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1. 发明申请

WO2010043595A1 BLOOD TREATMENT APPARATUS AND METHOD 审中-公开
标题翻译：血液处理装置和方法
公开(公告)号：WO2010043595A1
公开(公告)日：2010-04-22
申请号：PCT/EP2009/063290
申请日：2009-10-12
申请人： GAMBRO LUNDIA AB , HOLMER, Mattias , JÖNSSON, Lennart , WALLENBORG, Anders , HANSSON, Per
发明人： HOLMER, Mattias , JÖNSSON, Lennart , WALLENBORG, Anders , HANSSON, Per
IPC分类号： A61M1/10 , A61M1/16 , A61M1/30 , A61M1/34
CPC分类号： A61M1/16 , A61M1/1601 , A61M2205/50
摘要： A blood treatment apparatus, comprising a blood treatment unit (D) configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid, a pair of fluid pumps ( PF1, PF2; PF3, PF4) configured to pass blood treatment fluid through the blood treatment unit (D), a pair of blood pumps ( PB1, PB2) configured to extract untreated blood from a blood source (BS), pass extracted blood through the blood treatment unit (D) and deliver treated blood to a target vessel (BT), each blood pump comprising a pump chamber and a flexible member ( FM1; FM2) separating the pumping chamber into a first blood accumulating container (B1; B2) and a second working fluid accumulating container (F1; F2) where the flexible member is configured to vary a volume relationship between the first and the second accumulation containers. Further the apparatus comprises a control unit (P) and a measuring means configured to emit a feedback signal indicative of the amount of working fluid received into, or discharged from at least one of the second accumulation containers (F1; F2) whereby the pumped mass or volume of working fluid is determined by the control unit (P) at an arbitrary position of the flexible member (FM1, FM2).
摘要翻译：一种血液处理装置，包括：血液处理单元（D），被配置为接收未经处理的血液和新鲜血液处理液，并且发射处理过的血液和使用的血液处理液;一对流体泵（PF1，PF2; PF3，PF4）通过血液处理单元（D）通过血液处理液，构成为从血液源（BS）中提取未经处理的血液的一对血液泵（PB1，PB2），通过血液处理单元（D）将提取的血液通过，每个血液泵包括泵室和将泵送室分成第一血液积聚容器（B1; B2）和第二工作流体积聚容器（F1; B2）的柔性构件（FM1; FM2） F2），其中柔性构件构造成改变第一和第二蓄积容器之间的体积关系。此外，该装置包括控制单元（P）和测量装置，该测量装置被配置为发射指示接收到或从第二积聚容器（F1; F2）中的至少一个排出的工作流体的量的反馈信号，由此泵送的质量或者在柔性构件（FM1，FM2）的任意位置处由控制单元（P）确定工作流体的体积。

2. 发明申请

WO2009127624A3 BLOOD TREATMENT APPARATUS 审中-公开
公开(公告)号：WO2009127624A3
公开(公告)日：2009-10-22
申请号：PCT/EP2009/054406
申请日：2009-04-14
申请人： GAMBRO LUNDIA AB , JÖNSSON, Lennart , JANSSON, Olof , HOLMER, Mattias , STERNBY, Jan , NILSSON, Anders , HANSSON, Per
发明人： JÖNSSON, Lennart , JANSSON, Olof , HOLMER, Mattias , STERNBY, Jan , NILSSON, Anders , HANSSON, Per
IPC分类号： A61M1/10 , A61M1/16 , A61M1/30 , A61M1/34
摘要： A proposed blood treatment apparatus includes : a blood treatment unit (8), a pair of fluid pumps (14, 15) and a pair of blood pumps (1a, 1b). The blood treatment unit (8) is configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid. The fluid pumps (14, 15) are configured to pass blood treatment fluid through the blood treatment unit (8). The blood pumps (1a, 1b) are configured to extract untreated blood from a blood source (S), pass extracted blood through the blood treatment unit (8) and deliver treated blood to a target vessel (T). Additionally, the fluid pumps (14, 15) are configured to control the operation of the blood pumps (1a, 1b) via the blood treatment fluid. Moreover, a flow control means (16a) is configured to control a trans- membrane flow between the blood side (8B) and the a fluid side (8F) of the blood treatment unit (8). Hence, for instance ultrafiltration can be adjusted to a desired level in a very straightforward manner.

3. 发明申请

WO2005042059A2 A CIRCUIT FOR EXTRACORPOREAL BLOOD TREATMENT AND FLOW-INVERTING DEVICE UTILIZED THEREIN 审中-公开
标题翻译：用于体外血液处理的回路和用于其中的流动翻转装置
公开(公告)号：WO2005042059A2
公开(公告)日：2005-05-12
申请号：PCT/IB2004/003394
申请日：2004-10-18
申请人： GAMBRO LUNDIA AB , JONSSON, Lennart , HOLMER, Mattias , HANSSON, Per
发明人： JONSSON, Lennart , HOLMER, Mattias , HANSSON, Per
IPC分类号： A61M1/00
CPC分类号： A61M1/367 , A61M1/3658 , A61M39/223 , Y10T137/87249
摘要： It is disclosed a circuit for extracorporeal blood treatment in which a flow-inverting device is interposed between a blood treatment unit and a blood pump placed on an artery branch connected with a vascular access of a patient. The flow-inverting device allows the blood flow within the filtering unit to be kept unchanged even following an inverted circulation in the patient-side artery and vein branches controlled by the blood pump.
摘要翻译：公开了一种用于体外血液处理的电路，其中流动反转装置插入在血液处理单元和放置在与患者的血管通路连接的动脉分支上的血泵之间。即使在由血泵控制的患者侧动脉和静脉分支中的反向循环之后，流动反转装置也允许过滤单元内的血流保持不变。

4. 发明申请

WO2014095524A1 DETECTING PRESSURE PULSES IN A BLOOD PROCESSING APPARATUS 审中-公开
标题翻译：检测血液加压装置中的压力脉冲
公开(公告)号：WO2014095524A1
公开(公告)日：2014-06-26
申请号：PCT/EP2013/076233
申请日：2013-12-11
申请人： GAMBRO LUNDIA AB
发明人： STERNBY, Jan , HOLMER, Mattias , OLDE, Bo , SOLEM, Kristian , WALLENBORG, Anders , HANSSON, Per
IPC分类号： A61M1/36 , A61B5/00
CPC分类号： A61M1/14 , A61B5/7217 , A61M1/1605 , A61M1/1613 , A61M1/3639 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M1/3661 , A61M2205/13 , A61M2205/15 , A61M2205/3303 , A61M2205/3331 , A61M2205/3344 , A61M2205/50 , A61M2230/04
摘要： A monitoring device (7) operates on a pressure signal from a blood processing apparatus, e.g. a dialysis machine, which has an extracorporeal blood circuit connected to a vascular system of a subject for pumping blood through a dialyzer, and a treatment fluid supply system for pumping a treatment fluid through the dialyzer. The monitoring device (7) has a first input block (50) for obtaining a first pressure signal (y) from a first pressure sensor (6a) in the extracorporeal blood circuit, and a second input block (51) for obtaining a second pressure signal (w) from a second pressure sensor (6b) in the treatment fluid supply system. An emulation block (56) generates, as a function of the second pressure signal (w), an emulated first pressure signal (y) which emulates a concurrent signal response of the first pressure sensor (6a), and a filtering block (53) generates a filtered signal (y) as a function of the first pressure signal (y) and the emulated first pressure signal (y), so as to suppress, in the filtered signal (}y) compared to the first pressure signal (y), signal interferences originating from the treatment fluid supply system (lb). A pulse detection block (54) processes the filtered signal (y f ) for detection of subject pulses originating from the subject.
摘要翻译：监测装置（7）对来自血液处理装置的压力信号进行操作。透析机具有连接到受试者的血管系统的体外血液回路，用于通过透析器泵血，以及用于通过透析器泵送治疗流体的治疗液供给系统。监测装置（7）具有用于从体外血液回路中的第一压力传感器（6a）获得第一压力信号（y）的第一输入块（50）和用于获得第二压力来自处理液供给系统中的第二压力传感器（6b）的信号（w）。仿真块（56）根据第二压力信号（w）产生仿真第一压力传感器（6a）的并行信号响应的模拟第一压力信号（y）和滤波块（53），根据第一压力信号（y）和仿真的第一压力信号（y）产生滤波信号（y），以便抑制与第一压力信号（y）相比的滤波信号（y）来自治疗液供应系统（1b）的信号干扰。脉冲检测块（54）处理用于检测从被摄体发出的被摄体脉冲的滤波信号（yf）。

5. 发明申请

WO2010043593A1 BLOOD TREATMENT APPARATUS AND METHOD 审中-公开
标题翻译：血液处理装置和方法
公开(公告)号：WO2010043593A1
公开(公告)日：2010-04-22
申请号：PCT/EP2009/063285
申请日：2009-10-12
申请人： GAMBRO LUNDIA AB , HOLMER, Mattias , JÖNSSON, Lennart , WALLENBORG, Anders , HANSSON, Per
发明人： HOLMER, Mattias , JÖNSSON, Lennart , WALLENBORG, Anders , HANSSON, Per
IPC分类号： A61M1/16 , A61M1/30
CPC分类号： A61M1/16 , A61M1/1601 , A61M2205/50
摘要： A proposed blood treatment apparatus includes: a blood treatment unit (D), a pair of fluid pumps (PF1, PF2) and a pair of blood pumps (PB1, PB2). The blood treatment unit (D) is configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid. The fluid pumps (PF1, PF2) are configured to pass blood treatment fluid through the blood treatment unit (D). The blood pumps (PB1, PB2) are configured to extract untreated blood from a blood source ( BS), pass extracted blood through the blood treatment unit (D) and deliver treated blood to a target vessel (BT). Flow measurement means (Q1, Q2, P) determines at least one blood f low parameter ( BQFI) reflecting an average flow in relation to the blood treatment unit (D) during a well-defined period of operation (T) of the apparatus, for example while completing one operation cycle. The at least one blood flow parameter (BQFI) is determined based on a difference between (i) a first amount (DMI) of fresh blood treatment fluid received into the blood treatment unit (D), and (ii) a second amount (DMO) of used blood treatment fluid emitted from the blood treatment unit (D) during another well-defined period (T a ).
摘要翻译：提出的血液处理装置包括：血液处理单元（D），一对流体泵（PF1，PF2）和一对血液泵（PB1，PB2）。血液处理单元（D）构成为能够接受未经处理的血液和新鲜的血液处理液，并且排出处理过的血液和使用的血液处理液。流体泵（PF1，PF2）被配置为使血液处理液通过血液处理单元（D）。血液泵（PB1，PB2）被构造成从血液源（BS）中提取未经处理的血液，通过血液处理单元（D）提取血液并将处理的血液输送到目标血管（BT）。流量测量装置（Q1，Q2，P）在装置的良好定义的操作时段（T）期间确定反映相对于血液处理单元（D）的平均流量的至少一个血液参数（BQFI）例如在完成一个操作周期。基于（i）接收到血液处理单元（D）中的新鲜血液处理液的第一量（DMI）和（ii）第二量（DMO）之间的差异来确定至少一个血流参数（BQFI））在另一个明确定义的时期（Ta）期间从血液处理单元（D）发射的使用的血液处理液。

6. 发明申请

WO2012035040A1 BLOOD TREATMENT APPARATUS WITH FLOW DIVIDER FOR LIMITING AN ELECTRICAL CURRENT 审中-公开
标题翻译：用于限制电流的流量分配器的血液处理装置
公开(公告)号：WO2012035040A1
公开(公告)日：2012-03-22
申请号：PCT/EP2011/065894
申请日：2011-09-14
申请人： GAMBRO LUNDIA AB , HANSSON, Per , HERTZ, Thomas , HOLMER, Mattias , JÖNSSON, Lennart , NILSSON, Anders , WALLENBORG, Anders , ANDERSSON, Johan
发明人： HANSSON, Per , HERTZ, Thomas , HOLMER, Mattias , JÖNSSON, Lennart , NILSSON, Anders , WALLENBORG, Anders , ANDERSSON, Johan
IPC分类号： A61M1/14 , A61M1/36
CPC分类号： A61M1/367 , A61M1/14 , A61M1/1601 , A61M1/3621 , A61M2205/3317 , A61M2205/3334 , A61M2205/50 , Y10T29/49002
摘要： A blood treatment apparatus (2) comprising: a blood treatment unit (10); a blood line (20) configured to extract blood from a blood source (21), pass the blood through the blood treatment unit (10) and deliver treated blood to a target vessel (22); and a fluid line (30) configured pass treatment fluid through the blood treatment unit (10) and deliver used treatment fluid to a fluid sink (32). A flow divider (40) is arranged in the fluid line (30) separates treatment fluid into to a first fluid section (51) and a second fluid section (53), thereby electrically isolating the fluid sections (51, 53) such that electrical current flowing in the fluid line (30) between the fluid sections (51, 53) is limited. Related manufacturing and verification methods are also described.
摘要翻译：一种血液处理装置（2），包括：血液处理单元（10）; 构成为从血液源（21）取出血液的血液线（20），使血液通过血液处理单元（10），将处理后的血液输送到目标血管（22）。并且流体管线（30）构造成通过处理液通过血液处理单元（10）并将使用的处理流体输送到流体槽（32）。在流体管线（30）中布置有分流器（40），其将处理流体分离成第一流体部分（51）和第二流体部分（53），从而将流体部分（51,53）电隔离，使得电气在流体管线（30）内流动的流体部分（51,53）之间的电流受到限制。还描述了相关的制造和验证方法。

7. 发明申请

WO2011161054A1 BLOOD ACCESS DEVICE 审中-公开
标题翻译：血液接入装置
公开(公告)号：WO2011161054A1
公开(公告)日：2011-12-29
申请号：PCT/EP2011/060230
申请日：2011-06-20
申请人： GAMBRO LUNDIA AB , EKDAHL, Olof , ZANINI, Marco , HANSSON, Per , NILSSON, Eddie , JANSSON, Olof , JÖNSSON, Lennart
发明人： EKDAHL, Olof , ZANINI, Marco , HANSSON, Per , NILSSON, Eddie , JANSSON, Olof , JÖNSSON, Lennart
IPC分类号： A61M25/06 , A61M39/28
CPC分类号： A61M5/168 , A61M1/3621 , A61M1/3653 , A61M1/3655 , A61M1/3656 , A61M1/3661 , A61M5/158 , A61M5/16854 , A61M25/02 , A61M25/0637 , A61M39/281 , A61M39/284 , A61M2005/1586 , A61M2025/024
摘要： A blood access device comprises a fluid conduit (50) configured to convey a flow of fluid to a target vessel (2), a second lever element (20) pivotally and resiliently connected to a first lever element (10) such that it may move from a first position (P1) to a second position. A biasing force is exerted on the second lever element (20) for moving it from the first position (P1) to the second position, and a blocking member may be activated by the second lever element (20), such that a flow of fluid is decreased when the second lever element (20) is moved from the first position (P1) to the second position. The lever elements (10, 20) are configured to be fixed to the target vessel (2) when the second lever element (20) is in the first position (P1), and the second lever element (20) moves to the second position (P2) and activates the blocking member (14) if the fixation is at least partially lost. A related blood treatment apparatus is also described.
摘要翻译：血液进入装置包括被配置为将流体流传送到目标血管（2）的流体导管（50），枢转地并弹性地连接到第一杠杆元件（10）的第二杠杆元件（20），使得其可以移动从第一位置（P1）到第二位置。偏压力施加在第二杠杆元件20上，用于将其从第一位置（P1）移动到第二位置，并且阻挡构件可以由第二杠杆元件（20）启动，使得流体流动当第二杠杆元件（20）从第一位置（P1）移动到第二位置时减小。杠杆元件（10,20）构造成当第二杠杆元件（20）处于第一位置（P1）时固定到目标船舶（2），并且第二杠杆元件（20）移动到第二位置（P2）并且如果固定件至少部分损失则启动阻挡构件（14）。还描述了一种相关的血液处理装置。

8. 发明申请

WO2003066135A1 METHOD AND APPARATUS FOR DETERMINING ACCESS FLOW 审中-公开
标题翻译：用于确定访问流的方法和装置
公开(公告)号：WO2003066135A1
公开(公告)日：2003-08-14
申请号：PCT/IB2002/004537
申请日：2002-10-31
申请人： GAMBRO LUNDIA AB , BENE, Bernard , GOUX, Nicolas , HANSSON, Per , HERTZ, Thomas , JANSSON, Olof , PERSSON, Roland , STERNBY, Jan , ASBRINK, Perry
发明人： BENE, Bernard , GOUX, Nicolas , HANSSON, Per , HERTZ, Thomas , JANSSON, Olof , PERSSON, Roland , STERNBY, Jan , ASBRINK, Perry
IPC分类号： A61M1/16
CPC分类号： A61M1/30 , A61M1/16 , A61M1/1605 , A61M1/1617 , A61M1/3656 , A61M2202/0498 , A61M2205/13 , A61M2205/15 , A61M2205/3317 , A61M2205/3324 , A61M2205/50 , A61M2230/65
摘要： A method and apparatus for determining a fluid flow rate in a blood access having an upstream position and a downstream position using a blood treatment apparatus including a blood treatment unit having a semi permeable membrane delimiting a first chamber through which blood removed from said blood access passes and a second chamber through which dialysis liquid passes, an arterial line and a venous line, connected to an inlet and an outlet of the first chamber respectively. The method for determining the fluid flow rate involves measurement of the post dialyzer concentration or conductivity before and after a flow reversal. The invention further involves a method for checking the operating configuration of the arterial and venous lines of the blood treatment apparatus.
摘要翻译：一种用于使用血液处理设备来确定具有上游位置和下游位置的血液通路中的流体流量的方法和装置，所述血液处理设备包括血液处理单元，所述血液处理单元具有限定从所述血液存取通过的血液通过所述血液通过的第一室的半透膜以及透析液通过的第二室，分别连接到第一室的入口和出口的动脉线和静脉管。用于确定流体流速的方法涉及在逆流之前和之后测量后透析器浓度或电导率。本发明还涉及一种用于检查血液处理装置的动脉和静脉线的操作构造的方法。

9. 发明申请

WO2014147028A1 MONITORING OF CARDIAC ARREST IN A PATIENT CONNECTED TO AN EXTRACORPOREAL BLOOD PROCESSING APPARATUS 审中-公开
标题翻译：监测与病毒血液加工装置连接的患者的心脏病
公开(公告)号：WO2014147028A1
公开(公告)日：2014-09-25
申请号：PCT/EP2014/055309
申请日：2014-03-17
申请人： GAMBRO LUNDIA AB
发明人： HANSSON, Per , OLDE, Bo , SOLEM, Kristian , STERNBY, Jan
IPC分类号： A61B5/0215 , A61M1/36
CPC分类号： A61B5/6866 , A61B5/02125 , A61B5/0215 , A61B5/02158 , A61B5/4836 , A61B5/7246 , A61B5/7282 , A61B5/746 , A61M1/3639 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M1/3661 , A61M1/369 , A61M2230/04
摘要： A monitoring device (7) operates an input block (30) to acquire a pressure signal from a pressure sensor (6a-6c) in an apparatus for extracorporeal blood processing connected to the vascular system of the subject. A processing block (34) repeatedly processes the pressure signal for generation of a time-sequence of parameter values indicative of pressure pulsations originating from heartbeats in the subject, and an evaluation block (35) evaluates the parameter values for detection of cardiac arrest and, if cardiac arrest is detected, generates a dedicated alarm signal. To reduce the risk for false positives without increasing the risk for false negatives, the monitoring device (7) may acquire and process more than one pressure signal, and/or perform an initial viability check before the monitoring is initiated to ensure that pressure pulsations originating from heartbeats are detectable in the pressure signal(s), and/or separate the monitoring of the pressure signal(s) into a detection phase performed during regular operation of a blood pump in the apparatus, and a verification phase performed during a temporary shutdown of the blood pump.
摘要翻译：监视装置（7）操作输入块（30）以从连接到对象的血管系统的用于体外血液处理的装置中的压力传感器（6a-6c）获取压力信号。处理块（34）重复地处理压力信号以产生指示受试者心跳的压力脉动的参数值的时间序列，并且评估块（35）评估用于检测心跳骤停的参数值，如果检测到心跳停止，则产生专用报警信号。为了降低假阳性风险，而不增加假阴性的风险，监测装置（7）可以在开始监测之前获取并处理多于一个压力信号和/或执行初始生存力检查，以确保起始的压力脉动在压力信号中可以检测到心跳，和/或将压力信号的监测分离成在装置中的血泵的常规操作期间执行的检测阶段，以及在临时关闭期间执行的验证阶段的血泵。

10. 发明授权

EP2934622B1 DETECTING PRESSURE PULSES IN A BLOOD PROCESSING APPARATUS 有权
标题翻译：检测血液处理设备中的压力脉冲
公开(公告)号：EP2934622B1
公开(公告)日：2017-06-21
申请号：EP13811841.9
申请日：2013-12-11
申请人： Gambro Lundia AB
发明人： STERNBY, Jan , HOLMER, Mattias , OLDE, Bo , SOLEM, Kristian , WALLENBORG, Anders , HANSSON, Per
IPC分类号： A61M1/36 , A61B5/00
CPC分类号： A61M1/14 , A61B5/7217 , A61M1/1605 , A61M1/1613 , A61M1/3639 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M1/3661 , A61M2205/13 , A61M2205/15 , A61M2205/3303 , A61M2205/3331 , A61M2205/3344 , A61M2205/50 , A61M2230/04

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