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1. 发明申请

US20060206154A1 Combined neural stimulation and cardiac resynchronization therapy 有权
公开(公告)号：US20060206154A1
公开(公告)日：2006-09-14
申请号：US11078460
申请日：2005-03-11
申请人： Julia Moffitt , Sophia Wang , Bruce KenKnight , Imad Libbus
发明人： Julia Moffitt , Sophia Wang , Bruce KenKnight , Imad Libbus
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/056 , A61N1/0587 , A61N1/36114 , A61N1/3962
摘要： Methods and devices for delivering cardiac therapy to a patient are provided. Various implantable device embodiments comprise a plurality of leads and a controller. The leads include at least one lead to be positioned within a lead path to deliver ventricular pacing pulses and to deliver neural stimulation at a site proximate to the heart to inhibit sympathetic nerve activity. The controller controls delivery of the ventricular pacing pulses in accordance with a programmed pacing mode and controls delivery of the neural stimulation. The controller is programmed to deliver remodeling control therapy (RCT) by delivering ventricular pacing to pre-excite a ventricular myocardium region to mechanically unload that region during systole, and further is programmed to deliver anti-remodeling therapy (ART) by delivering neural stimulation to inhibit sympathetic nerve activity in conjunction with RCT. Other embodiments are provided herein.

2. 发明申请

US20080015648A1 COMBINED REMODELING CONTROL THERAPY AND ANTI-REMODELING THERAPY BY IMPLANTABLE CARDIAC DEVICE 有权
标题翻译：可重构心脏器械组合重组控制治疗与抗再感染治疗
公开(公告)号：US20080015648A1
公开(公告)日：2008-01-17
申请号：US11777394
申请日：2007-07-13
申请人： Imad Libbus , Bruce KenKnight , Julia Moffitt , Yatheendhar Manicka
发明人： Imad Libbus , Bruce KenKnight , Julia Moffitt , Yatheendhar Manicka
IPC分类号： A61N1/05
CPC分类号： A61N1/362 , A61N1/36114 , A61N1/3627
摘要： A method and device for delivering ventricular resynchronization pacing therapy in conjunction with electrical stimulation of nerves which alter the activity of the autonomic nervous system is disclosed. Such therapies may be delivered by an implantable device and are useful in preventing the deleterious ventricular remodeling which occurs as a result of a heart attack or heart failure. The device may perform an assessment of cardiac function in order to individually modulate the delivery of the two types of therapy.
摘要翻译：公开了一种用于将脑室再同步起搏治疗与神经改变自主神经系统的活动的电刺激结合的方法和装置。这样的治疗可以由可植入装置递送，并且可用于防止由于心脏病发作或心力衰竭而发生的有害心室重构。该装置可以执行心脏功能的评估，以便单独地调节两种类型的治疗的递送。

3. 发明申请

US20050261741A1 Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device 有权
标题翻译：通过可植入心脏装置的联合重塑控制治疗和抗重塑治疗
公开(公告)号：US20050261741A1
公开(公告)日：2005-11-24
申请号：US10850341
申请日：2004-05-20
申请人： Imad Libbus , Bruce KenKnight , Julia Moffitt , Yatheendhar Manicka
发明人： Imad Libbus , Bruce KenKnight , Julia Moffitt , Yatheendhar Manicka
IPC分类号： A61N1/36 , A61N1/362 , A61N1/18
CPC分类号： A61N1/362 , A61N1/36114 , A61N1/3627
摘要： A method and device for delivering ventricular resynchronization pacing therapy in conjunction with electrical stimulation of nerves which alter the activity of the autonomic nervous system is disclosed. Such therapies may be delivered by an implantable device and are useful in preventing the deleterious ventricular remodeling which occurs as a result of a heart attack or heart failure. The device may perform an assessment of cardiac function in order to individually modulate the delivery of the two types of therapy.
摘要翻译：公开了一种用于将脑室再同步起搏治疗与神经改变自主神经系统的活动的电刺激结合的方法和装置。这样的治疗可以由可植入装置递送，并且可用于防止由于心脏病发作或心力衰竭而发生的有害心室重构。该装置可以执行心脏功能的评估，以便单独地调节两种类型的治疗的递送。

4. 发明授权

US08131362B2 Combined neural stimulation and cardiac resynchronization therapy 有权
标题翻译：组合神经刺激和心脏再同步治疗
公开(公告)号：US08131362B2
公开(公告)日：2012-03-06
申请号：US12543654
申请日：2009-08-19
申请人： Julia Moffitt , Sophia Wang , Bruce H. KenKnight , Imad Libbus
发明人： Julia Moffitt , Sophia Wang , Bruce H. KenKnight , Imad Libbus
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/056 , A61N1/0587 , A61N1/36114 , A61N1/3962
摘要： Methods and devices for delivering cardiac therapy to a patient are provided. Various implantable device embodiments comprise a plurality of leads and a controller. The leads include at least one lead to be positioned within a lead path to deliver ventricular pacing pulses and to deliver neural stimulation at a site proximate to the heart to inhibit sympathetic nerve activity. The controller controls delivery of the ventricular pacing pulses in accordance with a programmed pacing mode and controls delivery of the neural stimulation. The controller is programmed to deliver remodeling control therapy (RCT) by delivering ventricular pacing to pre-excite a ventricular myocardium region to mechanically unload that region during systole, and further is programmed to deliver anti-remodeling therapy (ART) by delivering neural stimulation to inhibit sympathetic nerve activity in conjunction with RCT. Other embodiments are provided herein.
摘要翻译：提供了向患者输送心脏治疗的方法和装置。各种可植入装置实施例包括多个引线和控制器。引线包括至少一个引线定位在引导路径内以提供心室起搏脉冲并且在靠近心脏的部位输送神经刺激以抑制交感神经活动。控制器根据编程的起搏模式控制心室起搏脉冲的传递并控制神经刺激的传递。控制器被编程为通过提供心室起搏来预先激发心室心肌区域以在心脏收缩期间机械地卸载该区域来递送重建控制治疗（RCT），并且进一步被编程以通过递送神经刺激来递送抗重塑疗法（ART）与RCT结合抑制交感神经活动。本文提供了其他实施例。

5. 发明申请

US20060206153A1 Integrated lead for applying cardiac resynchronization therapy and neural stimulation therapy 有权
公开(公告)号：US20060206153A1
公开(公告)日：2006-09-14
申请号：US11077970
申请日：2005-03-11
申请人： Imad Libbus , Julio Spinelli , Randy Westlund , Julia Moffitt , Sophia Wang
发明人： Imad Libbus , Julio Spinelli , Randy Westlund , Julia Moffitt , Sophia Wang
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/0551 , A61N1/0556 , A61N1/0558 , A61N1/056 , A61N1/057 , A61N1/0587 , A61N1/36114 , A61N2001/0585
摘要： An embodiment includes a main lead assembly having a proximal portion adapted for connection to a device and a distal portion adapted for placement in a coronary sinus, the distal portion terminating in a distal end for placement proximal a left ventricle. Additionally, the main lead assembly includes a left ventricular electrode located at its distal end which is adapted to deliver cardiac resynchronization therapy to reduce ventricular wall stress. The main lead assembly also includes a fat pad electrode disposed along the main lead assembly a distance from the distal end to position the fat pad electrode proximal to at least one parasympathetic ganglia located in a fat pad bounded by an inferior vena cava and a left atrium. The fat pad electrode is adapted to stimulate the parasympathetic ganglia to reduce ventricular wall stress.

6. 发明申请

US20090306734A1 COMBINED NEURAL STIMULATION AND CARDIAC RESYNCHRONIZATION THERAPY 有权
标题翻译：组合神经刺激和心脏再生治疗
公开(公告)号：US20090306734A1
公开(公告)日：2009-12-10
申请号：US12543654
申请日：2009-08-19
申请人： Julia Moffitt , Sophia Wang , Bruce H. Kenknight , Imad Libbus
发明人： Julia Moffitt , Sophia Wang , Bruce H. Kenknight , Imad Libbus
IPC分类号： A61N1/365 , A61N1/362 , A61N1/39
CPC分类号： A61N1/3627 , A61N1/056 , A61N1/0587 , A61N1/36114 , A61N1/3962
摘要： Methods and devices for delivering cardiac therapy to a patient are provided. Various implantable device embodiments comprise a plurality of leads and a controller. The leads include at least one lead to be positioned within a lead path to deliver ventricular pacing pulses and to deliver neural stimulation at a site proximate to the heart to inhibit sympathetic nerve activity. The controller controls delivery of the ventricular pacing pulses in accordance with a programmed pacing mode and controls delivery of the neural stimulation. The controller is programmed to deliver remodeling control therapy (RCT) by delivering ventricular pacing to pre-excite a ventricular myocardium region to mechanically unload that region during systole, and further is programmed to deliver anti-remodeling therapy (ART) by delivering neural stimulation to inhibit sympathetic nerve activity in conjunction with RCT. Other embodiments are provided herein.
摘要翻译：提供了向患者输送心脏治疗的方法和装置。各种可植入装置实施例包括多个引线和控制器。引线包括至少一个引线定位在引导路径内以提供心室起搏脉冲并且在靠近心脏的部位输送神经刺激以抑制交感神经活动。控制器根据编程的起搏模式控制心室起搏脉冲的传递并控制神经刺激的传递。控制器被编程为通过提供心室起搏来预先激发心室心肌区域以在心脏收缩期间机械地卸载该区域来递送重建控制治疗（RCT），并且进一步被编程以通过递送神经刺激来递送抗重塑疗法（ART）与RCT结合抑制交感神经活动。本文提供了其他实施例。

7. 发明授权

US07587238B2 Combined neural stimulation and cardiac resynchronization therapy 有权
标题翻译：组合神经刺激和心脏再同步治疗
公开(公告)号：US07587238B2
公开(公告)日：2009-09-08
申请号：US11078460
申请日：2005-03-11
申请人： Julia Moffitt , Sophia Wang , Bruce H. KenKnight , Imad Libbus
发明人： Julia Moffitt , Sophia Wang , Bruce H. KenKnight , Imad Libbus
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/056 , A61N1/0587 , A61N1/36114 , A61N1/3962
摘要： Methods and devices for delivering cardiac therapy to a patient are provided. Various implantable device embodiments comprise a plurality of leads and a controller. The leads include at least one lead to be positioned within a lead path to deliver ventricular pacing pulses and to deliver neural stimulation at a site proximate to the heart to inhibit sympathetic nerve activity. The controller controls delivery of the ventricular pacing pulses in accordance with a programmed pacing mode and controls delivery of the neural stimulation. The controller is programmed to deliver remodeling control therapy (RCT) by delivering ventricular pacing to pre-excite a ventricular myocardium region to mechanically unload that region during systole, and further is programmed to deliver anti-remodeling therapy (ART) by delivering neural stimulation to inhibit sympathetic nerve activity in conjunction with RCT. Other embodiments are provided herein.
摘要翻译：提供了向患者输送心脏治疗的方法和装置。各种可植入装置实施例包括多个引线和控制器。引线包括至少一个引线定位在引导路径内以提供心室起搏脉冲并且在靠近心脏的部位输送神经刺激以抑制交感神经活动。控制器根据编程的起搏模式控制心室起搏脉冲的传递并控制神经刺激的传递。控制器被编程为通过提供心室起搏来预先激发心室心肌区域以在心脏收缩期间机械地卸载该区域来递送重建控制治疗（RCT），并且进一步被编程以通过递送神经刺激来递送抗重塑疗法（ART）与RCT结合抑制交感神经活动。本文提供了其他实施例。

8. 发明授权

US08929990B2 Transvascular neural stimulation device and method for treating hypertension 有权
标题翻译：血管神经刺激装置及治疗高血压的方法
公开(公告)号：US08929990B2
公开(公告)日：2015-01-06
申请号：US12968831
申请日：2010-12-15
申请人： Julia Moffitt , Imad Libbus
发明人： Julia Moffitt , Imad Libbus
IPC分类号： A61N1/36 , A61N1/05 , A61N1/362
CPC分类号： A61N1/37288 , A61M31/00 , A61N1/0558 , A61N1/056 , A61N1/36053 , A61N1/3611 , A61N1/36114 , A61N1/36117 , A61N1/362 , A61N1/3627 , A61N1/37217
摘要： This document discusses, among other things, apparatus, systems, and methods for transvascularly stimulation of a nerve or nerve trunk. In an example, an apparatus is configured to transvascularly stimulate a nerve trunk through a blood vessel. The apparatus includes an expandable electrode that is chronically implantable in a blood vessel proximate a nerve trunk. The expandable electrode is configured to abut a predetermined surface area of the vessel wall along a predetermined length of the vessel. An electrical lead is coupled to the expandable electrode. An implantable pulse generator is coupled to the lead and configured to deliver an electrical stimulation signal to the electrode through the lead. In an example method, an electrical signal is delivered from an implanted medical device to an electrode chronically implanted in a blood vessel proximate a nerve trunk to transvascularly deliver neural stimulation from the electrode to the nerve trunk.
摘要翻译：本文件还讨论了用于神经或神经干的经血管刺激的装置，系统和方法。在一个实例中，一种装置构造成通过血管经血管刺激神经干。该装置包括可长期植入在靠近神经干的血管中的可扩张电极。可膨胀电极构造成沿容器的预定长度邻接容器壁的预定表面积。电引线耦合到可扩张电极。可植入脉冲发生器耦合到引线并且被配置为通过引线将电刺激信号传递到电极。在一个示例性方法中，将电信号从植入的医疗装置输送到长期植入在靠近神经干的血管中的电极，从而将神经刺激从电极转移到神经干。

9. 发明申请

US20130190837A1 SYSTEM AND METHOD FOR CLOSED-LOOP NEURAL STIMULATION 审中-公开
标题翻译：闭环神经刺激的系统和方法
公开(公告)号：US20130190837A1
公开(公告)日：2013-07-25
申请号：US13792805
申请日：2013-03-11
申请人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
发明人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
IPC分类号： A61N1/36
CPC分类号： A61N1/36117 , A61N1/08 , A61N1/36171
摘要： Various aspects of the present subject matter provide a device. In various embodiments, the device comprises a port adapted to connect a lead, a pulse generator connected to the port and adapted to provide a neural stimulation signal to the lead, and a signal processing module connected to the port and adapted to receive and process a nerve traffic signal from the lead into a signal indicative of the nerve traffic. The device includes a controller connected to the pulse generator and the signal processing module. The controller is adapted to implement a stimulation protocol to provide the neural stimulation signal with desired neural stimulation parameters based on the signal indicative of the nerve traffic. Other aspects are provided herein.
摘要翻译：本主题的各个方面提供了一种装置。在各种实施例中，该装置包括适于连接引线的端口，连接到端口的脉冲发生器，并适于向引线提供神经刺激信号，以及信号处理模块，连接到端口并适于接收和处理神经交通信号从引导到指示神经交通的信号。该装置包括连接到脉冲发生器和信号处理模块的控制器。控制器适于实现刺激方案，以基于指示神经交通的信号向神经刺激信号提供期望的神经刺激参数。本文提供了其他方面。

10. 发明申请

US20120232604A1 SYSTEM TO TREAT AV-CONDUCTED VENTRICULAR TACHYARRHYTHMIA 有权
标题翻译：系统治疗AV导致的心室TachyarRHYTHMIA
公开(公告)号：US20120232604A1
公开(公告)日：2012-09-13
申请号：US13473774
申请日：2012-05-17
申请人： Julia Moffitt , Andrew P. Kramer , Imad Libbus
发明人： Julia Moffitt , Andrew P. Kramer , Imad Libbus
IPC分类号： A61N1/365 , A61N1/39
CPC分类号： A61N1/36114 , A61B5/0464 , A61N1/0587 , A61N1/3622 , A61N1/3627 , A61N1/368 , A61N1/3684 , A61N1/3962 , A61N2001/0585
摘要： Various aspects of the present subject matter provide devices and methods to treat AV-conducted ventricular tachyarrhythmia (AVCVT). According to various embodiments of the method, an AVCVT is sensed, an IVC-LA fat pad is stimulated when the AVCVT is sensed to block AV conduction, and bradycardia support pacing is provided while the IVC-LA fat pad is stimulated. Other aspects and embodiments are provided herein.
摘要翻译：本主题的各个方面提供了治疗AV进行性室性快速性心律失常（AVCVT）的装置和方法。根据该方法的各种实施例，感测到AVCVT，当检测到AVCVT以阻止AV传导时刺激IVC-LA脂肪垫，并且在IVC-LA脂肪垫被刺激的同时提供心动过缓支持起搏。本文提供了其它方面和实施例。

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