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    • 3. 发明授权
    • O/W/O type multiple emulsion and method of preparing the same
    • O / W / O型多重乳液及其制备方法
    • US5985177A
    • 1999-11-16
    • US739146
    • 1996-10-28
    • Katsunori YoshidaToshio YanakiMichihiro YamaguchiHiroko WatanabeTakafumi KurosawaKenzo Ito
    • Katsunori YoshidaToshio YanakiMichihiro YamaguchiHiroko WatanabeTakafumi KurosawaKenzo Ito
    • A61K8/06A61K9/113A61Q19/00A61K7/44B01J13/00
    • A61K9/113A61K8/066A61Q19/00A61Q17/04
    • This invention relates to an oil-in-water-in-oil (O/W/O) type multiple emulsion which contains an inner oil phase, a water phase, and an outer oil phase. The inner oil phase is first dispersed in water to form an oil-in-water (O/W) emulsion. Then, the O/W emulsion is further dispersed in the outer oil phase to form the O/W/O type multiple emulsion. The outer oil phase contains an organophilic clay mineral, which can effectively prevent the inter-mixing of the inner oil phase with the outer oil phase, thus, producing an O/W/O type multiple emulsion with excellent storage stability. Upon the using of an oil-soluble compound in the inner oil phase, this multiple emulsion system can prevent the oil-soluble compound from being oxidized. In addition, since different kinds of oils can be selected for the making of the inner and outer oil phases, respectively, the O/W/O type multiple emulsion system allows one to present two different kinds of oils, which have different properties independent from each other, in one emulsion system.
    • 本发明涉及含油内油相,水相和外油相的油包水包油型(O / W / O)型多重乳液。 内部油相首先分散在水中以形成水包油(O / W)乳液。 然后,O / W乳液进一步分散在外部油相中以形成O / W / O型多重乳液。 外油相含有亲有机质的粘土矿物,可有效防止内油相与外油相的相互混合,从而生产出具有良好储存稳定性的O / W / O型多重乳液。 在内油相中使用油溶性化合物时,该多重乳液体系可以防止油溶性化合物被氧化。 另外,由于可以分别选择不同种类的油来制造内外油相,所以O / W / O型多重乳液体系允许呈现两种不同种类的油,它们具有独立于 在一个乳液系统中。