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1. 发明申请

WO2011146858A3 FOAMS, INCLUDING MICROCELLULAR FOAMS, CONTAINING COLLOIDAL PARTICULATES 审中-公开
标题翻译： FOAMS，包括微胶囊，含有胶体颗粒
公开(公告)号：WO2011146858A3
公开(公告)日：2012-05-31
申请号：PCT/US2011037377
申请日：2011-05-20
申请人： HARVARD COLLEGE , BASF SE , LADAVAC KOSTA , GUERRA RODRIGO E , KAZ DAVID , MANOHARAN VINOTHAN , RIEGER JENS B , KOLTZENBURG ROLAND SEBASTIAN , WEITZ DAVID A
发明人： LADAVAC KOSTA , GUERRA RODRIGO E , KAZ DAVID , MANOHARAN VINOTHAN , RIEGER JENS B , KOLTZENBURG ROLAND SEBASTIAN , WEITZ DAVID A
IPC分类号： A61K9/12 , A61K9/14 , A61K9/51
CPC分类号： A61K9/122 , A61K9/143 , A61K9/146 , A61K9/5115
摘要： The present invention generally relates to foams and particles made from such foams, for applications such as drug delivery. The foams or particles may comprise a pharmaceutically acceptable polymeric carrier. In some cases, the foams may include colloidal particulates. A first aspect of the present invention is generally related to polymer-based foams or particles containing pharmaceutically active agents. In some cases, the foam or particle may contain smaller colloidal particulates therein. Such colloidal particulates may be used, for example, to limit the amount of material within certain regions of the foam, or exclude pharmaceutically active agents from being located within certain portions of the foam, which may useful for enhancing release of pharmaceutically active agents from the foam. In some cases, the colloidal particulates may cause the foam or particle to have an unexpectedly high specific surface area. The foam, in certain embodiments, can exhibit a relatively high loading of the pharmaceutically active agent. The foam may be microcellular in certain instances. The foam may also be created using a supercritical fluid, for example, supercritical C02. For instance, a precursor to the foam, containing a pharmaceutically active agent, a pharmaceutically acceptable polymeric carrier, and colloidal particulates, can be mixed with a foaming agent. The pressure may then be decreased, thereby causing the foaming agent to expand and causing a foam to form. The foam may also be ground or milled, or otherwise processed, to form particles such as nanoparticles.
摘要翻译：本发明一般涉及由这种泡沫制成的泡沫和颗粒，用于诸如药物递送的应用。泡沫或颗粒可以包含药学上可接受的聚合物载体。在一些情况下，泡沫可以包括胶体颗粒。本发明的第一方面通常涉及基于聚合物的泡沫或含有药物活性剂的颗粒。在一些情况下，泡沫或颗粒中可含有较小的胶体颗粒。这种胶体颗粒可以用于例如限制泡沫的某些区域内的物质的量，或者不排除药物活性剂位于泡沫的某些部分内，其可用于增强药物活性剂从泡沫。在一些情况下，胶体颗粒可能导致泡沫或颗粒具有出乎意料的高比表面积。在某些实施方案中，泡沫体可以表现出相对高的药物活性剂的负载量。泡沫在某些情况下可能是微孔的。泡沫也可以使用超临界流体，例如超临界CO 2来产生。例如，含有药物活性剂，药学上可接受的聚合物载体和胶体颗粒的泡沫的前体可与发泡剂混合。然后可以降低压力，从而使发泡剂膨胀并形成泡沫。泡沫也可以研磨或研磨或以其它方式处理，以形成颗粒如纳米颗粒。

2. 发明申请

WO2011146858A2 FOAMS, INCLUDING MICROCELLULAR FOAMS, CONTAINING COLLOIDAL PARTICULATES 审中-公开
标题翻译： FOAMS，包括微胶囊，含有胶体颗粒
公开(公告)号：WO2011146858A2
公开(公告)日：2011-11-24
申请号：PCT/US2011/037377
申请日：2011-05-20
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , BASF SE , LADAVAC, Kosta , GUERRA, Rodrigo, E. , KAZ, David , MANOHARAN, Vinothan , RIEGER, Jens, B. , KOLTZENBURG, Roland, Sebastian , WEITZ, David, A.
发明人： LADAVAC, Kosta , GUERRA, Rodrigo, E. , KAZ, David , MANOHARAN, Vinothan , RIEGER, Jens, B. , KOLTZENBURG, Roland, Sebastian , WEITZ, David, A.
IPC分类号： A61K9/12 , A61K9/14 , A61K9/51
CPC分类号： A61K9/122 , A61K9/143 , A61K9/146 , A61K9/5115
摘要： The present invention generally relates to foams and particles made from such foams, for applications such as drug delivery. The foams or particles may comprise a pharmaceutically acceptable polymeric carrier. In some cases, the foams may include colloidal particulates. A first aspect of the present invention is generally related to polymer-based foams or particles containing pharmaceutically active agents. In some cases, the foam or particle may contain smaller colloidal particulates therein. Such colloidal particulates may be used, for example, to limit the amount of material within certain regions of the foam, or exclude pharmaceutically active agents from being located within certain portions of the foam, which may useful for enhancing release of pharmaceutically active agents from the foam. In some cases, the colloidal particulates may cause the foam or particle to have an unexpectedly high specific surface area. The foam, in certain embodiments, can exhibit a relatively high loading of the pharmaceutically active agent. The foam may be microcellular in certain instances. The foam may also be created using a supercritical fluid, for example, supercritical C0 2 . For instance, a precursor to the foam, containing a pharmaceutically active agent, a pharmaceutically acceptable polymeric carrier, and colloidal particulates, can be mixed with a foaming agent. The pressure may then be decreased, thereby causing the foaming agent to expand and causing a foam to form. The foam may also be ground or milled, or otherwise processed, to form particles such as nanoparticles.
摘要翻译：本发明一般涉及由这种泡沫制成的泡沫和颗粒，用于诸如药物递送的应用。泡沫或颗粒可以包含药学上可接受的聚合物载体。在一些情况下，泡沫可以包括胶体颗粒。本发明的第一方面通常涉及基于聚合物的泡沫或含有药物活性剂的颗粒。在一些情况下，泡沫或颗粒中可含有较小的胶体颗粒。这种胶体颗粒可以用于例如限制泡沫的某些区域内的物质的量，或者不排除药物活性剂位于泡沫的某些部分内，其可用于增强药物活性剂从泡沫。在一些情况下，胶体颗粒可能导致泡沫或颗粒具有出乎意料的高比表面积。在某些实施方案中，泡沫体可以表现出相对高的药物活性剂的负载量。泡沫在某些情况下可能是微孔的。泡沫也可以使用超临界流体，例如超临界CO 2来产生。例如，含有药物活性剂，药学上可接受的聚合物载体和胶体颗粒的泡沫的前体可与发泡剂混合。然后可以降低压力，从而使发泡剂膨胀并形成泡沫。泡沫也可以研磨或研磨或以其它方式处理，以形成颗粒如纳米颗粒。

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