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1. 发明授权

US08275456B2 Implantable device for delivering cardiac drug therapy 失效
标题翻译：用于输送心脏药物治疗的植入式装置
公开(公告)号：US08275456B2
公开(公告)日：2012-09-25
申请号：US11425263
申请日：2006-06-20
申请人： Steven D. Girouard , Qingsheng Zhu
发明人： Steven D. Girouard , Qingsheng Zhu
IPC分类号： A61N1/00 , A61N5/04
CPC分类号： A61N1/36592 , A61B5/0452 , A61M5/14276 , A61M5/1723 , A61M2230/04 , A61N1/3622 , A61N1/36507 , A61N1/36585
摘要： An implantable medical device in which an electrogram is recorded and analyzed in order to detect changes indicative of cardiac ischemia. Cardiac ischemia may be detected by recording an electrogram from a sensing channel of the device and comparing the recorded electrogram with a reference electrogram. If cardiac ischemia is detected, a cardiac drug such as a thrombolytic agent is delivered.
摘要翻译：记录和分析电描记图以便检测指示心脏缺血的变化的可植入医疗装置。可以通过从装置的感测通道记录电描记图并将记录的电描记图与参考电描记图进行比较来检测心脏缺血。如果检测到心脏缺血，则输送心脏药物如血栓溶解剂。

2. 发明授权

US08078287B2 His bundle mapping, pacing, and injection lead 有权
标题翻译：他的束映射，起搏和注射导联
公开(公告)号：US08078287B2
公开(公告)日：2011-12-13
申请号：US11760294
申请日：2007-06-08
申请人： Lili Liu , Randy Westlund , Steven D. Girouard
发明人： Lili Liu , Randy Westlund , Steven D. Girouard
IPC分类号： A61N1/05
CPC分类号： A61N1/0568
摘要： A cardiac rhythm management system includes a lead assembly for intracardiac mapping, pacing, and drug delivery. The lead assembly includes an implantable endocardial lead having a proximal end for connection to an implantable cardiac rhythm management device and a distal end for disposal in an intracardiac region. The lead includes a pacing-sensing electrode and a drug delivery device, both located at or near the distal end. A lumen is within and extends throughout the lead, with an opening at or near the proximal end and another opening at or near the distal end. The lumen provides for access to the intracardiac region by a steerable stylet and a hollow needle, one at a time. The steerable stylet allows for electrophysiological mapping of the intracardiac region. The hollow needle allows for delivery of chemical, biochemical, and/or biological substance to the intracardiac region.
摘要翻译：心律管理系统包括用于心内测绘，起搏和药物递送的导联组件。引线组件包括可植入心内膜引线，其具有用于连接到可植入心律管理装置的近端和用于在心内区域中处置的远端。引线包括起搏感测电极和药物递送装置，两者都位于远端或靠近远端。管腔在整个引线内部并且贯穿整个引线，在近端处或近端处的开口以及在远端处或附近的另一个开口。管腔通过可导向的管心针和中空针头一次一个地进入心脏内区域。可导向的管心针允许心内区域的电生理作图。中空针允许将化学，生物化学和/或生物物质递送至心内区域。

3. 发明授权

US07840263B2 Method and apparatus for device controlled gene expression 有权
标题翻译：用于器官控制基因表达的方法和装置
公开(公告)号：US07840263B2
公开(公告)日：2010-11-23
申请号：US10788906
申请日：2004-02-27
申请人： Steven D. Girouard , Jeffrey Ross
发明人： Steven D. Girouard , Jeffrey Ross
IPC分类号： A61N1/02
CPC分类号： A61N1/3627 , A61K47/6957 , A61M5/14276 , A61M5/1723 , A61M2205/3523 , A61N1/326 , A61N1/362 , A61N1/36514 , A61N1/3962
摘要： A gene regulatory system controls gene therapy by emitting one or more forms of energy that regulate gene expression by triggering promoters. The system includes a sensor to sense a signal indicative of a need for the gene therapy as well as responses to the gene therapy. The regulation of the gene expression is controlled based on the sensed signal and/or a user command. In one embodiment, the system delivers one or more electrical therapies in conjunction with the gene therapy.
摘要翻译：基因调控系统通过发射通过触发启动子调节基因表达的一种或多种形式的能量来控制基因治疗。该系统包括感测指示基因治疗需要的信号以及对基因治疗的反应的传感器。基于感测信号和/或用户命令来控制基因表达的调节。在一个实施方案中，系统与基因治疗结合递送一种或多种电疗法。

4. 发明申请

US20100286592A1 METHOD TO MODULATE CELLULAR REGENERATION POST MYOCARDIAL INFARCT 审中-公开
标题翻译：调节细胞再生后的心肌梗死的方法
公开(公告)号：US20100286592A1
公开(公告)日：2010-11-11
申请号：US12843524
申请日：2010-07-26
申请人： Steven D. Girouard , Jeffrey Ross , Rodney W. Salo
发明人： Steven D. Girouard , Jeffrey Ross , Rodney W. Salo
IPC分类号： A61M37/00 , A61N1/362
CPC分类号： A61M5/14276 , A61M5/1723 , A61M2205/3523 , A61M2205/3561 , A61M2210/125 , A61M2230/00 , A61N1/36585
摘要： A system delivers cardiac pacing therapy and chemical and/or biological therapy to modulate myocardial tissue growth in a heart after myocardial infarction (MI). The system includes an agent delivery device to release one or more agents to an MI region to modulate myocardial tissue growth in that region, and a cardiac rhythm management (CRM) device to deliver pacing pulses to enhance the effects of the one or more agents by altering myocardial wall stress and cardiac workload. In one embodiment, the system is an implantable system including an implantable agent delivery device and an implantable CRM device.
摘要翻译：系统提供心脏起搏治疗和化学和/或生物治疗以调节心肌梗塞（MI）后心脏中的心肌组织生长。该系统包括用于将一个或多个药剂释放到MI区域以调节该区域中的心肌组织生长的药剂递送装置，以及心律管理（CRM）装置，以递送起搏脉冲以增强一种或多种药剂的作用改变心肌壁压力和心脏工作量。在一个实施例中，该系统是包括可植入剂递送装置和可植入CRM装置的可植入系统。

5. 发明授权

US07548780B2 Cell therapy and neural stimulation for cardiac repair 失效
标题翻译：细胞治疗和神经刺激用于心脏修复
公开(公告)号：US07548780B2
公开(公告)日：2009-06-16
申请号：US11063170
申请日：2005-02-22
申请人： Imad Libbus , Jeffrey Ross , Steven D. Girouard
发明人： Imad Libbus , Jeffrey Ross , Steven D. Girouard
IPC分类号： A61N1/18
CPC分类号： A61N1/36114 , A61K41/00 , A61N1/362
摘要： A method and system to enhance cell, gene and/or cytokine therapy for cardiac repair in a mammal.
摘要翻译：用于增强哺乳动物心脏修复的细胞，基因和/或细胞因子治疗的方法和系统。

6. 发明申请

US20080086185A1 DISTRIBUTED NEUROMODULATION SYSTEM FOR TREATMENT OF CARDIOVASCULAR DISEASE 有权
标题翻译：用于治疗心血管疾病的分布式神经调节系统
公开(公告)号：US20080086185A1
公开(公告)日：2008-04-10
申请号：US11539301
申请日：2006-10-06
申请人： Badri Amurthur , Steven D. Girouard , Imad Libbus
发明人： Badri Amurthur , Steven D. Girouard , Imad Libbus
IPC分类号： A61N1/00
CPC分类号： A61N1/37288 , A61N1/36114 , A61N1/37247 , A61N1/3787
摘要： A distributed system is described that employs electrical neural stimulation to modulate autonomic activity and which allows titration of the neural stimulation therapy in accordance with physiological measurements reflective of autonomic activity and/or physiological variables affected by the neural stimulation. Such a system may include a plurality of implantable neuromodulation units that communicate with one another over a network.
摘要翻译：描述了一种使用电神经刺激来调节自主活动的分布式系统，并且其允许根据反映受神经刺激影响的自主活动和/或生理变量的生理测量来滴定神经刺激疗法。这样的系统可以包括通过网络彼此通信的多个可植入神经调节单元。

7. 发明授权

US06775572B2 Method and system for automatic anti-tachycardia pacing 有权
标题翻译：自动抗心动过速起搏方法与系统
公开(公告)号：US06775572B2
公开(公告)日：2004-08-10
申请号：US10037302
申请日：2001-10-25
申请人： Qingsheng Zhu , Stephen John Hahn , Steven D. Girouard
发明人： Qingsheng Zhu , Stephen John Hahn , Steven D. Girouard
IPC分类号： A61N1365
CPC分类号： A61N1/3622 , A61N1/3712
摘要： A method and system for delivering anti-tachycardia pacing is disclosed. A cardiac rhythm management device, such as an implantable pacemaker having anti-tachycardia pacing capability, delivers anti-tachycardia pacing therapy in accordance with an anti-tachycardia pacing protocol upon detection of a terminable arrhythmia. The anti-tachycardia pacing is delivered as a burst of one or more pacing pulses at a specified coupling interval after a sensed ventricular polarization. By sensing if an evoked potential occurs, the device can determine whether or not the anti-tachycardia pacing burst has captured the ventricle and can adjust the coupling interval and/or other parameters accordingly.
摘要翻译：公开了用于递送抗心动过速起搏的方法和系统。具有抗心动过速起搏能力的心脏节律管理装置，例如具有抗心动过速起搏能力的可植入起搏器，在检测到可终止的心律失常时，根据抗心动过速起搏方案提供抗心动过速起搏治疗。抗心动过速起搏在感测到的心室极化之后以指定的耦合间隔作为一个或多个起搏脉冲的脉冲串发送。通过感测是否发生诱发电位，该装置可以确定抗心动过速起搏脉冲是否已经捕获到心室，并且可以相应地调整耦合间隔和/或其他参数。

8. 发明授权

US06687541B2 Method for delivering atrial defibrillation therapy 失效
标题翻译：交付心房除颤疗法
公开(公告)号：US06687541B2
公开(公告)日：2004-02-03
申请号：US10334397
申请日：2002-12-30
申请人： Alan F. Marcovecchio , Milton M. Morris , Steven D. Girouard , Douglas J. Lang
发明人： Alan F. Marcovecchio , Milton M. Morris , Steven D. Girouard , Douglas J. Lang
IPC分类号： A61N139
CPC分类号： A61N1/3987 , A61N1/36521 , A61N1/395 , A61N1/3956
摘要： An apparatus and method for delivering electrical shock therapy in order to treat atrial tachyarrhythmias such as fibrillation is disclosed. In accordance with the method, atrial defibrillation shocks are delivered synchronously with an R wave if the current R-R interval meets one or more safety criteria so as to be considered shockable. A shockable R-R interval may be defined as one that exceeds the previous QT interval by a specified therapy margin. In one embodiment, the previous QT interval is estimated based upon the measured preceding R-R interval.
摘要翻译：公开了一种用于递送电击治疗以治疗心房性心律失常如心律失常的装置和方法。根据该方法，如果当前的R-R间隔满足一个或多个安全标准以便被认为是可震荡的，则与R波同步地传送心房除颤电击。可震荡的R-R间隔可以定义为超过先前QT间隔指定治疗边缘的间隔。在一个实施例中，基于测量的先前的R-R间隔来估计先前的QT间隔。

9. 发明授权

US06361522B1 Drug delivery system for implantable cardiac device 有权
公开(公告)号：US06361522B1
公开(公告)日：2002-03-26
申请号：US09422433
申请日：1999-10-21
申请人： Avram Scheiner , Mark Herner , Ronald W. Heil, Jr. , Steven D. Girouard
发明人： Avram Scheiner , Mark Herner , Ronald W. Heil, Jr. , Steven D. Girouard
IPC分类号： A61M3100
CPC分类号： A61N1/30 , A61N1/3621 , Y10S128/12 , Y10S128/13
摘要： A drug delivery system incorporated into a cardiac device for delivering a dose of a drug to a patient upon detection of a particular medical condition. The cardiac device may be, for example, an implantable cardioverter/defibrillator, cardiac pacemaker, or combination device that communicates via a radio frequency link with a drug delivery device. The drug delivery device is preferably an electrically modulated transdermal drug delivery device for delivering the drug transdermally in accordance with a signal received from the cardiac device.

10. 发明授权

US09031792B2 Method of using a lead to regulate protein expression 有权
标题翻译：使用铅调节蛋白质表达的方法
公开(公告)号：US09031792B2
公开(公告)日：2015-05-12
申请号：US11277552
申请日：2006-03-27
申请人： Darrell O. Wagner , Haris J. Sih , Jihong Qu , Jeffrey Ross , Steven D. Girouard , Ronald W. Heil, Jr.
发明人： Darrell O. Wagner , Haris J. Sih , Jihong Qu , Jeffrey Ross , Steven D. Girouard , Ronald W. Heil, Jr.
IPC分类号： G01N33/48 , A61K48/00 , A61N1/05
CPC分类号： A61K48/0008 , A61K48/0083 , A61N1/05
摘要： A system and device are provided which include a gene regulatory system controlling expression of one or more expression cassettes present in or released by the device, by emitting one or more stimulations. An expression cassette includes a regulatable transcription control element that is responsive to the emitted stimulations linked to an open reading frame of interest. The system optionally includes a sensor to sense a parameter indicative of a need, a telemetry module to receive an external command, or a programmable device, for regulating gene expression of the open reading frame.
摘要翻译：提供了一种系统和装置，其包括通过发射一种或多种刺激来控制存在于或释放的装置中的一种或多种表达盒的表达的基因调控系统。表达盒包括可调节的转录控制元件，其响应于与感兴趣的开放阅读框架相关联的发射刺激。该系统可选地包括用于感测指示需要的参数的传感器，用于接收外部命令的遥测模块或用于调节开放阅读框的基因表达的可编程设备。

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