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1. 发明申请

US20050101606A1 Sustained-release preparation containing 5-acetyl-4,6-dimethyl-2[2-[4-(2-methoxyphenyl) piperazinyl]ethylamino]pyrimidine trihydrochloride as active ingredient 失效
标题翻译：含有5-乙酰基-4,6-二甲基-2 [2- [4-（2-甲氧基苯基）哌嗪基]乙基氨基]嘧啶三盐酸盐作为有效成分的缓释制剂
公开(公告)号：US20050101606A1
公开(公告)日：2005-05-12
申请号：US10399686
申请日：2001-10-22
申请人： Noboru Sekiya , Yoshinori Ii , Masayuki Ishikawa , Hiroshi Azuma
发明人： Noboru Sekiya , Yoshinori Ii , Masayuki Ishikawa , Hiroshi Azuma
IPC分类号： A61K9/16 , A61K9/28 , A61K9/50 , A61K31/506 , A61P13/00 , A61K9/22
CPC分类号： A61K31/506 , A61K9/167 , A61K9/28 , A61K9/5026 , Y10S514/964
摘要： A sustained-release formulation of 5-acetyl-4,6-dimethyl-2-[2-[4-(2-methoxyphenyl)piperazinyl]ethylamino]pyrimidine trihydrochloride coated with a release-controlling film comprising a water-insoluble polymer film having no hydrophilic group. The formulation of the present invention has such a release pattern that the drug release lasts for 20 hours or more, so that can be appropriately administered for treatment. Furthermore, the formulation itself is so stable that its release pattern does not change with pH and the formulation does not suffer from deterioration, coloration and the like with the lapse of time.
摘要翻译：用包含具有不溶性聚合物膜的释放控制膜涂覆的5-乙酰基-4,6-二甲基-2- [2- [4-（2-甲氧基苯基）哌嗪基]乙基氨基]嘧啶三盐酸盐的缓释制剂，无亲水基团。本发明的制剂具有药物释放持续20小时以上的释放模式，因此可以适当地施用于治疗。此外，制剂本身是稳定的，其释放模式不随pH变化，并且制剂随时间流逝不会劣化，着色等。

2. 发明授权

US07041317B2 Sustained-release preparation containing 5-acetyl-4,6-dimethyl-2[2-[4-(2-methoxyphenyl) piperazinyl]ethylamino] pyrimidine trihydrochloride as active ingredient 失效
标题翻译：含有5-乙酰基-4,6-二甲基-2 [2- [4-（2-甲氧基苯基）哌嗪基]乙基氨基]嘧啶三盐酸盐作为有效成分的缓释制剂
公开(公告)号：US07041317B2
公开(公告)日：2006-05-09
申请号：US10399686
申请日：2001-10-22
申请人： Noboru Sekiya , Yoshinori Ii , Masayuki Ishikawa , Hiroshi Azuma
发明人： Noboru Sekiya , Yoshinori Ii , Masayuki Ishikawa , Hiroshi Azuma
IPC分类号： A61K9/22 , A61K9/20
CPC分类号： A61K31/506 , A61K9/167 , A61K9/28 , A61K9/5026 , Y10S514/964
摘要： A sustained-release formulation of 5-acetyl-4,6-dimethyl-2-[2-[4-(2-methoxyphenyl)piperazinyl]ethylamino]pyrimidine trihydrochloride coated with a release-controlling film comprising a water-insoluble polymer film having no hydrophilic group. The formulation of the present invention has such a release pattern that the drug release lasts for 20 hours or more, so that can be appropriately administered for treatment. Furthermore, the formulation itself is so stable that its release pattern does not change with pH and the formulation does not suffer from deterioration, coloration and the like with the lapse of time.
摘要翻译：用包含具有不溶性聚合物膜的释放控制膜涂覆的5-乙酰基-4,6-二甲基-2- [2- [4-（2-甲氧基苯基）哌嗪基]乙基氨基]嘧啶三盐酸盐的缓释制剂，无亲水基团。本发明的制剂具有药物释放持续20小时以上的释放模式，因此可以适当地施用于治疗。此外，制剂本身是稳定的，其释放模式不随pH变化，并且制剂随时间流逝不会劣化，着色等。

3. 发明授权

US5145851A Method for treating urinary obstruction 失效
标题翻译：治疗尿路梗阻的方法
公开(公告)号：US5145851A
公开(公告)日：1992-09-08
申请号：US780405
申请日：1991-10-17
申请人： Masayuki Ishikawa , Hiroshi Azuma , Shigeru Ito , Tomohiro Yamaguchi
发明人： Masayuki Ishikawa , Hiroshi Azuma , Shigeru Ito , Tomohiro Yamaguchi
IPC分类号： C07D239/54 , A61K31/495 , A61K31/505 , A61K31/52 , A61P13/02 , A61P15/00
CPC分类号： A61K31/505
摘要： 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl)propyl]-amino]-1,3-dimethyluracil can be used as a therapeutic agent for urinary obstruction.
摘要翻译： 6 - [[3- [4-（2-甲氧基苯基）-1-哌嗪基）丙基] - 氨基] -1,3-二甲基丙烯酰胺可用作尿路梗阻的治疗剂。

4. 发明授权

US5075308A Method for treating urinary obstruction 失效
标题翻译：治疗尿路梗阻的方法
公开(公告)号：US5075308A
公开(公告)日：1991-12-24
申请号：US480237
申请日：1990-02-15
申请人： Masayuki Ishikawa , Hiroshi Azuma , Shigeru Ito
发明人： Masayuki Ishikawa , Hiroshi Azuma , Shigeru Ito
IPC分类号： C07D239/42 , A61K31/505 , A61P7/10 , A61P13/02 , A61P15/00 , C07D239/47 , C07D239/48
CPC分类号： A61K31/505
摘要： A method for treating urinary obstruction by administering a 2-(4-phenyl-1-piperazinylalkyl)aminopyrimidine derivative represented by the formula ##STR1## wherein R.sub.1 and R.sub.3 may be the same or different and independently represent hydrogen, halogen, an amino group, a hydroxyl group, a straight or branched chain lower alkyl group, a straight or branched chain lower alkoxy group, or a straight or branched chain hydroxy-lower alkyl group, R.sub.2 represents hydrogen, halogen, a carboxyl group, a straight or branched chain lower alkyl group, a straight or branched chain lower alkylcarbonyl group, or a straight or branched chain lower alkyloxycarbonyl group, R.sub.4 and R.sub.5 may be the same or different and independently represent hydrogen, halogen, a straight or branched chain lower alkyl group, or a straight or branched chain lower alkoxy group, and n represents an integer of 2 to 6 or a pharmaceutically acceptable acid addition salt thereof to a mammal including a human afflicted with urinary obstruction. The aminopyrimidine derivatives have a selective activity on the .alpha..sub.1 -adrenoceptors in the urinary tracts.
摘要翻译：一种通过施用式（IMAGE）表示的2-（4-苯基-1-哌嗪基烷基）氨基嘧啶衍生物治疗尿路梗阻的方法，其中R 1和R 3可以相同或不同并且独立地表示氢，卤素，氨基，羟基，直链或支链低级烷基，直链或支链低级烷氧基，或直链或支链羟基 - 低级烷基，R2表示氢，卤素，羧基，直链或支链低级烷基，直链或支链低级烷基羰基，或直链或支链低级烷氧基羰基，R4和R5可以相同或不同，独立地代表氢，卤素，直链或支链低级烷基或直链或支链低级烷氧基，n表示2〜6的整数或其药学上可接受的酸加成盐，其包括患有尿阻碍的人的哺乳动物离子。氨基嘧啶衍生物对尿道中的α1-肾上腺素能受体具有选择性活性。

5. 发明授权

US4517189A 2,6,7,8-Substituted quinazolines, process for production thereof, and use thereof 失效
标题翻译： 2,6,7,8-取代的喹唑啉，其制备方法及其用途
公开(公告)号：US4517189A
公开(公告)日：1985-05-14
申请号：US519235
申请日：1983-08-02
申请人： Masayuki Ishikawa , Hiroshi Azuma , Akiko Sugimoto , Noriko Takahashi , Yoshimi Takashima
发明人： Masayuki Ishikawa , Hiroshi Azuma , Akiko Sugimoto , Noriko Takahashi , Yoshimi Takashima
IPC分类号： C07D239/74 , A61K31/505
CPC分类号： C07D239/74
摘要： A 2,6,7,8-substituted quinazoline represented by the following formula ##STR1## wherein R.sub.1 and R.sub.3 each represent a lower alkyl group, R.sub.2 represents a lower alkoxy-carbonyl group, and A represents a lower alkyl group, or a phenyl or benzyl group which is unsubstituted or substituted by a substituent selected from the class consisting of halogen atoms, a trifluoromethyl group and lower alkyl groups, or its acid addition salt. The said compound can be prepared by reacting a compound represented by the following formula ##STR2## wherein R.sub.1, R.sub.2, R.sub.3 and A are as defined, with ammonia. A pharmaceutical composition comprising the said compound as an active ingredient is useful for the treatment of disorders of the circulatory system.
摘要翻译：由下式[IMAGE]表示的2,6,7,8-取代喹唑啉其中R1和R3各自表示低级烷基，R2表示低级烷氧基 - 羰基，A表示低级烷基或苯基或未取代或被选自卤素原子，三氟甲基和低级烷基的取代基取代的苄基或其酸加成盐。所述化合物可以通过使下式（其中R 1，R 2，R 3和A如上所定义）与氨反应的化合物制备。包含所述化合物作为活性成分的药物组合物可用于治疗循环系统疾病。

6. 发明授权

US08904772B2 Engine exhaust gas heat exchanger and energy supplying device using the same 有权
标题翻译：发动机废气换热器和使用其的能量供应装置
公开(公告)号：US08904772B2
公开(公告)日：2014-12-09
申请号：US13583774
申请日：2011-03-10
申请人： Hiroshi Azuma , Kosuke Matsuura
发明人： Hiroshi Azuma , Kosuke Matsuura
IPC分类号： F01N3/02 , F01N3/28 , F01N5/02 , F28F9/02 , F28F13/02 , F28F13/06 , F28D7/00 , F28D7/10 , F28F1/10 , F28D21/00
CPC分类号： F01N3/2889 , F01N5/02 , F01N2260/08 , F01N2470/04 , F01N2470/18 , F01N2470/24 , F28D7/0066 , F28D7/103 , F28D7/106 , F28D21/0003 , F28F1/10 , F28F9/0246 , F28F13/02 , F28F13/06 , F28F2265/26 , Y02B30/52 , Y02T10/16
摘要： Regarding an engine exhaust gas heat exchanger that allows exhaust gas to collide with a coolant passage through apertures, a configuration that can improve efficiency of heat exchange is provided. The engine exhaust gas heat exchanger 1 is provided with multiple stages of unit exhaust gas passages 3a, 3b, 3c that are configured with a first exhaust gas passage A in which a plane facing an inlet is blocked and that has a plurality of apertures 30 in a circumferential direction and in a flow direction, and a second exhaust gas passage B that has a dividing wall facing the apertures 30 and also serving as the coolant passage 20 and an outlet that also serves as an inlet of the first exhaust gas passage A of a next stage or an outlet 26 of the engine exhaust gas heat exchanger 1.
摘要翻译：关于允许废气与通过孔的冷却剂通道碰撞的发动机排气热交换器，提供了可以提高热交换效率的构造。发动机废气热交换器1具有多级单元排气通路3a，3b，3c，其具有第一排气通道A，其中面向入口的面被封闭，并且具有多个孔30 圆周方向和流动方向的第二排气通道A和第二排气通道B，其具有面向孔30并且还用作冷却剂通道20的分隔壁和还用作第一排气通道A的入口的出口发动机排气热交换器1的下一级或出口26。

7. 发明授权

US07860237B2 Information input device, and electronic apparatus using the same 失效
标题翻译：信息输入装置以及使用其的电子装置
公开(公告)号：US07860237B2
公开(公告)日：2010-12-28
申请号：US10476762
申请日：2002-05-31
申请人： Kouichiro Takashima , Shun Kayama , Yasuhiro Kataoka , Hiroshi Azuma , Yoshihiro Tanabe , Tsuyoshi Uchida
发明人： Kouichiro Takashima , Shun Kayama , Yasuhiro Kataoka , Hiroshi Azuma , Yoshihiro Tanabe , Tsuyoshi Uchida
IPC分类号： H04M9/00 , H04M1/00
CPC分类号： G06F3/04842 , G01D5/145 , G06F3/0338 , G06F3/0362 , G06F3/0482 , G06F3/0485 , G06F2203/04806 , H01H25/008 , H01H25/065 , H01H2003/506 , H01H2019/146 , H01H2231/022 , H04M1/233 , H04M1/274525 , H04M1/72583
摘要： An information input device is provided which is to make input of information by operating a disk-shaped rotating member. The device includes the rotating member (36) which is rotatable with one main side thereof being operated, rotation detecting means (23, 32) for detecting a rotation of the rotating member (36), a central switch activator (26) provided at the center of rotation of the rotating member (36), a central switch (270) which is activated by operating the central switch activator (26), and a plurality of peripheral switches (27) which are turned on when a portion, apart from the center of rotation, of the rotating member (36) is pressed. Rotating the rotating member and pressing the apart portion makes input of information, and operating the central switch activator sets the information thus entered.
摘要翻译：提供一种信息输入装置，其通过操作盘形旋转构件来进行信息输入。该装置包括可旋转的旋转构件（36），其一个主侧被操作，用于检测旋转构件（36）的旋转的旋转检测装置（23,32），设置在该旋转构件旋转构件（36）的旋转中心，通过操作中心开关启动器（26）而启动的中央开关（270）和多个外围开关（27），当外部开关旋转构件（36）的旋转中心被按压。旋转旋转构件并按压分开部分进行信息输入，并且操作中央开关启动器设置由此输入的信息。

8. 发明申请

US20100188372A1 Information input device, and electronic apparatus using same 失效
标题翻译：信息输入装置和使用它的电子装置
公开(公告)号：US20100188372A1
公开(公告)日：2010-07-29
申请号：US12662030
申请日：2010-03-29
申请人： Kouichiro Takashima , Shun Kayama , Yasuhiro Kataoka , Hiroshi Azuma , Yoshihiro Tanabe , Tsuyoshi Uchida
发明人： Kouichiro Takashima , Shun Kayama , Yasuhiro Kataoka , Hiroshi Azuma , Yoshihiro Tanabe , Tsuyoshi Uchida
IPC分类号： G09G5/00
CPC分类号： G06F3/04842 , G01D5/145 , G06F3/0338 , G06F3/0362 , G06F3/0482 , G06F3/0485 , G06F2203/04806 , H01H25/008 , H01H25/065 , H01H2003/506 , H01H2019/146 , H01H2231/022 , H04M1/233 , H04M1/274525 , H04M1/72583
摘要： An information input device is provided which is to make input of information by operating a disk-shaped rotating member. The device includes the rotating member (36) which is rotatable with one main side thereof being operated, rotation detecting means (23, 32) for detecting a rotation of the rotating member (36), a central switch activator (26) provided at the center of rotation of the rotating member (36), a central switch (270) which is activated by operating the central switch activator (26), and a plurality of peripheral switches (27) which are turned on when a portion, apart from the center of rotation, of the rotating member (36) is pressed. Rotating the rotating member and pressing the apart portion makes input of information, and operating the central switch activator sets the information thus entered.
摘要翻译：提供一种信息输入装置，其通过操作盘形旋转构件来进行信息输入。该装置包括可旋转的旋转构件（36），其一个主侧被操作，用于检测旋转构件（36）的旋转的旋转检测装置（23,32），设置在该旋转构件旋转构件（36）的旋转中心，通过操作中心开关启动器（26）而启动的中央开关（270）和多个外围开关（27），当外部开关旋转构件（36）的旋转中心被按压。旋转旋转构件并按压分开部分进行信息输入，并且操作中央开关启动器设置由此输入的信息。

9. 发明授权

US07161269B2 Vibration generator and electronic apparatus 有权
标题翻译：振动发生器及电子仪器
公开(公告)号：US07161269B2
公开(公告)日：2007-01-09
申请号：US10522337
申请日：2004-06-03
申请人： Shun Kayama , Yukiko Shimizu , Masahiro Suzuki , Toshinori Yamasue , Hiroshi Azuma , Hirokazu Kitamura
发明人： Shun Kayama , Yukiko Shimizu , Masahiro Suzuki , Toshinori Yamasue , Hiroshi Azuma , Hirokazu Kitamura
IPC分类号： H02K7/06
CPC分类号： B06B1/045 , G10K9/13 , H02K5/1677 , H02K7/063 , H02K7/09
摘要： There is provided a vibration generator (40) in which a rotor with an unbalancer is rotated. The vibration generator includes a bottom plate (47) having a flat coil substrate (120) installed thereto, a stationary shaft (91) provided perpendicularly to the bottom plate, a magnet (85) installed on the stationary shaft (91) with a freely rotatable bearing being disposed between them and opposite to the surface of the flat coil substrate (120) with a slight clearance defined between them, and a weight (87) installed to the magnet (85). For generating a vibration, a current is supplied to the coil on the flat coil substrate (120) to rotate the magnet (85) and weight (87). The bottom plate (47) is formed from a nonmagnetic material. A thin magnetic plate (48) is installed at the side opposite to the magnet (85) with the bottom plate (47) being placed between the thin magnetic plate (48) and magnet (85).
摘要翻译：提供了一种振动发生器（40），其中具有不平衡器的转子旋转。所述振动发生器包括具有安装在其上的扁平线圈基板（120）的底板（47），垂直于所述底板设置的固定轴（91），具有自由地安装在所述固定轴（91）上的磁体（85）可旋转轴承设置在它们之间并且在它们之间具有微小间隙并且安装到磁体（85）上的重物（87）布置在平面线圈基板（120）的表面上。为了产生振动，向扁平线圈基板（120）上的线圈提供电流以使磁体（85）和重物（87）旋转。底板（47）由非磁性材料形成。薄磁板（48）安装在与磁体（85）相对的一侧，底板（47）位于薄磁板（48）和磁体（85）之间。

10. 发明授权

US08724068B2 Liquid crystal display device 有权
标题翻译：液晶显示装置
公开(公告)号：US08724068B2
公开(公告)日：2014-05-13
申请号：US13276675
申请日：2011-10-19
申请人： Hiroshi Azuma , Hideyuki Takahashi
发明人： Hiroshi Azuma , Hideyuki Takahashi
IPC分类号： G02F1/1343
CPC分类号： G02F1/136286 , G02F1/133784 , G02F1/134309
摘要： According to one embodiment, a liquid crystal display device includes a first substrate including a gate line extending in a first direction, a source line including an oblique line portion extending in a third direction which crosses at an acute angle a second direction perpendicular to the first direction, a pixel electrode including an oblique electrode portion extending in the third direction, and a first alignment film covering the pixel electrode, a second substrate including a counter-electrode which is opposed to the pixel electrode, and a second alignment film covering the counter-electrode, and a liquid crystal layer held between the first substrate and the second substrate. A first rubbing direction of the first alignment film is a direction which crosses the third direction at an acute angle, and an angle formed between the first rubbing direction and the third direction is 3.6° or more.
摘要翻译：根据一个实施例，液晶显示装置包括：第一基板，包括沿第一方向延伸的栅极线;源极线，包括沿与第一方向垂直的第二方向以锐角交叉的第三方向延伸的斜线部分; 方向，包括在第三方向上延伸的倾斜电极部分的像素电极和覆盖像素电极的第一取向膜，包括与像素电极相对的对置电极的第二基板和覆盖该计数器的第二取向膜电极和保持在第一基板和第二基板之间的液晶层。第一取向膜的第一摩擦方向是以锐角与第三方向交叉的方向，并且在第一摩擦方向和第三方向之间形成的角度为3.6°以上。

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