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1. 发明申请

WO2010104597A2 SCALE-UP OF MICROFLUIDIC DEVICES 审中-公开
标题翻译：微流量装置的升级
公开(公告)号：WO2010104597A2
公开(公告)日：2010-09-16
申请号：PCT/US2010000753
申请日：2010-03-12
申请人： HARVARD COLLEGE , ROMANOWSKY MARK , ABATE ADAM R , WEITZ DAVID A
发明人： ROMANOWSKY MARK , ABATE ADAM R , WEITZ DAVID A
IPC分类号： B01J19/00
CPC分类号： B01F13/0062 , B01F3/0807 , B01F3/0811 , B01F2215/0037 , B01J19/0093 , B01J2219/00015 , B01J2219/00783 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00837 , B01J2219/00889 , B01J2219/00891 , B01J2219/0097 , B01J2219/00975 , B01L3/502784 , B01L2200/0636 , B01L2200/0673 , B01L2300/0816 , B01L2300/0861 , Y10T137/0318 , Y10T137/8593
摘要： Parallel uses of microfluidic methods and devices for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid are described. In some aspects, the present invention relates generally to flow-focusing-type technology, and also to microfluidics, and more particularly parallel use of microfluidic systems arranged to control a dispersed phase within a dispersant, and the size, and size distribution, of a dispersed phase in a multi-phase fluid system, and systems for delivery of fluid components to multiple such devices.
摘要翻译：描述了用于在流体中聚焦和/或形成类似或不同尺寸的不连续部分的微流体方法和装置的并行使用。在一些方面，本发明一般涉及流动聚焦型技术，还涉及微流体，更具体地说，并行使用布置成控制分散剂内分散相的微流体系统，以及尺寸和尺寸分布分散相在多相流体系统中，以及用于将流体组分输送到多个这样的装置的系统。

2. 发明申请

WO2011028760A3 MULTIPLE EMULSIONS CREATED USING JUNCTIONS 审中-公开
标题翻译：使用连接产生多种乳液
公开(公告)号：WO2011028760A3
公开(公告)日：2011-07-14
申请号：PCT/US2010047458
申请日：2010-09-01
申请人： HARVARD COLLEGE , BASF SE , WEITZ DAVID A , ROMANOWSKY MARK , HOLTZE CHRISTIAN
发明人： WEITZ DAVID A , ROMANOWSKY MARK , HOLTZE CHRISTIAN
IPC分类号： B01F5/00 , B01F3/08 , B01F15/04
CPC分类号： B01F13/0084 , B01F3/0807 , B01F2003/0838 , Y10T137/0318 , Y10T137/87571
摘要： The present invention generally relates to emulsions, and more particularly, to multiple emulsions. In one aspect, multiple emulsions are formed using a plurality of channels, such as microfluidic channels, that meet at a common intersection. The multiple emulsions may be created at a single common intersection in some embodiments, unlike other prior art systems where multiple channel intersections are required to create multiple emulsions. For instance, in one set of embodiments, three, four, or more microfluidic channels may intersect at a common intersection, with two or three serving as inlets and one serving as the outlet. In some embodiments, a first fluidic channel may be relatively hydrophobic, while a second fluidic channel is relatively hydrophilic. The third channel, if present, may be relatively hydrophilic or hydrophobic, depending on the application. The outlet channel may be hydrophobic, hydrophilic, or may comprise at least one portion that is relatively hydrophilic and at least one portion that is relatively hydrophilic. By controlling the flow of fluids through the hydrophilic and hydrophobic portions of the channels, multiple emulsions may be created proximate the common intersection, due to interactions between the fluids entering the common intersection. In other embodiments, different patterns of hydrophilic or hydrophobic channels may be used. Other aspects of the invention are generally directed to methods of making and using such systems, kits involving such systems, emulsions created using such systems, or the like.
摘要翻译：本发明一般涉及乳剂，更具体地说涉及多重乳液。在一个方面，使用多个通道（例如微流体通道）形成多个乳液，其在共同的交叉处相遇。在一些实施例中，可以在单个公共交叉点处产生多个乳液，与需要多个通道交叉点以产生多个乳液的其它现有技术系统不同。例如，在一组实施例中，三个，四个或更多个微流体通道可以在共同的交叉点相交，其中两个或三个用作入口，一个用作出口。在一些实施例中，第一流体通道可以是相对疏水的，而第二流体通道是相对亲水的。根据应用，第三通道（如果存在）可以是相对亲水或疏水的。出口通道可以是疏水的，亲水的，或者可以包括至少一个相对亲水的部分和至少一个相对亲水的部分。通过控制流体通过通道的亲水和疏水部分的流动，由于进入公共交叉点的流体之间的相互作用，可能在公共交叉点附近产生多个乳液。在其它实施方案中，可以使用不同的亲水或疏水通道图案。本发明的其它方面通常涉及制造和使用这种系统的方法，涉及这种系统的试剂盒，使用这种系统产生的乳液等。

3. 发明申请

WO2011028760A2 MULTIPLE EMULSIONS CREATED USING JUNCTIONS 审中-公开
标题翻译：使用结果创建的多个乳液
公开(公告)号：WO2011028760A2
公开(公告)日：2011-03-10
申请号：PCT/US2010/047458
申请日：2010-09-01
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , BASF SE , WEITZ, David, A. , ROMANOWSKY, Mark , HOLTZE, Christian
发明人： WEITZ, David, A. , ROMANOWSKY, Mark , HOLTZE, Christian
IPC分类号： B01F5/00 , B01F3/08 , B01F15/04
CPC分类号： B01F13/0084 , B01F3/0807 , B01F2003/0838 , Y10T137/0318 , Y10T137/87571
摘要： The present invention generally relates to emulsions, and more particularly, to multiple emulsions. In one aspect, multiple emulsions are formed using a plurality of channels, such as microfluidic channels, that meet at a common intersection. The multiple emulsions may be created at a single common intersection in some embodiments, unlike other prior art systems where multiple channel intersections are required to create multiple emulsions. For instance, in one set of embodiments, three, four, or more microfluidic channels may intersect at a common intersection, with two or three serving as inlets and one serving as the outlet. In some embodiments, a first fluidic channel may be relatively hydrophobic, while a second fluidic channel is relatively hydrophilic. The third channel, if present, may be relatively hydrophilic or hydrophobic, depending on the application. The outlet channel may be hydrophobic, hydrophilic, or may comprise at least one portion that is relatively hydrophilic and at least one portion that is relatively hydrophilic. By controlling the flow of fluids through the hydrophilic and hydrophobic portions of the channels, multiple emulsions may be created proximate the common intersection, due to interactions between the fluids entering the common intersection. In other embodiments, different patterns of hydrophilic or hydrophobic channels may be used. Other aspects of the invention are generally directed to methods of making and using such systems, kits involving such systems, emulsions created using such systems, or the like.
摘要翻译：本发明一般涉及乳液，并且更具体地涉及多重乳液。在一个方面，使用多个通道（诸如微流体通道）在相同的交叉点处相遇来形成多个乳液。在一些实施例中，可以在单个通用交叉点处创建多重乳液，这与需要多通道交叉点以产生多重乳液的其他现有技术系统不同。例如，在一组实施例中，三个，四个或更多个微流体通道可以在共同的交叉点处相交，其中两个或三个用作入口，一个用作出口。在一些实施例中，第一流体通道可以是相对疏水的，而第二流体通道是相对亲水的。取决于应用，第三通道（如果存在）可以是相对亲水的或疏水的。出口通道可以是疏水的，亲水的，或者可以包含至少一个相对亲水的部分和至少一个相对亲水的部分。通过控制通过通道的亲水部分和疏水部分的流体流动，由于流体进入共同交叉点之间的相互作用，可以在公共交叉点附近形成多个乳液。在其他实施例中，可以使用不同图案的亲水或疏水通道。本发明的其他方面通常涉及制造和使用这样的系统的方法，涉及这种系统的试剂盒，使用这种系统创建的乳剂等。

4. 发明申请

WO2010104597A3 SCALE - UP OF FLOW - FOCUSING MICROFLUIDIC DEVICES 审中-公开
公开(公告)号：WO2010104597A3
公开(公告)日：2010-09-16
申请号：PCT/US2010/000753
申请日：2010-03-12
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , ROMANOWSKY, Mark , ABATE, Adam, R. , WEITZ, David, A.
发明人： ROMANOWSKY, Mark , ABATE, Adam, R. , WEITZ, David, A.
IPC分类号： B01J19/00 , B01F13/00 , B01F3/08
摘要： Parallel uses of microfluidic methods and devices for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid are described. In some aspects, the present invention relates generally to flow-focusing-type technology, and also to microfluidics, and more particularly parallel use of microfluidic systems arranged to control a dispersed phase within a dispersant, and the size, and size distribution, of a dispersed phase in a multi-phase fluid system, and systems for delivery of fluid components to multiple such devices.

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