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    • 2. 发明授权
    • Anti-wrinkle agents
    • 抗皱剂
    • US08835498B2
    • 2014-09-16
    • US13126714
    • 2009-11-12
    • Noriko SuenobuChihiro KondoTakashi Yamasaki
    • Noriko SuenobuChihiro KondoTakashi Yamasaki
    • A61K8/46A61K8/44C07C321/14C07C309/04C07C309/07C07C309/18A61Q19/08A61K8/42A61K31/198
    • A61K31/198A61K8/42A61K8/46A61K8/466A61Q19/08
    • Provided are anti-wrinkle agents having a novel scaffold that is suitable as components for external skin preparations such as cosmetics. The anti-wrinkle agents comprise compounds represented by general formula (1), stereoisomers thereof, or pharmacologically acceptable salts thereof. Said anti-wrinkle agents have excellent efficacy in improving wrinkles and sagging that are caused by skin aging with increased age or occur as a result of photoaging due to ultraviolet rays exposure. [In the formula, R1 represents a hydrogen atom or a 1 to 8 carbon straight or branched alkyl group. R2 represents —SH, —SO3H, —S—S—X1, —S—X2, —SO—X3, —SO2—X4, —SO2—NY1—X5 or —SO2—NY2—Y3. X1-X5 independently are hydrogen atoms or 1 to 8 carbon aliphatic hydrocarbon groups or 5 to 12 carbon aromatic moiety wherein carbon atoms may be substituted with heteroatoms. Y1 to Y3 independently represent hydrogen atoms or 1 to 8 carbon linear or branched alkyl groups. R3 represents a hydrogen atom or acyl group having a 1 to 8 carbon straight or branched alkyl chain. R4 represents a 5 to 12 carbon aromatic group or polycyclic condensed aromatic group that may have unsubstituted or substituted groups. m represents an integer 0-3 and n represents an integer 1 or 2].
    • 提供了具有适合作为外用皮肤制剂如化妆品的组分的新型支架的抗皱剂。 抗皱剂包括由通式(1)表示的化合物,其立体异构体或其药理学上可接受的盐。 所述抗皱剂在改善由老化引起的皱纹和下垂的作用方面具有优异的效果,或者由于紫外线暴露引起的光老化而发生。 [式中,R 1表示氢原子或1〜8碳直链或支链烷基。 R2表示-SH,-SO3H,-S-S-X1,-S-X2,-SO-X3,-SO2-X4,-SO2-NY1-X5或-SO2-NY2-Y3。 X 1 -X 5独立地是氢原子或1至8个碳脂族烃基或5至12个碳芳族部分,其中碳原子可以被杂原子取代。 Y 1〜Y 3独立地表示氢原子或1〜8个碳直链或支链烷基。 R3表示氢原子或具有1-8个碳直链或支链烷基链的酰基。 R 4表示可以具有未取代或取代基的5〜12个碳芳香族基团或多环稠合芳香族基团。 m表示0-3的整数,n表示1或2的整数]。
    • 5. 发明授权
    • Power converter
    • 电源转换器
    • US5608614A
    • 1997-03-04
    • US280552
    • 1994-07-26
    • Masahito OhnishiShozo KataokaTakashi KandaTakashi YamasakiKazuo Yoshida
    • Masahito OhnishiShozo KataokaTakashi KandaTakashi YamasakiKazuo Yoshida
    • H02J1/00H02M1/42H02M3/00H02M3/07H02M7/06H02M3/18
    • H02M1/4208H02M3/07Y02B70/126
    • A power converter has two switched capacitor circuits each including at least a plurality of sets of capacitors and switching elements, first of which circuits is provided for supplying a DC power to a load while second of which accumulates a power in a period receiving a higher input voltage, and the first switched capacitor circuit being made to receive, in a period receiving a lower input voltage, a power supplied from a DC power source and also the power supplied from the second switched capacitor circuit for supplying to the load the DC power of a constant voltage, in which an input current collectively taken up by the two switched capacitor circuits is made similar in the waveform to the input voltage to eliminate any harmonics distortion of the current drawn from the source, for attaining the supply of the DC power of the constant voltage to the load, whereby the power converter is rendered not to require any large inductor to be capable of being minimized in size and restraining any noise radiation from occurring.
    • 功率转换器具有两个开关电容器电路,每个开关电容器电路至少包括多组电容器和开关元件,其中首先提供用于向负载提供DC电力的电路,其中第二个电容器在接收较高输入的时段内积累功率 电压,并且第一开关电容器电路在接收较低输入电压的时间段内接收从直流电源提供的电力,以及从第二开关电容器电路提供的电力,以向负载提供直流电力 恒定电压,其中由两个开关电容器电路共同占据的输入电流在波形中与输入电压相似,以消除从源极吸取的电流的任何谐波失真,以获得 对负载的恒定电压,从而使得功率转换器不需要任何大的电感器能够在尺寸上最小化并限制 g发生任何噪音辐射。
    • 6. 发明授权
    • Prophylactic or ameliorating agent for pigmentation
    • 预防或改善色素沉着剂
    • US09066914B2
    • 2015-06-30
    • US13521028
    • 2011-01-12
    • Takashi YamasakiYuko SaitohChihiro Kondo
    • Takashi YamasakiYuko SaitohChihiro Kondo
    • A61K31/196A61K31/198A61K8/46A61K9/00A61K9/10A61Q19/02C07C309/18
    • A61K31/198A61K8/466A61K9/0014A61K9/10A61Q19/02C07C309/18
    • An object of the present invention is to provide a prophylactic or ameliorating agent for pigmentation having a novel scaffold and an external preparation for skin containing the same as a component. The object is achieved by providing a prophylactic or ameliorating agent for pigmentation comprising a compound represented by the following general formula (1), an isomer thereof, and/or a pharmacologically acceptable salt thereof and an external preparation for skin containing the same as a component: [wherein R1 represents a hydrogen atom or a linear chain or branched alkyl group having 1 to 8 carbon atom(s); R2 represents a hydrogen atom, a substituted or unsubstituted aliphatic hydrocarbon group having 1 to 8 carbon atom(s), a substituted or unsubstituted aromatic group, a substituted or unsubstituted polycyclic fused aromatic group, or a substituted or unsubstituted heterocyclic group having a 5 to 12 carbon atoms; R3 represents a substituted or unsubstituted aromatic group, a substituted or unsubstituted polycyclic fused aromatic group, or a substituted or unsubstituted heterocyclic group having a 5 to 15 carbon atoms; n represents an integer of 1 or 2; and m represents an integer of 0 to 3.]
    • 本发明的目的是提供一种具有新型支架和含有其作为组分的皮肤外用剂的着色剂的预防或改善剂。 该目的通过提供一种色素沉着预防或改善剂来实现,所述预防或改善剂包含由以下通式(1)表示的化合物,其异构体和/或其药理学可接受的盐以及含有其作为成分的皮肤外用制剂 [式中,R 1表示氢原子或碳原子数1〜8的直链状或支链状的烷基。 R2表示氢原子,取代或未取代的碳原子数1〜8的脂肪族烃基,取代或未取代的芳香族基团,取代或未取代的多环稠合芳香族基团或取代或未取代的具有5〜 12个碳原子; R 3表示取代或未取代的芳族基团,取代或未取代的多环稠合芳香族基团,或取代或未取代的碳原子数5〜15的杂环基。 n表示1或2的整数; m表示0〜3的整数。]
    • 9. 发明授权
    • High-speed internal clock synchronizing method and circuit
    • 高速内部时钟同步方式和电路
    • US6021504A
    • 2000-02-01
    • US97671
    • 1998-06-16
    • Takashi Yamasaki
    • Takashi Yamasaki
    • G06F15/16G06F1/10G06F1/12G06F15/177H03L7/00H03L7/085H03L7/099H04L7/00H04L7/033
    • H03L7/0993G06F1/10H03L7/085H04L7/0008
    • An internal clock synchronizing circuit capable of solving a problem involved in a conventional high speed microcomputer system in that it takes a long time to establish clock synchronization between system component circuits of the microcomputer system. The internal clock synchronizing circuit includes a clock generator for generating an internal clock signal by dividing an original clock signal; a clock comparator for comparing the internal clock signal with a reference clock signal; a compared result holding circuit for holding, in synchronism with the original clock signal, a compared result signal output from the clock comparator; and a clock switching circuit for switching supply of the original clock signal to the clock generator in response to the compared result signal held in the compared result holding circuit.
    • 一种内部时钟同步电路,能够解决传统的高速微型计算机系统中涉及的问题,因为在微计算机系统的系统组件电路之间建立时钟同步需要很长时间。 内部时钟同步电路包括时钟发生器,用于通过分割原始时钟信号来产生内部时钟信号; 时钟比较器,用于将内部时钟信号与参考时钟信号进行比较; 比较结果保持电路,与原时钟信号同步地保持从时钟比较器输出的比较结果信号; 以及时钟切换电路,用于响应于保持在比较结果保持电路中的比较结果信号,将原始时钟信号的电源切换到时钟发生器。
    • 10. 发明授权
    • Microcomputer having multiplexable input-output port
    • 微电脑具有可复用的输入输出端口
    • US5652870A
    • 1997-07-29
    • US420168
    • 1995-04-11
    • Takashi YamasakiHiroshi SasaharaTadahiko Komatsu
    • Takashi YamasakiHiroshi SasaharaTadahiko Komatsu
    • G06F13/42G06F13/16
    • G06F13/4226
    • A microcomputer or a one-chip computer has address pins and data pins provided separately, and when a specified control signal is provided, the address pins act as multiplex pins for address and data signals. Further, a combination of bits for address signals and bits for data signals to be provided to the multiplex pins are changed according to a width of an external bus. For example, the data bits D.sub.i are combined with the address bits A.sub.i, as used previously. Further, the data bits D.sub.i-1 are combined with the address bits A.sub.i by shifting by one bit with respect to the address bits. One of the two types of the combination can be selected. If the microcomputer has 16-bit address pins, it can be connected to 8-bit memories having independent address and data pins, while it can also be connected to 8-bit peripherals having multiplex pins without using an external circuit for separating address and data signals.
    • 微型计算机或单片机具有单独提供的地址引脚和数据引脚,并且当提供指定的控制信号时,地址引脚用作地址和数据信号的多路复用引脚。 此外,根据外部总线的宽度来改变要提供给多路复用引脚的用于地址信号的比特和用于数据信号的比特的组合。 例如,数据位Di与以前使用的地址位Ai组合。 此外,通过相对于地址位移位一位,数据位Di-1与地址位Ai组合。 可以选择两种类型的组合之一。 如果微型计算机具有16位地址引脚,则可以连接到具有独立地址和数据引脚的8位存储器,同时也可以连接到具有多路复用引脚的8位外设,而无需使用外部电路来分离地址和数据 信号。