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1. 发明申请

US20080280341A1 System And Method For Local Field Stimulation 审中-公开
标题翻译：本地场刺激的系统和方法
公开(公告)号：US20080280341A1
公开(公告)日：2008-11-13
申请号：US11745717
申请日：2007-05-08
申请人： Bruce KenKnight , Steven D. Girouard
发明人： Bruce KenKnight , Steven D. Girouard
IPC分类号： C12N13/00 , C12M1/42
CPC分类号： C12N13/00 , A61M5/14276 , A61N1/362 , A61N1/3627
摘要： A system is provided for stimulating one or more cells, wherein the stimulation is sub-threshold and may alter a transmembrane potential of the one or more cells. For some populations of cells it may be possible to affect the transmembrane potential to gain a therapeutic benefit. Cells of the sino-atrial node spontaneously depolarize predominantly due to the slow depolarization of transmembrane potential. The present system may provide sino-atrial cells with a local field stimulation that while not eliciting an action potential may nonetheless alter local transmembrane potential. Such alteration of transmembrane potential may permit an increase or decrease in a rate of depolarization, and hence modify heart rate.
摘要翻译：提供了一种用于刺激一个或多个细胞的系统，其中所述刺激是次阈值的，并且可以改变所述一个或多个细胞的跨膜电位。对于一些细胞群体，可能影响跨膜电位以获得治疗益处。由于跨膜电位缓慢去极化，中心节点的细胞主要去极化。本发明的系统可以为中心细胞提供局部场刺激，尽管不引起动作电位也可能改变局部跨膜电位。跨膜电位的这种改变可以允许去极化率的增加或减少，从而改变心率。

2. 发明申请

US20080281369A1 System And Method For Determining The Origin Of A Sensed Beat 有权
标题翻译：确定感觉节拍的起源的系统和方法
公开(公告)号：US20080281369A1
公开(公告)日：2008-11-13
申请号：US11745667
申请日：2007-05-08
申请人： Bruce KenKnight , Steven D. Girouard
发明人： Bruce KenKnight , Steven D. Girouard
IPC分类号： A61N1/36
CPC分类号： A61B5/04525 , A61B5/042 , A61B5/0456 , A61B5/7239 , A61N1/3702
摘要： A method for monitoring a biological cardiac pacemaker is provided. The method may include stimulating a heart at a region selected for implantation of a biological pacemaker and sensing at least one electrical signal indicative of a cardiac depolarization originating in the region selected for implantation of the biological pacemaker. The method may further include sensing at least one subsequent electrical signal produced by the heart and determining if the subsequent electrical signal originated in the region selected for the biological pacemaker or another region of the heart. In an alternative embodiment, the method may include determining a template time difference between two points on cardiac complexes sensed in two or more different cardiac locations during normal sinus rhythm. The method may further include determining a time difference between two points on a subsequent cardiac complex sensed in two or more different cardiac locations. The time differences may be compared to determine if the subsequently-sensed cardiac complex originates in a left ventricular biological pacemaker site or in another cardiac site.
摘要翻译：提供了一种用于监测生物心脏起搏器的方法。该方法可以包括在选择用于植入生物起搏器的区域处刺激心脏，并感测至少一个电信号，其指示源于选择用于植入生物起搏器的区域的心脏去极化。该方法还可以包括感测由心脏产生的至少一个随后的电信号，并确定后续的电信号是否起源于为生物起搏器或心脏另一区域选择的区域。在替代实施例中，该方法可以包括确定在正常窦性心律期间在两个或更多个不同心脏位置中感测到的心脏复合体上的两个点之间的模板时间差。该方法还可以包括确定在两个或更多个不同心脏位置中感测到的随后的心脏复合体上的两个点之间的时间差。可以比较时间差以确定随后感测的心脏复合物是否起源于左心室生物起搏器位点或另一心脏位点。

3. 发明授权

US08442631B2 System and method for determining the origin of a sensed beat 有权
标题翻译：用于确定感测拍子的原点的系统和方法
公开(公告)号：US08442631B2
公开(公告)日：2013-05-14
申请号：US11745667
申请日：2007-05-08
申请人： Bruce KenKnight , Steven D. Girouard
发明人： Bruce KenKnight , Steven D. Girouard
IPC分类号： A61N1/36
CPC分类号： A61B5/04525 , A61B5/042 , A61B5/0456 , A61B5/7239 , A61N1/3702
摘要： A method for monitoring a biological cardiac pacemaker. The method may include stimulating a heart at a region selected for implantation of a biological pacemaker and sensing at least one electrical signal indicative of a cardiac depolarization originating in the region selected for implantation of the biological pacemaker. The method may further include sensing at least one subsequent electrical signal produced by the heart and determining if the subsequent electrical signal originated in the region selected for the biological pacemaker or another region of the heart.
摘要翻译：监测生物心脏起搏器的方法。该方法可以包括在选择用于植入生物起搏器的区域处刺激心脏，并感测至少一个电信号，其指示源于选择用于植入生物起搏器的区域的心脏去极化。该方法还可以包括感测由心脏产生的至少一个随后的电信号，并确定后续的电信号是否起源于为生物起搏器或心脏另一区域选择的区域。

4. 发明申请

US20080281371A1 Method For Controlling Pacemaker Therapy 有权
标题翻译：控制起搏器治疗的方法
公开(公告)号：US20080281371A1
公开(公告)日：2008-11-13
申请号：US11745823
申请日：2007-05-08
申请人： Bruce KenKnight , Steven D. Girouard
发明人： Bruce KenKnight , Steven D. Girouard
IPC分类号： A61N1/365
CPC分类号： A61N1/365 , A61B5/0468 , A61N1/36514 , A61N1/36592 , A61N1/3688 , A61N1/3702
摘要： The present invention includes a method for controlling pacemaker therapy in a patient with an implanted biological pacemaker. The method may include pacing a heart at a predetermined rate using an electronic pacemaker and configuring the pacemaker to periodically enter a biological pacemaker weaning mode. The weaning mode may include ceasing pacing for at least a predetermined length of time and monitoring the heart to detect electrical depolarizations of a ventricle of the heart during the predetermined length of time. The weaning mode may further include determining the length of time between the cessation of pacing and the detected electrical depolarization and determining if the length of time between the cessation of pacing and the detected electrical depolarization is less than a maximum predetermined interval. The pacemaker therapy may be withheld as long as the length of time is less than the maximum predetermined interval. Further, if the length of time exceeds a maximum interval, the pacemaker will exit the weaning mode.
摘要翻译：本发明包括一种用植入式生物起搏器控制患者起搏器治疗的方法。该方法可以包括使用电子起搏器以预定速率起搏心脏并且配置起搏器周期性地进入生物起搏器断奶模式。断奶模式可以包括停止至少预定时间长度的起搏并监测心脏以在预定时间长度内检测心脏心室的电去极化。断奶模式还可以包括确定停止起搏和检测到的电去极化之间的时间长度，并确定停止起搏和检测到的电去极化之间的时间长度是否小于最大预定间隔。只要时间长度小于最大预定间隔，就可以禁止起搏器治疗。此外，如果时间长度超过最大间隔，则起搏器将退出断奶模式。

5. 发明授权

US09150832B2 Cell training for local field stimulation 有权
标题翻译：局部场刺激的细胞训练
公开(公告)号：US09150832B2
公开(公告)日：2015-10-06
申请号：US11745620
申请日：2007-05-08
申请人： Bruce KenKnight , Steven D. Girouard
发明人： Bruce KenKnight , Steven D. Girouard
IPC分类号： C12N13/00 , A61N1/362 , C12N5/077 , A61K35/12 , A61M37/00 , A61B17/34 , A61B17/00 , A61B18/00 , A61N1/32
CPC分类号： C12N5/0657 , A61B17/3468 , A61B2017/00247 , A61B2017/00256 , A61B2018/00392 , A61K35/12 , A61M37/0069 , A61N1/326 , A61N1/362
摘要： A system is provided for stimulating one or more cells, wherein the stimulation is sub-threshold and may alter a transmembrane potential of the one or more cells. For some populations of cells it may be possible to affect the transmembrane potential to gain a therapeutic benefit. Cells of the sino-atrial node spontaneously depolarize predominantly due to the slow depolarization of transmembrane potential. The present system may provide sino-atrial cells with a local field stimulation that while not eliciting an action potential may nonetheless alter local transmembrane potential. Such alteration of transmembrane potential may permit an increase or decrease in a rate of depolarization, and hence modify heart rate.
摘要翻译：提供了一种用于刺激一个或多个细胞的系统，其中所述刺激是次阈值的并且可以改变所述一个或多个细胞的跨膜电位。对于一些细胞群体，可能影响跨膜电位以获得治疗益处。由于跨膜电位缓慢去极化，中心节点的细胞主要去极化。本发明的系统可以为中心细胞提供局部场刺激，尽管不引起动作电位也可能改变局部跨膜电位。跨膜电位的这种改变可以允许去极化率的增加或减少，从而改变心率。

6. 发明授权

US08224443B2 Method for controlling pacemaker therapy 有权
标题翻译：控制起搏器治疗的方法
公开(公告)号：US08224443B2
公开(公告)日：2012-07-17
申请号：US11745823
申请日：2007-05-08
申请人： Bruce KenKnight , Steven D. Girouard
发明人： Bruce KenKnight , Steven D. Girouard
IPC分类号： A61N1/362
CPC分类号： A61N1/365 , A61B5/0468 , A61N1/36514 , A61N1/36592 , A61N1/3688 , A61N1/3702
摘要： The present invention includes a method for controlling pacemaker therapy in a patient with an implanted biological pacemaker. The method may include pacing a heart at a predetermined rate using an electronic pacemaker and configuring the pacemaker to periodically enter a biological pacemaker weaning mode. The weaning mode may include ceasing pacing for at least a predetermined length of time and monitoring the heart to detect electrical depolarizations of a ventricle of the heart during the predetermined length of time. The weaning mode may further include determining the length of time between the cessation of pacing and the detected electrical depolarization and determining if the length of time between the cessation of pacing and the detected electrical depolarization is less than a maximum predetermined interval. The pacemaker therapy may be withheld as long as the length of time is less than the maximum predetermined interval. Further, if the length of time exceeds a maximum interval, the pacemaker will exit the weaning mode.
摘要翻译：本发明包括一种用植入式生物起搏器控制患者起搏器治疗的方法。该方法可以包括使用电子起搏器以预定速率起搏心脏并且配置起搏器周期性地进入生物起搏器断奶模式。断奶模式可以包括停止至少预定时间长度的起搏并监测心脏以在预定时间长度内检测心脏心室的电去极化。断奶模式还可以包括确定停止起搏和检测到的电去极化之间的时间长度，并确定停止起搏和检测到的电去极化之间的时间长度是否小于最大预定间隔。只要时间长度小于最大预定间隔，就可以禁止起搏器治疗。此外，如果时间长度超过最大间隔，则起搏器将退出断奶模式。

7. 发明授权

US08027719B2 Method and apparatus for delivering defibrillation shock therapy while reducing electrical dispersion due to ventricular conduction disorder 有权
标题翻译：用于递送除颤休克疗法同时减少由于心室传导障碍引起的电离散的方法和装置
公开(公告)号：US08027719B2
公开(公告)日：2011-09-27
申请号：US12051997
申请日：2008-03-20
申请人： Jeffrey E. Stahmann , Jesse W. Hartley , Steven D. Girouard
发明人： Jeffrey E. Stahmann , Jesse W. Hartley , Steven D. Girouard
IPC分类号： A61N1/00
CPC分类号： A61N1/3622 , A61N1/3627 , A61N1/3684 , A61N1/3962
摘要： A method and device for delivering defibrillation shock therapy in patients having an inter-ventricular conduction disorder is presented. Ventricular resynchronization therapy is employed to reduce the dispersion of ventricular depolarization which takes place due to the conduction disorder and reduces the safety margin of shocks delivered synchronously with ventricular beats. The method may be employed in the treatment of atrial or ventricular tachyarrhythmias.
摘要翻译：提出了一种用于在患有心室间传导障碍的患者中递送除颤休克疗法的方法和装置。采用心室再同步治疗来减少由于传导障碍引起的心室去极化的分散，降低与心室搏动同步传递的休克的安全余量。该方法可用于治疗心房或室性快速性心律失常。

8. 发明申请

US20100081948A1 METHOD AND APPARATUS FOR LOCALIZING MYOCARDIAL INFARCTION DURING CATHETERIZATION 审中-公开
标题翻译：用于在导管期间定位心肌梗塞的方法和装置
公开(公告)号：US20100081948A1
公开(公告)日：2010-04-01
申请号：US12628390
申请日：2009-12-01
申请人： Joseph M. Pastore , Steven D. Girouard
发明人： Joseph M. Pastore , Steven D. Girouard
IPC分类号： A61B5/02
CPC分类号： A61B5/4839 , A61B5/0071 , A61B5/0084 , A61B5/0265 , A61B5/1107 , A61B5/6869 , A61B8/12 , A61B2562/0219 , A61N1/3702
摘要： A catheter with a tissue property sensor provides for localization of myocardial infarction (MI) by utilizing one or more differences between properties of infarcted myocardial tissue and properties of normal myocardial tissue. The tissue property sensor is to be placed on endocardial wall or epicardial wall during catheterization to sense at least one tissue property allowing for detection of MI. Examples of the tissue property sensor include, but are not limited to, an optical sensor, an acoustic sensor, a contractility sensor, a temperature sensor, and a drug response sensor. In one embodiment, the tissue property sensor senses a tissue property in various locations on endocardial wall or epicardial wall and detects substantial changes in the tissue property that indicate a boundary between infarcted tissue and normal tissue.
摘要翻译：具有组织属性传感器的导管通过利用梗死心肌组织的性质与正常心肌组织的性质之间的一个或多个差异来提供心肌梗死（MI）的定位。在导管插入期间，将组织性质传感器放置在心内膜壁或心外膜上以感测至少一个允许检测MI的组织特性。组织性质传感器的实例包括但不限于光学传感器，声学传感器，收缩性传感器，温度传感器和药物响应传感器。在一个实施例中，组织性质传感器检测心内膜壁或心外壁上各种位置的组织特性，并且检测指示梗塞组织与正常组织之间的边界的组织性质的实质性变化。

9. 发明授权

US07245973B2 His bundle mapping, pacing, and injection lead 有权
标题翻译：他的束映射，起搏和注射导联
公开(公告)号：US07245973B2
公开(公告)日：2007-07-17
申请号：US10745302
申请日：2003-12-23
申请人： Lili Liu , Randy Westlund , Steven D. Girouard
发明人： Lili Liu , Randy Westlund , Steven D. Girouard
IPC分类号： A61N1/05
CPC分类号： A61N1/0568
摘要： A cardiac rhythm management system includes a lead assembly for intracardiac mapping, pacing, and drug delivery. The lead assembly includes an implantable endocardial lead having a proximal end for connection to an implantable cardiac rhythm management device and a distal end for disposal in an intracardiac region. The lead includes a pacing-sensing electrode and a drug delivery device, both located at or near the distal end. A lumen is within and extends throughout the lead, with an opening at or near the proximal end and another opening at or near the distal end. The lumen provides for access to the intracardiac region by a steerable stylet and a hollow needle, one at a time. The steerable stylet allows for electrophysiological mapping of the intracardiac region. The hollow needle allows for delivery of chemical, biochemical, and/or biological substance to the intracardiac region.
摘要翻译：心律管理系统包括用于心内测绘，起搏和药物递送的导联组件。引线组件包括可植入心内膜引线，其具有用于连接到可植入心律管理装置的近端和用于在心内区域中处置的远端。引线包括起搏感测电极和药物递送装置，两者都位于远端或靠近远端。管腔在整个引线内部并且贯穿整个引线，在近端处或近端处的开口以及在远端处或附近的另一个开口。管腔通过可导向的管心针和中空针头一次一个地进入心脏内区域。可导向的管心针允许心内区域的电生理作图。中空针允许将化学，生物化学和/或生物物质递送至心内区域。

10. 发明授权

US07072711B2 Implantable device for delivering cardiac drug therapy 失效
标题翻译：用于输送心脏药物治疗的植入式装置
公开(公告)号：US07072711B2
公开(公告)日：2006-07-04
申请号：US10293907
申请日：2002-11-12
申请人： Steven D. Girouard , Qingsheng Zhu
发明人： Steven D. Girouard , Qingsheng Zhu
IPC分类号： A61N1/372
CPC分类号： A61N1/36592 , A61B5/0452 , A61M5/14276 , A61M5/1723 , A61M2230/04 , A61N1/3622 , A61N1/36507 , A61N1/36585
摘要： An implantable medical device in which an electrogram is recorded and analyzed in order to detect changes indicative of cardiac ischemia. Cardiac ischemia may be detected by recording an electrogram from a sensing channel of the device and comparing the recorded electrogram with a reference electrogram. If cardiac ischemia is detected, a cardiac drug such as a thrombolytic agent is delivered.
摘要翻译：记录和分析电描记图以便检测指示心脏缺血的变化的可植入医疗装置。可以通过从装置的感测通道记录电描记图并将记录的电描记图与参考电描记图进行比较来检测心脏缺血。如果检测到心脏缺血，则输送心脏药物如血栓溶解剂。

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