a low frequency, LF, and a very low frequency, VLF, Mayer wave component in the measured parameter, and analyzer that automatically analyzes the determined Mayer wave component in relation to a predetermined reference value to determine the status of the cardiovascular disease. The detector is a cardio-mechanical parameter detector that measures, as said physiologic parameter, a mechanical change in at least one of the four chambers of the heart. In a corresponding method for monitoring the status of a cardiovascular disease associated with sympathetic activation of a patient having an implantable electric heart stimulator a physiologic parameter affected by the cardiac disease is measured. At least one of a low frequency, LF, and a very low frequency, VLF, Mayer wave component in the parameter is determined, and the wave component is analyzed in relation to a predetermined reference value to determine the status of the cardiovascular disease. A mechanical change in at least one of the four chambers of the heart is measured as the physiologic parameter.
摘要翻译：可植入心脏装置具有用于电刺激患者心脏的心脏刺激器，所述心脏刺激器测量受到与交感神经激活相关的心血管疾病状态影响的生理参数的检测器，信号处理器确定低频 LF，以及在测量参数中的非常低频VLF，Mayer波分量，以及分析仪，其自动分析与预定参考值相关的确定的Mayer波分量，以确定心血管疾病的状态。检测器是心机械参数检测器，其作为所述生理参数测量心脏的四个腔室中的至少一个中的机械变化。在用于监测与具有可植入电心脏刺激器的患者的交感神经激活相关的心血管疾病的状态的相应方法中，测量受心脏病影响的生理参数。确定参数中的低频，低频和极低频VLF，迈耶波分量中的至少一个，并且相对于预定参考值分析波分量以确定心血管疾病的状态。心脏的四个腔室中的至少一个的机械变化被测量为生理参数。

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