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1. 发明授权

US5538728A Hydrophilic polymer-silicate mineral complex material and use thereof 失效
标题翻译：亲水性聚合物 - 硅酸盐矿物复合材料及其用途
公开(公告)号：US5538728A
公开(公告)日：1996-07-23
申请号：US46840
申请日：1993-04-14
申请人： Toshio Yanaki , Tadahito Takahashi , Yoko Nagasawa , Michihiro Yamaguchi
发明人： Toshio Yanaki , Tadahito Takahashi , Yoko Nagasawa , Michihiro Yamaguchi
IPC分类号： A61K8/26 , A61K8/81 , A61K9/00 , A61K47/02 , A61K47/32 , A61Q1/02 , A61Q19/00 , A61Q19/10 , C01B33/44 , C08K3/34 , A61K9/02
CPC分类号： A61K9/0014 , A61K47/02 , A61K47/32 , A61K8/26 , A61K8/8147 , A61Q19/00 , C01B33/44 , C08K3/34 , A61Q1/02 , A61Q19/10 , Y10S424/15 , Y10S514/892 , Y10S514/925 , Y10S514/937 , Y10S514/944 , Y10S514/966
摘要： A complex material of a hydrophilic polymer-silicate mineral comprising a carboxyl group containing hydrophilic polymer and a water swellable silicate mineral, and having a new absorption spectrum not existing in both starting materials in the IR-ray absorption spectrum within the range of 1000 to 1300 cm.sup.-1, and pharmaceutical and cosmetic compositions comprising same.
摘要翻译：亲水性聚合物 - 硅酸盐矿物的复合材料，其包含含羧基的亲水性聚合物和水溶胀性硅酸盐矿物，并且在IR-射线吸收光谱中的原始材料中不存在1000至1300范围内的新吸收光谱 cm -1，以及包含它们的药物和化妆品组合物。

2. 发明授权

US5849834A W/O type emulsified composition and cosmetic 失效
标题翻译： W / O型乳化组合物和化妆品
公开(公告)号：US5849834A
公开(公告)日：1998-12-15
申请号：US814183
申请日：1997-03-10
申请人： Fumiaki Matsuzaki , Toshio Yanaki , Michihiro Yamaguchi
发明人： Fumiaki Matsuzaki , Toshio Yanaki , Michihiro Yamaguchi
IPC分类号： A61K8/06 , A61K8/73 , A61Q5/00 , A61Q5/10 , A61Q17/04 , A61Q19/00 , C08J3/00
CPC分类号： A61Q19/00 , A61K8/06 , A61K8/064 , A61K8/731 , A61K2800/5422 , A61K2800/5426 , A61Q17/04 , A61Q5/00 , A61Q5/10
摘要： A W/O type emulsified composition comprising an oil phase containing ethyl cellulose and a solvent capable of swelling ethyl cellulose and a water phase containing a water soluble polymer(s) emulsified as a water-in-oil type (W/O type) emulsion. A W/O type emulsified composition comprising an oil phase containing ethyl cellulose and a solvent capable of swelling ethyl cellulose and a water phase containing a polyion complex comprising cationized cellulose and sodium hyaluronate emulsified as a water-in-oil type (W/O type) emulsion.
摘要翻译：一种W / O型乳化组合物，其包含含有乙基纤维素的油相和能够溶胀乙基纤维素的溶剂和含有作为油包水型（W / O型）乳液乳化的水溶性聚合物的水相。 AW / O型乳化组合物，其包含含有乙基纤维素的油相和能够溶胀乙基纤维素的溶剂和含有阳离子化纤维素和透明质酸钠的聚离子配位化合物的水相，其被乳化为油包水型（W / O型）乳液。

3. 发明授权

US5985177A O/W/O type multiple emulsion and method of preparing the same 失效
标题翻译： O / W / O型多重乳液及其制备方法
公开(公告)号：US5985177A
公开(公告)日：1999-11-16
申请号：US739146
申请日：1996-10-28
申请人： Katsunori Yoshida , Toshio Yanaki , Michihiro Yamaguchi , Hiroko Watanabe , Takafumi Kurosawa , Kenzo Ito
发明人： Katsunori Yoshida , Toshio Yanaki , Michihiro Yamaguchi , Hiroko Watanabe , Takafumi Kurosawa , Kenzo Ito
IPC分类号： A61K8/06 , A61K9/113 , A61Q19/00 , A61K7/44 , B01J13/00
CPC分类号： A61K9/113 , A61K8/066 , A61Q19/00 , A61Q17/04
摘要： This invention relates to an oil-in-water-in-oil (O/W/O) type multiple emulsion which contains an inner oil phase, a water phase, and an outer oil phase. The inner oil phase is first dispersed in water to form an oil-in-water (O/W) emulsion. Then, the O/W emulsion is further dispersed in the outer oil phase to form the O/W/O type multiple emulsion. The outer oil phase contains an organophilic clay mineral, which can effectively prevent the inter-mixing of the inner oil phase with the outer oil phase, thus, producing an O/W/O type multiple emulsion with excellent storage stability. Upon the using of an oil-soluble compound in the inner oil phase, this multiple emulsion system can prevent the oil-soluble compound from being oxidized. In addition, since different kinds of oils can be selected for the making of the inner and outer oil phases, respectively, the O/W/O type multiple emulsion system allows one to present two different kinds of oils, which have different properties independent from each other, in one emulsion system.
摘要翻译：本发明涉及含油内油相，水相和外油相的油包水包油型（O / W / O）型多重乳液。内部油相首先分散在水中以形成水包油（O / W）乳液。然后，O / W乳液进一步分散在外部油相中以形成O / W / O型多重乳液。外油相含有亲有机质的粘土矿物，可有效防止内油相与外油相的相互混合，从而生产出具有良好储存稳定性的O / W / O型多重乳液。在内油相中使用油溶性化合物时，该多重乳液体系可以防止油溶性化合物被氧化。另外，由于可以分别选择不同种类的油来制造内外油相，所以O / W / O型多重乳液体系允许呈现两种不同种类的油，它们具有独立于在一个乳液系统中。

4. 发明授权

US5817155A Emulsion for hair treatment 失效
标题翻译：乳液用于头发处理
公开(公告)号：US5817155A
公开(公告)日：1998-10-06
申请号：US761387
申请日：1996-12-06
申请人： Masaaki Yasuda , Yasuhiro Arai , Fumiaki Matsuzaki , Toshio Yanaki , Hideo Nakajima , Michihiro Yamaguchi , Kimio Ohno
发明人： Masaaki Yasuda , Yasuhiro Arai , Fumiaki Matsuzaki , Toshio Yanaki , Hideo Nakajima , Michihiro Yamaguchi , Kimio Ohno
IPC分类号： A61K7/06 , A61K7/13
CPC分类号： A61K8/06 , A61K8/342 , A61K8/731 , A61Q5/10
摘要： An emulsion for hair treatment is provided which is characterized by the following: the formulation (I) is composed of a W/O type emulsion, which allows the main agent to be stable, and contains preferably an oil soluble polymer compound for the emulsifier; the formulation (I), upon being mixed with formulation (II), can easily undergo demulsification and a phase inversion into an O/W type emulsion; and the emulsion has adequate viscosity to prevent dripping from the hair and a superior dyeing capability. Also, 2-formulation type oxidation hair dye with an excellent hair dyeing effect is provided by adding isostearyl alcohol.
摘要翻译：提供了一种用于头发处理的乳液，其特征在于：制剂（I）由W / O型乳液组成，其允许主剂稳定，并且优选含有用于乳化剂的油溶性高分子化合物; 制剂（I）在与制剂（II）混合后可容易地发生破乳和相转化成O / W型乳液; 并且乳液具有足够的粘度以防止从头发滴落和优异的染色能力。此外，通过加入异硬脂醇提供具有优异染发效果的2-配方型氧化染发剂。

5. 发明授权

US6150425A O/W/O type multiphase emulsion 有权
标题翻译： O / W / O型多相乳液
公开(公告)号：US6150425A
公开(公告)日：2000-11-21
申请号：US147821
申请日：1999-03-15
申请人： Tomoko Sekine , Fumiaki Matsuzaki , Toshio Yanaki , Michihiro Yamaguchi
发明人： Tomoko Sekine , Fumiaki Matsuzaki , Toshio Yanaki , Michihiro Yamaguchi
IPC分类号： A61K8/06 , A61K9/113 , A61Q19/00 , B01F17/28 , B01F3/08 , B01F17/54
CPC分类号： A61Q19/00 , A61K8/066 , A61K9/113 , Y10S514/941 , Y10S514/943 , Y10S514/944 , Y10S514/975 , Y10S516/902
摘要： An O/W/O type multiple emulsion in which an O/W type emulsion is dispersed in the outer phase oil wherein the O/W type emulsion in the inner phase contains water, an oil based ingredient, a surfactant and an amphiphilic substance chosen from those which can form a gel at ordinal temperature or higher in an amphiphilic substance-surfactant-oil-water system or N-long chain acyl acidic amino acid monosalt and an amphiphilic substance chosen from those which can form a gel at ordinal temperature or higher in an amphiphilic substance-N-long chain acyl acidic amino acid monosalt-oil-water system, said outer phase oil contains organophilic modified clay minerals and an emulsifying agent with a HLB of 7 or lower, and the weight ratio of the O/W type emulsion and the outer phase oil is 2:3-19:1. An O/W/O type multiple emulsion with superior stability over time and good usability.
摘要翻译： PCT No.PCT / JP98 / 03187 Sec。 371 1999年3月15日 102（e）1999年3月15日PCT提交1998年7月15日PCT公布。公开号WO99 / 03572 日期1999年1月28日其中O / W型乳液分散在外相油中的O / W / O型多重乳液，其中内相中的O / W型乳液含有水，油基成分，表面活性剂和两亲物质，其选自可以在两亲物质 - 表面活性剂 - 油 - 水体系或N-长链酰基酸性氨基酸单糖盐和选自可以形成凝胶的那些的两亲物质中在顺序温度或更高温度下形成凝胶的物质在两亲物质N-长链酰基酸性氨基酸单糖 - 油 - 水系统中的序数温度以上，所述外相油含有亲有机质改性粘土矿物和HLB为7以下的乳化剂，重量比的O / W型乳液和外相油为2:3-19:1。一种O / W / O型多重乳液，具有优异的稳定性和良好的使用性。

6. 发明授权

US5679657A Low molecular weight acetylhyaluronate, skin-softening composition, method of manufacturing the same, and method of purifying the same 失效
标题翻译：低分子量乙酰透明质酸盐，皮肤软化组合物，其制造方法及其纯化方法
公开(公告)号：US5679657A
公开(公告)日：1997-10-21
申请号：US624634
申请日：1996-08-02
申请人： Takashi Oka , Toshio Yanaki , Michihiro Yamaguchi
发明人： Takashi Oka , Toshio Yanaki , Michihiro Yamaguchi
IPC分类号： A61K8/73 , A61Q19/00 , C08B37/08 , A61K31/715 , C07H1/00 , C07H5/06 , C07H13/04
CPC分类号： A61Q19/00 , A61K8/735 , C08B37/0072 , A61Q19/10 , A61Q5/00
摘要： Low molecular weight acetylhyaluronate has the following characteristics: intrinsic viscosity: 50 to 200 cm.sup.3 /g substitution degree of acetyl group: 2.6 to 3.6 (excluding N-acetyl group) A skin-softening composition is mainly composed of this low molecular weight acetylhyaluronate. It can exhibit excellent skin-softening effect and moisturizing effect, while appropriately suppressing the thread-forming ability inherent in hyaluronic acid. A method of manufacturing acetylhyaluronate comprises the steps of suspending hyaluronic acid powder in an acetic anhydride solvent and then adding concentrated sulfuric acid thereto to effect acetylation. A method of purifying acetylhyaluronate comprises the steps of adding raw acetylhyaluronate to an aqueous acetone solution, adding and dissolving sodium lactate therein, and then adding highly concentrated acetone thereto to precipitate highly pure acetylhyaluronate. Acetylhyaluronate having highly purity can be obtained inexpensively.
摘要翻译： PCT No.PCT / JP95 / 01613 Sec。 371日期：1996年8月2日 102（e）日期1996年8月2日PCT提交1995年8月11日PCT公布。公开号WO96 / 05233 日期：1996年2月22日低分子量乙酰透明质酸盐具有以下特征：特性粘度：50〜200cm 3 / g乙酰基取代度：2.6〜3.6（不含N-乙酰基）皮肤柔软性组合物主要由该低分子量乙酰透明质酸盐。它可以表现出优异的皮肤软化效果和保湿效果，同时适当地抑制透明质酸固有的丝线形成能力。制造乙酰透明质酸盐的方法包括将透明质酸粉末悬浮于乙酸酐溶剂中，然后向其中加入浓硫酸进行乙酰化的步骤。一种纯化乙酰透明质酸的方法包括以下步骤：向丙酮水溶液中加入原料乙酰透明质酸盐，加入乳酸钠溶解并溶解，然后加入高浓度的丙酮以沉淀出高纯度的乙酰基透明质酸盐。可以廉价地获得高纯度的乙酰基乙酸酯。

7. 发明授权

US5532305A Controlled release preparation for bioactive substances 失效
标题翻译：生物活性物质的控制释放制剂
公开(公告)号：US5532305A
公开(公告)日：1996-07-02
申请号：US280736
申请日：1994-07-26
申请人： Fumiaki Matsuzaki , Toshio Yanaki , Michihiro Yamaguchi
发明人： Fumiaki Matsuzaki , Toshio Yanaki , Michihiro Yamaguchi
IPC分类号： A61K9/00 , A61K9/20 , A61K31/405 , A61K31/435 , A61K47/32 , A61K47/36 , A61P11/14 , A61P25/04 , A61P29/00 , C08B37/08 , C08F20/06 , A61K47/00
CPC分类号： A61K9/2027 , A61K9/205
摘要： To provide a base suitable for a controlled release preparation and the controlled release preparation. A bioactive substance(s) is introduced in a poly-ion complex of hyaluronic acid and a cationic polyacrylic acid derivative(s).
摘要翻译：提供适用于控制释放制剂和控制释放制剂的碱。将生物活性物质引入透明质酸和阳离子聚丙烯酸衍生物的多离子络合物中。

8. 发明授权

US5219847A Antipruritic composition 失效
标题翻译：止痒组合物
公开(公告)号：US5219847A
公开(公告)日：1993-06-15
申请号：US918800
申请日：1992-07-27
申请人： Shigeru Taguchi , Takashi Suzuki , Chikao Nishino , Yoshimori Fujinuma , Chuji Yanagawa , Michihiro Yamaguchi , Miwako Yamato , Noriko Nakajima , Mie Kitano , Tomomi Okazaki , Masaki Uemura , Ryuhei Inada , Yoshiko Tonomura
发明人： Shigeru Taguchi , Takashi Suzuki , Chikao Nishino , Yoshimori Fujinuma , Chuji Yanagawa , Michihiro Yamaguchi , Miwako Yamato , Noriko Nakajima , Mie Kitano , Tomomi Okazaki , Masaki Uemura , Ryuhei Inada , Yoshiko Tonomura
IPC分类号： A61K8/27 , A61K8/49 , A61K31/315 , A61K31/44 , A61K31/555 , A61K33/30 , A61Q17/00
CPC分类号： A61Q17/00 , A61K31/315 , A61K31/44 , A61K31/555 , A61K33/30 , A61K8/27 , A61K8/4926 , A61K2800/75
摘要： An antipruritic composition for an oral medicine, injection, and external medicine, comprising an effective amount of a chelated zinc (e.g., zinc picolinate) as an antipruritic agent.
摘要翻译：用于口服药物，注射剂和外用药物的止痒剂组合物，其包含有效量的作为止痒剂的螯合锌（例如吡啶甲锌）。

9. 发明授权

US6063283A Method for analyzing a sample by using a liquid chromatograph 失效
标题翻译：使用液相色谱仪分析样品的方法
公开(公告)号：US6063283A
公开(公告)日：2000-05-16
申请号：US5161
申请日：1998-01-09
申请人： Osamu Shirota , Ayako Suzuki , Yutaka Ohtsu , Michihiro Yamaguchi , Hisao Tsuruta
发明人： Osamu Shirota , Ayako Suzuki , Yutaka Ohtsu , Michihiro Yamaguchi , Hisao Tsuruta
IPC分类号： G01N1/00 , G01N30/02 , G01N30/08 , G01N30/20 , G01N30/24 , G01N30/34 , G01N30/38 , G01N30/44 , G01N30/46 , G01N30/56 , B01D15/08
CPC分类号： G01N30/56 , G01N30/08 , G01N30/20 , G01N30/24 , G01N30/34 , G01N30/482 , G01N35/1097 , B01J2220/54 , G01N2030/027 , G01N2030/347 , G01N2030/445 , G01N30/38 , G01N30/461 , G01N35/1095
摘要： A liquid chromatograph includes pumps for supplying solvents, a mixer for mixing the solvents, a controller for controlling a mixing ratio of the solvents in the mixer, a chromatograph column for separating a sample carried with the solvents, a flow path control valve for supplying the sample together with the solvents to the chromatograph column, and a detector for detecting the sample supplied thereto, wherein the mixer includes a mixing chamber and a porous medium accommodated in the mixing chamber, the porous medium having a size and shape in conformity with a size and shape of said mixing chamber such that no substantial gap is formed between an outer surface of the porous medium and an inner surface of the mixing chamber.
摘要翻译：液相色谱仪包括用于供应溶剂的泵，用于混合溶剂的混合器，用于控制混合器中溶剂的混合比的控制器，用于分离带有溶剂的样品的色谱柱，用于供应溶剂的流路控制阀将样品与溶剂一起与色谱柱一起检测，以及用于检测供应给其的样品的检测器，其中混合器包括混合室和容纳在混合室中的多孔介质，多孔介质的尺寸和形状与尺寸和所述混合室的形状，使得在多孔介质的外表面和混合室的内表面之间不会形成实质的间隙。

10. 发明授权

US5785961A Mixing-at the time of use-type hair-treating composition 失效
标题翻译：在使用时混合 - 型头发处理组合物
公开(公告)号：US5785961A
公开(公告)日：1998-07-28
申请号：US750115
申请日：1996-11-26
申请人： Yasunari Nakama , Yoko Takeshita , Yasuhiro Arai , Michihiro Yamaguchi , Masa'aki Yasuda
发明人： Yasunari Nakama , Yoko Takeshita , Yasuhiro Arai , Michihiro Yamaguchi , Masa'aki Yasuda
IPC分类号： A61K8/36 , A61K8/39 , A61K8/44 , A61K8/46 , A61K8/73 , A61K8/81 , A61K8/84 , A61Q5/08 , A61Q5/10 , A61K7/06
CPC分类号： A61Q5/08 , A61K8/361 , A61K8/39 , A61K8/44 , A61K8/463 , A61K8/466 , A61K8/731 , A61K8/8182 , A61K8/84 , A61Q5/10 , A61K2800/5426 , A61K2800/88
摘要： A hair-treating composition having convenient usability and excellent dyeability or hair-bleachability is provided. The composition having the above excellent properties contains at least one member selected from amphoteric surface active agents or semipolar surface active agents according to circumstances, and cationic polymers, in combination with an anionic surface active agent and a higher fatty acid, and further contains a dye or an alkalinizing agent.
摘要翻译： PCT No.PCT / JP95 / 01527 Sec。 371日期1996年11月26日 102（e）日期1996年11月26日PCT提交1995年8月1日PCT公布。公开号WO96 / 29976 日期1996年10月3日提供了方便使用性和优异的染色性或毛发漂白性的头发处理组合物。具有上述优异性质的组合物根据情况含有选自两性表面活性剂或半极性表面活性剂中的至少一种，阳离子聚合物与阴离子表面活性剂和高级脂肪酸组合，并且还含有染料或碱化剂。

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