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1. 发明授权

US08630700B2 Implantable heart monitoring device, system and method 有权
标题翻译：可植入心脏监测装置，系统及方法
公开(公告)号：US08630700B2
公开(公告)日：2014-01-14
申请号：US12808041
申请日：2007-12-19
申请人： Andreas Blomqvist , Nils Holmstöm , Sven-Erik Hedberg , Malin Öhlander
发明人： Andreas Blomqvist , Nils Holmstöm , Sven-Erik Hedberg , Malin Öhlander
IPC分类号： A61B5/053
CPC分类号： A61N1/36521 , A61B5/0456 , A61B5/053 , A61B5/0538 , A61N1/3622 , A61N1/3684
摘要： In an implantable heart monitoring device and a monitoring method, an impedance is measured across at least part of an atrium, such that variation of the impedance is related to the volume change of the atrium. Values are stored at different occasions that indicate the rate of change of the measured impedance. The stored values are determined such that, when the device is used in a living being, the variation of the stored values will be related to the variation of the speed with which the atrium is filled with blood during the atrial diastole.
摘要翻译：在可植入心脏监测装置和监测方法中，跨越心房的至少一部分测量阻抗，使得阻抗的变化与心房的体积变化相关。值存储在指示测量阻抗的变化率的不同场合。确定所存储的值，使得当在生物体中使用该装置时，存储值的变化将与在心房舒张期期间心房充满血液的速度的变化相关。

2. 发明授权

US08244337B2 Method and implantable medical device for classifying sensor signals 有权
标题翻译：用于分类传感器信号的方法和可植入医疗装置
公开(公告)号：US08244337B2
公开(公告)日：2012-08-14
申请号：US12280505
申请日：2006-02-28
申请人： Nils Holmström , Malin Öhlander
发明人： Nils Holmström , Malin Öhlander
IPC分类号： A61B5/04
CPC分类号： A61N1/3627 , A61B5/0402 , A61B5/7264 , A61N1/36514 , A61N1/3702
摘要： In a method and an apparatus for creating hemodynamic sensor signal templates using an implantable medical device connectable to a patient heart activity of the patient is sensed in order to identify a paste or sensed sequence of events of a heart cycle. Hemodynamic sensor signals for consecutive heart cycles are sensed and the sensed hemodynamic sensor signals for consecutive heart cycles are stored. The sensed sensor signals are classified dependent on at least one predetermined heart event sequence condition. A template may be created using the classified sensor signals.
摘要翻译：在用于创建血液动力学传感器信号模板的方法和装置中，使用可植入的医疗装置来感测患者的心脏活动，以识别患者心脏周期的糊状物或感测的事件序列。感测连续心脏循环的血液动力学传感器信号，并存储感测到的连续心脏循环的血液动力学传感器信号。感测的传感器信号根据至少一个预定的心脏事件序列条件进行分类。可以使用分类的传感器信号来创建模板。

3. 发明申请

US20100268102A1 IMPLANTABLE HEART MONITORING DEVICE, SYSTEM AND METHOD 有权
标题翻译：可植入心脏监测装置，系统和方法
公开(公告)号：US20100268102A1
公开(公告)日：2010-10-21
申请号：US12808041
申请日：2007-12-19
申请人： Andreas Blomqvist , Nils Holmstöm , Sven-Erik Hedberg , Malin Öhlander
发明人： Andreas Blomqvist , Nils Holmstöm , Sven-Erik Hedberg , Malin Öhlander
IPC分类号： A61B5/0472
CPC分类号： A61N1/36521 , A61B5/0456 , A61B5/053 , A61B5/0538 , A61N1/3622 , A61N1/3684
摘要： In an implantable heart monitoring device and a monitoring method, an impedance is measured across at least part of an atrium, such that variation of the impedance is related to the volume change of the atrium. Values are stored at different occasions that indicate the rate of change of the measured impedance. The stored values are determined such that, when the device is used in a living being, the variation of the stored values will be related to the variation of the speed with which the atrium is filled with blood during the atrial diastole.
摘要翻译：在可植入心脏监测装置和监测方法中，跨越心房的至少一部分测量阻抗，使得阻抗的变化与心房的体积变化相关。值存储在指示测量阻抗的变化率的不同场合。确定所存储的值，使得当在生物体中使用该装置时，存储值的变化将与在心房舒张期期间心房充满血液的速度的变化相关。

4. 发明授权

US08321016B2 Implantable medical device and a method comprising means for detecting and classifying ventricular tachyarrhythmias 有权
标题翻译：植入式医疗装置和包括用于检测和分类室性快速性心律失常的装置的方法
公开(公告)号：US08321016B2
公开(公告)日：2012-11-27
申请号：US12602533
申请日：2007-06-13
申请人： Nils Holmström , Andreas Blomqvist , Sven-Erik Hedberg , Malin Öhlander
发明人： Nils Holmström , Andreas Blomqvist , Sven-Erik Hedberg , Malin Öhlander
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/3702 , A61B5/0464 , A61B5/053 , A61B5/7264
摘要： In a method and implantable medical device for ventricular tachyarrhythmia detection and classification, upon detection of a ventricular tachyarrhythmia based on an electrocardiogram signal, cardiogenic impedance data representative of ventricular volume dynamics are collected and used for classifying the detected tachyarrhythmia as stable or unstable. In the latter case but typically not in the former case, defibrillation shocks or other forms of therapy are applied to combat the unstable ventricular tachyarrhythmia.
摘要翻译：在用于室性快速性心律失常检测和分类的方法和可植入医疗装置中，在基于心电图信号检测到心室快速性心律失常时，收集表示心室容积动力学的心源阻抗数据，并用于将检测到的心律失常分类为稳定或不稳定。在后一种情况下，但通常不是在前一种情况下，应用除颤电击或其他形式的治疗来对抗不稳定性室性快速性心律失常。

5. 发明申请

US20100324432A1 METHOD AND DEVICE TO DETECT EATING, TO CONTROL ARTIFICIAL GASTRIC STIMULATION 审中-公开
标题翻译：检测药物的方法和装置，控制人造气刺激
公开(公告)号：US20100324432A1
公开(公告)日：2010-12-23
申请号：US12526137
申请日：2007-02-21
申请人： Anders Björling , Kjell Norén , Malin Öhlander
发明人： Anders Björling , Kjell Norén , Malin Öhlander
IPC分类号： A61B5/026
CPC分类号： A61N1/36007 , A61B5/026 , A61B5/0261 , A61B5/0265 , A61B5/028 , A61B5/0295 , A61B5/0535 , A61B5/4238 , A61B5/6876 , A61B5/6884 , A61B8/06
摘要： In a method and device for detecting the intake of food in a subject at least one parameter related to the blood flow and/or perfusion of a blood vessel and/or an organ in the digestive system of a patient is monitored by a sensor attached to, or in, a blood vessel or organ of the digestive system. The value of each monitored parameter is analyzed and may be used to control the activity of a gastric stimulator.
摘要翻译：在用于检测受试者中食物摄入的方法和装置中，与患者的消化系统中的血流和/或器官的血流和/或器官相关的至少一个参数由附接到或在消化系统的血管或器官中。分析每个监测参数的值，并可用于控制胃刺激剂的活性。

6. 发明申请

US20100298904A1 IMPLANTABLE HEART STIMULATOR FOR MEASURING DYSSYNCHRONY USING IMPEDANCE 有权
标题翻译：用于测量使用阻抗的DYSSYNCHRONY的可植入心脏刺激仪
公开(公告)号：US20100298904A1
公开(公告)日：2010-11-25
申请号：US12863381
申请日：2008-01-28
申请人： Andreas Blomqvist , Nils Holmström , Malin Öhlander , Sven-Erik Hedberg
发明人： Andreas Blomqvist , Nils Holmström , Malin Öhlander , Sven-Erik Hedberg
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61B5/053 , A61B5/0538 , A61N1/3684
摘要： Implantable heart stimulator connectable to an electrode arrangement has a pulse generator adapted to deliver stimulation pulses to a heart of a subject; an impedance measurement unit adapted monitor at least one heart chamber of the heart of the subject to measure the impedance in the at least one monitored heart chamber for generating an impedance signal corresponding to the measured impedance. The impedance signal is applied to a processor where the signal is processed, according to specified criteria, and a fractionation index value is determined represented by the curve length of the impedance signal during a predetermined measurement period. The fractionation index value is a measure of different degrees of mechanical dyssynchrony of the heart.
摘要翻译：可连接到电极装置的可植入心脏刺激器具有适于将刺激脉冲输送到受试者心脏的脉冲发生器; 阻抗测量单元适于监测所述受试者心脏的至少一个心室，以测量所述至少一个监测的心室中的阻抗，以产生对应于所测量的阻抗的阻抗信号。根据规定的标准，将阻抗信号施加到处理器，信号被处理，并且在预定测量期间由阻抗信号的曲线长度确定分数指数值。分离指数值是心脏不同程度的机械不同步的度量。

7. 发明申请

US20100113961A1 MEDICAL DEVICE FOR DETERMINING THE POSTURE OF PATIENT 有权
标题翻译：用于确定患者症状的医疗装置
公开(公告)号：US20100113961A1
公开(公告)日：2010-05-06
申请号：US11993254
申请日：2005-06-29
申请人： Malin Öhlander , Nils Holmström , Kjell Norén
发明人： Malin Öhlander , Nils Holmström , Kjell Norén
IPC分类号： A61B5/053
CPC分类号： G06F19/34 , A61B5/0031 , A61B5/01 , A61B5/029 , A61B5/053 , A61B5/0816 , A61B5/1116 , A61B5/4561 , A61B5/686
摘要： The present invention relates to a method for determining the posture of a patient. The method comprises the steps of: initiating (50, 52) a patient posture determining session by performing an electrical bio-impedance measurement session in at least one of a number of different electrode configurations in order to measure an impedance value for the at least one configuration; obtaining reference impedance values (54) stored in advance for the at least one configuration and for at least one potential posture of the patient; comparing (54) the measured impedance value for the at least one configuration with corresponding stored reference impedance values for at least one potential posture of the patient; and determining (56) the present posture of the patient by using results from the comparison between measured impedance values and the stored reference impedance values. Furthermore, the invention relates to a medical device for determining the posture of a patient and a computer readable medium comprising instructions for bringing a computer to perform the inventive method.
摘要翻译：本发明涉及一种用于确定患者姿势的方法。该方法包括以下步骤：通过在多个不同电极配置中的至少一个中执行电生物阻抗测量会话来启动（50,52）患者姿势确定会话，以便测量至少一个组态; 获得针对所述至少一个配置和所述患者的至少一个潜在姿势预先存储的参考阻抗值（54）; 将所述至少一个配置的测量阻抗值与所述患者的至少一个潜在姿势的对应存储的参考阻抗值进行比较（54）; 以及通过使用测量的阻抗值与所存储的参考阻抗值之间的比较的结果来确定（56）患者的当前姿势。此外，本发明涉及一种用于确定患者姿势的医疗装置和包括用于使计算机执行本发明的方法的指令的计算机可读介质。

8. 发明授权

US08790254B2 Medical device for determining the posture of patient 有权
标题翻译：用于确定患者姿势的医疗装置
公开(公告)号：US08790254B2
公开(公告)日：2014-07-29
申请号：US11993254
申请日：2005-06-29
申请人： Malin Öhlander , Nils Holmström , Kjell Norén
发明人： Malin Öhlander , Nils Holmström , Kjell Norén
IPC分类号： A61B5/00 , G06F19/00 , A61B5/053
CPC分类号： G06F19/34 , A61B5/0031 , A61B5/01 , A61B5/029 , A61B5/053 , A61B5/0816 , A61B5/1116 , A61B5/4561 , A61B5/686
摘要： In a method and a device for determining the posture of a patient, a bio-impedance measurement device, having a number of electrodes configured to interact with the patient in a number of different electrode configurations, is operated to initiate a patient posture determining session by measuring an impedance value of the patient with the electrodes in at least one configuration among the number of configurations. A reference impedance value from among a number of stored reference impedance values for the at least one configuration is selected. The number of stored reference impedance values are respectively associated with different postures of the patient, and the posture associated with the selected reference impedance value represents a candidate posture. The measured impedance value is compared with the selected reference impedance value, thereby obtaining a comparison result. Dependent on said comparison result, it is automatically determined whether the current posture of the patient conforms to the candidate posture.
摘要翻译：在用于确定患者姿势的方法和装置中，操作具有多个电极的生物阻抗测量装置，其被配置成以多个不同的电极配置与患者相互作用，以通过以下方式启动患者姿势确定会话：在配置数量中，至少一个配置中测量具有电极的患者的阻抗值。选择用于至少一个配置的多个存储的参考阻抗值中的参考阻抗值。存储的参考阻抗值的数量分别与患者的不同姿势相关联，并且与所选择的参考阻抗值相关联的姿势表示候选姿势。将测量的阻抗值与所选择的参考阻抗值进行比较，从而获得比较结果。根据所述比较结果，自动确定患者的当前姿势是否符合候选姿势。

9. 发明授权

US08565866B2 Method and device for monitoring acute decompensated heart failure 有权
标题翻译：监测急性失代偿性心力衰竭的方法和装置
公开(公告)号：US08565866B2
公开(公告)日：2013-10-22
申请号：US12809255
申请日：2007-12-21
申请人： Andreas Blomqvist , Nils Holmström , Sven-Erik Hedberg , Malin Öhlander
发明人： Andreas Blomqvist , Nils Holmström , Sven-Erik Hedberg , Malin Öhlander
IPC分类号： A61B5/0295
CPC分类号： A61B5/053 , A61B5/0245 , A61B5/0452
摘要： An implantable medical device has an impedance determiner for determining a cardiogenic impedance signal based on electric signals sensed by connected electrodes. A parameter calculator processes the impedance signal to calculate an impedance parameter representative of the cardiogenic impedance in connection with the diastolic phase of a heart cycle. This parameter is then employed by the device for monitoring acute decompensated heart failure status of a subject.
摘要翻译：可植入医疗装置具有用于基于由连接电极感测的电信号确定心源阻抗信号的阻抗确定器。参数计算器处理阻抗信号以计算代表与心脏周期的舒张期相关的心源阻抗的阻抗参数。该参数随后被该装置用于监测受试者的急性失代偿性心力衰竭状态。

10. 发明授权

US08355782B2 Implantable heart stimulator for measuring dyssynchrony using impedance 有权
标题翻译：用于测量使用阻抗的不同步的可植入心脏刺激器
公开(公告)号：US08355782B2
公开(公告)日：2013-01-15
申请号：US12863381
申请日：2008-01-28
申请人： Andreas Blomqvist , Nils Holmström , Malin Öhlander , Sven-Erik Hedberg
发明人： Andreas Blomqvist , Nils Holmström , Malin Öhlander , Sven-Erik Hedberg
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61B5/053 , A61B5/0538 , A61N1/3684
摘要： Implantable heart stimulator connectable to an electrode arrangement has a pulse generator adapted to deliver stimulation pulses to a heart of a subject; an impedance measurement unit adapted monitor at least one heart chamber of the heart of the subject to measure the impedance in the at least one monitored heart chamber for generating an impedance signal corresponding to the measured impedance. The impedance signal is applied to a processor where the signal is processed, according to specified criteria, and a fractionation index value is determined represented by the curve length of the impedance signal during a predetermined measurement period. The fractionation index value is a measure of different degrees of mechanical dyssynchrony of the heart.
摘要翻译：可连接到电极装置的可植入心脏刺激器具有适于将刺激脉冲输送到受试者心脏的脉冲发生器; 阻抗测量单元适于监测所述受试者心脏的至少一个心室，以测量所述至少一个监测的心室中的阻抗，以产生对应于所测量的阻抗的阻抗信号。根据规定的标准，将阻抗信号施加到处理器，信号被处理，并且在预定测量期间由阻抗信号的曲线长度确定分数指数值。分离指数值是心脏不同程度的机械不同步的度量。

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