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1. 发明申请

US20060206154A1 Combined neural stimulation and cardiac resynchronization therapy 有权
公开(公告)号：US20060206154A1
公开(公告)日：2006-09-14
申请号：US11078460
申请日：2005-03-11
申请人： Julia Moffitt , Sophia Wang , Bruce KenKnight , Imad Libbus
发明人： Julia Moffitt , Sophia Wang , Bruce KenKnight , Imad Libbus
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/056 , A61N1/0587 , A61N1/36114 , A61N1/3962
摘要： Methods and devices for delivering cardiac therapy to a patient are provided. Various implantable device embodiments comprise a plurality of leads and a controller. The leads include at least one lead to be positioned within a lead path to deliver ventricular pacing pulses and to deliver neural stimulation at a site proximate to the heart to inhibit sympathetic nerve activity. The controller controls delivery of the ventricular pacing pulses in accordance with a programmed pacing mode and controls delivery of the neural stimulation. The controller is programmed to deliver remodeling control therapy (RCT) by delivering ventricular pacing to pre-excite a ventricular myocardium region to mechanically unload that region during systole, and further is programmed to deliver anti-remodeling therapy (ART) by delivering neural stimulation to inhibit sympathetic nerve activity in conjunction with RCT. Other embodiments are provided herein.

2. 发明申请

US20080015648A1 COMBINED REMODELING CONTROL THERAPY AND ANTI-REMODELING THERAPY BY IMPLANTABLE CARDIAC DEVICE 有权
标题翻译：可重构心脏器械组合重组控制治疗与抗再感染治疗
公开(公告)号：US20080015648A1
公开(公告)日：2008-01-17
申请号：US11777394
申请日：2007-07-13
申请人： Imad Libbus , Bruce KenKnight , Julia Moffitt , Yatheendhar Manicka
发明人： Imad Libbus , Bruce KenKnight , Julia Moffitt , Yatheendhar Manicka
IPC分类号： A61N1/05
CPC分类号： A61N1/362 , A61N1/36114 , A61N1/3627
摘要： A method and device for delivering ventricular resynchronization pacing therapy in conjunction with electrical stimulation of nerves which alter the activity of the autonomic nervous system is disclosed. Such therapies may be delivered by an implantable device and are useful in preventing the deleterious ventricular remodeling which occurs as a result of a heart attack or heart failure. The device may perform an assessment of cardiac function in order to individually modulate the delivery of the two types of therapy.
摘要翻译：公开了一种用于将脑室再同步起搏治疗与神经改变自主神经系统的活动的电刺激结合的方法和装置。这样的治疗可以由可植入装置递送，并且可用于防止由于心脏病发作或心力衰竭而发生的有害心室重构。该装置可以执行心脏功能的评估，以便单独地调节两种类型的治疗的递送。

3. 发明申请

US20050261741A1 Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device 有权
标题翻译：通过可植入心脏装置的联合重塑控制治疗和抗重塑治疗
公开(公告)号：US20050261741A1
公开(公告)日：2005-11-24
申请号：US10850341
申请日：2004-05-20
申请人： Imad Libbus , Bruce KenKnight , Julia Moffitt , Yatheendhar Manicka
发明人： Imad Libbus , Bruce KenKnight , Julia Moffitt , Yatheendhar Manicka
IPC分类号： A61N1/36 , A61N1/362 , A61N1/18
CPC分类号： A61N1/362 , A61N1/36114 , A61N1/3627
摘要： A method and device for delivering ventricular resynchronization pacing therapy in conjunction with electrical stimulation of nerves which alter the activity of the autonomic nervous system is disclosed. Such therapies may be delivered by an implantable device and are useful in preventing the deleterious ventricular remodeling which occurs as a result of a heart attack or heart failure. The device may perform an assessment of cardiac function in order to individually modulate the delivery of the two types of therapy.
摘要翻译：公开了一种用于将脑室再同步起搏治疗与神经改变自主神经系统的活动的电刺激结合的方法和装置。这样的治疗可以由可植入装置递送，并且可用于防止由于心脏病发作或心力衰竭而发生的有害心室重构。该装置可以执行心脏功能的评估，以便单独地调节两种类型的治疗的递送。

4. 发明授权

US08285378B1 System and method for determining patient-specific implantable medical device programming parameters 有权
标题翻译：用于确定患者特异性可植入医疗装置编程参数的系统和方法
公开(公告)号：US08285378B1
公开(公告)日：2012-10-09
申请号：US10950876
申请日：2004-09-27
申请人： Bruce KenKnight , Eric Lovett , Adam W. Cates , Amir Tehrani
发明人： Bruce KenKnight , Eric Lovett , Adam W. Cates , Amir Tehrani
IPC分类号： A61N1/02
CPC分类号： A61N1/37235 , A61N1/37282 , G06F19/00 , G16H40/40
摘要： A system and method for determining patient-specific implantable medical device programming parameters are presented. A set of physiological measures collected through a plurality of sensors monitoring physiological functions in a patient are assimilated. The physiological measures set are analyzed to identify physiological idiosyncrasies specific to the patient and to optimize the therapy to be delivered through an implantable medical device. A patient profile is formed including a plurality of programming parameters and the patient profile is preprogrammed into the implantable medical device prior to implantation in the patient.
摘要翻译：提出了一种用于确定患者特异性可植入医疗器械编程参数的系统和方法。通过监测患者生理功能的多个传感器收集的一组生理测量被同化。分析生理测量集以确定特定于患者的生理特征并优化通过可植入医疗装置递送的治疗。形成包括多个编程参数的患者轮廓，并且在植入患者之前将患者轮廓预编程到可植入医疗装置中。

5. 发明申请

US20080281369A1 System And Method For Determining The Origin Of A Sensed Beat 有权
标题翻译：确定感觉节拍的起源的系统和方法
公开(公告)号：US20080281369A1
公开(公告)日：2008-11-13
申请号：US11745667
申请日：2007-05-08
申请人： Bruce KenKnight , Steven D. Girouard
发明人： Bruce KenKnight , Steven D. Girouard
IPC分类号： A61N1/36
CPC分类号： A61B5/04525 , A61B5/042 , A61B5/0456 , A61B5/7239 , A61N1/3702
摘要： A method for monitoring a biological cardiac pacemaker is provided. The method may include stimulating a heart at a region selected for implantation of a biological pacemaker and sensing at least one electrical signal indicative of a cardiac depolarization originating in the region selected for implantation of the biological pacemaker. The method may further include sensing at least one subsequent electrical signal produced by the heart and determining if the subsequent electrical signal originated in the region selected for the biological pacemaker or another region of the heart. In an alternative embodiment, the method may include determining a template time difference between two points on cardiac complexes sensed in two or more different cardiac locations during normal sinus rhythm. The method may further include determining a time difference between two points on a subsequent cardiac complex sensed in two or more different cardiac locations. The time differences may be compared to determine if the subsequently-sensed cardiac complex originates in a left ventricular biological pacemaker site or in another cardiac site.
摘要翻译：提供了一种用于监测生物心脏起搏器的方法。该方法可以包括在选择用于植入生物起搏器的区域处刺激心脏，并感测至少一个电信号，其指示源于选择用于植入生物起搏器的区域的心脏去极化。该方法还可以包括感测由心脏产生的至少一个随后的电信号，并确定后续的电信号是否起源于为生物起搏器或心脏另一区域选择的区域。在替代实施例中，该方法可以包括确定在正常窦性心律期间在两个或更多个不同心脏位置中感测到的心脏复合体上的两个点之间的模板时间差。该方法还可以包括确定在两个或更多个不同心脏位置中感测到的随后的心脏复合体上的两个点之间的时间差。可以比较时间差以确定随后感测的心脏复合物是否起源于左心室生物起搏器位点或另一心脏位点。

6. 发明申请

US20080280339A1 Cell Training For Local Field Stimulation 有权
标题翻译：局部场刺激的细胞训练
公开(公告)号：US20080280339A1
公开(公告)日：2008-11-13
申请号：US11745620
申请日：2007-05-08
申请人： Bruce KenKnight , Steve D. Girouard
发明人： Bruce KenKnight , Steve D. Girouard
IPC分类号： C12N13/00 , A61M37/00 , C12N5/06
CPC分类号： C12N5/0657 , A61B17/3468 , A61B2017/00247 , A61B2017/00256 , A61B2018/00392 , A61K35/12 , A61M37/0069 , A61N1/326 , A61N1/362
摘要： A system is provided for stimulating one or more cells, wherein the stimulation is sub-threshold and may alter a transmembrane potential of the one or more cells. For some populations of cells it may be possible to affect the transmembrane potential to gain a therapeutic benefit. Cells of the sino-atrial node spontaneously depolarize predominantly due to the slow depolarization of transmembrane potential. The present system may provide sino-atrial cells with a local field stimulation that while not eliciting an action potential may nonetheless alter local transmembrane potential. Such alteration of transmembrane potential may permit an increase or decrease in a rate of depolarization, and hence modify heart rate.
摘要翻译：提供了一种用于刺激一个或多个细胞的系统，其中所述刺激是次阈值的并且可以改变所述一个或多个细胞的跨膜电位。对于一些细胞群体，可能影响跨膜电位以获得治疗益处。由于跨膜电位缓慢去极化，中心节点的细胞主要去极化。本发明的系统可以为中心细胞提供局部场刺激，尽管不引起动作电位也可能改变局部跨膜电位。跨膜电位的这种改变可以允许去极化率的增加或减少，从而改变心率。

7. 发明申请

US20080208014A1 SYSTEM AND METHOD FOR SOLICITING DIRECTLY-COLLECTED NORMALIZED VOICE FEEDBACK FOR USE IN AUTOMATED PATIENT CARE 审中-公开
标题翻译：用于自动化患者护理用于直接收集的正规语音反馈的系统和方法
公开(公告)号：US20080208014A1
公开(公告)日：2008-08-28
申请号：US12026473
申请日：2008-02-05
申请人： Bruce KenKnight , Gust H. Bardy
发明人： Bruce KenKnight , Gust H. Bardy
IPC分类号： A61B5/00
CPC分类号： G06Q50/24 , A61B5/0031 , G06F19/3418 , G16H10/60 , G16H40/63 , G16H50/30 , Y10S128/903 , Y10S128/904
摘要： A system and method for transacting an automated patient communications session is described. A patent health condition is monitored by regularly collecting physiological measures through an implantable medical device. A patient communications session is activated through a patient communications interface including, an implantable microphone and an implantable speaker in response to a patient-provided activation code. An identification of the patient is authenticated based on pre-defined uniquely identifying patient characteristics. Spoken patient information is received through the implantable microphone and verbal system information is played through the implantable speaker. The patient communications session is terminated by closing the patient communications interface. The physiological measures and the spoken patient information are sent.
摘要翻译：描述用于交互自动化患者通信会话的系统和方法。通过可植入医疗设备定期收集生理措施来监测专利健康状况。响应于患者提供的激活码，通过病人通信接口激活病人通信会话，包括可植入麦克风和可植入扬声器。基于预定义的唯一识别患者特征来鉴定患者的身份。通过可植入麦克风接收口语患者信息，通过可植入扬声器播放语言系统信息。通过关闭患者通信接口来终止患者通信会话。发送生理措施和口头患者信息。

8. 发明申请

US20080097538A1 APPARATUS AND METHOD FOR SPATIALLY AND TEMPORALLY DISTRIBUTING CARDIAC ELECTRICAL STIMULATION 有权
标题翻译：用于空间和时间分布的心脏电刺激的装置和方法
公开(公告)号：US20080097538A1
公开(公告)日：2008-04-24
申请号：US11931779
申请日：2007-10-31
申请人： Rodney Salo , Julio Spinelli , Bruce KenKnight
发明人： Rodney Salo , Julio Spinelli , Bruce KenKnight
IPC分类号： A61N1/368 , A61N1/365
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3627
摘要： A cardiac electro-stimulatory device and method for operating same in which stimulation pulses are distributed among a plurality of electrodes fixed at different sites of the myocardium in order to reduce myocardial hypertrophy brought about by repeated pacing at a single site and/or increase myocardial contractility. In order to spatially and temporally distribute the stimulation, the pulses are delivered through a switchable pulse output configuration during a single cardiac cycle, with each configuration comprising one or more electrodes fixed to different sites in the myocardium.
摘要翻译：一种心脏电刺激装置及其操作方法，其中刺激脉冲分布在固定在心肌不同部位的多个电极之间，以便通过在单个部位重复起搏而引起的心肌肥大和/或增加心肌收缩力。为了空间和时间地分布刺激，脉冲在单个心动周期期间通过可切换的脉冲输出配置递送，每个配置包括一个或多个电极固定在心肌中的不同部位。

9. 发明申请

US20060052829A1 Adapative anti-tachycardia therapy apparatus and method 有权
公开(公告)号：US20060052829A1
公开(公告)日：2006-03-09
申请号：US11267071
申请日：2005-11-03
申请人： Weimin Sun , Bruce KenKnight , Martin Tze , Yatheendhar Manicka
发明人： Weimin Sun , Bruce KenKnight , Martin Tze , Yatheendhar Manicka
IPC分类号： A61N1/39
CPC分类号： A61N1/3962
摘要： A method and apparatus for delivering anti-tachycardia pacing in an adaptive manner is disclosed. A cardiac rhythm management device, such as an implantable pacemaker, having anti-tachycardia pacing capability delivers anti-tachycardia pacing therapy in accordance with a selected pacing protocol upon detection of a terminable arrhythmia. The protocol is selected from a library of available protocols. A record of the successes and failures of each available protocol in converting tachyarrhythmias is maintained in a result table for use in selecting the protocol.

10. 发明申请

US20050240236A1 Implantable medical device with voice responding and recording capacity 失效
标题翻译：具有语音响应和记录能力的植入式医疗设备
公开(公告)号：US20050240236A1
公开(公告)日：2005-10-27
申请号：US11071984
申请日：2005-03-04
申请人： Douglas Daum , Qingsheng Zhu , Bruce KenKnight
发明人： Douglas Daum , Qingsheng Zhu , Bruce KenKnight
IPC分类号： A61N1/362 , A61N1/372
CPC分类号： A61N1/37217 , A61N1/3625 , A61N1/3627 , A61N1/37247
摘要： An implantable medical device such as a cardiac pacemaker or implantable cardioverter/defibrillator with the capability of receiving communications in the form of speech spoken by the patient. An acoustic transducer is incorporated within the device which along with associated filtering circuitry enables the voice communication to be used to affect the operation of the device or recorded for later playback.
摘要翻译：一种可植入医疗装置，例如心脏起搏器或植入式心律转复除颤器，具有以患者所说话语的形式接收通信的能力。声学换能器结合在该装置内，连同相关联的滤波电路使声音通信能够用于影响装置的操作或被记录以供稍后播放。

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