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1. 发明授权

US08835498B2 Anti-wrinkle agents 有权
标题翻译：抗皱剂
公开(公告)号：US08835498B2
公开(公告)日：2014-09-16
申请号：US13126714
申请日：2009-11-12
申请人： Noriko Suenobu , Chihiro Kondo , Takashi Yamasaki
发明人： Noriko Suenobu , Chihiro Kondo , Takashi Yamasaki
IPC分类号： A61K8/46 , A61K8/44 , C07C321/14 , C07C309/04 , C07C309/07 , C07C309/18 , A61Q19/08 , A61K8/42 , A61K31/198
CPC分类号： A61K31/198 , A61K8/42 , A61K8/46 , A61K8/466 , A61Q19/08
摘要： Provided are anti-wrinkle agents having a novel scaffold that is suitable as components for external skin preparations such as cosmetics. The anti-wrinkle agents comprise compounds represented by general formula (1), stereoisomers thereof, or pharmacologically acceptable salts thereof. Said anti-wrinkle agents have excellent efficacy in improving wrinkles and sagging that are caused by skin aging with increased age or occur as a result of photoaging due to ultraviolet rays exposure. [In the formula, R1 represents a hydrogen atom or a 1 to 8 carbon straight or branched alkyl group. R2 represents —SH, —SO3H, —S—S—X1, —S—X2, —SO—X3, —SO2—X4, —SO2—NY1—X5 or —SO2—NY2—Y3. X1-X5 independently are hydrogen atoms or 1 to 8 carbon aliphatic hydrocarbon groups or 5 to 12 carbon aromatic moiety wherein carbon atoms may be substituted with heteroatoms. Y1 to Y3 independently represent hydrogen atoms or 1 to 8 carbon linear or branched alkyl groups. R3 represents a hydrogen atom or acyl group having a 1 to 8 carbon straight or branched alkyl chain. R4 represents a 5 to 12 carbon aromatic group or polycyclic condensed aromatic group that may have unsubstituted or substituted groups. m represents an integer 0-3 and n represents an integer 1 or 2].
摘要翻译：提供了具有适合作为外用皮肤制剂如化妆品的组分的新型支架的抗皱剂。抗皱剂包括由通式（1）表示的化合物，其立体异构体或其药理学上可接受的盐。所述抗皱剂在改善由老化引起的皱纹和下垂的作用方面具有优异的效果，或者由于紫外线暴露引起的光老化而发生。 [式中，R 1表示氢原子或1〜8碳直链或支链烷基。 R2表示-SH，-SO3H，-S-S-X1，-S-X2，-SO-X3，-SO2-X4，-SO2-NY1-X5或-SO2-NY2-Y3。 X 1 -X 5独立地是氢原子或1至8个碳脂族烃基或5至12个碳芳族部分，其中碳原子可以被杂原子取代。 Y 1〜Y 3独立地表示氢原子或1〜8个碳直链或支链烷基。 R3表示氢原子或具有1-8个碳直链或支链烷基链的酰基。 R 4表示可以具有未取代或取代基的5〜12个碳芳香族基团或多环稠合芳香族基团。 m表示0-3的整数，n表示1或2的整数]。

2. 发明申请

US20110245343A1 ANTI-WRINKLE AGENTS 有权
标题翻译：防皱剂
公开(公告)号：US20110245343A1
公开(公告)日：2011-10-06
申请号：US13126714
申请日：2009-11-12
申请人： Noriko Suenobu , Chihiro Kondo , Takashi Yamasaki
发明人： Noriko Suenobu , Chihiro Kondo , Takashi Yamasaki
IPC分类号： A61K8/46 , C07C321/14 , C07C309/18 , A61Q19/08
CPC分类号： A61K31/198 , A61K8/42 , A61K8/46 , A61K8/466 , A61Q19/08
摘要： Provided are anti-wrinkle agents having a novel scaffold that is suitable as components for external skin preparations such as cosmetics. The anti-wrinkle agents comprise compounds represented by general formula (1), stereoisomers thereof, or pharmacologically acceptable salts thereof. Said anti-wrinkle agents have excellent efficacy in improving wrinkles and sagging that are caused by skin aging with increased age or occur as a result of photoaging due to ultraviolet rays exposure. [In the formula, R1 represents a hydrogen atom or a 1 to 8 carbon straight or branched alkyl group. R2 represents —SH, —SO3H, —S—S—X1, —S—X2, —SO—X3, —SO2—X4, —SO2—NY1—X5 or —SO2—NY2—Y3. X1-X5 independently are hydrogen atoms or 1 to 8 carbon aliphatic hydrocarbon groups or 5 to 12 carbon aromatic moiety wherein carbon atoms may be substituted with heteroatoms. Y1 to Y3 independently represent hydrogen atoms or 1 to 8 carbon linear or branched alkyl groups. R3 represents a hydrogen atom or acyl group having a 1 to 8 carbon straight or branched alkyl chain. R4 represents a 5 to 12 carbon aromatic group or polycyclic condensed aromatic group that may have unsubstituted or substituted groups. m represents an integer 0-3 and n represents an integer 1 or 2.]
摘要翻译：提供了具有适合作为外用皮肤制剂如化妆品的组分的新型支架的抗皱剂。抗皱剂包括由通式（1）表示的化合物，其立体异构体或其药理学上可接受的盐。所述抗皱剂在改善由老化引起的皱纹和下垂的作用方面具有优异的效果，或者由于紫外线暴露引起的光老化而发生。 [式中，R 1表示氢原子或1〜8碳直链或支链烷基。 R2表示-SH，-SO3H，-S-S-X1，-S-X2，-SO-X3，-SO2-X4，-SO2-NY1-X5或-SO2-NY2-Y3。 X 1 -X 5独立地是氢原子或1至8个碳脂族烃基或5至12个碳芳族部分，其中碳原子可以被杂原子取代。 Y 1〜Y 3独立地表示氢原子或1〜8个碳直链或支链烷基。 R3表示氢原子或具有1-8个碳直链或支链烷基链的酰基。 R 4表示可以具有未取代或取代基的5〜12个碳芳香族基团或多环稠合芳香族基团。 m表示0-3的整数，n表示1或2的整数]

3. 发明授权

US06797711B2 Benzofuran derivatives and pharmaceutical compositions containing the same 失效
标题翻译：苯并呋喃衍生物和含有它们的药物组合物
公开(公告)号：US06797711B2
公开(公告)日：2004-09-28
申请号：US10450842
申请日：2003-06-26
申请人： Nobuyuki Kawakatsu , Takayuki Namiki , Norihisa Yamazaki , Masayuki Yuasa , Toyohiko Miki , Noriko Suenobu , Tomomasa Shimanuki
发明人： Nobuyuki Kawakatsu , Takayuki Namiki , Norihisa Yamazaki , Masayuki Yuasa , Toyohiko Miki , Noriko Suenobu , Tomomasa Shimanuki
IPC分类号： A61K31495
CPC分类号： C07D307/79 , A61K31/496 , C07D307/81 , C07D307/85
摘要： Benzofuran derivatives represented by formula (I) or salts thereof: (wherein R1 represents a phenyl group or a hydrogen atom; k is 0 or 1; each of m, n, o, p, and q is an integer of 0 to 5; and each of R2 and R3 represents a hydrogen atom or a hydroxyl group, or R2 and R3 together represent an oxygen atom, with proviso that k, q, and m, or n, o, and p are not simultaneously 0). The compounds inhibit phosphorylation of STAT 6 and are useful in the treatment or prevention of allergic diseases.
摘要翻译：由式（I）表示的苯并呋喃衍生物或其盐：（其中R 1表示苯基或氢原子; k为0或1; m，n，o，p和q各自为0 至5; R 2和R 3各自表示氢原子或羟基，或R 2和R 3一起表示氧原子，条件是k，q和m，或n，o和p不同时为0）。化合物抑制STAT6的磷酸化，可用于治疗或预防过敏性疾病。

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