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    • 7. 发明授权
    • Anti-wrinkle agents
    • 抗皱剂
    • US08835498B2
    • 2014-09-16
    • US13126714
    • 2009-11-12
    • Noriko SuenobuChihiro KondoTakashi Yamasaki
    • Noriko SuenobuChihiro KondoTakashi Yamasaki
    • A61K8/46A61K8/44C07C321/14C07C309/04C07C309/07C07C309/18A61Q19/08A61K8/42A61K31/198
    • A61K31/198A61K8/42A61K8/46A61K8/466A61Q19/08
    • Provided are anti-wrinkle agents having a novel scaffold that is suitable as components for external skin preparations such as cosmetics. The anti-wrinkle agents comprise compounds represented by general formula (1), stereoisomers thereof, or pharmacologically acceptable salts thereof. Said anti-wrinkle agents have excellent efficacy in improving wrinkles and sagging that are caused by skin aging with increased age or occur as a result of photoaging due to ultraviolet rays exposure. [In the formula, R1 represents a hydrogen atom or a 1 to 8 carbon straight or branched alkyl group. R2 represents —SH, —SO3H, —S—S—X1, —S—X2, —SO—X3, —SO2—X4, —SO2—NY1—X5 or —SO2—NY2—Y3. X1-X5 independently are hydrogen atoms or 1 to 8 carbon aliphatic hydrocarbon groups or 5 to 12 carbon aromatic moiety wherein carbon atoms may be substituted with heteroatoms. Y1 to Y3 independently represent hydrogen atoms or 1 to 8 carbon linear or branched alkyl groups. R3 represents a hydrogen atom or acyl group having a 1 to 8 carbon straight or branched alkyl chain. R4 represents a 5 to 12 carbon aromatic group or polycyclic condensed aromatic group that may have unsubstituted or substituted groups. m represents an integer 0-3 and n represents an integer 1 or 2].
    • 提供了具有适合作为外用皮肤制剂如化妆品的组分的新型支架的抗皱剂。 抗皱剂包括由通式(1)表示的化合物,其立体异构体或其药理学上可接受的盐。 所述抗皱剂在改善由老化引起的皱纹和下垂的作用方面具有优异的效果,或者由于紫外线暴露引起的光老化而发生。 [式中,R 1表示氢原子或1〜8碳直链或支链烷基。 R2表示-SH,-SO3H,-S-S-X1,-S-X2,-SO-X3,-SO2-X4,-SO2-NY1-X5或-SO2-NY2-Y3。 X 1 -X 5独立地是氢原子或1至8个碳脂族烃基或5至12个碳芳族部分,其中碳原子可以被杂原子取代。 Y 1〜Y 3独立地表示氢原子或1〜8个碳直链或支链烷基。 R3表示氢原子或具有1-8个碳直链或支链烷基链的酰基。 R 4表示可以具有未取代或取代基的5〜12个碳芳香族基团或多环稠合芳香族基团。 m表示0-3的整数,n表示1或2的整数]。
    • 10. 发明授权
    • Power converter
    • 电源转换器
    • US5608614A
    • 1997-03-04
    • US280552
    • 1994-07-26
    • Masahito OhnishiShozo KataokaTakashi KandaTakashi YamasakiKazuo Yoshida
    • Masahito OhnishiShozo KataokaTakashi KandaTakashi YamasakiKazuo Yoshida
    • H02J1/00H02M1/42H02M3/00H02M3/07H02M7/06H02M3/18
    • H02M1/4208H02M3/07Y02B70/126
    • A power converter has two switched capacitor circuits each including at least a plurality of sets of capacitors and switching elements, first of which circuits is provided for supplying a DC power to a load while second of which accumulates a power in a period receiving a higher input voltage, and the first switched capacitor circuit being made to receive, in a period receiving a lower input voltage, a power supplied from a DC power source and also the power supplied from the second switched capacitor circuit for supplying to the load the DC power of a constant voltage, in which an input current collectively taken up by the two switched capacitor circuits is made similar in the waveform to the input voltage to eliminate any harmonics distortion of the current drawn from the source, for attaining the supply of the DC power of the constant voltage to the load, whereby the power converter is rendered not to require any large inductor to be capable of being minimized in size and restraining any noise radiation from occurring.
    • 功率转换器具有两个开关电容器电路,每个开关电容器电路至少包括多组电容器和开关元件,其中首先提供用于向负载提供DC电力的电路,其中第二个电容器在接收较高输入的时段内积累功率 电压,并且第一开关电容器电路在接收较低输入电压的时间段内接收从直流电源提供的电力,以及从第二开关电容器电路提供的电力,以向负载提供直流电力 恒定电压,其中由两个开关电容器电路共同占据的输入电流在波形中与输入电压相似,以消除从源极吸取的电流的任何谐波失真,以获得 对负载的恒定电压,从而使得功率转换器不需要任何大的电感器能够在尺寸上最小化并限制 g发生任何噪音辐射。