专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09066914B2 Prophylactic or ameliorating agent for pigmentation 有权
标题翻译：预防或改善色素沉着剂
公开(公告)号：US09066914B2
公开(公告)日：2015-06-30
申请号：US13521028
申请日：2011-01-12
申请人： Takashi Yamasaki , Yuko Saitoh , Chihiro Kondo
发明人： Takashi Yamasaki , Yuko Saitoh , Chihiro Kondo
IPC分类号： A61K31/196 , A61K31/198 , A61K8/46 , A61K9/00 , A61K9/10 , A61Q19/02 , C07C309/18
CPC分类号： A61K31/198 , A61K8/466 , A61K9/0014 , A61K9/10 , A61Q19/02 , C07C309/18
摘要： An object of the present invention is to provide a prophylactic or ameliorating agent for pigmentation having a novel scaffold and an external preparation for skin containing the same as a component. The object is achieved by providing a prophylactic or ameliorating agent for pigmentation comprising a compound represented by the following general formula (1), an isomer thereof, and/or a pharmacologically acceptable salt thereof and an external preparation for skin containing the same as a component: [wherein R1 represents a hydrogen atom or a linear chain or branched alkyl group having 1 to 8 carbon atom(s); R2 represents a hydrogen atom, a substituted or unsubstituted aliphatic hydrocarbon group having 1 to 8 carbon atom(s), a substituted or unsubstituted aromatic group, a substituted or unsubstituted polycyclic fused aromatic group, or a substituted or unsubstituted heterocyclic group having a 5 to 12 carbon atoms; R3 represents a substituted or unsubstituted aromatic group, a substituted or unsubstituted polycyclic fused aromatic group, or a substituted or unsubstituted heterocyclic group having a 5 to 15 carbon atoms; n represents an integer of 1 or 2; and m represents an integer of 0 to 3.]
摘要翻译：本发明的目的是提供一种具有新型支架和含有其作为组分的皮肤外用剂的着色剂的预防或改善剂。该目的通过提供一种色素沉着预防或改善剂来实现，所述预防或改善剂包含由以下通式（1）表示的化合物，其异构体和/或其药理学可接受的盐以及含有其作为成分的皮肤外用制剂 [式中，R 1表示氢原子或碳原子数1〜8的直链状或支链状的烷基。 R2表示氢原子，取代或未取代的碳原子数1〜8的脂肪族烃基，取代或未取代的芳香族基团，取代或未取代的多环稠合芳香族基团或取代或未取代的具有5〜 12个碳原子; R 3表示取代或未取代的芳族基团，取代或未取代的多环稠合芳香族基团，或取代或未取代的碳原子数5〜15的杂环基。 n表示1或2的整数; m表示0〜3的整数。]

2. 发明申请

US20120282203A1 PROPHYLACTIC OR AMELIORATING AGENT FOR PIGMENTATION 有权
标题翻译：用于染色的预防或调理剂
公开(公告)号：US20120282203A1
公开(公告)日：2012-11-08
申请号：US13521028
申请日：2011-01-12
申请人： Takashi Yamasaki , Yuko Saitoh , Chihiro Kondo
发明人： Takashi Yamasaki , Yuko Saitoh , Chihiro Kondo
IPC分类号： A61K8/46 , A61Q19/02 , C07C309/18
CPC分类号： A61K31/198 , A61K8/466 , A61K9/0014 , A61K9/10 , A61Q19/02 , C07C309/18
摘要： An object of the present invention is to provide a prophylactic or ameliorating agent for pigmentation having a novel scaffold and an external preparation for skin containing the same as a component. The object is achieved by providing a prophylactic or ameliorating agent for pigmentation comprising a compound represented by the following general formula (1), an isomer thereof, and/or a pharmacologically acceptable salt thereof and an external preparation for skin containing the same as a component: [wherein R1 represents a hydrogen atom or a linear chain or branched alkyl group having 1 to 8 carbon atom(s); R2 represents a hydrogen atom, a substituted or unsubstituted aliphatic hydrocarbon group having 1 to 8 carbon atom(s), a substituted or unsubstituted aromatic group, a substituted or unsubstituted polycyclic fused aromatic group, or a substituted or unsubstituted heterocyclic group having a 5 to 12 carbon atoms; R3 represents a substituted or unsubstituted aromatic group, a substituted or unsubstituted polycyclic fused aromatic group, or a substituted or unsubstituted heterocyclic group having a 5 to 15 carbon atoms; n represents an integer of 1 or 2; and m represents an integer of 0 to 3.]
摘要翻译：本发明的目的是提供一种具有新型支架和含有其作为组分的皮肤外用剂的着色剂的预防或改善剂。该目的通过提供一种色素沉着预防或改善剂来实现，所述预防或改善剂包含由以下通式（1）表示的化合物，其异构体和/或其药理学可接受的盐以及含有其作为成分的皮肤外用制剂 [式中，R 1表示氢原子或碳原子数1〜8的直链状或支链状的烷基。 R2表示氢原子，取代或未取代的碳原子数1〜8的脂肪族烃基，取代或未取代的芳香族基团，取代或未取代的多环稠合芳香族基团或取代或未取代的具有5〜 12个碳原子; R 3表示取代或未取代的芳族基团，取代或未取代的多环稠合芳香族基团，或取代或未取代的碳原子数5〜15的杂环基。 n表示1或2的整数; m表示0〜3的整数。]

3. 发明申请

US20120258063A1 PREVENTING OR AMELIORATING AGENT FOR PIGMENTATION 审中-公开
标题翻译：防止或修复染色剂
公开(公告)号：US20120258063A1
公开(公告)日：2012-10-11
申请号：US13516170
申请日：2010-12-16
申请人： Yuko Saitoh , Chihiro Kondo , Takashi Yamasaki
发明人： Yuko Saitoh , Chihiro Kondo , Takashi Yamasaki
IPC分类号： A61K8/44 , C07C235/52 , A61Q19/02 , C07C233/83
CPC分类号： A61K8/44 , A61K8/442 , A61K31/198 , A61K31/223 , A61Q19/02 , C07C233/63 , C07C233/83 , C07C235/52
摘要： An object is to provide an external preparation for skin preferably usable to prevent or ameliorate pigmentation. The object is achieved by providing a preventing or ameliorating agent for pigmentation, consisting of a compound represented by the following general formula (1), an isomer thereof, and/or a pharmacologically acceptable salt thereof, and an external preparation for skin containing the same as a component: [wherein R1 represents an unsubstituted aromatic group or an aromatic group having any substituent; R2 represents a hydrogen atom, a linear chain or branched chain alkyl group having a number of carbon atom or atoms of 1 to 4, or an acyl group having a linear or branched alkyl chain having a number of carbon atom or atoms of 1 to 4; and R3 represents a hydrogen atom or a linear chain or branched chain alkyl group having a number of carbon atom or atoms of 1 to 4.]
摘要翻译：本发明的目的是为皮肤提供外用制剂，其优选可用于预防或改善色素沉着。本发明的目的是通过提供由以下通式（1）表示的化合物，其异构体和/或其药理学可接受的盐组成的化合物的预防或改善剂，以及含有其的皮肤外用剂作为成分：[式中，R 1表示未取代的芳香族基团或具有任意取代基的芳香族基团。 R2表示氢原子，碳原子数为1〜4的直链或支链烷基，或碳原子数为1〜4的直链或支链烷基链的酰基 ; R3表示氢原子或碳原子数为1〜4的直链或支链烷基。]

4. 发明授权

US08846012B2 Melanin production inhibitor 有权
标题翻译：黑色素生成抑制剂
公开(公告)号：US08846012B2
公开(公告)日：2014-09-30
申请号：US13131827
申请日：2009-12-22
申请人： Kouji Yokoyama , Makoto Kimura , Masashi Tamai , Yuko Saitoh , Tomomi Kato , Yu Ikeda
发明人： Kouji Yokoyama , Makoto Kimura , Masashi Tamai , Yuko Saitoh , Tomomi Kato , Yu Ikeda
IPC分类号： A61K8/49 , C07D233/58 , C07D401/06 , A61K8/44 , A61K8/41 , A61K8/34 , C07D207/404 , A61Q19/02 , C07D213/38 , C07D213/30 , C07D295/03 , C07D207/12 , C07D295/096
CPC分类号： A61K8/4946 , A61K8/31 , A61K8/34 , A61K8/41 , A61K8/411 , A61K8/418 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/4913 , A61K8/4926 , A61K8/494 , A61K2800/74 , A61Q19/02 , C07D207/12 , C07D207/404 , C07D213/30 , C07D213/38 , C07D233/58 , C07D295/03 , C07D295/096 , C07D401/06
摘要： Disclosed is a melanin production inhibitor which has an excellent inhibitory activity on the production of melanin and is highly safe. The melanin production inhibitor is represented by general formula (1) (excluding clotrimazole) and/or a pharmacologically acceptable salt thereof. In the formula, A1, A2 and A3 are independently selected from a hydrogen atom, an aryl group which may have a substituent, and an aromatic heterocyclic group which may have a substituent. At least one of A1, A2 and A3 is selected from the aryl group and the aromatic heterocyclic group, the total number of carbon atoms contained in A1, A2 and A3 is 6 to 50 and, when at least two of A1, A2 and A3 represent the aryl groups or the aromatic heterocyclic groups, the adjacent two aryl or aromatic heterocyclic groups may be bound to each other via an alkyl chain or an alkenyl chain to form a ring; m represents an integer of 0 to 2; X represents a hetero atom, a hydrogen atom, or a carbon atom; R1 and R2 are independently selected from a hydrogen atom and an oxo group. When one of R1 and R2 is an oxo group, the other is not present. R3 is selected from a hydrogen atom, and a C1-8 hydrocarbon group in which one or some of hydrogen atoms or carbon atoms may be substituted by a hetero atom or hetero atoms. The number of R3's present in the compound corresponds to X and, when two or more R3's are present, the R3's are independently present and the adjacent two R3's may be bound to each other to form, together with X, a ring, and the terminal of R3 may be bound to a carbon atom to which A1, A2 and A3 are bound, thereby forming a ring.
摘要翻译：公开了一种黑色素产生抑制剂，其对黑色素的生成具有优异的抑制活性，并且是高度安全的。黑色素产生抑制剂由通式（1）表示（不包括克霉唑）和/或其药理学上可接受的盐。在该式中，A1，A2和A3独立地选自氢原子，可以具有取代基的芳基和可以具有取代基的芳族杂环基。 A1，A2和A3中的至少一个选自芳基和芳族杂环基，A1，A2和A3中所含的碳原子总数为6〜50，A1，A2和A3中的至少2个表示芳基或芳族杂环基，相邻的两个芳基或芳族杂环基可以通过烷基链或烯基链彼此结合形成环; m表示0〜2的整数。 X表示杂原子，氢原子或碳原子; R 1和R 2独立地选自氢原子和氧代基。当R1和R2中的一个是氧代基时，另一个不存在。 R3选自氢原子和碳原子数为1〜8的烃基，其中一个或几个氢原子或碳原子可以被杂原子或杂原子取代。化合物中存在的R3的数目对应于X，并且当存在两个或更多个R 3时，R 3独立地存在，并且相邻的两个R 3可以彼此结合形成与X一起形成环，并且末端的R3可以结合到与A1，A2和A3结合的碳原子上，从而形成环。

5. 发明申请

US20110243865A1 MELANIN PRODUCTION INHIBITOR 有权
标题翻译： MELANIN生产抑制剂
公开(公告)号：US20110243865A1
公开(公告)日：2011-10-06
申请号：US13131827
申请日：2009-12-22
申请人： Kouji Yokoyama , Makoto Kimura , Masashi Tamai , Yuko Saitoh , Tomomi Kato , Yu Ikeda
发明人： Kouji Yokoyama , Makoto Kimura , Masashi Tamai , Yuko Saitoh , Tomomi Kato , Yu Ikeda
IPC分类号： A61K8/49 , C07D233/58 , C07D401/06 , A61K8/44 , C07C229/36 , A61K8/34 , C07C43/178 , A61K8/41 , C07C215/20 , C07C43/205 , C07C43/23 , C07C211/03 , C07D207/04 , C07D211/70 , C07D213/36 , C07D207/40 , C07D265/30 , C07D241/04 , A61Q19/02
CPC分类号： A61K8/4946 , A61K8/31 , A61K8/34 , A61K8/41 , A61K8/411 , A61K8/418 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/4913 , A61K8/4926 , A61K8/494 , A61K2800/74 , A61Q19/02 , C07D207/12 , C07D207/404 , C07D213/30 , C07D213/38 , C07D233/58 , C07D295/03 , C07D295/096 , C07D401/06
摘要： Disclosed is a melanin production inhibitor which has an excellent inhibitory activity on the production of melanin and is highly safe. The melanin production inhibitor comprises a compound represented by general formula (1) (excluding clotrimazole), and/or a pharmacologically acceptable salt thereof. In the formula, A1, A2 and A3 are independently selected from a hydrogen atom, an aryl group which may have a substituent, and an aromatic heterocyclic group which may have a substituent, wherein at least one of A1, A2 and A3 is selected from the aryl group and the aromatic heterocyclic group, the total number of carbon atoms contained in A1, A2 and A3 is 6 to 50 and, when at least two of A1, A2 and A3 represent the aryl groups or the aromatic heterocyclic groups, the adjacent two aryl or aromatic heterocyclic groups may be bound to each other via an alkyl chain or an alkenyl chain to form a ring; m represents an integer of 0 to 2; X represents a hetero atom, a hydrogen atom, or a carbon atom; R1 and R2 are independently selected from a hydrogen atom and an oxo group, wherein when one of R1 and R2 is an oxo group, the other is not present; and R3 is selected from a hydrogen atom, and a C1-8 hydrocarbon group in which one or some of hydrogen atoms or carbon atoms may be substituted by a hetero atom or hetero atoms, wherein the number of R3's present in the compound corresponds to the number of X's and, when two or more R3's are present, the R3's are independently present and the adjacent two R3's may be bound to each other to form, together with X, a ring, and the terminal of R3 may be bound to a carbon atom to which A1, A2 and A3 are bound, thereby forming a ring.
摘要翻译：公开了一种黑色素产生抑制剂，其对黑色素的生成具有优异的抑制活性，并且是高度安全的。黑色素生成抑制剂包含通式（1）表示的化合物（克霉唑除外）和/或其药理学上可接受的盐。在该式中，A1，A2和A3独立地选自氢原子，可以具有取代基的芳基和可以具有取代基的芳族杂环基，其中A1，A2和A3中的至少一个选自芳基和芳香族杂环基时，A1，A2，A3中含有的碳原子总数为6〜50，A1，A2，A3中的至少2个为芳基或芳香族杂环基时，两个芳基或芳族杂环基可以通过烷基链或烯基链彼此结合形成环; m表示0〜2的整数。 X表示杂原子，氢原子或碳原子; R 1和R 2独立地选自氢原子和氧代基，其中当R 1和R 2之一是氧代基时，另一个不存在; 和R3选自氢原子，其中一个或几个氢原子或碳原子可以被杂原子或杂原子取代的C1-8烃基，其中存在于化合物中的R3的数目对应于 X的数目，当存在两个或更多个R3时，R3独立地存在，并且相邻的两个R 3可以彼此结合形成与X一起形成环，并且R 3的末端可以与碳结合与A1，A2和A3结合的原子，从而形成环。

6. 发明申请

US20090054515A1 SKIN-WHITENING COSMETIC 审中-公开
标题翻译：皮肤化妆品
公开(公告)号：US20090054515A1
公开(公告)日：2009-02-26
申请号：US12162977
申请日：2007-02-06
申请人： Takayuki Katagiri , Kouji Yokoyama , Makoto Kimura , Yuko Saitoh
发明人： Takayuki Katagiri , Kouji Yokoyama , Makoto Kimura , Yuko Saitoh
IPC分类号： A61K31/381 , C07D333/22
CPC分类号： A61K8/4986 , A61K31/381 , A61Q19/02 , C07D333/22
摘要： Disclosed are: a novel skin-whitening agent; and a skin-whitening cosmetic or quasi-drug which is highly effective for prevention/amelioration of melanopathy and is prepared using the skin-whitening agent. The cosmetic contains a compound represented by the general formula (I) and/or a salt thereof as an active ingredient. In the general formula (I), R1 and R2 independently represent a secondary or tertiary alkyl group having 3 to 7 carbon atoms; and R3 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to carbon atoms.
摘要翻译：公开的是：一种新型的皮肤美白剂; 以及对预防/改善黑色素病高度有效的皮肤美白化妆品或准药物，并使用皮肤增白剂制备。化妆品含有由通式（I）表示的化合物和/或其盐作为活性成分。在通式（I）中，R 1和R 2独立地表示碳原子数3〜7的仲或叔烷基。 R3表示氢原子，碳原子数为1〜4的烷基或碳原子数为1的烷氧基。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式