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1. 发明授权

US5985177A O/W/O type multiple emulsion and method of preparing the same 失效
标题翻译： O / W / O型多重乳液及其制备方法
公开(公告)号：US5985177A
公开(公告)日：1999-11-16
申请号：US739146
申请日：1996-10-28
申请人： Katsunori Yoshida , Toshio Yanaki , Michihiro Yamaguchi , Hiroko Watanabe , Takafumi Kurosawa , Kenzo Ito
发明人： Katsunori Yoshida , Toshio Yanaki , Michihiro Yamaguchi , Hiroko Watanabe , Takafumi Kurosawa , Kenzo Ito
IPC分类号： A61K8/06 , A61K9/113 , A61Q19/00 , A61K7/44 , B01J13/00
CPC分类号： A61K9/113 , A61K8/066 , A61Q19/00 , A61Q17/04
摘要： This invention relates to an oil-in-water-in-oil (O/W/O) type multiple emulsion which contains an inner oil phase, a water phase, and an outer oil phase. The inner oil phase is first dispersed in water to form an oil-in-water (O/W) emulsion. Then, the O/W emulsion is further dispersed in the outer oil phase to form the O/W/O type multiple emulsion. The outer oil phase contains an organophilic clay mineral, which can effectively prevent the inter-mixing of the inner oil phase with the outer oil phase, thus, producing an O/W/O type multiple emulsion with excellent storage stability. Upon the using of an oil-soluble compound in the inner oil phase, this multiple emulsion system can prevent the oil-soluble compound from being oxidized. In addition, since different kinds of oils can be selected for the making of the inner and outer oil phases, respectively, the O/W/O type multiple emulsion system allows one to present two different kinds of oils, which have different properties independent from each other, in one emulsion system.
摘要翻译：本发明涉及含油内油相，水相和外油相的油包水包油型（O / W / O）型多重乳液。内部油相首先分散在水中以形成水包油（O / W）乳液。然后，O / W乳液进一步分散在外部油相中以形成O / W / O型多重乳液。外油相含有亲有机质的粘土矿物，可有效防止内油相与外油相的相互混合，从而生产出具有良好储存稳定性的O / W / O型多重乳液。在内油相中使用油溶性化合物时，该多重乳液体系可以防止油溶性化合物被氧化。另外，由于可以分别选择不同种类的油来制造内外油相，所以O / W / O型多重乳液体系允许呈现两种不同种类的油，它们具有独立于在一个乳液系统中。

2. 发明授权

US5579769A Coupling medium for probe of ultrasonograph 失效
标题翻译：超声波探头用耦合介质
公开(公告)号：US5579769A
公开(公告)日：1996-12-03
申请号：US284420
申请日：1994-08-02
申请人： Katsunori Yoshida , Toshio Yanaki , . Michihiro Yamaguchi
发明人： Katsunori Yoshida , Toshio Yanaki , . Michihiro Yamaguchi
IPC分类号： A61K49/22 , C08J3/075 , C08L5/00 , C08L5/04 , G10K11/02 , A61B8/00
CPC分类号： C08J3/075 , A61K49/226 , C08L5/00 , G10K11/02 , C08J2305/00 , C08L5/04
摘要： A coupling medium for a probe of an ultrasonograph comprising a gel composed of .beta.-1,3 glucan as the main component, or a gel obtained by high pressure treatment or chemical cross-linking of the same, or a gel containing .beta.-1,3 glucan and a complex forming compound capable of forming a complex with .beta.-1,3 glucan.
摘要翻译： PCT No.PCT / JP93 / 01759 Sec。 371日期1994年8月2日 102（e）日期1994年8月2日PCT 1993年12月2日PCT公布。出版物WO94 / 12105 PCT 日期1994年6月9日，包含由β-1,3-葡聚糖作为主要成分的凝胶的超声波检查用探针的偶联介质，或通过高压处理或其化学交联得到的凝胶，或凝胶含有β-1,3葡聚糖和能够与β-1,3葡聚糖形成复合物的络合物形成化合物。

3. 发明授权

US5817155A Emulsion for hair treatment 失效
标题翻译：乳液用于头发处理
公开(公告)号：US5817155A
公开(公告)日：1998-10-06
申请号：US761387
申请日：1996-12-06
申请人： Masaaki Yasuda , Yasuhiro Arai , Fumiaki Matsuzaki , Toshio Yanaki , Hideo Nakajima , Michihiro Yamaguchi , Kimio Ohno
发明人： Masaaki Yasuda , Yasuhiro Arai , Fumiaki Matsuzaki , Toshio Yanaki , Hideo Nakajima , Michihiro Yamaguchi , Kimio Ohno
IPC分类号： A61K7/06 , A61K7/13
CPC分类号： A61K8/06 , A61K8/342 , A61K8/731 , A61Q5/10
摘要： An emulsion for hair treatment is provided which is characterized by the following: the formulation (I) is composed of a W/O type emulsion, which allows the main agent to be stable, and contains preferably an oil soluble polymer compound for the emulsifier; the formulation (I), upon being mixed with formulation (II), can easily undergo demulsification and a phase inversion into an O/W type emulsion; and the emulsion has adequate viscosity to prevent dripping from the hair and a superior dyeing capability. Also, 2-formulation type oxidation hair dye with an excellent hair dyeing effect is provided by adding isostearyl alcohol.
摘要翻译：提供了一种用于头发处理的乳液，其特征在于：制剂（I）由W / O型乳液组成，其允许主剂稳定，并且优选含有用于乳化剂的油溶性高分子化合物; 制剂（I）在与制剂（II）混合后可容易地发生破乳和相转化成O / W型乳液; 并且乳液具有足够的粘度以防止从头发滴落和优异的染色能力。此外，通过加入异硬脂醇提供具有优异染发效果的2-配方型氧化染发剂。

4. 发明授权

US06440431B1 Cosmetic composition 有权
标题翻译：化妆品组成
公开(公告)号：US06440431B1
公开(公告)日：2002-08-27
申请号：US09464749
申请日：1999-12-16
申请人： Katsunori Yoshida , Toshio Yanaki , Isamu Kaneda
发明人： Katsunori Yoshida , Toshio Yanaki , Isamu Kaneda
IPC分类号： A61K700
CPC分类号： A61Q19/00 , A61K8/86 , A61K8/87 , A61K2800/48 , A61Q1/02 , A61Q3/02 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q17/04 , C08G18/283 , C08G18/4833 , C08G18/73
摘要： In order to provide a cosmetic composition which is excellent in stability of viscosity and usability, the cosmetic composition of the present invention comprises an associative thickener, which is composed of a compound shown in Formula (1), and the cosmetic composition is an oil-in-water emulsion composition, which further comprises a water-soluble polymer: R1—{(O—R2)k—OCONH—R3[—NHCOO—(R4—O)n—R5]h}m (1) wherein R1, R2, and R4 each is a hydrocarbon group, which may be the same or different each other; R3 is a hydrocarbon group, which may have urethane bond; R5 is a straight chain, branched chain or secondary hydrocarbon group; m is an integer of 2 or more; h is an integer of 1 or more; and k and n each is an integer within the range of 0 to 1000, respectively.
摘要翻译：为了提供粘度和用途的稳定性优异的化妆品组合物，本发明的化妆品组合物包括由式（1）所示的化合物组成的缔合增稠剂，并且化妆品组合物是油 - 水性乳液组合物，其还包含水溶性聚合物：其中R 1，R 2和R 4各自为烃基，其可以相同或不同; R3是可以具有氨基甲酸酯键的烃基; R5是直链，支链或次级烃基; m为2以上的整数， h为1以上的整数， k和n分别为0〜1000的整数。

5. 发明授权

US5849834A W/O type emulsified composition and cosmetic 失效
标题翻译： W / O型乳化组合物和化妆品
公开(公告)号：US5849834A
公开(公告)日：1998-12-15
申请号：US814183
申请日：1997-03-10
申请人： Fumiaki Matsuzaki , Toshio Yanaki , Michihiro Yamaguchi
发明人： Fumiaki Matsuzaki , Toshio Yanaki , Michihiro Yamaguchi
IPC分类号： A61K8/06 , A61K8/73 , A61Q5/00 , A61Q5/10 , A61Q17/04 , A61Q19/00 , C08J3/00
CPC分类号： A61Q19/00 , A61K8/06 , A61K8/064 , A61K8/731 , A61K2800/5422 , A61K2800/5426 , A61Q17/04 , A61Q5/00 , A61Q5/10
摘要： A W/O type emulsified composition comprising an oil phase containing ethyl cellulose and a solvent capable of swelling ethyl cellulose and a water phase containing a water soluble polymer(s) emulsified as a water-in-oil type (W/O type) emulsion. A W/O type emulsified composition comprising an oil phase containing ethyl cellulose and a solvent capable of swelling ethyl cellulose and a water phase containing a polyion complex comprising cationized cellulose and sodium hyaluronate emulsified as a water-in-oil type (W/O type) emulsion.
摘要翻译：一种W / O型乳化组合物，其包含含有乙基纤维素的油相和能够溶胀乙基纤维素的溶剂和含有作为油包水型（W / O型）乳液乳化的水溶性聚合物的水相。 AW / O型乳化组合物，其包含含有乙基纤维素的油相和能够溶胀乙基纤维素的溶剂和含有阳离子化纤维素和透明质酸钠的聚离子配位化合物的水相，其被乳化为油包水型（W / O型）乳液。

6. 发明授权

US5538728A Hydrophilic polymer-silicate mineral complex material and use thereof 失效
标题翻译：亲水性聚合物 - 硅酸盐矿物复合材料及其用途
公开(公告)号：US5538728A
公开(公告)日：1996-07-23
申请号：US46840
申请日：1993-04-14
申请人： Toshio Yanaki , Tadahito Takahashi , Yoko Nagasawa , Michihiro Yamaguchi
发明人： Toshio Yanaki , Tadahito Takahashi , Yoko Nagasawa , Michihiro Yamaguchi
IPC分类号： A61K8/26 , A61K8/81 , A61K9/00 , A61K47/02 , A61K47/32 , A61Q1/02 , A61Q19/00 , A61Q19/10 , C01B33/44 , C08K3/34 , A61K9/02
CPC分类号： A61K9/0014 , A61K47/02 , A61K47/32 , A61K8/26 , A61K8/8147 , A61Q19/00 , C01B33/44 , C08K3/34 , A61Q1/02 , A61Q19/10 , Y10S424/15 , Y10S514/892 , Y10S514/925 , Y10S514/937 , Y10S514/944 , Y10S514/966
摘要： A complex material of a hydrophilic polymer-silicate mineral comprising a carboxyl group containing hydrophilic polymer and a water swellable silicate mineral, and having a new absorption spectrum not existing in both starting materials in the IR-ray absorption spectrum within the range of 1000 to 1300 cm.sup.-1, and pharmaceutical and cosmetic compositions comprising same.
摘要翻译：亲水性聚合物 - 硅酸盐矿物的复合材料，其包含含羧基的亲水性聚合物和水溶胀性硅酸盐矿物，并且在IR-射线吸收光谱中的原始材料中不存在1000至1300范围内的新吸收光谱 cm -1，以及包含它们的药物和化妆品组合物。

7. 发明授权

US06649154B1 Hairdressing cosmetic preparation and hairdressing method using the same 失效
标题翻译：理发美容准备和美发方法使用相同
公开(公告)号：US06649154B1
公开(公告)日：2003-11-18
申请号：US09584338
申请日：2000-06-01
申请人： Katsunori Yoshida , Daigo Mizumoto , Tomoyuki Kawasoe , Yoshiharu Tsuji , Toshio Yanaki , Masaaki Uemura , Kaoru Ichikawa , Hideko Saito
发明人： Katsunori Yoshida , Daigo Mizumoto , Tomoyuki Kawasoe , Yoshiharu Tsuji , Toshio Yanaki , Masaaki Uemura , Kaoru Ichikawa , Hideko Saito
IPC分类号： A61K706
CPC分类号： A61Q5/06 , A61K8/73 , A61K2800/24 , A61K2800/244
摘要： The hairdressing cosmetic preparation of the present invention is characterized by comprising a heat-gelling polymer which becomes to gel upon heating. The gelling temperature of the heat-gelling polymer is preferably 60° C. or higher. Preferable heat-gelling polymer is polysaccharides such as &bgr;-1,3-glucan, &bgr;-1,3-xylan, curdlan and the like. The hair dressing preparation of the present invention, due to using such heat-gelling polymer, can give excellent hairdressing effect and hair-setting power when hair applied with the hairdressing preparation is treated with heating.
摘要翻译：本发明的美发化妆品的特征在于包含在加热时凝胶化的热凝胶聚合物。热凝胶聚合物的凝胶化温度优选为60℃以上。优选的热凝胶聚合物是诸如β-1,3-葡聚糖，β-1,3-木聚糖，凝胶多糖等多糖。由于使用这样的热凝胶聚合物，本发明的发型制剂在加热处理美发制品的毛发时可以赋予优异的美发效果和发丝功能。

8. 发明授权

US6150425A O/W/O type multiphase emulsion 有权
标题翻译： O / W / O型多相乳液
公开(公告)号：US6150425A
公开(公告)日：2000-11-21
申请号：US147821
申请日：1999-03-15
申请人： Tomoko Sekine , Fumiaki Matsuzaki , Toshio Yanaki , Michihiro Yamaguchi
发明人： Tomoko Sekine , Fumiaki Matsuzaki , Toshio Yanaki , Michihiro Yamaguchi
IPC分类号： A61K8/06 , A61K9/113 , A61Q19/00 , B01F17/28 , B01F3/08 , B01F17/54
CPC分类号： A61Q19/00 , A61K8/066 , A61K9/113 , Y10S514/941 , Y10S514/943 , Y10S514/944 , Y10S514/975 , Y10S516/902
摘要： An O/W/O type multiple emulsion in which an O/W type emulsion is dispersed in the outer phase oil wherein the O/W type emulsion in the inner phase contains water, an oil based ingredient, a surfactant and an amphiphilic substance chosen from those which can form a gel at ordinal temperature or higher in an amphiphilic substance-surfactant-oil-water system or N-long chain acyl acidic amino acid monosalt and an amphiphilic substance chosen from those which can form a gel at ordinal temperature or higher in an amphiphilic substance-N-long chain acyl acidic amino acid monosalt-oil-water system, said outer phase oil contains organophilic modified clay minerals and an emulsifying agent with a HLB of 7 or lower, and the weight ratio of the O/W type emulsion and the outer phase oil is 2:3-19:1. An O/W/O type multiple emulsion with superior stability over time and good usability.
摘要翻译： PCT No.PCT / JP98 / 03187 Sec。 371 1999年3月15日 102（e）1999年3月15日PCT提交1998年7月15日PCT公布。公开号WO99 / 03572 日期1999年1月28日其中O / W型乳液分散在外相油中的O / W / O型多重乳液，其中内相中的O / W型乳液含有水，油基成分，表面活性剂和两亲物质，其选自可以在两亲物质 - 表面活性剂 - 油 - 水体系或N-长链酰基酸性氨基酸单糖盐和选自可以形成凝胶的那些的两亲物质中在顺序温度或更高温度下形成凝胶的物质在两亲物质N-长链酰基酸性氨基酸单糖 - 油 - 水系统中的序数温度以上，所述外相油含有亲有机质改性粘土矿物和HLB为7以下的乳化剂，重量比的O / W型乳液和外相油为2:3-19:1。一种O / W / O型多重乳液，具有优异的稳定性和良好的使用性。

9. 发明授权

US5679657A Low molecular weight acetylhyaluronate, skin-softening composition, method of manufacturing the same, and method of purifying the same 失效
标题翻译：低分子量乙酰透明质酸盐，皮肤软化组合物，其制造方法及其纯化方法
公开(公告)号：US5679657A
公开(公告)日：1997-10-21
申请号：US624634
申请日：1996-08-02
申请人： Takashi Oka , Toshio Yanaki , Michihiro Yamaguchi
发明人： Takashi Oka , Toshio Yanaki , Michihiro Yamaguchi
IPC分类号： A61K8/73 , A61Q19/00 , C08B37/08 , A61K31/715 , C07H1/00 , C07H5/06 , C07H13/04
CPC分类号： A61Q19/00 , A61K8/735 , C08B37/0072 , A61Q19/10 , A61Q5/00
摘要： Low molecular weight acetylhyaluronate has the following characteristics: intrinsic viscosity: 50 to 200 cm.sup.3 /g substitution degree of acetyl group: 2.6 to 3.6 (excluding N-acetyl group) A skin-softening composition is mainly composed of this low molecular weight acetylhyaluronate. It can exhibit excellent skin-softening effect and moisturizing effect, while appropriately suppressing the thread-forming ability inherent in hyaluronic acid. A method of manufacturing acetylhyaluronate comprises the steps of suspending hyaluronic acid powder in an acetic anhydride solvent and then adding concentrated sulfuric acid thereto to effect acetylation. A method of purifying acetylhyaluronate comprises the steps of adding raw acetylhyaluronate to an aqueous acetone solution, adding and dissolving sodium lactate therein, and then adding highly concentrated acetone thereto to precipitate highly pure acetylhyaluronate. Acetylhyaluronate having highly purity can be obtained inexpensively.
摘要翻译： PCT No.PCT / JP95 / 01613 Sec。 371日期：1996年8月2日 102（e）日期1996年8月2日PCT提交1995年8月11日PCT公布。公开号WO96 / 05233 日期：1996年2月22日低分子量乙酰透明质酸盐具有以下特征：特性粘度：50〜200cm 3 / g乙酰基取代度：2.6〜3.6（不含N-乙酰基）皮肤柔软性组合物主要由该低分子量乙酰透明质酸盐。它可以表现出优异的皮肤软化效果和保湿效果，同时适当地抑制透明质酸固有的丝线形成能力。制造乙酰透明质酸盐的方法包括将透明质酸粉末悬浮于乙酸酐溶剂中，然后向其中加入浓硫酸进行乙酰化的步骤。一种纯化乙酰透明质酸的方法包括以下步骤：向丙酮水溶液中加入原料乙酰透明质酸盐，加入乳酸钠溶解并溶解，然后加入高浓度的丙酮以沉淀出高纯度的乙酰基透明质酸盐。可以廉价地获得高纯度的乙酰基乙酸酯。

10. 发明授权

US5532305A Controlled release preparation for bioactive substances 失效
标题翻译：生物活性物质的控制释放制剂
公开(公告)号：US5532305A
公开(公告)日：1996-07-02
申请号：US280736
申请日：1994-07-26
申请人： Fumiaki Matsuzaki , Toshio Yanaki , Michihiro Yamaguchi
发明人： Fumiaki Matsuzaki , Toshio Yanaki , Michihiro Yamaguchi
IPC分类号： A61K9/00 , A61K9/20 , A61K31/405 , A61K31/435 , A61K47/32 , A61K47/36 , A61P11/14 , A61P25/04 , A61P29/00 , C08B37/08 , C08F20/06 , A61K47/00
CPC分类号： A61K9/2027 , A61K9/205
摘要： To provide a base suitable for a controlled release preparation and the controlled release preparation. A bioactive substance(s) is introduced in a poly-ion complex of hyaluronic acid and a cationic polyacrylic acid derivative(s).
摘要翻译：提供适用于控制释放制剂和控制释放制剂的碱。将生物活性物质引入透明质酸和阳离子聚丙烯酸衍生物的多离子络合物中。

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