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1. 发明授权

US5145851A Method for treating urinary obstruction 失效
标题翻译：治疗尿路梗阻的方法
公开(公告)号：US5145851A
公开(公告)日：1992-09-08
申请号：US780405
申请日：1991-10-17
申请人： Masayuki Ishikawa , Hiroshi Azuma , Shigeru Ito , Tomohiro Yamaguchi
发明人： Masayuki Ishikawa , Hiroshi Azuma , Shigeru Ito , Tomohiro Yamaguchi
IPC分类号： C07D239/54 , A61K31/495 , A61K31/505 , A61K31/52 , A61P13/02 , A61P15/00
CPC分类号： A61K31/505
摘要： 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl)propyl]-amino]-1,3-dimethyluracil can be used as a therapeutic agent for urinary obstruction.
摘要翻译： 6 - [[3- [4-（2-甲氧基苯基）-1-哌嗪基）丙基] - 氨基] -1,3-二甲基丙烯酰胺可用作尿路梗阻的治疗剂。

2. 发明授权

US5075308A Method for treating urinary obstruction 失效
标题翻译：治疗尿路梗阻的方法
公开(公告)号：US5075308A
公开(公告)日：1991-12-24
申请号：US480237
申请日：1990-02-15
申请人： Masayuki Ishikawa , Hiroshi Azuma , Shigeru Ito
发明人： Masayuki Ishikawa , Hiroshi Azuma , Shigeru Ito
IPC分类号： C07D239/42 , A61K31/505 , A61P7/10 , A61P13/02 , A61P15/00 , C07D239/47 , C07D239/48
CPC分类号： A61K31/505
摘要： A method for treating urinary obstruction by administering a 2-(4-phenyl-1-piperazinylalkyl)aminopyrimidine derivative represented by the formula ##STR1## wherein R.sub.1 and R.sub.3 may be the same or different and independently represent hydrogen, halogen, an amino group, a hydroxyl group, a straight or branched chain lower alkyl group, a straight or branched chain lower alkoxy group, or a straight or branched chain hydroxy-lower alkyl group, R.sub.2 represents hydrogen, halogen, a carboxyl group, a straight or branched chain lower alkyl group, a straight or branched chain lower alkylcarbonyl group, or a straight or branched chain lower alkyloxycarbonyl group, R.sub.4 and R.sub.5 may be the same or different and independently represent hydrogen, halogen, a straight or branched chain lower alkyl group, or a straight or branched chain lower alkoxy group, and n represents an integer of 2 to 6 or a pharmaceutically acceptable acid addition salt thereof to a mammal including a human afflicted with urinary obstruction. The aminopyrimidine derivatives have a selective activity on the .alpha..sub.1 -adrenoceptors in the urinary tracts.
摘要翻译：一种通过施用式（IMAGE）表示的2-（4-苯基-1-哌嗪基烷基）氨基嘧啶衍生物治疗尿路梗阻的方法，其中R 1和R 3可以相同或不同并且独立地表示氢，卤素，氨基，羟基，直链或支链低级烷基，直链或支链低级烷氧基，或直链或支链羟基 - 低级烷基，R2表示氢，卤素，羧基，直链或支链低级烷基，直链或支链低级烷基羰基，或直链或支链低级烷氧基羰基，R4和R5可以相同或不同，独立地代表氢，卤素，直链或支链低级烷基或直链或支链低级烷氧基，n表示2〜6的整数或其药学上可接受的酸加成盐，其包括患有尿阻碍的人的哺乳动物离子。氨基嘧啶衍生物对尿道中的α1-肾上腺素能受体具有选择性活性。

3. 发明授权

US07041317B2 Sustained-release preparation containing 5-acetyl-4,6-dimethyl-2[2-[4-(2-methoxyphenyl) piperazinyl]ethylamino] pyrimidine trihydrochloride as active ingredient 失效
标题翻译：含有5-乙酰基-4,6-二甲基-2 [2- [4-（2-甲氧基苯基）哌嗪基]乙基氨基]嘧啶三盐酸盐作为有效成分的缓释制剂
公开(公告)号：US07041317B2
公开(公告)日：2006-05-09
申请号：US10399686
申请日：2001-10-22
申请人： Noboru Sekiya , Yoshinori Ii , Masayuki Ishikawa , Hiroshi Azuma
发明人： Noboru Sekiya , Yoshinori Ii , Masayuki Ishikawa , Hiroshi Azuma
IPC分类号： A61K9/22 , A61K9/20
CPC分类号： A61K31/506 , A61K9/167 , A61K9/28 , A61K9/5026 , Y10S514/964
摘要： A sustained-release formulation of 5-acetyl-4,6-dimethyl-2-[2-[4-(2-methoxyphenyl)piperazinyl]ethylamino]pyrimidine trihydrochloride coated with a release-controlling film comprising a water-insoluble polymer film having no hydrophilic group. The formulation of the present invention has such a release pattern that the drug release lasts for 20 hours or more, so that can be appropriately administered for treatment. Furthermore, the formulation itself is so stable that its release pattern does not change with pH and the formulation does not suffer from deterioration, coloration and the like with the lapse of time.
摘要翻译：用包含具有不溶性聚合物膜的释放控制膜涂覆的5-乙酰基-4,6-二甲基-2- [2- [4-（2-甲氧基苯基）哌嗪基]乙基氨基]嘧啶三盐酸盐的缓释制剂，无亲水基团。本发明的制剂具有药物释放持续20小时以上的释放模式，因此可以适当地施用于治疗。此外，制剂本身是稳定的，其释放模式不随pH变化，并且制剂随时间流逝不会劣化，着色等。

4. 发明授权

US4517189A 2,6,7,8-Substituted quinazolines, process for production thereof, and use thereof 失效
标题翻译： 2,6,7,8-取代的喹唑啉，其制备方法及其用途
公开(公告)号：US4517189A
公开(公告)日：1985-05-14
申请号：US519235
申请日：1983-08-02
申请人： Masayuki Ishikawa , Hiroshi Azuma , Akiko Sugimoto , Noriko Takahashi , Yoshimi Takashima
发明人： Masayuki Ishikawa , Hiroshi Azuma , Akiko Sugimoto , Noriko Takahashi , Yoshimi Takashima
IPC分类号： C07D239/74 , A61K31/505
CPC分类号： C07D239/74
摘要： A 2,6,7,8-substituted quinazoline represented by the following formula ##STR1## wherein R.sub.1 and R.sub.3 each represent a lower alkyl group, R.sub.2 represents a lower alkoxy-carbonyl group, and A represents a lower alkyl group, or a phenyl or benzyl group which is unsubstituted or substituted by a substituent selected from the class consisting of halogen atoms, a trifluoromethyl group and lower alkyl groups, or its acid addition salt. The said compound can be prepared by reacting a compound represented by the following formula ##STR2## wherein R.sub.1, R.sub.2, R.sub.3 and A are as defined, with ammonia. A pharmaceutical composition comprising the said compound as an active ingredient is useful for the treatment of disorders of the circulatory system.
摘要翻译：由下式[IMAGE]表示的2,6,7,8-取代喹唑啉其中R1和R3各自表示低级烷基，R2表示低级烷氧基 - 羰基，A表示低级烷基或苯基或未取代或被选自卤素原子，三氟甲基和低级烷基的取代基取代的苄基或其酸加成盐。所述化合物可以通过使下式（其中R 1，R 2，R 3和A如上所定义）与氨反应的化合物制备。包含所述化合物作为活性成分的药物组合物可用于治疗循环系统疾病。

5. 发明申请

US20050101606A1 Sustained-release preparation containing 5-acetyl-4,6-dimethyl-2[2-[4-(2-methoxyphenyl) piperazinyl]ethylamino]pyrimidine trihydrochloride as active ingredient 失效
标题翻译：含有5-乙酰基-4,6-二甲基-2 [2- [4-（2-甲氧基苯基）哌嗪基]乙基氨基]嘧啶三盐酸盐作为有效成分的缓释制剂
公开(公告)号：US20050101606A1
公开(公告)日：2005-05-12
申请号：US10399686
申请日：2001-10-22
申请人： Noboru Sekiya , Yoshinori Ii , Masayuki Ishikawa , Hiroshi Azuma
发明人： Noboru Sekiya , Yoshinori Ii , Masayuki Ishikawa , Hiroshi Azuma
IPC分类号： A61K9/16 , A61K9/28 , A61K9/50 , A61K31/506 , A61P13/00 , A61K9/22
CPC分类号： A61K31/506 , A61K9/167 , A61K9/28 , A61K9/5026 , Y10S514/964
摘要： A sustained-release formulation of 5-acetyl-4,6-dimethyl-2-[2-[4-(2-methoxyphenyl)piperazinyl]ethylamino]pyrimidine trihydrochloride coated with a release-controlling film comprising a water-insoluble polymer film having no hydrophilic group. The formulation of the present invention has such a release pattern that the drug release lasts for 20 hours or more, so that can be appropriately administered for treatment. Furthermore, the formulation itself is so stable that its release pattern does not change with pH and the formulation does not suffer from deterioration, coloration and the like with the lapse of time.
摘要翻译：用包含具有不溶性聚合物膜的释放控制膜涂覆的5-乙酰基-4,6-二甲基-2- [2- [4-（2-甲氧基苯基）哌嗪基]乙基氨基]嘧啶三盐酸盐的缓释制剂，无亲水基团。本发明的制剂具有药物释放持续20小时以上的释放模式，因此可以适当地施用于治疗。此外，制剂本身是稳定的，其释放模式不随pH变化，并且制剂随时间流逝不会劣化，着色等。

6. 发明授权

US4293553A 1-Phthalazone derivatives, and use thereof 失效
标题翻译： 1-酞皮酮衍生物及其用途
公开(公告)号：US4293553A
公开(公告)日：1981-10-06
申请号：US64368
申请日：1979-08-07
申请人： Masayuki Ishikawa , Hiromichi Tanaka , Yukuo Eguchi , Shigeru Ito , Yoshimi Takashima , Masahiko Kobayashi
发明人： Masayuki Ishikawa , Hiromichi Tanaka , Yukuo Eguchi , Shigeru Ito , Yoshimi Takashima , Masahiko Kobayashi
IPC分类号： C07D237/32
CPC分类号： C07D237/32
摘要： Novel 1-phthalazone derivatives of the following formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are as defined in claim 1, and pharmaceutically acceptable acid addition salts thereof; a process for production thereof; a pharmaceutical composition containing said compound; and a method for treating a thrombotic disease using said compound.
摘要翻译：下列通式的新的1-酞嗪衍生物：其中R1，R2和R3如权利要求1所定义，及其药学上可接受的酸加成盐; 其生产方法; 含有所述化合物的药物组合物; 以及使用所述化合物治疗血栓形成疾病的方法。

7. 发明授权

US4276295A 3-Aromatic moiety substituted-4(3H)-quinazolinones, process for production thereof, and use thereof 失效
标题翻译： 3-芳族部分取代-4（3H） - 喹唑啉酮，其制备方法及其用途
公开(公告)号：US4276295A
公开(公告)日：1981-06-30
申请号：US103841
申请日：1979-12-14
申请人： Masayuki Ishikawa , Hiromichi Tanaka , Yukuo Eguchi , Shigeru Ito , Yoshimi Takashima , Masahiko Kobayashi
发明人： Masayuki Ishikawa , Hiromichi Tanaka , Yukuo Eguchi , Shigeru Ito , Yoshimi Takashima , Masahiko Kobayashi
IPC分类号： C07D239/91 , A61K31/505 , C07D239/90
CPC分类号： C07D239/91
摘要： Novel 3-aromatic moiety substituted-4(3H)-quinazolinone derivatives useful as a vasodilators, hypotensive and antiatherosclerotic agents having the formula of ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and Q are as defined in the accompanying specification or its acid addition salt; and a process for producing the same.
摘要翻译：可用作血管扩张剂的新型3-芳族部分取代-4（3H） - 喹唑啉酮衍生物，具有下式的降压药和抗动脉粥样硬化剂：其中R1，R2，R3，R4和Q如所附说明书所定义或其酸加成盐; 及其制造方法。

8. 发明申请

US20130015027A1 HYDRAULIC SHOCK ABSORBER 有权
标题翻译：液压减震器
公开(公告)号：US20130015027A1
公开(公告)日：2013-01-17
申请号：US13521631
申请日：2010-12-01
申请人： Eiko Miyasato , Akira Hiroki , Junya Kaneko , Youji Takakuwa , Kengo Monden , Masayuki Ishikawa , Mariko Kessoku
发明人： Eiko Miyasato , Akira Hiroki , Junya Kaneko , Youji Takakuwa , Kengo Monden , Masayuki Ishikawa , Mariko Kessoku
IPC分类号： F16F9/19 , F16F9/36
CPC分类号： F16F9/363
摘要： A hydraulic shock absorber that can reduce outflow amount of oil by maximally removing an oil film attached to an outer periphery of a rod and that can achieve securement of high slidability between the rod and a rod packing and prevention of wear of the rod packing. A rod packing interposed between an outer periphery of a rod and an inner periphery of a rod-side end wall includes a first lip for scrapping off an oil film attached to the outer periphery of the rod, and a ring-shaped grease holding member for supplying holding grease to the outer periphery of the rod. The grease holding member is in contact with the outer periphery of the rod at a position closer to a rod distal end than the first lip.
摘要翻译：一种液压减震器，其可以通过最大限度地除去附着在杆的外周上的油膜，从而可以减少杆和杆状填料之间的高滑动性，并防止杆状填料的磨损，从而减少油的流出量。插入在杆的外周和杆侧端壁的内周之间的杆状填料包括用于废除附着在杆的外周的油膜的第一唇缘和用于向杆的外周供给保持油脂。润滑脂保持构件在比第一唇缘更靠近杆远端的位置处与杆的外周接触。

9. 发明申请

US20120282123A1 ELECTRIC COMPRESSOR AND ASSEMBLY METHOD THEREOF 有权
标题翻译：电动压缩机及其装配方法
公开(公告)号：US20120282123A1
公开(公告)日：2012-11-08
申请号：US13519926
申请日：2010-08-26
申请人： Yuki Ichise , Takayuki Hagita , Masayuki Ishikawa , Takeshi Hirano , Takayuki Watanabe
发明人： Yuki Ichise , Takayuki Hagita , Masayuki Ishikawa , Takeshi Hirano , Takayuki Watanabe
IPC分类号： F04D25/06 , B23P15/00
CPC分类号： F04B39/14 , F04C18/0215 , F04C23/008 , F04C29/0078 , F04C2230/60 , H02K1/28 , H02K5/1732 , H02K7/083 , H02K15/0012 , Y10T29/49245
摘要： A main-bearing outer diameter of an electric motor is made smaller than a rotor outer diameter without causing a drop in production efficiency, and the ease of performing a shrink-fitting step is also enhanced by making it possible to mount a rotor to a main shaft in an early stage. A bearing journal portion (14b) of a main shaft (14) of an electric motor is formed in a shape into which an inner race (18b) of a main bearing (18) can be press-fitted from both sides in the axial direction thereof, and, in addition, an outer diameter of the bearing journal portion (14b) is made larger than an outer diameter of a rotor press-fitting portion (14a), whereas a bearing bore portion (5a) of a partition member (5) is formed in a shape into which an outer race (18a) can be press-fitted from both sides in the axial direction thereof. It is preferable that a space (S) into which a press-fitting tool for press-fitting the main bearing (18) can be inserted be provided between the rotor press-fitting portion (14a) of the main shaft (14) and the bearing journal portion (14b) thereof.
摘要翻译：电动机的主轴承外径小于转子外径而不会导致生产效率下降，并且通过使转子能够安装到主体上也可以提高进行收缩装配步骤的容易性轴早期阶段。电动机的主轴（14）的轴承轴颈部（14b）形成为主轴承（18）的内圈（18b）能够沿轴向从两侧压配合成的形状并且另外，使轴承轴颈部（14b）的外径大于转子压配部（14a）的外径，而分隔部件（5）的轴承孔部（5a））形成为能够沿其轴向方向从两侧压配合外圈（18a）的形状。优选的是，可以插入用于压配主轴承（18）的压配工具的空间（S），该主体轴（14）的转子压配合部（14a）和轴承轴颈部分（14b）。

10. 发明申请

US20110297980A1 SEMICONDUCTOR LIGHT EMITTING DEVICE AND METHOD FOR MANUFACTURING SAME 有权
标题翻译：半导体发光器件及其制造方法
公开(公告)号：US20110297980A1
公开(公告)日：2011-12-08
申请号：US12886709
申请日：2010-09-21
申请人： Yoshiaki Sugizaki , Hideki Shibata , Akihiro Kojima , Masayuki Ishikawa , Hideo Tamura , Tetsuro Komatsu
发明人： Yoshiaki Sugizaki , Hideki Shibata , Akihiro Kojima , Masayuki Ishikawa , Hideo Tamura , Tetsuro Komatsu
IPC分类号： H01L33/44 , H01L33/50
CPC分类号： H01L33/0066 , H01L27/15 , H01L33/0075 , H01L33/0079 , H01L33/38 , H01L33/44 , H01L33/48 , H01L33/486 , H01L33/50 , H01L33/62 , H01L2924/0002 , H01L2933/0041 , H01L2933/005 , H01L2933/0066 , H01L2924/00
摘要： According to one embodiment, a semiconductor light emitting device includes a light emitting chip and a fluorescent material layer. The light emitting chip includes a semiconductor layer, a first electrode, a second electrode, an insulating layer, a first interconnect layer, a second interconnect layer, a first metal pillar, a second metal pillar, and a resin layer. The semiconductor layer includes a light emitting layer, a first major surface, and a second major surface formed on a side opposite to the first major surface. The fluorescent material layer is provided on the first major surface and has a larger planer size than the light emitting chip.
摘要翻译：根据一个实施例，半导体发光器件包括发光芯片和荧光材料层。发光芯片包括半导体层，第一电极，第二电极，绝缘层，第一互连层，第二互连层，第一金属柱，第二金属柱和树脂层。半导体层包括形成在与第一主表面相对的一侧上的发光层，第一主表面和第二主表面。荧光材料层设置在第一主表面上，并且具有比发光芯片更大的平面尺寸。

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