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1. 发明专利

JP2004161685A Yolk-related protein and application thereof 审中-公开
公开(公告)号：JP2004161685A
公开(公告)日：2004-06-10
申请号：JP2002330226
申请日：2002-11-14
申请人： Bl:Kk , Frontier Science Co Ltd , 株式会社ビーエル , 株式会社フロンティア・サイエンス
发明人： HARA AKIHIKO , NANBA YASUHARU , ITO KEIZO
IPC分类号： G01N33/53 , C07K14/46 , C07K16/18 , G01N33/543 , G01N33/545 , G01N33/553
摘要： PROBLEM TO BE SOLVED: To provide a substitution method of a conventional measuring system of an environmental hormone disruptor by detecting vitellogenin by providing a new female-specific yolk-related protein (YRP) derived from Oryzias latipes and an antibody against the protein. SOLUTION: The female-specific yolk-related protein derived from the Oryzias latipes has substantially 460 kDa molecular weight measured by gel filtration, and substantially 130 kDa molecular weight measured by dodecyl sodium sulfate-polyacrylamide gel electrophoresis. The antibody against the protein, and various kinds of immunological measuring methods of the yolk-related protein by using the antibody are also provided. COPYRIGHT: (C)2004,JPO

2. 发明专利

JP2005242507A Consignment/trust management system by collaboration whose security is strengthened 审中-公开
标题翻译：通过合作加强安全管理体系
公开(公告)号：JP2005242507A
公开(公告)日：2005-09-08
申请号：JP2004049029
申请日：2004-02-25
申请人： Frontier Science Co Ltd , Hitachi Instruments Service Co Ltd , 日立計測器サービス株式会社 , 株式会社フロンティア・サイエンス
发明人： SATO KIYOE , WATABE SATOSHI , ITO KEIZO
IPC分类号： G06Q50/26 , G06Q50/00 , G06F17/60
摘要： PROBLEM TO BE SOLVED: To enable a researcher side who requests a research task to easily and properly retrieve a trust destination without sparing any huge time or labor, and to enable a trustee side to effectively demonstrate own technology level, and to provide equipment and devices whose conditions are always maintained in the optimal status in order to smoothly and quickly perform a trusted task. SOLUTION: This consignment/trust system is configured by connecting the respective computers of a plurality of research facility groups and a first group where trust facilities are connected through a local network to each other and the respective computers of a maintenance company 4, consignment/trust management company 3 which performs collaboration, a talent sending company 5, a sample pickup/delivery company, a reagent manufacturing/selling company and an equipment manufacturing/selling company to a wide range network. The trust facilities connected to the local area network and the consignment/trust management company are respectively provided with a network monitoring unit. Thus, the equipment which has been purchased with university budgets or national budgets can be validly used, or a trusted task can be performed in a university or a research institute by utilizing talents. Also, a research institution which is common to all the fields of study such as an advanced technology research center or a central laboratory can be utilized as the window. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：为了使请求研究任务的研究人员能够轻松，正确地检索信任目的地，而不用花费任何巨大的时间或劳动力，并使受托方有效地展示自己的技术水平，并提供条件总是保持在最佳状态的设备和设备，以便顺利和快速地执行可信任务。解决方案：通过将多个研究设施组的各个计算机和信任设施通过本地网络彼此连接的第一组以及维护公司4的各个计算机连接来配置该委托/信任系统，执行协作的托运/信托管理公司3，人才招聘公司5，抽样/递送公司，试剂制造/销售公司和设备制造/销售公司到广泛的网络。与局域网和托运/信托管理公司相连的信托设施分别设有网络监控单元。因此，用大学预算或国家预算购买的设备可以有效利用，也可以通过利用人才在大学或研究所进行信任任务。另外，可以利用先进技术研究中心或中心实验室等所有领域的共同研究机构作为窗口。版权所有（C）2005，JPO＆NCIPI

3. 发明专利

JP2005341937A Oral vaccine carrier system 有权
标题翻译：口腔疫苗载体系统
公开(公告)号：JP2005341937A
公开(公告)日：2005-12-15
申请号：JP2004169259
申请日：2004-06-07
申请人： Frontier Science Co Ltd , Hokkaido Green Bio Kenkyusho:Kk , Kitasato Inst:The , National Institute Of Advanced Industrial & Technology , 株式会社フロンティア・サイエンス , 株式会社北海道グリーンバイオ研究所 , 独立行政法人産業技術総合研究所 , 社団法人北里研究所
发明人： MATSUMURA TAKESHI , ITO AKIRA , KOBAYASHI EIKI , KUME KATSUMI , ITO KEIZO , ITSUCHIYOUDA NORIKO , SUGIMOTO CHIHIRO
IPC分类号： A01H5/00 , A61K36/00 , A61K36/81 , A61K38/00 , A61K39/00 , A61P37/00 , C12N15/09 , C12N15/82 , A61K35/78
CPC分类号： A61K36/81 , A61K38/00 , A61K2039/517 , A61K2039/542 , C12N15/8258 , C12N2770/16022
摘要： PROBLEM TO BE SOLVED: To obtain a system for exhibiting the function of a peptide by oral administration of a recombinant plant body expressing an objective peptide and a gene recombination plant. SOLUTION: The carrier means for oral administration of the objective peptide comprises oral administration of a plant body (potato) expressing a gene by fusion between LRE1 gene encoding the objective gene such as immunogenic peptide LRE1 derived from a second schizont of Leucocytozoon caulleryi and Norwalk virus envelope gene. The gene recombination plant is obtained. The orally administered objective peptide reaches an objective location (intestinal mucosa, etc.) without being hydrolyzed in the digestive tract to induce the function of the objective peptide. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：通过口服施用表达目标肽的重组植物体和基因重组植物来获得表现出肽功能的系统。口服给药目的肽的载体包括口服施用表达基因的植物体（马铃薯），所述基因通过编码目标基因的LRE1基因（例如衍生自白细胞介素的第二裂殖体的免疫原性LRE1）和诺瓦克病毒包膜基因。获得基因重组。口服给药的目的肽达到客观位置（肠粘膜等），而不在消化道中水解以诱导目的肽的功能。版权所有（C）2006，JPO＆NCIPI

4. 发明专利

JP2005233847A Surface plasmon resonance phenomenon measuring instrument 有权
标题翻译：表面等离子体共振测量仪器
公开(公告)号：JP2005233847A
公开(公告)日：2005-09-02
申请号：JP2004045270
申请日：2004-02-20
申请人： Able Corp , Taiichi Asano , Eliotec:Kk , Frontier Science Co Ltd , Toshihiko Imato , Noriaki Kaneki , Mebius Advanced Technology:Kk , エイブル株式会社 , 稔彦今任 , 有限会社メビウスアドバンストテクノロジー , 株式会社エリオテック , 株式会社フロンティア・サイエンス , 泰一浅野 , 則明金木
发明人： KANEKI NORIAKI , IMATO TOSHIHIKO , UCHIYAMA KAZUMI , SHIMADA KOJI , ASANO TAIICHI , HENMI AKIHIDE , OINUMA TOSHIAKI , ITO KEIZO , ISHIKAWA YOICHI
IPC分类号： G01N21/27
摘要： PROBLEM TO BE SOLVED: To provide a surface plasmon resonance phenomenon measuring instrument for realizing a real time multichannel multipoint measurement by a surface plasmon resonance phenomenon (SPR) method in a portable type. SOLUTION: The surface plasmon resonance phenomenon measuring instrument has (1) a sensor 100 wherein a plurality of measuring cells are formed on the metal film on the surface of a prism in one row, (2) a light source 3, (3) a first optical system 200 for irradiating a plurality of the measuring cells formed on the sensor with the irradiation light of the light source at an incident angle including a plasmon resonance angle so as to form a linear focal point on the measuring cells, (4) a second optical system 300 for converting the reflected light emitted from the sensor to parallel reflected light and (5) the linear CCP 318 arranged in a state that the focal point axial direction of the linear focal point and the arranging direction of the photodetection element 319 of the linear CCP 318 are made parallel and attached to a stage 322 having a means moving the plane vertical in the optical axis direction of parallel reflected light. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种表面等离子体共振现象测量仪器，用于通过便携式的表面等离子体共振现象（SPR）方法实现实时多通道多点测量。表面等离子共振现象测量仪器具有（1）传感器100，其中在一行的棱镜的表面上的金属膜上形成多个测量单元，（2）光源3（ 3）第一光学系统200，用于以包含等离子体共振角的入射角照射光源的照射光，形成在传感器上的多个测量单元，以便在测量单元上形成直线焦点; 4）第二光学系统300，用于将从传感器发射的反射光转换成平行反射光;以及（5）以直线焦点的焦点轴向和光电检测的排列方向布置的线性CCP 318 线性CCP 318的元件319被平行并且附接到具有在平行反射光的光轴方向上垂直移动平面的平台的平台322。版权所有（C）2005，JPO＆NCIPI

5. 发明专利

JP2004135662A Transformant for measuring dioxins, method for detecting same by using same, method for quantitatively analyzing same and method for screening same 审中-公开
标题翻译：用于测量二氧化碳的变换，使用其检测相同的方法，数量分析方法及其筛选方法
公开(公告)号：JP2004135662A
公开(公告)日：2004-05-13
申请号：JP2003328258
申请日：2003-09-19
申请人： Frontier Science Co Ltd , 株式会社フロンティア・サイエンス
发明人： ITO KEIZO , KATO MIHOKO
IPC分类号： G01N27/62 , C12N5/10 , C12N15/09 , C12Q1/02 , C12Q1/66 , C12Q1/68 , G01N31/00 , G01N33/00 , G01N33/15
摘要： PROBLEM TO BE SOLVED: To provide a transformant for measuring dioxins, capable of rapidly measuring large amounts of specimens which are required to be treated for surveying environmental pollution and capable of evaluating biological effects without causing inconvenience, to provide a method for detecting the dioxins by using the transformant, to provide a method for quantitatively analyzing the dioxins, and to provide a method for screening the dioxins. SOLUTION: This transformant for measuring the dioxins constantly produces or induces an AhR and an Arnt, and produces a reporter protein through combination with a transcription control region of a complex containing the dioxins, the AhR, and the Arnt. The dioxins are detected by using the transformant. The dioxins are measured by GC-MS after the reporter protein is measured. Concentrations of the dioxins are measured based on an expression level of the reporter protein. Biological action levels of the dioxins are evaluated and screened by using the method for detecting the dioxins or the method for quantitatively analyzing the dioxins. COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：提供一种用于测量二恶英的转化体，其能够快速测量需要处理的大量样品以测量环境污染并能够评估生物效应而不引起不便，提供一种检测方法通过使用转化体的二恶英，提供定量分析二恶英的方法，并提供筛选二恶英的方法。解决方案：用于测量二恶英的转化体不断产生或诱导AhR和Arnt，并通过与含有二恶英，AhR和Arnt的络合物的转录控制区组合产生报道蛋白。通过使用转化体检测二恶英。测量报道蛋白后，通过GC-MS测量二恶英。基于报道蛋白的表达水平测定二恶英的浓度。通过使用检测二恶英的方法或定量分析二恶英的方法来评价和筛选二恶英的生物作用水平。版权所有（C）2004，JPO

6. 发明专利

AU2005264220B2 Peroral vaccine carrier system 未知
公开(公告)号：AU2005264220B2
公开(公告)日：2010-11-11
申请号：AU2005264220
申请日：2005-06-07
申请人： FRONTIER SCIENCE CO LTD , AIST , THE HOKUREN FEDERATION OF AGRICULTURAL COOP , THE KITASATO INST
发明人： ITO AKIRA , SUGIMOTO CHIHIRO , ITO KEIZO , KOBAYASHI SHIGEKI , MATSUMURA TAKESHI , KUME KATSUMI , ITCHODA NORIKO
IPC分类号： A01H5/00 , A61K36/00 , A61K36/81 , A61K38/00 , A61K39/00 , A61P37/00 , C12N15/09 , C12N15/82

7. 发明专利

AT426664T 未知
公开(公告)号：AT426664T
公开(公告)日：2009-04-15
申请号：AT05748996
申请日：2005-06-07
申请人： NAT INST OF ADVANCED IND SCIEN , FRONTIER SCIENCE CO LTD , KITASATO INST , HOKUREN
发明人： MATSUMURA T , ITO AKIRA , KOBAYASHI SHIGEKI , KUME KATSUMI , ITO KEIZO , ITCHODA NORIKO , SUGIMOTO CHIHIRO
IPC分类号： A01H5/00 , C12N15/09 , A61K36/00 , A61K36/81 , A61K38/00 , A61K39/00 , A61P37/00 , C12N15/82

8. 发明专利

AU2005264220A1 Peroral vaccine carrier system 未知
公开(公告)号：AU2005264220A1
公开(公告)日：2006-01-26
申请号：AU2005264220
申请日：2005-06-07
申请人： NAT INST OF ADVANCED IND SCIEN , KITASATO INST , FRONTIER SCIENCE CO LTD , HOKUREN
发明人： ITO AKIRA , SUGIMOTO CHIHIRO , ITO KEIZO , KOBAYASHI SHIGEKI , MATSUMURA TAKESHI , KUME KATSUMI , ITCHODA NORIKO
IPC分类号： A01H5/00 , A61K36/00 , A61K36/81 , A61K38/00 , A61K39/00 , A61P37/00 , C12N15/09 , C12N15/82

9. 发明专利

DE602005013529D1 未知
公开(公告)号：DE602005013529D1
公开(公告)日：2009-05-07
申请号：DE602005013529
申请日：2005-06-07
申请人： NAT INST OF ADVANCED IND SCIEN , FRONTIER SCIENCE CO LTD , KITASATO INST , HOKUREN
发明人： MATSUMURA T , ITO AKIRA , KOBAYASHI SHIGEKI , KUME KATSUMI , ITO KEIZO , ITCHODA NORIKO , SUGIMOTO CHIHIRO
IPC分类号： A01H5/00 , C12N15/09 , A61K36/00 , A61K36/81 , A61K38/00 , A61K39/00 , A61P37/00 , C12N15/82

10. 发明公开

EP1767626A4 PERORAL VACCINE CARRIER SYSTEM 有权
标题翻译：口服疫苗传递系统
公开(公告)号：EP1767626A4
公开(公告)日：2007-11-14
申请号：EP05748996
申请日：2005-06-07
申请人： NAT INST OF ADVANCED IND SCIEN , FRONTIER SCIENCE CO LTD , KITASATO INST , HOKUREN
发明人： MATSUMURA T , ITO AKIRA , KOBAYASHI SHIGEKI , KUME KATSUMI , ITO KEIZO , ITCHODA NORIKO , SUGIMOTO CHIHIRO
IPC分类号： A01H5/00 , C12N15/09 , A61K36/00 , A61K36/81 , A61K38/00 , A61K39/00 , A61P37/00 , C12N15/82
CPC分类号： A61K36/81 , A61K38/00 , A61K2039/517 , A61K2039/542 , C12N15/8258 , C12N2770/16022
摘要： A system in which a recombinant plant expressing a target peptide is orally administered to thereby achieve exertion of the function of the peptide; and a relevant genetically modified plant. There is provided carrier means for oral administration of a target peptide through oral administration of a plant (potato) expressing a target peptide, for example, effecting expression of a fused gene consisting of LRE1 gene coding for immunogenic peptide LRE1 derived from leucocytozoon caulleryi 2nd generation schizont and gene for Norwalk virus coat protein; and provided such a genetically modified plant. Thus, the target peptide orally administered would reach an intended destination (intestinal mucosa, etc.) without being decomposed in the digestive tract and would be able to induce exertion of the function of the target peptide.

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