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1. 发明授权

US07228172B2 Bi-ventricular pacer, system and method 有权
标题翻译：双心室起搏器，系统及方法
公开(公告)号：US07228172B2
公开(公告)日：2007-06-05
申请号：US10734767
申请日：2003-12-13
申请人： Karin Järverud , Nils Holmström , Anders Björling , Asa Uhrenius , Sven-Erik Hedberg , Göran Budgifvars , Hans Strandberg
发明人： Karin Järverud , Nils Holmström , Anders Björling , Asa Uhrenius , Sven-Erik Hedberg , Göran Budgifvars , Hans Strandberg
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3684 , A61N1/3712
摘要： An implantable bi-ventricular heart stimulating device and system, suitable for treating congestive heart failure, have a control circuit with first and second pacing circuits and first and second sensing circuits. The device operates with time cycles corresponding to normal heart cycles. The control circuit determines: (a) whether a signal typical of an evoked response to a pacing pulse delivered by the first pacing circuit is sensed within a first time interval and (b) whether a signal typical for an R-wave transferred from the second ventricle, or from some other part of the heart, to the first ventricle is detected within a first time window. The operation of the device depends on whether the conditions (a) and (b) are fulfilled.
摘要翻译：适用于治疗充血性心力衰竭的可植入式双心室心脏刺激装置和系统具有具有第一和第二起搏电路和第一和第二感测电路的控制电路。该装置以对应于正常心脏周期的时间周期运行。控制电路确定：（a）在第一时间间隔内是否感测到由第一起搏电路传送的起搏脉冲的典型诱发响应的信号，以及（b）是否从第二时间间隔传送的R波的典型信号在第一时间窗口内检测到心室或心脏的其他部分到第一脑室。设备的操作取决于条件（a）和（b）是否得到满足。

2. 发明授权

US07085602B2 Implantable bi-ventricular stimulation device and system, and bi-ventricular stimulation and sensing method 有权
标题翻译：可植入双心室刺激装置和系统，以及双心室刺激和感测方法
公开(公告)号：US07085602B2
公开(公告)日：2006-08-01
申请号：US10720449
申请日：2003-11-24
申请人： Sven-Erik Hedberg , Asa Uhrenius , Karin Jarverud , Hans Strandberg , Nils Holmström , Anders Björling , Göran Budgifvars
发明人： Sven-Erik Hedberg , Asa Uhrenius , Karin Jarverud , Hans Strandberg , Nils Holmström , Anders Björling , Göran Budgifvars
IPC分类号： A61N1/365
CPC分类号： A61N1/368 , A61N1/056 , A61N1/3684 , A61N2001/0585
摘要： An implantable bi-ventricular heart stimulating device (10) has a control circuit with first and second sensing circuits for respectively sensing in the two ventricles and first and second stimulation circuits for respectively stimulating the two ventricles. The control circuit determines whether a signal, sensed by said second sensing circuit, occurs essentially simultaneously with a signal sensed by the first sensing circuit. Furthermore, the control circuit determines whether a further signal is sensed by said second sensing circuit within a predetermined time interval which follows after the signal sensed by the second sensing circuit but within the same time cycle as that signal. If this occurs, the control circuit determines whether the sensed signals represent actual cardiac events, or are likely the result of far field detection.
摘要翻译：可植入式双心室心脏刺激装置（10）具有控制电路，该控制电路具有用于分别感测两个心室的第一和第二感测电路以及分别刺激两个脑室的第一和第二刺激电路。控制电路确定由所述第二感测电路检测到的信号是否基本上与由第一感测电路感测的信号同时发生。此外，控制电路确定在由第二感测电路感测到的信号之后但在与该信号相同的时间周期内的预定时间间隔内，所述第二感测电路是否感测到另外的信号。如果发生这种情况，则控制电路确定感测到的信号是否代表实际的心脏事件，或者很可能是远场检测的结果。

3. 发明授权

US06961613B2 Implantable bi-ventricular stimulation device and system, and bi-ventricular stimulation and sensing method 有权
标题翻译：可植入双心室刺激装置和系统，以及双心室刺激和感测方法
公开(公告)号：US06961613B2
公开(公告)日：2005-11-01
申请号：US10712437
申请日：2003-11-13
申请人： Anders Björling , Nils Holmström , Sven-Erik Hedberg , Asa Uhrenius
发明人： Anders Björling , Nils Holmström , Sven-Erik Hedberg , Asa Uhrenius
IPC分类号： A61N1/368 , A61N1/37 , A61N1/365
CPC分类号： A61N1/3712 , A61N1/368 , A61N1/3684
摘要： An implantable bi-ventricular heart stimulating device has a control circuit that within a time cycle, delivers pacing pulses with both first and second pacing circuits with a time gap between a pacing pulse delivered by these pacing circuits. The time gap can be such that a pacing pulse delivered by the second pacing circuits falls substantially within a first time interval in which an evoked response can be expected to a pacing pulse delivered by the first pacing circuit. The control circuit performs a temporary modification of the operation of the device such that during at least one time cycle no pacing pulse is delivered by the second pacing circuit during the first time interval.
摘要翻译：可植入的双心室心脏刺激装置具有控制电路，其在一个时间周期内，通过第一起搏电路和第二起搏电路之间的时间间隔在由这些起搏电路输送的起搏脉冲之间提供起搏脉冲。时间间隙可以使得由第二起搏电路传送的起搏脉冲基本上落在第一时间间隔内，其中诱发响应可以预期到由第一起搏电路传送的起搏脉冲。控制电路对装置的操作进行暂时的修改，使得在至少一个时间周期期间，第一起搏电路在第一时间间隔期间不发出起搏脉冲。

4. 发明授权

US06473650B1 Evoked response detector for a heart stimulator 失效
标题翻译：心脏刺激器的诱发反应检测器
公开(公告)号：US06473650B1
公开(公告)日：2002-10-29
申请号：US09719738
申请日：2001-02-23
申请人： Berit Larsson , Asa Uhrenius , Peter Andersson , Göran Budgivars
发明人： Berit Larsson , Asa Uhrenius , Peter Andersson , Göran Budgivars
IPC分类号： A61N137
CPC分类号： A61N1/3712
摘要： A heart stimulator has an evoked response detector for determining evoked response in the presence of polarization. The heart stimulator produces stimulation pulses of different amplitudes via a lead introduced to the heart of the patient. The evoked response detector measures an electrode signal picked up by the lead after each stimulation pulse. In order to set an evoked response threshold value, the pulse generator of the stimulator is controlled to deliver at least two stimulation pulses with different amplitudes, at least one of these stimulation pulses having a high amplitude that exceeds the stimulation threshold value. A measuring unit in the evoked response detector measures the picked up electrode signals, and a calculating unit in the evoked response detector calculates the polarization for the high stimulation amplitude and identifies a measured electrode signal for the lowest possible stimulation amplitude from the measured electrode signals. The evoked response detector also has an analyzing unit which sets a threshold value for the measured electrode signal from the calculated polarization and lowest possible stimulation amplitude.
摘要翻译：心脏刺激器具有用于在存在极化的情况下确定诱发反应的诱发响应检测器。心脏刺激器通过导入患者心脏的导线产生不同振幅的刺激脉冲。诱发响应检测器测量在每个刺激脉冲之后由引线拾取的电极信号。为了设定诱发响应阈值，刺激器的脉冲发生器被控制以递送具有不同振幅的至少两个刺激脉冲，这些刺激脉冲中的至少一个具有超过刺激阈值的高幅度。诱发响应检测器中的测量单元测量所拾取的电极信号，并且所述诱发响应检测器中的计算单元计算所述高刺激振幅的极化，并且从所测量的电极信号识别用于可能的最低刺激振幅的测量电极信号。诱发响应检测器还具有分析单元，该分析单元根据所计算的极化和最低可能的刺激幅度来设置测量的电极信号的阈值。

5. 发明授权

US6029088A Heart stimulator with an evoked response detector 有权
标题翻译：心脏刺激器与诱发响应检测器
公开(公告)号：US6029088A
公开(公告)日：2000-02-22
申请号：US161665
申请日：1998-09-29
申请人： Goran Budgifvars , Asa Uhrenius , Peter Andersson
发明人： Goran Budgifvars , Asa Uhrenius , Peter Andersson
IPC分类号： A61N1/37 , A61N1/18
CPC分类号： A61N1/3712 , A61N1/3716
摘要： An evoked response detector for a heart stimulator determines evoked response in the presence of polarization. The heart stimulator has a pulse generator which produces stimulation pulses of varying amplitudes, and a lead adapted for introduction into the heart of a patient is connected to the pulse generator for delivering stimulation pulses to the heart. The evoked response detector includes measuring and memory circuitry for measuring and storing the electrode signals picked up by the lead in response to the delivered stimulation pulses, at least one of these stimulation pulses having a sufficiently high amplitude for obtaining capture. Each measured electrode signal contains two signal components, one of these signal components being proportional to the amplitude of the associated stimulation pulse and the other signal component being substantially constant, independent of the associated stimulation pulse amplitude. An analyzing unit determines the evoked response signal from a predetermined relation between the amplitudes of at least two stimulation pulses of different amplitudes and the resulting measured electrode signals.
摘要翻译：用于心脏刺激器的诱发响应检测器确定在存在极化的情况下的诱发反应。心脏刺激器具有产生不同振幅的刺激脉冲的脉冲发生器，并且适于引入患者心脏的引线连接到脉冲发生器以将刺激脉冲传送到心脏。诱发响应检测器包括测量和存储电路，用于测量和存储由引导响应于所传递的刺激脉冲而拾取的电极信号，这些刺激脉冲中的至少一个具有足够高的振幅以获得捕获。每个测量的电极信号包含两个信号分量，这些信号分量之一与相关联的刺激脉冲的幅度成比例，而另一个信号分量基本上是恒定的，与相关联的刺激脉冲幅度无关。分析单元根据不同振幅的至少两个刺激脉冲的振幅与所测得的电极信号之间的预定关系确定诱发响应信号。

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