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1. 发明授权

US08285378B1 System and method for determining patient-specific implantable medical device programming parameters 有权
标题翻译：用于确定患者特异性可植入医疗装置编程参数的系统和方法
公开(公告)号：US08285378B1
公开(公告)日：2012-10-09
申请号：US10950876
申请日：2004-09-27
申请人： Bruce KenKnight , Eric Lovett , Adam W. Cates , Amir Tehrani
发明人： Bruce KenKnight , Eric Lovett , Adam W. Cates , Amir Tehrani
IPC分类号： A61N1/02
CPC分类号： A61N1/37235 , A61N1/37282 , G06F19/00 , G16H40/40
摘要： A system and method for determining patient-specific implantable medical device programming parameters are presented. A set of physiological measures collected through a plurality of sensors monitoring physiological functions in a patient are assimilated. The physiological measures set are analyzed to identify physiological idiosyncrasies specific to the patient and to optimize the therapy to be delivered through an implantable medical device. A patient profile is formed including a plurality of programming parameters and the patient profile is preprogrammed into the implantable medical device prior to implantation in the patient.
摘要翻译：提出了一种用于确定患者特异性可植入医疗器械编程参数的系统和方法。通过监测患者生理功能的多个传感器收集的一组生理测量被同化。分析生理测量集以确定特定于患者的生理特征并优化通过可植入医疗装置递送的治疗。形成包括多个编程参数的患者轮廓，并且在植入患者之前将患者轮廓预编程到可植入医疗装置中。

2. 发明授权

US08792979B2 Method and apparatus for preventing cardiac arrhythmias with endovascular stimulation 有权
标题翻译：用血管内刺激预防心律失常的方法和装置
公开(公告)号：US08792979B2
公开(公告)日：2014-07-29
申请号：US11549704
申请日：2006-10-16
申请人： Adam W. Cates
发明人： Adam W. Cates
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/3962
摘要： Certain cardiac arrhythmias can be prevented by appropriate electrical stimulation of autonomic nerves innervating the heart. An implantable cardiac rhythm management device is configured to deliver such stimulation when an autonomic imbalance is predicted to be present via an endovascular electrode. Autonomic imbalance may be predicted to be present based upon circadian rhythms, detected heart rates, or detected heart rate variability.
摘要翻译：某些心律失常可以通过适当的电刺激自主神经来保护心脏来预防。植入式心律管理装置被配置为当预测通过血管内电极存在自主神经不平衡时递送这种刺激。可以基于昼夜节律，检测到的心率或检测到的心率变异性来预测自主不平衡存在。

3. 发明授权

US07047071B2 Patient stratification for implantable subcutaneous cardiac monitoring and therapy 失效
标题翻译：可植入式皮下心脏监测和治疗的患者分层
公开(公告)号：US07047071B2
公开(公告)日：2006-05-16
申请号：US10799341
申请日：2004-03-12
申请人： Darrell Orvin Wagner , Adam W. Cates , Curtis Charles Lindstrom
发明人： Darrell Orvin Wagner , Adam W. Cates , Curtis Charles Lindstrom
IPC分类号： A61N1/18 , A61N1/38
CPC分类号： A61N1/3962 , A61N1/05 , A61N1/36542 , A61N1/36585 , A61N1/3956
摘要： Systems and methods of verifying that implantable cardiac devices operate as intended in a particular patient involve one or more of determining proper placement of system components, determining stimulus levels useful for individual patient stratification, and determining stimulus levels that indicate efficacy of devices, implantable within a given patient. A pacing stimulus set at a surface pacing level is delivered to a patient's heart using surface electrodes. The patient is determined to not be a candidate for implantation of a subcutaneous defibrillation system if the surface pacing level needed to capture the heart exceeds a predetermined level. The patient may be determined to be a candidate for implantation of a subcutaneous system if the surface pacing level needed to effect capture is within an acceptance level. Such determinations are preferably based on a proportionality relationship between a subcutaneous defibrillation level and a surface pacing level.
摘要翻译：验证可植入心脏装置如预期在特定患者中操作的系统和方法涉及确定系统组件的适当放置的一个或多个，确定对于个体患者分层有用的刺激水平，以及确定指示可植入在内部的装置的功效的刺激水平给予病人使用表面电极将设置在表面起搏水平的起搏刺激传递给患者的心脏。如果需要捕获心脏的表面起搏水平超过预定水平，则患者被确定为不是用于植入皮下除颤系统的候选者。如果需要进行捕获的表面起搏水平处于接受程度之内，则患者可能被确定为植入皮下系统的候选者。这种测定优选基于皮下除颤水平和表面起搏水平之间的比例关系。

4. 发明授权

US07392081B2 Subcutaneous cardiac stimulator employing post-shock transthoracic asystole prevention pacing 有权
标题翻译：皮下心脏刺激器采用后休克经胸痛预防起搏
公开(公告)号：US07392081B2
公开(公告)日：2008-06-24
申请号：US10377274
申请日：2003-02-28
申请人： Darrell Orvin Wagner , Adam W. Cates , Kristine M. Larsen-Kelly
发明人： Darrell Orvin Wagner , Adam W. Cates , Kristine M. Larsen-Kelly
IPC分类号： A61N1/00
CPC分类号： A61N1/3962 , A61N1/3756 , A61N1/3918
摘要： Transthoracic cardiac stimulation therapies provide for detection and treatment of cardiac asystole subsequent to delivery of a defibrillation therapy. A pacing therapy is transthoracicly delivered to terminate detected cardiac asystole using residual energy from a defibrillation energy storage source. The residual energy usable for the pacing therapy is sufficient to transthoracicly deliver at least one pacing pulse, and is typically sufficient to deliver a series of pacing pulses, prior to depletion of the defibrillation energy storage source. Detection of cardiac asystole is performed following delivery of each pacing pulse, and subcutaneous pacing support is terminated in response to detecting cardiac asystole termination.
摘要翻译：经胸静脉心脏刺激治疗提供了在除颤治疗后的心脏停搏时的检测和治疗。通过经胸廓输送起搏治疗，以使用来自除颤能量存储源的剩余能量终止检测到的心脏停搏。可用于起搏治疗的剩余能量足以经胸输送至少一个起搏脉冲，并且通常足以在除颤能量存储源耗尽之前递送一系列起搏脉冲。在每次起搏脉搏输送后进行心脏停搏的检测，响应检测心脏停搏停止而终止皮下起搏支持。

5. 发明授权

US07349742B2 Expandable fixation elements for subcutaneous electrodes 失效
标题翻译：用于皮下电极的可膨胀固定元件
公开(公告)号：US07349742B2
公开(公告)日：2008-03-25
申请号：US10745341
申请日：2003-12-23
申请人： Ron Heil , Darrell Orvin Wagner , Adam W. Cates , Curtis Charles Lindstrom
发明人： Ron Heil , Darrell Orvin Wagner , Adam W. Cates , Curtis Charles Lindstrom
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61B17/320068 , A61B17/3203 , A61B17/3415 , A61B17/3417 , A61B90/30 , A61B2017/00243 , A61B2017/00247 , A61B2017/320044 , A61B2017/320084 , A61B2018/00392 , A61B2090/3945 , A61B2217/005 , A61B2217/007 , A61N1/056 , A61N1/0568 , A61N1/0587 , A61N1/08 , A61N1/36542 , A61N1/36585 , A61N1/3956 , A61N1/3962
摘要： Subcutaneous systems and leads may be fixed in tissue after placement by use of one or more expanding fixation elements. An expanding fixation element is provided on an implantable lead and configured to secure one or both of a subcutaneous electrode and the lead body within subcutaneous non-intrathoracic tissue. A delivery apparatus comprising a sheath may be included that is configured to introduce the lead to a desired subcutaneous non-intrathoracic location within the patient. A method of lead delivery typically involves introducing a sheath into a subcutaneous non-intrathoracic body location of a patient, providing a lead comprising a lead body and an electrode, and advancing the lead through the sheath and to the subcutaneous non-intrathoracic body location. The method further involves fixing the lead to subcutaneous non-intrathoracic tissue using an expanding fixation element and thereafter removing the sheath from the patient.
摘要翻译：皮下系统和引线可以在通过使用一个或多个扩张固定元件放置之后固定在组织中。在可植入引线上设置有扩张的固定元件，并且构造成将皮下电极和引线体中的一个或两个固定在皮下非胸内组织内。可以包括包括护套的递送装置，其被配置为将引入物导入患者体内期望的皮下非胸内位置。引线递送的方法通常包括将鞘导入患者的皮下非胸内体位置，提供包括引线主体和电极的引线，并且使引线穿过护套和皮下非胸内体位置。该方法还包括使用扩张的固定元件将引线固定到皮下的非胸腔内组织，然后从患者中除去鞘。

6. 发明授权

US07123959B2 Method and apparatus for preventing cardiac arrhythmias with endovascular stimulation 有权
公开(公告)号：US07123959B2
公开(公告)日：2006-10-17
申请号：US10105941
申请日：2002-03-25
申请人： Adam W. Cates
发明人： Adam W. Cates
IPC分类号： A61N1/18
CPC分类号： A61N1/36114 , A61N1/3962
摘要： Certain cardiac arrhythmias can be prevented by appropriate electrical stimulation of autonomic nerves innervating the heart. An implantable cardiac rhythm management device is configured to deliver such stimulation when an autonomic imbalance is predicted to be present via an endovascular electrode. Autonomic imbalance may be predicted to be present based upon circadian rhythms, detected heart rates, or detected heart rate variability.

7. 发明授权

US08725268B2 Method and apparatus for indication-based programming of cardiac rhythm management devices 有权
标题翻译：用于心律管理装置的基于指示的编程的方法和装置
公开(公告)号：US08725268B2
公开(公告)日：2014-05-13
申请号：US11831683
申请日：2007-07-31
申请人： Adam W. Cates , James O. Gilkerson , Kenneth P. Hoyme
发明人： Adam W. Cates , James O. Gilkerson , Kenneth P. Hoyme
IPC分类号： A61N1/362
CPC分类号： A61N1/37235 , A61N1/362 , A61N1/365 , A61N1/37211 , A61N1/37247 , A61N1/37252 , A61N1/37264 , A61N1/3956 , G06F19/00 , G06F19/3418 , G16H10/60 , G16H40/40 , G16H40/63 , G16H50/20
摘要： A cardiac rhythm management (CRM) system includes a programming device that determines parameters for programming an implantable medical device based on patient-specific information including indications for use of the implantable medical device. By executing an indication-based programming algorithm, the programming device substantially automates the process between the diagnosis of a patient and the programming of an implantable medical device using parameters individually determined for that patient.
摘要翻译：心律管理（CRM）系统包括编程设备，其基于患者特定信息确定用于编程可植入医疗设备的参数，包括可植入医疗设备的使用的指示。通过执行基于指示的编程算法，编程设备使用为该患者单独确定的参数，使患者的诊断和可植入医疗设备的编程之间的过程基本上自动化。

8. 发明授权

US07570997B2 Subcutaneous cardiac rhythm management with asystole prevention therapy 有权
标题翻译：经皮心脏心律管理与心搏预防治疗
公开(公告)号：US07570997B2
公开(公告)日：2009-08-04
申请号：US10820642
申请日：2004-04-08
申请人： Eric G. Lovett , Adam W. Cates , Darrell Orvin Wagner , Mike Favet , Apurv Kamath
发明人： Eric G. Lovett , Adam W. Cates , Darrell Orvin Wagner , Mike Favet , Apurv Kamath
IPC分类号： A61N1/362
CPC分类号： A61N1/3962 , A61B5/0031 , A61B5/0205 , A61B17/3415 , A61B17/3417 , A61B2017/00243 , A61B2017/320044 , A61N1/05 , A61N1/0563 , A61N1/0568 , A61N1/0587 , A61N1/08 , A61N1/36542 , A61N1/36585 , A61N1/3956
摘要： Systems and methods provide for sensing of cardiac activity from a subcutaneous, non-intrathoracic location, and detecting a cardiac condition necessitating treatment in response to the sensed cardiac activity. One of a number of cardiac therapies may be selectively delivered to treat the detected cardiac condition, such cardiac therapies including at least a tachycardia therapy, a bradycardia therapy, and an asystole prevention therapy.
摘要翻译：系统和方法提供用于感测来自皮下，非胸内位置的心脏活动，以及检测响应于所感测的心脏活动而需要治疗的心脏状况。可以选择性地递送许多心脏疗法中的一种以治疗所检测到的心脏病，所述心脏治疗至少包括心动过速治疗，心动过缓治疗和心搏停止治疗。

9. 发明授权

US07499758B2 Helical fixation elements for subcutaneous electrodes 有权
标题翻译：皮下电极的螺旋固定元件
公开(公告)号：US07499758B2
公开(公告)日：2009-03-03
申请号：US10739918
申请日：2003-12-18
申请人： Adam W. Cates , Ron Heil , Pete Kelley , Curtis Charles Lindstrom , Jason Alan Shiroff
发明人： Adam W. Cates , Ron Heil , Pete Kelley , Curtis Charles Lindstrom , Jason Alan Shiroff
IPC分类号： A61N1/00
CPC分类号： A61B17/320068 , A61B17/3203 , A61B17/3415 , A61B17/3417 , A61B90/30 , A61B2017/00243 , A61B2017/00247 , A61B2017/320044 , A61B2017/320084 , A61B2018/00392 , A61B2090/3945 , A61B2217/005 , A61B2217/007 , A61N1/05 , A61N1/056 , A61N1/0568 , A61N1/0587 , A61N1/08 , A61N1/36542 , A61N1/36585 , A61N1/3956 , A61N1/3962
摘要： Subcutaneous leads that incorporate active fixation elements including, for example, helical coils, provide for fixation of cardiac lead components within a patient. An implantable lead includes a lead body with a supported electrode configured for subcutaneous non-intrathoracic placement within a patient. A fixation element is provided on the implantable lead and configured to actively secure one or both of the subcutaneous electrode and the lead body in tissue. A delivery apparatus comprising a sheath may be employed that is configured to introduce the lead to a desired subcutaneous non-intrathoracic location. Lead delivery typically involves introducing a sheath into a subcutaneous non-intrathoracic body location of a patient, providing a lead supporting an electrode, advancing the lead through the sheath, actively fixing the lead to tissue, and thereafter removing the sheath from the patient.
摘要翻译：引入包括例如螺旋线圈的活性固定元件的皮下引线提供患者内的心脏铅成分的固定。可植入引线包括具有被配置用于在患者体内皮下非胸腔内放置的支撑电极的引线体。固定元件设置在可植入引线上并且被配置为主动地将皮下电极和引线主体中的一个或两个固定在组织中。可以使用包括护套的递送装置，其被配置为将引入物导入所需的皮下非胸膜内位置。引线递送通常包括将鞘导入患者的皮下非胸内体位置，提供支撑电极的引线，使引线穿过护套，将引线主动固定到组织上，然后从患者中移除护套。

10. 发明申请

US20080167696A1 STIMULUS WAVEFORMS FOR BAROREFLEX ACTIVATION 审中-公开
标题翻译：刺激激活的刺激波形
公开(公告)号：US20080167696A1
公开(公告)日：2008-07-10
申请号：US11963357
申请日：2007-12-21
申请人： Adam W. Cates , Martin A. Rossing
发明人： Adam W. Cates , Martin A. Rossing
IPC分类号： A61N1/18
CPC分类号： A61N1/0556 , A61N1/36114 , A61N1/36117
摘要： A method and apparatus for stimulation of a baroreflex system of a patient is provided. A method comprises establishing a therapy regimen including at least one pulse which includes at least two phases. Each phase has a polarity which is different than that of the other phase. The baroreflex system of the patient is activated with at least one baroreflex activation device which is responsive to the therapy regimen.
摘要翻译：提供了用于刺激患者的压力反射系统的方法和装置。一种方法包括建立包括至少一个包括至少两个相的脉冲的治疗方案。每相具有与另一相不同的极性。患者的压力反射系统通过响应于治疗方案的至少一个压力反射激活装置来激活。

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