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1. 发明申请

WO2010104593A2 SYSTEMS AND METHODS OF TEMPLATING USING PARTICLES SUCH AS COLLOIDAL PARTICLES 审中-公开
标题翻译：使用颗粒作为胶体颗粒的系统和方法
公开(公告)号：WO2010104593A2
公开(公告)日：2010-09-16
申请号：PCT/US2010000748
申请日：2010-03-12
申请人： HARVARD COLLEGE , BASF SE , WEITZ DAVID A , KOLTZENBURG ROLAND S , RIEGER JENS B , STUDART ANDRE R , WILKING JAMES N
发明人： WEITZ DAVID A , KOLTZENBURG ROLAND S , RIEGER JENS B , STUDART ANDRE R , WILKING JAMES N
IPC分类号： B01J2/22
CPC分类号： B01J2/22 , B01J2/08 , Y10T428/249954
摘要： The present invention generally relates to systems and methods for using particle templating, e.g., to produce composites, discrete particles, or the like. In some embodiments, the present invention generally relates to the production of particles using the interstitial spaces between templating elements in a template structure. For example, a plurality of templating elements, which can include colloidal particles, may be arranged to form a template structure. The interstices of the templating elements can provide regions in which a fluid may be introduced. The fluid may be hardened (e.g., solidified) in some cases, e.g., to form a composite comprising the templating elements and the interstitial segments. In certain embodiments, the template structure may then be broken down to release the hardened fluid, e.g., as a plurality of discrete particles.
摘要翻译：本发明一般涉及使用颗粒模板法，例如生产复合材料，离散颗粒等的系统和方法。在一些实施方案中，本发明通常涉及使用模板结构中的模板元件之间的间隙空间来生产颗粒。例如，可以布置多个可以包括胶体颗粒的模板元件以形成模板结构。模板元件的间隙可以提供其中可以引入流体的区域。在一些情况下，流体可以被硬化（例如，固化），例如形成包含模板元件和间隙段的复合材料。在某些实施例中，然后可以将模板结构分解以释放硬化的流体，例如作为多个离散颗粒。

2. 发明申请

WO2012027378A2 PARTICLES FOR DRUG DELIVERY AND OTHER APPLICATIONS 审中-公开
标题翻译：用于药物递送和其他应用的颗粒
公开(公告)号：WO2012027378A2
公开(公告)日：2012-03-01
申请号：PCT/US2011048822
申请日：2011-08-23
申请人： HARVARD COLLEGE , BASF SE , FAN BEN , KOLTZENBURG ROLAND S , RIEGER JENS B , WEITZ DAVID A
发明人： FAN BEN , KOLTZENBURG ROLAND S , RIEGER JENS B , WEITZ DAVID A
IPC分类号： A61K9/14 , A61K9/16 , A61K31/565 , A61K31/58
CPC分类号： A61K9/143 , A61K9/1694 , A61K31/565 , A61K31/58
摘要： The present invention generally relates to particles for drug delivery and other applications. In one aspect, the present invention relates to a technique for reacting precursor compounds in the presence of a pharmaceutically- active agent to form product (e.g., in the form of particles) in which the agent is substantially contained within the product, and the product is soluble within typical gastric fluid of a mammal. In another aspect, the present invention is generally directed to particles comprising an inorganic pharmaceutically acceptable carrier, such as CaCO3, and an agent. In some cases, at least some of the agent contained within the particles is fluidically inaccessible from externally of the particle. For instance, the agent may be present in isolated domains within the particle. In another aspect, the present invention is generally directed to methods of creating particles. For instance, according to one set of embodiments, two fluids containing reactants are mixed where, upon reaction of the reactants, an insoluble product is formed, which precipitates to form particles. In one example, a first fluid containing dissolved carbonate ions and a second fluid containing dissolved calcium ions and a pharmaceutically- active agent are mixed together; upon mixing of the first and second fluids, the calcium ions and the carbonate ions form calcium carbonate, which precipitates to form a co-precipitate with the pharmaceutically- active agent. Yet other aspects of the present invention are directed to particles formed from such reactions, methods of using such reactions, methods of promoting such reactions, kits involving particles, or the like.
摘要翻译：本发明总体上涉及用于药物递送和其他应用的颗粒。在一个方面，本发明涉及一种用于使前体化合物在药物活性剂存在下反应以形成其中药剂基本上包含在产品内的产品（例如，以颗粒形式）的技术，并且产品可溶于哺乳动物的典型胃液中。另一方面，本发明一般涉及包含无机药学上可接受的载体如CaCO 3和药剂的颗粒。在一些情况下，包含在颗粒内的至少一些试剂从颗粒的外部流体不可接近。例如，该药剂可能存在于颗粒内的分离域中。另一方面，本发明总体上涉及产生颗粒的方法。例如，根据一组实施方案，混合含有反应物的两种流体，其中在反应物反应时形成不溶产物，其沉淀形成颗粒。在一个实例中，将含有溶解的碳酸根离子的第一流体和含有溶解的钙离子的第二流体与药物活性剂混合在一起; 在混合第一流体和第二流体时，钙离子和碳酸根离子形成碳酸钙，其沉淀与药物活性剂形成共沉淀物。本发明的其他方面涉及由这些反应形成的颗粒，使用这些反应的方法，促进这种反应的方法，涉及颗粒的试剂盒等。

3. 发明申请

WO2011146852A8 FOAMS OR PARTICLES FOR APPLICATIONS SUCH AS DRUG DELIVERY 审中-公开
标题翻译：用于药物递送应用的FOAMS或颗粒
公开(公告)号：WO2011146852A8
公开(公告)日：2013-03-07
申请号：PCT/US2011037363
申请日：2011-05-20
申请人： HARVARD COLLEGE , BASF SE , LADAVAC KOSTA , GUERRA RODRIGO E , KAZ DAVID , MANOHARAN VINOTHAM , RIEGER JENS B , KOLTZENBURG ROLAND SEBASTIAN , WEITZ DAVID A
发明人： LADAVAC KOSTA , GUERRA RODRIGO E , KAZ DAVID , MANOHARAN VINOTHAM , RIEGER JENS B , KOLTZENBURG ROLAND SEBASTIAN , WEITZ DAVID A
IPC分类号： A61K9/12 , A61K9/14 , A61K47/32
CPC分类号： A61K9/122 , A61K9/146 , A61K47/32
摘要： The present invention generally relates to foams and, in particular, to foams for applications such as drug delivery, and particles that are made from such foams. One aspect relates to foams or particles containing pharmaceutically active agents. The foam may comprise a pharmaceutically acceptable polymeric carrier. In some cases, the foam or particle has an unexpectedly high specific surface area. A high specific surface area may, in some cases, facilitate delivery or release of the pharmaceutically active agent when the foam or particles made from the foam (e.g., by milling) are administered to a subject. The foam may also exhibit a relatively high loading of the pharmaceutically active agent. In some cases, the foam may be a microcellular foam. In one set of embodiments, the foam is created using a supercritical fluid, such as supercritical C02. For example, a precursor to the foam, containing a pharmaceutically active agent, may be mixed with a foaming agent, then the pressure decreased to cause the foaming agent to expand, thereby causing a foam to form. The foam may then be subsequently ground or milled, or otherwise processed to form particles.
摘要翻译：本发明一般涉及泡沫，特别是泡沫用于例如药物递送的泡沫，以及由这种泡沫制成的颗粒。一个方面涉及含有药物活性剂的泡沫或颗粒。泡沫可以包含药学上可接受的聚合物载体。在一些情况下，泡沫或颗粒具有出乎意料的高比表面积。在一些情况下，当由泡沫制成的泡沫或颗粒（例如通过研磨））施用于受试者时，高比表面积可能有助于药物活性剂的递送或释放。泡沫体也可表现出相当高的药物活性剂负荷。在一些情况下，泡沫可以是微孔泡沫。在一组实施方案中，使用超临界流体（例如超临界CO 2）产生泡沫。例如，含有药物活性剂的泡沫体的前体可与发泡剂混合，然后降低压力，引起发泡剂膨胀，从而形成泡沫。然后可以将泡沫研磨或研磨，或以其它方式加工形成颗粒。

4. 发明申请

WO2011146852A3 FOAM OR PARTICLES FOR APPLICATIONS SUCH AS DRUG DELIVERY 审中-公开
标题翻译：用于药物递送应用的泡沫或颗粒
公开(公告)号：WO2011146852A3
公开(公告)日：2012-07-05
申请号：PCT/US2011037363
申请日：2011-05-20
申请人： HARVARD COLLEGE , BASF SE , LADAVAC KOSTA , GUERRA RODRIGO E , KAZ DAVID , MANOHARAN VINOTHAM , RIEGER JENS B , KOLTZENBURG ROLAND SEBASTIAN , WEITZ DAVID A
发明人： LADAVAC KOSTA , GUERRA RODRIGO E , KAZ DAVID , MANOHARAN VINOTHAM , RIEGER JENS B , KOLTZENBURG ROLAND SEBASTIAN , WEITZ DAVID A
IPC分类号： A61K9/12 , A61K9/14 , A61K47/32
CPC分类号： A61K9/122 , A61K9/146 , A61K47/32
摘要： The present invention generally relates to foams and, in particular, to foams for applications such as drug delivery, and particles that are made from such foams. One aspect relates to foams or particles containing pharmaceutically active agents. The foam may comprise a pharmaceutically acceptable polymeric carrier. In some cases, the foam or particle has an unexpectedly high specific surface area. A high specific surface area may, in some cases, facilitate delivery or release of the pharmaceutically active agent when the foam or particles made from the foam (e.g., by milling) are administered to a subject. The foam may also exhibit a relatively high loading of the pharmaceutically active agent. In some cases, the foam may be a microcellular foam. In one set of embodiments, the foam is created using a supercritical fluid, such as supercritical C02. For example, a precursor to the foam, containing a pharmaceutically active agent, may be mixed with a foaming agent, then the pressure decreased to cause the foaming agent to expand, thereby causing a foam to form. The foam may then be subsequently ground or milled, or otherwise processed to form particles.
摘要翻译：本发明一般涉及泡沫，特别是泡沫用于例如药物递送的泡沫，以及由这种泡沫制成的颗粒。一个方面涉及含有药物活性剂的泡沫或颗粒。泡沫可以包含药学上可接受的聚合物载体。在一些情况下，泡沫或颗粒具有出乎意料的高比表面积。在一些情况下，当由泡沫制成的泡沫或颗粒（例如通过研磨））施用于受试者时，高比表面积可能有助于药物活性剂的递送或释放。泡沫体也可表现出相当高的药物活性剂负荷。在一些情况下，泡沫可以是微孔泡沫。在一组实施方案中，使用超临界流体（例如超临界CO 2）产生泡沫。例如，含有药物活性剂的泡沫体的前体可与发泡剂混合，然后降低压力，引起发泡剂膨胀，从而形成泡沫。然后可以将泡沫研磨或研磨，或以其它方式加工形成颗粒。

5. 发明申请

WO2011146858A3 FOAMS, INCLUDING MICROCELLULAR FOAMS, CONTAINING COLLOIDAL PARTICULATES 审中-公开
标题翻译： FOAMS，包括微胶囊，含有胶体颗粒
公开(公告)号：WO2011146858A3
公开(公告)日：2012-05-31
申请号：PCT/US2011037377
申请日：2011-05-20
申请人： HARVARD COLLEGE , BASF SE , LADAVAC KOSTA , GUERRA RODRIGO E , KAZ DAVID , MANOHARAN VINOTHAN , RIEGER JENS B , KOLTZENBURG ROLAND SEBASTIAN , WEITZ DAVID A
发明人： LADAVAC KOSTA , GUERRA RODRIGO E , KAZ DAVID , MANOHARAN VINOTHAN , RIEGER JENS B , KOLTZENBURG ROLAND SEBASTIAN , WEITZ DAVID A
IPC分类号： A61K9/12 , A61K9/14 , A61K9/51
CPC分类号： A61K9/122 , A61K9/143 , A61K9/146 , A61K9/5115
摘要： The present invention generally relates to foams and particles made from such foams, for applications such as drug delivery. The foams or particles may comprise a pharmaceutically acceptable polymeric carrier. In some cases, the foams may include colloidal particulates. A first aspect of the present invention is generally related to polymer-based foams or particles containing pharmaceutically active agents. In some cases, the foam or particle may contain smaller colloidal particulates therein. Such colloidal particulates may be used, for example, to limit the amount of material within certain regions of the foam, or exclude pharmaceutically active agents from being located within certain portions of the foam, which may useful for enhancing release of pharmaceutically active agents from the foam. In some cases, the colloidal particulates may cause the foam or particle to have an unexpectedly high specific surface area. The foam, in certain embodiments, can exhibit a relatively high loading of the pharmaceutically active agent. The foam may be microcellular in certain instances. The foam may also be created using a supercritical fluid, for example, supercritical C02. For instance, a precursor to the foam, containing a pharmaceutically active agent, a pharmaceutically acceptable polymeric carrier, and colloidal particulates, can be mixed with a foaming agent. The pressure may then be decreased, thereby causing the foaming agent to expand and causing a foam to form. The foam may also be ground or milled, or otherwise processed, to form particles such as nanoparticles.
摘要翻译：本发明一般涉及由这种泡沫制成的泡沫和颗粒，用于诸如药物递送的应用。泡沫或颗粒可以包含药学上可接受的聚合物载体。在一些情况下，泡沫可以包括胶体颗粒。本发明的第一方面通常涉及基于聚合物的泡沫或含有药物活性剂的颗粒。在一些情况下，泡沫或颗粒中可含有较小的胶体颗粒。这种胶体颗粒可以用于例如限制泡沫的某些区域内的物质的量，或者不排除药物活性剂位于泡沫的某些部分内，其可用于增强药物活性剂从泡沫。在一些情况下，胶体颗粒可能导致泡沫或颗粒具有出乎意料的高比表面积。在某些实施方案中，泡沫体可以表现出相对高的药物活性剂的负载量。泡沫在某些情况下可能是微孔的。泡沫也可以使用超临界流体，例如超临界CO 2来产生。例如，含有药物活性剂，药学上可接受的聚合物载体和胶体颗粒的泡沫的前体可与发泡剂混合。然后可以降低压力，从而使发泡剂膨胀并形成泡沫。泡沫也可以研磨或研磨或以其它方式处理，以形成颗粒如纳米颗粒。

6. 发明专利

BRPI1009399A2 sistema e métodos para modelagem usando partículas tais como partículas coloidais 未知
公开(公告)号：BRPI1009399A2
公开(公告)日：2016-03-08
申请号：BRPI1009399
申请日：2010-03-12
申请人： BASF SE , HARVARD COLLEGE
发明人： STUDART ANDRE R , WEITZ DAVID A , WILKING JAMES N , RIEGER JENS B , KOLTZENBURG ROLAND S
IPC分类号： B01J2/08 , B01J2/22

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