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1. 发明授权

US07228172B2 Bi-ventricular pacer, system and method 有权
标题翻译：双心室起搏器，系统及方法
公开(公告)号：US07228172B2
公开(公告)日：2007-06-05
申请号：US10734767
申请日：2003-12-13
申请人： Karin Järverud , Nils Holmström , Anders Björling , Asa Uhrenius , Sven-Erik Hedberg , Göran Budgifvars , Hans Strandberg
发明人： Karin Järverud , Nils Holmström , Anders Björling , Asa Uhrenius , Sven-Erik Hedberg , Göran Budgifvars , Hans Strandberg
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3684 , A61N1/3712
摘要： An implantable bi-ventricular heart stimulating device and system, suitable for treating congestive heart failure, have a control circuit with first and second pacing circuits and first and second sensing circuits. The device operates with time cycles corresponding to normal heart cycles. The control circuit determines: (a) whether a signal typical of an evoked response to a pacing pulse delivered by the first pacing circuit is sensed within a first time interval and (b) whether a signal typical for an R-wave transferred from the second ventricle, or from some other part of the heart, to the first ventricle is detected within a first time window. The operation of the device depends on whether the conditions (a) and (b) are fulfilled.
摘要翻译：适用于治疗充血性心力衰竭的可植入式双心室心脏刺激装置和系统具有具有第一和第二起搏电路和第一和第二感测电路的控制电路。该装置以对应于正常心脏周期的时间周期运行。控制电路确定：（a）在第一时间间隔内是否感测到由第一起搏电路传送的起搏脉冲的典型诱发响应的信号，以及（b）是否从第二时间间隔传送的R波的典型信号在第一时间窗口内检测到心室或心脏的其他部分到第一脑室。设备的操作取决于条件（a）和（b）是否得到满足。

2. 发明授权

US07089058B2 Multi-chamber pacing system 失效
标题翻译：多室起搏系统
公开(公告)号：US07089058B2
公开(公告)日：2006-08-08
申请号：US10813776
申请日：2004-03-31
申请人： Sven-Erik Hedberg , Anders Björling , Nils Holmström , Karin Järverud
发明人： Sven-Erik Hedberg , Anders Björling , Nils Holmström , Karin Järverud
IPC分类号： A61N1/368
CPC分类号： A61N1/3702 , A61N1/3684
摘要： A multi-chamber pacing system has a pulse generator for successively delivering pacing pulses to chambers of a patient's heart. Evoked response detectors having blanking intervals following the delivery of pacing pulses include sensing elements for sensing IEGM-signals from each of the heart chambers and an integrating unit that integrates the IEGM-signal within evoked response detection time windows after delivery of pacing pulses for detecting evoked response. The evoked response detection time window for a heart chamber contain at least one blanking interval resulting from delivery of a pacing pulse to another chamber and each of the sensed IEGM signals having a generally known morphology. An integral reconstructing unit reconstructs the time integral of the IEGM signal from one of the heart chambers in the blanking interval following delivery of a pacing pulse to another heart chamber.
摘要翻译：多室起搏系统具有脉冲发生器，用于连续地向患者心脏的腔室输送起搏脉冲。在递送起搏脉冲之后具有消隐间隔的诱发响应检测器包括用于感测来自每个心室的IEGM信号的感测元件和在递送用于检测诱发的起搏脉冲之后的诱发响应检测时间窗口内积分IEGM信号的积分单元响应。心室的诱发反应检测时间窗口包含至少一个消隐间隔，其由将起搏脉冲递送到另一个腔室而产生，每个感测的IEGM信号具有通常已知的形态。整体重建单元在将起搏脉冲递送到另一个心室之后的消隐间隔中的一个心室重建IEGM信号的时间积分。

3. 发明申请

US20100099994A1 IMPLANTABLE HEART ANALYZING DEVICE, SYSTEM AND METHOD 审中-公开
标题翻译：可植入心脏分析装置，系统和方法
公开(公告)号：US20100099994A1
公开(公告)日：2010-04-22
申请号：US12528160
申请日：2007-02-28
申请人： Nils Holmström , Andreas Blomqvist , Berit Larsson , Karin Järverud , Sven-Erik Hedberg
发明人： Nils Holmström , Andreas Blomqvist , Berit Larsson , Karin Järverud , Sven-Erik Hedberg
IPC分类号： A61B5/02
CPC分类号： A61B5/1107 , A61B5/0051 , A61B5/4519 , A61B5/6869 , A61N1/36578
摘要： An implantable heart analyzing device has a housing and a control circuit located within said housing. The control circuit generates an output signal adapted to actuate an activator, which is able to make a wall of the heart deflect or vibrate. The control circuit also communicates with a sensor, which can be identical with the activator, with which the movement of the heart wall can be sensed. The control circuit executes a procedure that involves the generation of an output signal and sensing a corresponding sensor signal, and to be able to derive information concerning the tension of the heart wall. An implantable heart analyzing includes the aforementioned heart analyzing device, as well as the activator and the sensor. The heart analyzing device and the system implement a method that results in generation of the aforementioned information concerning the tension of the heart wall.
摘要翻译：可植入心脏分析装置具有壳体和位于所述壳体内的控制电路。控制电路产生适于致动激活器的输出信号，其能够使心脏的壁发生偏转或振动。控制电路还与传感器通信，传感器可以与激活器相同，通过该传感器可以感测心脏壁的移动。控制电路执行涉及生成输出信号并感测相应的传感器信号的过程，并且能够得出关于心壁的张力的信息。可植入心脏分析包括上述心脏分析装置，以及活化剂和传感器。心脏分析装置和系统实施导致产生上述关于心脏壁张力的信息的方法。

4. 发明申请

US20100041970A1 IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：可植入医疗器械
公开(公告)号：US20100041970A1
公开(公告)日：2010-02-18
申请号：US12532186
申请日：2007-11-27
申请人： Sven-Erik Hedberg , Andreas Blomqvist , Karin Järverud , Karin Ljungström , Leif Lindkvist , Urban Lönn , Nils Holmström
发明人： Sven-Erik Hedberg , Andreas Blomqvist , Karin Järverud , Karin Ljungström , Leif Lindkvist , Urban Lönn , Nils Holmström
IPC分类号： A61B5/1459
CPC分类号： A61N1/3702 , A61B5/14542 , A61B5/1459 , A61N1/056 , A61N1/36557
摘要： An implantable medical device has an oxygen sensor adapted to measure the level of oxygen in oxygenized blood, and to generate an oxygen measurement signal in dependence of the level of oxygen. The oxygen sensor is adapted to perform measurements inside the heart, of blood entering the left atrium of a patient's heart. The obtained oxygen measurement signal is compared to a predetermined threshold level and an indication signal is generated in dependence of the comparison. The, indication signal is indicative of the lung functionality of the patient.
摘要翻译：可植入医疗装置具有适于测量氧合血液中的氧气水平的氧传感器，并且根据氧气水平产生氧测量信号。氧传感器适于在心脏内进行血液进入患者心脏左心房的血液。将获得的氧测量信号与预定阈值电平进行比较，并根据比较产生指示信号。该指示信号表示患者的肺功能。

5. 发明授权

US07184816B2 Cardiac stimulating and detecting device, system and method for identifying far field signals 有权
标题翻译：用于识别远场信号的心脏刺激和检测装置，系统和方法
公开(公告)号：US07184816B2
公开(公告)日：2007-02-27
申请号：US10864064
申请日：2004-06-09
申请人： Anders Björling , Sven-Erik Hedberg , Nils Holmström
发明人： Anders Björling , Sven-Erik Hedberg , Nils Holmström
IPC分类号： A61B5/04
CPC分类号： A61N1/37 , A61N1/3627 , A61N1/3684 , Y10S128/901
摘要： In an implantable heart stimulating device, system and method, a control circuit has first and second circuits for sensing and pacing. The first circuit can be connected to a first electrode member suited to be positioned in or at a first ventricle of the heart. The second circuit can be connected to a second electrode member suited to be positioned in or at a second ventricle of the heart. The control circuit is able to detect whether signals sensed by the second circuit are likely to be far field signals. The control circuit performs this detection by at least determining whether, during a predetermined time (length, more signals are sensed by the second circuit than by the first circuit.
摘要翻译：在可植入心脏刺激装置，系统和方法中，控制电路具有用于感测和起搏的第一和第二电路。第一电路可以连接到适于定位在心脏的第一心室中或第一心室处的第一电极构件。第二电路可以连接到适于定位在心脏的第二心室中或第二心室处的第二电极构件。控制电路能够检测由第二电路感测的信号是否可能是远场信号。控制电路通过至少确定在预定时间（长度，由第二电路感测到的信号多于第一电路的信号）来执行该检测。

6. 发明授权

US06961613B2 Implantable bi-ventricular stimulation device and system, and bi-ventricular stimulation and sensing method 有权
标题翻译：可植入双心室刺激装置和系统，以及双心室刺激和感测方法
公开(公告)号：US06961613B2
公开(公告)日：2005-11-01
申请号：US10712437
申请日：2003-11-13
申请人： Anders Björling , Nils Holmström , Sven-Erik Hedberg , Asa Uhrenius
发明人： Anders Björling , Nils Holmström , Sven-Erik Hedberg , Asa Uhrenius
IPC分类号： A61N1/368 , A61N1/37 , A61N1/365
CPC分类号： A61N1/3712 , A61N1/368 , A61N1/3684
摘要： An implantable bi-ventricular heart stimulating device has a control circuit that within a time cycle, delivers pacing pulses with both first and second pacing circuits with a time gap between a pacing pulse delivered by these pacing circuits. The time gap can be such that a pacing pulse delivered by the second pacing circuits falls substantially within a first time interval in which an evoked response can be expected to a pacing pulse delivered by the first pacing circuit. The control circuit performs a temporary modification of the operation of the device such that during at least one time cycle no pacing pulse is delivered by the second pacing circuit during the first time interval.
摘要翻译：可植入的双心室心脏刺激装置具有控制电路，其在一个时间周期内，通过第一起搏电路和第二起搏电路之间的时间间隔在由这些起搏电路输送的起搏脉冲之间提供起搏脉冲。时间间隙可以使得由第二起搏电路传送的起搏脉冲基本上落在第一时间间隔内，其中诱发响应可以预期到由第一起搏电路传送的起搏脉冲。控制电路对装置的操作进行暂时的修改，使得在至少一个时间周期期间，第一起搏电路在第一时间间隔期间不发出起搏脉冲。

7. 发明授权

US07085602B2 Implantable bi-ventricular stimulation device and system, and bi-ventricular stimulation and sensing method 有权
标题翻译：可植入双心室刺激装置和系统，以及双心室刺激和感测方法
公开(公告)号：US07085602B2
公开(公告)日：2006-08-01
申请号：US10720449
申请日：2003-11-24
申请人： Sven-Erik Hedberg , Asa Uhrenius , Karin Jarverud , Hans Strandberg , Nils Holmström , Anders Björling , Göran Budgifvars
发明人： Sven-Erik Hedberg , Asa Uhrenius , Karin Jarverud , Hans Strandberg , Nils Holmström , Anders Björling , Göran Budgifvars
IPC分类号： A61N1/365
CPC分类号： A61N1/368 , A61N1/056 , A61N1/3684 , A61N2001/0585
摘要： An implantable bi-ventricular heart stimulating device (10) has a control circuit with first and second sensing circuits for respectively sensing in the two ventricles and first and second stimulation circuits for respectively stimulating the two ventricles. The control circuit determines whether a signal, sensed by said second sensing circuit, occurs essentially simultaneously with a signal sensed by the first sensing circuit. Furthermore, the control circuit determines whether a further signal is sensed by said second sensing circuit within a predetermined time interval which follows after the signal sensed by the second sensing circuit but within the same time cycle as that signal. If this occurs, the control circuit determines whether the sensed signals represent actual cardiac events, or are likely the result of far field detection.
摘要翻译：可植入式双心室心脏刺激装置（10）具有控制电路，该控制电路具有用于分别感测两个心室的第一和第二感测电路以及分别刺激两个脑室的第一和第二刺激电路。控制电路确定由所述第二感测电路检测到的信号是否基本上与由第一感测电路感测的信号同时发生。此外，控制电路确定在由第二感测电路感测到的信号之后但在与该信号相同的时间周期内的预定时间间隔内，所述第二感测电路是否感测到另外的信号。如果发生这种情况，则控制电路确定感测到的信号是否代表实际的心脏事件，或者很可能是远场检测的结果。

8. 发明申请

US20120089035A1 IMPLANTABLE CARDIAC STIMULATOR, SYSTEM, DEVICE AND METHOD FOR MONITORING CARDIAC SYNCHRONY 有权
标题翻译：可注射的心脏刺激器，系统，设备和监测心脏同步的方法
公开(公告)号：US20120089035A1
公开(公告)日：2012-04-12
申请号：US13271548
申请日：2011-10-12
申请人： KARIN JÄRVERUD , Kenth Nilsson , Sven-Erik Hedberg
发明人： KARIN JÄRVERUD , Kenth Nilsson , Sven-Erik Hedberg
IPC分类号： A61N1/368 , A61B5/0245
CPC分类号： A61N1/3627 , A61B5/1107 , A61B5/6869 , A61B2562/0219 , A61N1/36514 , A61N1/36578
摘要： In a system and method for monitoring cardiac synchrony in a human heart, a first sensor is positioned at a first cardiac wall location that is subject to movements related to longitudinal valve plane movements along the longitudinal axis of the heart, and measures the cardiac wall movements at the first cardiac wall location and a second sensor is positioned at a second cardiac wall location that is subject to movements related to longitudinal valve plane movements along the longitudinal axis of the heart, and measures the cardiac wall movements at the second cardiac wall location. A lead arrangement conducts respective output signals from the first and second sensors to processing circuitry that processes the first and second sensor output signals to produce a synchronization signal therefrom indicative of synchrony in the respective valve plane movements at the first and second cardiac wall locations.
摘要翻译：在用于监测人心脏心脏同步的系统和方法中，第一传感器位于第一心脏壁位置，该第一心脏壁位置受到与心脏的纵向轴线的纵向瓣膜平面运动有关的运动，并且测量心脏壁移动在第一心脏壁位置处，并且第二传感器定位在第二心脏壁位置处，所述第二心脏壁位置受到与沿着心脏的纵向轴线的纵向瓣膜平面运动相关的运动，并且测量第二心脏壁位置处的心脏壁运动。引线装置将来自第一和第二传感器的相应输出信号传导到处理电路，处理电路处理第一和第二传感器输出信号以产生同步信号，表示在第一和第二心脏壁位置处的各个阀平面运动中的同步。

9. 发明申请

US20110319769A1 ISCHEMIC STATUS MONITORING 审中-公开
标题翻译： ISCHEMIC状态监测
公开(公告)号：US20110319769A1
公开(公告)日：2011-12-29
申请号：US13255460
申请日：2009-03-13
申请人： Sven-Erik Hedberg , Tomas Svensson , Michael Broomé , Karin Järverud , Stefan Hjelm
发明人： Sven-Erik Hedberg , Tomas Svensson , Michael Broomé , Karin Järverud , Stefan Hjelm
IPC分类号： A61N1/365 , A61B5/026
CPC分类号： A61B5/0452 , A61B5/026 , A61B5/053 , A61B5/1116 , A61B5/1118 , A61B5/4836 , A61B5/6846 , A61B5/7405 , A61B5/7455 , A61N1/3702
摘要： An ischemia monitoring system has detectors for detecting the onset of an ischemic event of a tissue in subject, the end of the ischemic event and the end of a following recovery from the ischemic event, respectively. A time processor determines the duration of the ischemic event and the recovery period based on the detected onset and end times. A status processor co-processes the two determined time durations for the purpose of monitoring the ischemic status of the subject and detecting any deterioration in ischemic status for the latest ischemic event as compared to previous ischemic events that have occurred in the subject's tissue.
摘要翻译：缺血监测系统具有检测器，用于分别检测受试者组织的缺血事件的发作，缺血事件的结束以及从缺血事件中恢复的结束。时间处理器基于检测到的开始和结束时间来确定缺血事件的持续时间和恢复期。状态处理器协调处理两个确定的持续时间以便监测受试者的缺血状态并且检测与在受试者组织中发生的先前缺血事件相比，最新缺血事件的缺血状态的任何恶化。

10. 发明授权

US08346353B2 Implantable medical system for detecting incipient edema 有权
标题翻译：用于检测初期水肿的植入式医疗系统
公开(公告)号：US08346353B2
公开(公告)日：2013-01-01
申请号：US12531793
申请日：2007-04-24
申请人： Sven-Erik Hedberg , Andreas Blomqvist , Karin Järverud , Karin Ljungström , Leif Lindqvist , Urban Lönn
发明人： Sven-Erik Hedberg , Andreas Blomqvist , Karin Järverud , Karin Ljungström , Leif Lindqvist , Urban Lönn
IPC分类号： A61B5/05
CPC分类号： A61N1/05 , A61B5/0084 , A61B5/0086 , A61B5/08 , A61B5/1116 , A61B5/1118 , A61B5/4878 , A61B5/7207 , A61N1/025 , A61N1/056 , A61N1/362
摘要： An implantable medical system for detecting incipient edema has an implantable medical lead including an optical sensor having a light source and a light detector. The medical system further has an edema detection circuit that activates the light source to emit light, the light being directed into lung tissue of a patient and that obtains a light intensity value corresponding to an intensity of light received by the light detector, and that evaluates the light intensity value to detect a consistency with incipient edema.
摘要翻译：用于检测初期水肿的可植入医疗系统具有包括具有光源和光检测器的光学传感器的可植入医疗引线。医疗系统还具有水肿检测电路，其激活光源发光，将光引导到患者的肺组织，并获得与由光检测器接收的光的强度对应的光强度值，并且评估光强值检测与初期水肿的一致性。

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