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1. 发明申请

WO2011116154A3 MELT EMULSIFICATION 审中-公开
公开(公告)号：WO2011116154A3
公开(公告)日：2012-06-07
申请号：PCT/US2011028754
申请日：2011-03-17
申请人： HARVARD COLLEGE , BASF SE , SHUM HO CHEUNG , SUN BINGJIE , WEITZ DAVID A , HOLTZE CHRISTIAN
发明人： SHUM HO CHEUNG , SUN BINGJIE , WEITZ DAVID A , HOLTZE CHRISTIAN
IPC分类号： B01J13/00 , A01N25/28 , A61K9/50 , B01J13/04 , C09B67/00 , C11D3/50 , C11D17/00
CPC分类号： B01J13/0086 , B01F3/0807 , B01F13/0062 , B01F2005/0034 , B01J13/04 , C09B67/0009 , C09B67/0097 , G01N2015/1413
摘要： The present invention generally relates to colloidal systems, which may include colloidal particles and/or other types of particles. One aspect of the invention is generally directed to a system comprising fluidic droplets that can be at least partially solidified, e.g., to form colloidal particles. In some embodiments, particles comprising an at least partially solid outer phase encapsulating an inner phase are formed. The inner phase may be any phase, e.g., a solid, a liquid, or a gas. In some cases, solidifying at least a portion of the outer phase of the droplets to form particles may increase the stability of the particles and/or the colloidal system containing the particles. In one set of embodiments, melting or liquefying the outer phase of the particles (for example, by heating the particle to a temperature above a threshold temperature) can allow release of an agent contained within the inner phase, and/or allow the inner phase to coalesce with a phase external to the particles. The melting temperature of the outer phase can be controlled in some embodiments such that the outer phase will melt above a predetermined temperature. In some embodiments, the particles may be formed to be essentially free of an auxiliary stabilizing agent. In some embodiments, an agent may be encapsulated within a particle with relatively high efficiency. Other aspects of the invention are generally directed to methods of making and using such colloidal systems, e.g., containing such particles, kits involving such colloidal systems, or the like.
摘要翻译：本发明一般涉及胶体体系，其可以包括胶体颗粒和/或其它类型的颗粒。本发明的一个方面通常涉及包含流体液滴的系统，其可以至少部分地固化，例如形成胶体颗粒。在一些实施方案中，形成包含至少部分固体外层的包封内相的颗粒。内相可以是任何相，例如固体，液体或气体。在一些情况下，固化液滴的外相的至少一部分以形成颗粒可以增加包含颗粒的颗粒和/或胶体体系的稳定性。在一组实施方案中，熔化或液化颗粒的外相（例如，通过将颗粒加热到高于阈值温度的温度）可以允许包含在内相内的试剂的释放和/或允许内相以颗粒外部的相合并。在一些实施方案中，可以控制外相的熔融温度，使得外相将在预定温度以上熔化。在一些实施方案中，颗粒可以形成为基本上不含辅助稳定剂。在一些实施方案中，试剂可以以相对高的效率封装在颗粒内。本发明的其它方面通常涉及制备和使用这种胶体体系的方法，例如含有这种颗粒，涉及这种胶体系的试剂盒等。

2. 发明申请

WO2013032709A2 SYSTEMS AND METHODS FOR SHELL ENCAPSULATION 审中-公开
标题翻译：用于壳体封装的系统和方法
公开(公告)号：WO2013032709A2
公开(公告)日：2013-03-07
申请号：PCT/US2012050916
申请日：2012-08-15
申请人： HARVARD COLLEGE , BASF SE , WEITZ DAVID A , SHUM HO CHEUNG , ZHAO YUANJIN , SUN BINGJIE , HOLTZE CHRISTIAN
发明人： WEITZ DAVID A , SHUM HO CHEUNG , ZHAO YUANJIN , SUN BINGJIE , HOLTZE CHRISTIAN
IPC分类号： B01J13/20
CPC分类号： B01J13/203 , A01N25/28 , A23L29/015 , A23P10/30 , A61K9/501 , A61K9/5036 , A61K9/5089 , C09B67/0097 , C11D17/0039 , A01N59/02 , A01N59/06 , A01N59/16
摘要： The present invention generally relates to particles, including particles for drug delivery and other applications. Certain aspects of the invention are generally directed to particles comprising a shell and an interior at least partially contained by the shell. In some embodiments, the particles may be treated to enhance the containment of the interior, for example to reduce transport of an agent into or out of the interior. Such particles may exhibit increased ability to encapsulate agents and/or increased storage life (e.g., due to reduced leakage). For instance, in certain embodiments, any defects, such as cracks, pores, etc. within the shell may be sealed or otherwise treated to reduce transport therethrough, for example, with a solid. In some embodiments, for instance, a first reactant in the interior of a particle may come into contact with a second reactant outside of the particle to form a solid, or other suitable product. The shell may also be treated, e.g., at a later point in time, to cause release of an agent contained within the interior, in certain aspects. For example, the shell may be heated to cause the release of the agent from the particle, or the shell may be exposed to chemical or enzymatic degradation, or a change in osmolarity, to cause release of an agent. Still other aspects of the present invention are generally directed to methods of making or using such particles, kits or devices including such particles, or the like.
摘要翻译：本发明通常涉及包括用于药物递送的颗粒和其它应用的颗粒。本发明的某些方面通常涉及包含壳体和至少部分地由壳体包含的内部的颗粒。在一些实施方案中，可以处理颗粒以增强内部的容纳，例如减少试剂进入或流出内部的运输。这样的颗粒可以表现出增加的包封剂的能力和/或增加的储存寿命（例如，由于泄漏减少）。例如，在某些实施例中，壳体内的任何缺陷，例如裂缝，孔隙等可被密封或以其他方式处理，以减少例如通过固体的运输。在一些实施方案中，例如，颗粒内部的第一反应物可能与颗粒外部的第二反应物接触以形成固体或其它合适的产物。在某些方面，外壳也可以例如在稍后的时间点处理，以引起包含在内部中的试剂的释放。例如，可以加热外壳以使试剂从颗粒中释放，或者壳可能暴露于化学或酶降解或渗透压的变化，导致试剂的释放。本发明的其它方面通常涉及制造或使用这种颗粒，包括这种颗粒的试剂盒或装置等的方法。

3. 发明专利

BR112012023441A2 emulsificação por fusão 未知
公开(公告)号：BR112012023441A2
公开(公告)日：2016-05-24
申请号：BR112012023441
申请日：2011-03-17
申请人： BASF SE , PRESIDENT AND FELLOWS OF HAVARD COLLEGE
发明人： SUN BINGJIE , HOLTZE CHRISTIAN , WEITZ DAVID A , SHUM HO CHEUNG
IPC分类号： A61K9/50 , A01N25/28 , B01J13/00 , B01J13/04 , C09B67/00 , C11D3/50 , C11D17/00
摘要： emulsificação por fusão. a presente invenção refere-se de modo geral a sistemas coloidais, que podem incluir partículas coloidais e/ou outros tipos de partículas. um aspecto da invenção está direcionada geralmente a um sistema que compreende gotículas fluídicas que podem ser pelo menos parcialmente solidificadas, por exemplo, para formar partículas coloidais. em algumas modalidades, são formadas partículas que compreendem pelo menos uma fase externa parcialmente sólida que encapsula uma fase interna. a fase interna pode ser qualquer fase, por exemplo, um sólido, um líquido ou um gás. em alguns casos, solidificar pelo menos uma porção da fase externa das gotículas para formar partículas pode aumentar a estabilidade das partículas e/ou do sistema coloidal que contém as partículas. em um grupo de modalidades, fundir ou liquefazer a fase externa das partículas (por exemplo, pelo aquecimento da partícula a uma temperatura acima da temperatura limiar) pode permitir a liberação de um agente contido dentro da fase interna e/ou permitir que a fase interna aglutine com a fase externa das partículas. a temperatura de fusão da fase externa pode ser controlada em algumas modalidades tal que a fase externa fundirá acima de uma temperatura predeterminada. em algumas modalidades, as partículas podem ser formadas para serem essencialmente livre de um agente estabilizador auxiliar. em algumas modalidades, um agente pode ser encapsulado dentro de uma partícula com eficiência relativamente alta. outros aspectos da invenção são direcionados de modo geral para métodos de fazer e usar tais sistemas coloidais, por exemplo, contendo tais partículas, kits que envolvem tais sistemas coloidais ousimilaressimilares.

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