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1. 发明申请

WO2011146858A3 FOAMS, INCLUDING MICROCELLULAR FOAMS, CONTAINING COLLOIDAL PARTICULATES 审中-公开
标题翻译： FOAMS，包括微胶囊，含有胶体颗粒
公开(公告)号：WO2011146858A3
公开(公告)日：2012-05-31
申请号：PCT/US2011037377
申请日：2011-05-20
申请人： HARVARD COLLEGE , BASF SE , LADAVAC KOSTA , GUERRA RODRIGO E , KAZ DAVID , MANOHARAN VINOTHAN , RIEGER JENS B , KOLTZENBURG ROLAND SEBASTIAN , WEITZ DAVID A
发明人： LADAVAC KOSTA , GUERRA RODRIGO E , KAZ DAVID , MANOHARAN VINOTHAN , RIEGER JENS B , KOLTZENBURG ROLAND SEBASTIAN , WEITZ DAVID A
IPC分类号： A61K9/12 , A61K9/14 , A61K9/51
CPC分类号： A61K9/122 , A61K9/143 , A61K9/146 , A61K9/5115
摘要： The present invention generally relates to foams and particles made from such foams, for applications such as drug delivery. The foams or particles may comprise a pharmaceutically acceptable polymeric carrier. In some cases, the foams may include colloidal particulates. A first aspect of the present invention is generally related to polymer-based foams or particles containing pharmaceutically active agents. In some cases, the foam or particle may contain smaller colloidal particulates therein. Such colloidal particulates may be used, for example, to limit the amount of material within certain regions of the foam, or exclude pharmaceutically active agents from being located within certain portions of the foam, which may useful for enhancing release of pharmaceutically active agents from the foam. In some cases, the colloidal particulates may cause the foam or particle to have an unexpectedly high specific surface area. The foam, in certain embodiments, can exhibit a relatively high loading of the pharmaceutically active agent. The foam may be microcellular in certain instances. The foam may also be created using a supercritical fluid, for example, supercritical C02. For instance, a precursor to the foam, containing a pharmaceutically active agent, a pharmaceutically acceptable polymeric carrier, and colloidal particulates, can be mixed with a foaming agent. The pressure may then be decreased, thereby causing the foaming agent to expand and causing a foam to form. The foam may also be ground or milled, or otherwise processed, to form particles such as nanoparticles.
摘要翻译：本发明一般涉及由这种泡沫制成的泡沫和颗粒，用于诸如药物递送的应用。泡沫或颗粒可以包含药学上可接受的聚合物载体。在一些情况下，泡沫可以包括胶体颗粒。本发明的第一方面通常涉及基于聚合物的泡沫或含有药物活性剂的颗粒。在一些情况下，泡沫或颗粒中可含有较小的胶体颗粒。这种胶体颗粒可以用于例如限制泡沫的某些区域内的物质的量，或者不排除药物活性剂位于泡沫的某些部分内，其可用于增强药物活性剂从泡沫。在一些情况下，胶体颗粒可能导致泡沫或颗粒具有出乎意料的高比表面积。在某些实施方案中，泡沫体可以表现出相对高的药物活性剂的负载量。泡沫在某些情况下可能是微孔的。泡沫也可以使用超临界流体，例如超临界CO 2来产生。例如，含有药物活性剂，药学上可接受的聚合物载体和胶体颗粒的泡沫的前体可与发泡剂混合。然后可以降低压力，从而使发泡剂膨胀并形成泡沫。泡沫也可以研磨或研磨或以其它方式处理，以形成颗粒如纳米颗粒。

2. 发明申请

WO2011146852A8 FOAMS OR PARTICLES FOR APPLICATIONS SUCH AS DRUG DELIVERY 审中-公开
标题翻译：用于药物递送应用的FOAMS或颗粒
公开(公告)号：WO2011146852A8
公开(公告)日：2013-03-07
申请号：PCT/US2011037363
申请日：2011-05-20
申请人： HARVARD COLLEGE , BASF SE , LADAVAC KOSTA , GUERRA RODRIGO E , KAZ DAVID , MANOHARAN VINOTHAM , RIEGER JENS B , KOLTZENBURG ROLAND SEBASTIAN , WEITZ DAVID A
发明人： LADAVAC KOSTA , GUERRA RODRIGO E , KAZ DAVID , MANOHARAN VINOTHAM , RIEGER JENS B , KOLTZENBURG ROLAND SEBASTIAN , WEITZ DAVID A
IPC分类号： A61K9/12 , A61K9/14 , A61K47/32
CPC分类号： A61K9/122 , A61K9/146 , A61K47/32
摘要： The present invention generally relates to foams and, in particular, to foams for applications such as drug delivery, and particles that are made from such foams. One aspect relates to foams or particles containing pharmaceutically active agents. The foam may comprise a pharmaceutically acceptable polymeric carrier. In some cases, the foam or particle has an unexpectedly high specific surface area. A high specific surface area may, in some cases, facilitate delivery or release of the pharmaceutically active agent when the foam or particles made from the foam (e.g., by milling) are administered to a subject. The foam may also exhibit a relatively high loading of the pharmaceutically active agent. In some cases, the foam may be a microcellular foam. In one set of embodiments, the foam is created using a supercritical fluid, such as supercritical C02. For example, a precursor to the foam, containing a pharmaceutically active agent, may be mixed with a foaming agent, then the pressure decreased to cause the foaming agent to expand, thereby causing a foam to form. The foam may then be subsequently ground or milled, or otherwise processed to form particles.
摘要翻译：本发明一般涉及泡沫，特别是泡沫用于例如药物递送的泡沫，以及由这种泡沫制成的颗粒。一个方面涉及含有药物活性剂的泡沫或颗粒。泡沫可以包含药学上可接受的聚合物载体。在一些情况下，泡沫或颗粒具有出乎意料的高比表面积。在一些情况下，当由泡沫制成的泡沫或颗粒（例如通过研磨））施用于受试者时，高比表面积可能有助于药物活性剂的递送或释放。泡沫体也可表现出相当高的药物活性剂负荷。在一些情况下，泡沫可以是微孔泡沫。在一组实施方案中，使用超临界流体（例如超临界CO 2）产生泡沫。例如，含有药物活性剂的泡沫体的前体可与发泡剂混合，然后降低压力，引起发泡剂膨胀，从而形成泡沫。然后可以将泡沫研磨或研磨，或以其它方式加工形成颗粒。

3. 发明申请

WO2011146852A3 FOAM OR PARTICLES FOR APPLICATIONS SUCH AS DRUG DELIVERY 审中-公开
标题翻译：用于药物递送应用的泡沫或颗粒
公开(公告)号：WO2011146852A3
公开(公告)日：2012-07-05
申请号：PCT/US2011037363
申请日：2011-05-20
申请人： HARVARD COLLEGE , BASF SE , LADAVAC KOSTA , GUERRA RODRIGO E , KAZ DAVID , MANOHARAN VINOTHAM , RIEGER JENS B , KOLTZENBURG ROLAND SEBASTIAN , WEITZ DAVID A
发明人： LADAVAC KOSTA , GUERRA RODRIGO E , KAZ DAVID , MANOHARAN VINOTHAM , RIEGER JENS B , KOLTZENBURG ROLAND SEBASTIAN , WEITZ DAVID A
IPC分类号： A61K9/12 , A61K9/14 , A61K47/32
CPC分类号： A61K9/122 , A61K9/146 , A61K47/32
摘要： The present invention generally relates to foams and, in particular, to foams for applications such as drug delivery, and particles that are made from such foams. One aspect relates to foams or particles containing pharmaceutically active agents. The foam may comprise a pharmaceutically acceptable polymeric carrier. In some cases, the foam or particle has an unexpectedly high specific surface area. A high specific surface area may, in some cases, facilitate delivery or release of the pharmaceutically active agent when the foam or particles made from the foam (e.g., by milling) are administered to a subject. The foam may also exhibit a relatively high loading of the pharmaceutically active agent. In some cases, the foam may be a microcellular foam. In one set of embodiments, the foam is created using a supercritical fluid, such as supercritical C02. For example, a precursor to the foam, containing a pharmaceutically active agent, may be mixed with a foaming agent, then the pressure decreased to cause the foaming agent to expand, thereby causing a foam to form. The foam may then be subsequently ground or milled, or otherwise processed to form particles.
摘要翻译：本发明一般涉及泡沫，特别是泡沫用于例如药物递送的泡沫，以及由这种泡沫制成的颗粒。一个方面涉及含有药物活性剂的泡沫或颗粒。泡沫可以包含药学上可接受的聚合物载体。在一些情况下，泡沫或颗粒具有出乎意料的高比表面积。在一些情况下，当由泡沫制成的泡沫或颗粒（例如通过研磨））施用于受试者时，高比表面积可能有助于药物活性剂的递送或释放。泡沫体也可表现出相当高的药物活性剂负荷。在一些情况下，泡沫可以是微孔泡沫。在一组实施方案中，使用超临界流体（例如超临界CO 2）产生泡沫。例如，含有药物活性剂的泡沫体的前体可与发泡剂混合，然后降低压力，引起发泡剂膨胀，从而形成泡沫。然后可以将泡沫研磨或研磨，或以其它方式加工形成颗粒。

4. 发明申请

WO2012027378A2 PARTICLES FOR DRUG DELIVERY AND OTHER APPLICATIONS 审中-公开
标题翻译：用于药物递送和其他应用的颗粒
公开(公告)号：WO2012027378A2
公开(公告)日：2012-03-01
申请号：PCT/US2011048822
申请日：2011-08-23
申请人： HARVARD COLLEGE , BASF SE , FAN BEN , KOLTZENBURG ROLAND S , RIEGER JENS B , WEITZ DAVID A
发明人： FAN BEN , KOLTZENBURG ROLAND S , RIEGER JENS B , WEITZ DAVID A
IPC分类号： A61K9/14 , A61K9/16 , A61K31/565 , A61K31/58
CPC分类号： A61K9/143 , A61K9/1694 , A61K31/565 , A61K31/58
摘要： The present invention generally relates to particles for drug delivery and other applications. In one aspect, the present invention relates to a technique for reacting precursor compounds in the presence of a pharmaceutically- active agent to form product (e.g., in the form of particles) in which the agent is substantially contained within the product, and the product is soluble within typical gastric fluid of a mammal. In another aspect, the present invention is generally directed to particles comprising an inorganic pharmaceutically acceptable carrier, such as CaCO3, and an agent. In some cases, at least some of the agent contained within the particles is fluidically inaccessible from externally of the particle. For instance, the agent may be present in isolated domains within the particle. In another aspect, the present invention is generally directed to methods of creating particles. For instance, according to one set of embodiments, two fluids containing reactants are mixed where, upon reaction of the reactants, an insoluble product is formed, which precipitates to form particles. In one example, a first fluid containing dissolved carbonate ions and a second fluid containing dissolved calcium ions and a pharmaceutically- active agent are mixed together; upon mixing of the first and second fluids, the calcium ions and the carbonate ions form calcium carbonate, which precipitates to form a co-precipitate with the pharmaceutically- active agent. Yet other aspects of the present invention are directed to particles formed from such reactions, methods of using such reactions, methods of promoting such reactions, kits involving particles, or the like.
摘要翻译：本发明总体上涉及用于药物递送和其他应用的颗粒。在一个方面，本发明涉及一种用于使前体化合物在药物活性剂存在下反应以形成其中药剂基本上包含在产品内的产品（例如，以颗粒形式）的技术，并且产品可溶于哺乳动物的典型胃液中。另一方面，本发明一般涉及包含无机药学上可接受的载体如CaCO 3和药剂的颗粒。在一些情况下，包含在颗粒内的至少一些试剂从颗粒的外部流体不可接近。例如，该药剂可能存在于颗粒内的分离域中。另一方面，本发明总体上涉及产生颗粒的方法。例如，根据一组实施方案，混合含有反应物的两种流体，其中在反应物反应时形成不溶产物，其沉淀形成颗粒。在一个实例中，将含有溶解的碳酸根离子的第一流体和含有溶解的钙离子的第二流体与药物活性剂混合在一起; 在混合第一流体和第二流体时，钙离子和碳酸根离子形成碳酸钙，其沉淀与药物活性剂形成共沉淀物。本发明的其他方面涉及由这些反应形成的颗粒，使用这些反应的方法，促进这种反应的方法，涉及颗粒的试剂盒等。

5. 发明申请

WO2010104593A2 SYSTEMS AND METHODS OF TEMPLATING USING PARTICLES SUCH AS COLLOIDAL PARTICLES 审中-公开
标题翻译：使用颗粒作为胶体颗粒的系统和方法
公开(公告)号：WO2010104593A2
公开(公告)日：2010-09-16
申请号：PCT/US2010000748
申请日：2010-03-12
申请人： HARVARD COLLEGE , BASF SE , WEITZ DAVID A , KOLTZENBURG ROLAND S , RIEGER JENS B , STUDART ANDRE R , WILKING JAMES N
发明人： WEITZ DAVID A , KOLTZENBURG ROLAND S , RIEGER JENS B , STUDART ANDRE R , WILKING JAMES N
IPC分类号： B01J2/22
CPC分类号： B01J2/22 , B01J2/08 , Y10T428/249954
摘要： The present invention generally relates to systems and methods for using particle templating, e.g., to produce composites, discrete particles, or the like. In some embodiments, the present invention generally relates to the production of particles using the interstitial spaces between templating elements in a template structure. For example, a plurality of templating elements, which can include colloidal particles, may be arranged to form a template structure. The interstices of the templating elements can provide regions in which a fluid may be introduced. The fluid may be hardened (e.g., solidified) in some cases, e.g., to form a composite comprising the templating elements and the interstitial segments. In certain embodiments, the template structure may then be broken down to release the hardened fluid, e.g., as a plurality of discrete particles.
摘要翻译：本发明一般涉及使用颗粒模板法，例如生产复合材料，离散颗粒等的系统和方法。在一些实施方案中，本发明通常涉及使用模板结构中的模板元件之间的间隙空间来生产颗粒。例如，可以布置多个可以包括胶体颗粒的模板元件以形成模板结构。模板元件的间隙可以提供其中可以引入流体的区域。在一些情况下，流体可以被硬化（例如，固化），例如形成包含模板元件和间隙段的复合材料。在某些实施例中，然后可以将模板结构分解以释放硬化的流体，例如作为多个离散颗粒。

6. 发明申请

WO2011116154A3 MELT EMULSIFICATION 审中-公开
公开(公告)号：WO2011116154A3
公开(公告)日：2012-06-07
申请号：PCT/US2011028754
申请日：2011-03-17
申请人： HARVARD COLLEGE , BASF SE , SHUM HO CHEUNG , SUN BINGJIE , WEITZ DAVID A , HOLTZE CHRISTIAN
发明人： SHUM HO CHEUNG , SUN BINGJIE , WEITZ DAVID A , HOLTZE CHRISTIAN
IPC分类号： B01J13/00 , A01N25/28 , A61K9/50 , B01J13/04 , C09B67/00 , C11D3/50 , C11D17/00
CPC分类号： B01J13/0086 , B01F3/0807 , B01F13/0062 , B01F2005/0034 , B01J13/04 , C09B67/0009 , C09B67/0097 , G01N2015/1413
摘要： The present invention generally relates to colloidal systems, which may include colloidal particles and/or other types of particles. One aspect of the invention is generally directed to a system comprising fluidic droplets that can be at least partially solidified, e.g., to form colloidal particles. In some embodiments, particles comprising an at least partially solid outer phase encapsulating an inner phase are formed. The inner phase may be any phase, e.g., a solid, a liquid, or a gas. In some cases, solidifying at least a portion of the outer phase of the droplets to form particles may increase the stability of the particles and/or the colloidal system containing the particles. In one set of embodiments, melting or liquefying the outer phase of the particles (for example, by heating the particle to a temperature above a threshold temperature) can allow release of an agent contained within the inner phase, and/or allow the inner phase to coalesce with a phase external to the particles. The melting temperature of the outer phase can be controlled in some embodiments such that the outer phase will melt above a predetermined temperature. In some embodiments, the particles may be formed to be essentially free of an auxiliary stabilizing agent. In some embodiments, an agent may be encapsulated within a particle with relatively high efficiency. Other aspects of the invention are generally directed to methods of making and using such colloidal systems, e.g., containing such particles, kits involving such colloidal systems, or the like.
摘要翻译：本发明一般涉及胶体体系，其可以包括胶体颗粒和/或其它类型的颗粒。本发明的一个方面通常涉及包含流体液滴的系统，其可以至少部分地固化，例如形成胶体颗粒。在一些实施方案中，形成包含至少部分固体外层的包封内相的颗粒。内相可以是任何相，例如固体，液体或气体。在一些情况下，固化液滴的外相的至少一部分以形成颗粒可以增加包含颗粒的颗粒和/或胶体体系的稳定性。在一组实施方案中，熔化或液化颗粒的外相（例如，通过将颗粒加热到高于阈值温度的温度）可以允许包含在内相内的试剂的释放和/或允许内相以颗粒外部的相合并。在一些实施方案中，可以控制外相的熔融温度，使得外相将在预定温度以上熔化。在一些实施方案中，颗粒可以形成为基本上不含辅助稳定剂。在一些实施方案中，试剂可以以相对高的效率封装在颗粒内。本发明的其它方面通常涉及制备和使用这种胶体体系的方法，例如含有这种颗粒，涉及这种胶体系的试剂盒等。

7. 发明申请

WO2012162296A2 CONTROL OF EMULSIONS, INCLUDING MULTIPLE EMULSIONS 审中-公开
标题翻译：乳液控制，包括多种乳剂
公开(公告)号：WO2012162296A2
公开(公告)日：2012-11-29
申请号：PCT/US2012038957
申请日：2012-05-22
申请人： HARVARD COLLEGE , BASF SE , ROTEM ASSAF , WEITZ DAVID A , ABATE ADAM R , HOLTZE CHRISTIAN
发明人： ROTEM ASSAF , WEITZ DAVID A , ABATE ADAM R , HOLTZE CHRISTIAN
IPC分类号： B01F13/00 , B01F3/08
CPC分类号： B01F3/0811 , B01F3/0807 , B01F13/0062 , B01F13/0084 , Y10T137/87571
摘要： The present invention generally relates to emulsions, and more particularly, to double and other multiple emulsions. Certain aspects of the present invention are generally directed to the creation of double emulsions and other multiple emulsions at a common junction of microfluidic channels. In some cases, the microfluidic channels at the common junction may have substantially the same hydrophobicity. In one set of embodiments, a device may include a common junction of six or more channels, where a first fluid flows through one channel, a second fluid flows through two channels, and a third or carrying fluid flows through two more channels, such that a double emulsion of a first droplet of the first fluid, contained in a second droplet of the second fluid, contained by the carrying fluid, flows away from the common junction through a sixth channel. Other aspects of the invention are generally directed to methods of making and using such systems, kits involving such systems, emulsions created using such systems, or the like.
摘要翻译：本发明一般涉及乳液，更具体地说涉及双重和其它多重乳液。本发明的某些方面通常涉及在微流体通道的共同连接处产生双重乳液和其它多重乳液。在一些情况下，共同连接处的微流体通道可具有基本上相同的疏水性。在一组实施例中，装置可以包括六个或更多个通道的公共接头，其中第一流体流过一个通道，第二流体流过两个通道，并且第三或承载流体流过两个以上通道，使得包含在第二流体的第二液滴中的第一流体的第一液滴的双重乳液由携带流体包含，通过第六通道从公共接头流出。本发明的其它方面通常涉及制造和使用这种系统的方法，涉及这种系统的试剂盒，使用这种系统产生的乳液等。

8. 发明申请

WO2012087350A2 SPRAY DRYING TECHNIQUES 审中-公开
标题翻译：喷雾干燥技术
公开(公告)号：WO2012087350A2
公开(公告)日：2012-06-28
申请号：PCT/US2011001993
申请日：2011-12-20
申请人： HARVARD COLLEGE , BASF SE , ABATE ADAM R , THIELE JULIAN W P , WEITZ DAVID A , WINDBERGS MAIKE , HOLTZE CHRISTIAN
发明人： ABATE ADAM R , THIELE JULIAN W P , WEITZ DAVID A , WINDBERGS MAIKE , HOLTZE CHRISTIAN
IPC分类号： B01J2/04 , B05B7/04
CPC分类号： B01D1/18 , A61K31/58 , F26B3/12
摘要： The present invention generally relates to microfluidics, and to spray drying and other drying techniques. In some aspects, an article containing one or more channels or microfiuidic channels is used to mix one or more fluids prior to spray drying. The mixing may occur immediately before the fluids are expelled through a nozzle or other opening into a drying region of the spray dryer. In one set of embodiments, for example, a first fluid is exposed to a second fluid, then the fluids are exposed to air or other gases before being expelled through a nozzle. In certain instances, the first fluid may contain a dissolved species that may precipitate upon exposure to the second fluid; such precipitation may occur immediately before expulsion through a nozzle or other opening, thereby resulting in controlled precipitation as part of the spray drying process.
摘要翻译：本发明一般涉及微流体，以及喷雾干燥和其它干燥技术。在一些方面，使用含有一种或多种通道或微流体通道的制品在喷雾干燥之前混合一种或多种流体。在流体通过喷嘴或其它开口排出到喷雾干燥器的干燥区域之前，混合可能发生。在一组实施例中，例如，第一流体暴露于第二流体，然后在通过喷嘴排出之前将流体暴露于空气或其它气体。在某些情况下，第一流体可以含有在暴露于第二流体时可能沉淀的溶解物质; 这种沉淀可能在通过喷嘴或其他开口排出之前立即发生，从而导致作为喷雾干燥过程的一部分的受控沉淀。

9. 发明申请

WO2013032709A2 SYSTEMS AND METHODS FOR SHELL ENCAPSULATION 审中-公开
标题翻译：用于壳体封装的系统和方法
公开(公告)号：WO2013032709A2
公开(公告)日：2013-03-07
申请号：PCT/US2012050916
申请日：2012-08-15
申请人： HARVARD COLLEGE , BASF SE , WEITZ DAVID A , SHUM HO CHEUNG , ZHAO YUANJIN , SUN BINGJIE , HOLTZE CHRISTIAN
发明人： WEITZ DAVID A , SHUM HO CHEUNG , ZHAO YUANJIN , SUN BINGJIE , HOLTZE CHRISTIAN
IPC分类号： B01J13/20
CPC分类号： B01J13/203 , A01N25/28 , A23L29/015 , A23P10/30 , A61K9/501 , A61K9/5036 , A61K9/5089 , C09B67/0097 , C11D17/0039 , A01N59/02 , A01N59/06 , A01N59/16
摘要： The present invention generally relates to particles, including particles for drug delivery and other applications. Certain aspects of the invention are generally directed to particles comprising a shell and an interior at least partially contained by the shell. In some embodiments, the particles may be treated to enhance the containment of the interior, for example to reduce transport of an agent into or out of the interior. Such particles may exhibit increased ability to encapsulate agents and/or increased storage life (e.g., due to reduced leakage). For instance, in certain embodiments, any defects, such as cracks, pores, etc. within the shell may be sealed or otherwise treated to reduce transport therethrough, for example, with a solid. In some embodiments, for instance, a first reactant in the interior of a particle may come into contact with a second reactant outside of the particle to form a solid, or other suitable product. The shell may also be treated, e.g., at a later point in time, to cause release of an agent contained within the interior, in certain aspects. For example, the shell may be heated to cause the release of the agent from the particle, or the shell may be exposed to chemical or enzymatic degradation, or a change in osmolarity, to cause release of an agent. Still other aspects of the present invention are generally directed to methods of making or using such particles, kits or devices including such particles, or the like.
摘要翻译：本发明通常涉及包括用于药物递送的颗粒和其它应用的颗粒。本发明的某些方面通常涉及包含壳体和至少部分地由壳体包含的内部的颗粒。在一些实施方案中，可以处理颗粒以增强内部的容纳，例如减少试剂进入或流出内部的运输。这样的颗粒可以表现出增加的包封剂的能力和/或增加的储存寿命（例如，由于泄漏减少）。例如，在某些实施例中，壳体内的任何缺陷，例如裂缝，孔隙等可被密封或以其他方式处理，以减少例如通过固体的运输。在一些实施方案中，例如，颗粒内部的第一反应物可能与颗粒外部的第二反应物接触以形成固体或其它合适的产物。在某些方面，外壳也可以例如在稍后的时间点处理，以引起包含在内部中的试剂的释放。例如，可以加热外壳以使试剂从颗粒中释放，或者壳可能暴露于化学或酶降解或渗透压的变化，导致试剂的释放。本发明的其它方面通常涉及制造或使用这种颗粒，包括这种颗粒的试剂盒或装置等的方法。

10. 发明申请

WO2011028760A3 MULTIPLE EMULSIONS CREATED USING JUNCTIONS 审中-公开
标题翻译：使用连接产生多种乳液
公开(公告)号：WO2011028760A3
公开(公告)日：2011-07-14
申请号：PCT/US2010047458
申请日：2010-09-01
申请人： HARVARD COLLEGE , BASF SE , WEITZ DAVID A , ROMANOWSKY MARK , HOLTZE CHRISTIAN
发明人： WEITZ DAVID A , ROMANOWSKY MARK , HOLTZE CHRISTIAN
IPC分类号： B01F5/00 , B01F3/08 , B01F15/04
CPC分类号： B01F13/0084 , B01F3/0807 , B01F2003/0838 , Y10T137/0318 , Y10T137/87571
摘要： The present invention generally relates to emulsions, and more particularly, to multiple emulsions. In one aspect, multiple emulsions are formed using a plurality of channels, such as microfluidic channels, that meet at a common intersection. The multiple emulsions may be created at a single common intersection in some embodiments, unlike other prior art systems where multiple channel intersections are required to create multiple emulsions. For instance, in one set of embodiments, three, four, or more microfluidic channels may intersect at a common intersection, with two or three serving as inlets and one serving as the outlet. In some embodiments, a first fluidic channel may be relatively hydrophobic, while a second fluidic channel is relatively hydrophilic. The third channel, if present, may be relatively hydrophilic or hydrophobic, depending on the application. The outlet channel may be hydrophobic, hydrophilic, or may comprise at least one portion that is relatively hydrophilic and at least one portion that is relatively hydrophilic. By controlling the flow of fluids through the hydrophilic and hydrophobic portions of the channels, multiple emulsions may be created proximate the common intersection, due to interactions between the fluids entering the common intersection. In other embodiments, different patterns of hydrophilic or hydrophobic channels may be used. Other aspects of the invention are generally directed to methods of making and using such systems, kits involving such systems, emulsions created using such systems, or the like.
摘要翻译：本发明一般涉及乳剂，更具体地说涉及多重乳液。在一个方面，使用多个通道（例如微流体通道）形成多个乳液，其在共同的交叉处相遇。在一些实施例中，可以在单个公共交叉点处产生多个乳液，与需要多个通道交叉点以产生多个乳液的其它现有技术系统不同。例如，在一组实施例中，三个，四个或更多个微流体通道可以在共同的交叉点相交，其中两个或三个用作入口，一个用作出口。在一些实施例中，第一流体通道可以是相对疏水的，而第二流体通道是相对亲水的。根据应用，第三通道（如果存在）可以是相对亲水或疏水的。出口通道可以是疏水的，亲水的，或者可以包括至少一个相对亲水的部分和至少一个相对亲水的部分。通过控制流体通过通道的亲水和疏水部分的流动，由于进入公共交叉点的流体之间的相互作用，可能在公共交叉点附近产生多个乳液。在其它实施方案中，可以使用不同的亲水或疏水通道图案。本发明的其它方面通常涉及制造和使用这种系统的方法，涉及这种系统的试剂盒，使用这种系统产生的乳液等。

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