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1. 发明专利

JP2004161685A Yolk-related protein and application thereof 审中-公开
公开(公告)号：JP2004161685A
公开(公告)日：2004-06-10
申请号：JP2002330226
申请日：2002-11-14
申请人： Bl:Kk , Frontier Science Co Ltd , 株式会社ビーエル , 株式会社フロンティア・サイエンス
发明人： HARA AKIHIKO , NANBA YASUHARU , ITO KEIZO
IPC分类号： G01N33/53 , C07K14/46 , C07K16/18 , G01N33/543 , G01N33/545 , G01N33/553
摘要： PROBLEM TO BE SOLVED: To provide a substitution method of a conventional measuring system of an environmental hormone disruptor by detecting vitellogenin by providing a new female-specific yolk-related protein (YRP) derived from Oryzias latipes and an antibody against the protein. SOLUTION: The female-specific yolk-related protein derived from the Oryzias latipes has substantially 460 kDa molecular weight measured by gel filtration, and substantially 130 kDa molecular weight measured by dodecyl sodium sulfate-polyacrylamide gel electrophoresis. The antibody against the protein, and various kinds of immunological measuring methods of the yolk-related protein by using the antibody are also provided. COPYRIGHT: (C)2004,JPO

2. 发明专利

JP2009002822A Immuno-chromatography measuring method and kit 有权
标题翻译：免疫色谱测量方法和试剂盒
公开(公告)号：JP2009002822A
公开(公告)日：2009-01-08
申请号：JP2007164600
申请日：2007-06-22
申请人： Bl:Kk , 株式会社ビーエル
发明人： NANBA YASUHARU
IPC分类号： G01N33/543 , G01N33/53 , G01N33/548
摘要： PROBLEM TO BE SOLVED: To provide an immuno-chromatography measuring method which obtains high measuring sensitivity even in a case that a sample to be examined containing a reaction inhibitor is used or in a case that the sample to be examined containing a specimen of high concentration is used like the detection of specific IgG in blood. SOLUTION: In the immuno-chromatography measuring method, a membrane carrier 3, which is equipped with a capture region 31 formed by preliminarily fixing a first substance which is immunologically reacted with the specimen at a predetermined position, is prepared and, after the sample to be examined is chromatographically developed on the membrane carrier toward the capture region to be passed through the capture region, a developing solvent containing a second substance, which is immunologically reacted with the specimen, is chromatographically developed on the membrane carrier toward the capture region in the direction reverse to the chromatographic developing direction of the sample to be examined to sandwich the specimen between the first and second substances in the capture region to detect it. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供即使在使用含有反应抑制剂的待检样品的情况下也可获得高测量灵敏度的免疫色谱测量方法，或者在待检样品含有样品的情况下使用高浓度的血清中特异性IgG的检测。解决方案：在免疫色谱测定方法中，制备膜载体3，膜载体3配备有通过预先固定在预定位置与样品免疫反应的第一物质形成的捕获区域31，并且之后将待检样品在膜载体上以捕获区域色谱显影以通过捕获区域，含有与样品免疫反应的第二物质的显影溶剂在膜载体上被层析显影，以捕获区域，其与待检样品的色谱显影方向相反的方向将样品夹在捕获区域中的第一和第二物质之间以检测它。版权所有（C）2009，JPO＆INPIT

3. 发明专利

JP2006071631A Detection method for virus in pestivirus of fravivirus, and use thereof in immuno-chromatography 审中-公开
标题翻译：番茄病毒的病毒检测方法及其在免疫色谱中的应用
公开(公告)号：JP2006071631A
公开(公告)日：2006-03-16
申请号：JP2005224860
申请日：2005-08-03
申请人： Bl:Kk , 株式会社ビーエル
发明人： KIDA HIROSHI , SAKOTA YOSHIHIRO , NANBA YASUHARU , MOCHIZUKI TAKESHI
IPC分类号： G01N33/569 , C12N15/09 , G01N33/48 , G01N33/543 , G01N33/577
CPC分类号： Y02A50/60
摘要： PROBLEM TO BE SOLVED: To provide a method and a measuring instrument detecting quickly and easily viruses over a wide range in Pestivirus of Fravivirus. SOLUTION: This method for detecting the virus in Pestivirus of Fravivirus comprises a sandwich type immunoassay using the first antibody and the second antibody to an NS3 protein of the virus in Pestivirus of Fravivirus, in particular, an immuno-chromatographic measuring method and an immuno-chromatographic test strip. Either or both of the first antibody and the second antibody are preferably monoclonal antibodies reacting with the NS3 protein both in an immunostaining method and a Western blotting method. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供在弗拉维瓦病毒的瘟病毒中广泛范围内快速和容易地检测病毒的方法和测量仪器。解决方案：用于检测弗拉维瓦病毒的瘟病毒的病毒的方法包括使用第一抗体和第二抗体对弗拉维瓦病毒的瘟病毒中的病毒的NS3蛋白进行夹心型免疫测定，特别是免疫色谱测量方法和免疫色谱测试条。第一抗体和第二抗体中的任一种或两者优选是在免疫染色方法和Western印迹法中与NS3蛋白反应的单克隆抗体。版权所有（C）2006，JPO＆NCIPI

4. 发明专利

JP2008196967A Influenza virus h5 subtype immunoassay 有权
标题翻译： INFLUENZA VIRUS H5 SUBTYPE IMMUNOASSAY
公开(公告)号：JP2008196967A
公开(公告)日：2008-08-28
申请号：JP2007032346
申请日：2007-02-13
申请人： Bl:Kk , 株式会社ビーエル
发明人： NANBA YASUHARU
IPC分类号： G01N33/569 , C07K16/10 , C12P21/08 , G01N33/543 , G01N33/553 , G01N33/577
摘要： PROBLEM TO BE SOLVED: To provide a method and a measuring instrument capable of detecting specifically, quickly and easily an influenza virus H5 subtype. SOLUTION: The present invention discloses an antibody, in particular, a monoclonal antibody reacting specifically with a specified epitope of hemaglutinin protein of the influenza virus H5 subtype. The epitope contains the amino acid in the 88th, 145th, 157th, 159th, or 205th of an amino acid sequence of the hemaglutinin protein indicated in the sequence number 1, and contains preferably the amino acid in 157th or 205th to detect a weak virulent strain and a strong virulent strain over a wide range. The present invention discloses an immunoassay using the antibody, in particular, a sandwich type immunoassay using the first antibody and the second antibody to the hemaglutinin protein, in particular, an immunochromatography, and an immunochromatographic test strip. At least one of the first antibody and the second antibody is preferably the monoclonal antibody. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供能够快速且容易地检测流感病毒H5亚型的方法和测量仪器。解决方案：本发明公开了抗体，特别是与流感病毒H5亚型的血凝素蛋白的特定表位特异性反应的单克隆抗体。表位含有序列号1所示的血凝蛋白蛋白质的氨基酸序列的第88位，第145位，第159位，第159位，第159位或第205位的氨基酸，优选在第157位或第205位含有氨基酸以检测弱毒性菌株和强烈的毒性应变在广泛的范围。本发明公开了使用该抗体的免疫测定法，特别是使用第一抗体和第二抗体对血凝素蛋白质，特别是免疫色谱法和免疫色谱测试条的夹心型免疫测定法。第一抗体和第二抗体中的至少一种优选为单克隆抗体。版权所有（C）2008，JPO＆INPIT

5. 发明专利

JP2006138748A Container and kit for extracting specimen 有权
标题翻译：用于提取样品的容器和工具箱
公开(公告)号：JP2006138748A
公开(公告)日：2006-06-01
申请号：JP2004328700
申请日：2004-11-12
申请人： Bl:Kk , 株式会社ビーエル
发明人： NANBA YASUHARU
IPC分类号： G01N33/48 , G01N1/10 , G01N33/543
摘要： PROBLEM TO BE SOLVED: To provide a container for extracting specimen capable of extracting a specimen sampled using a swab into an extracting solvent by simple operation and capable of being safely discarded after use, and a kit.
SOLUTION: The container for extracting specimen is composed of a tubular body (1) having an opening end (11) and the closing end (12) opposed to it, the first lid (2) attached to the opening end (11) of the body (1) in a detachable manner, the nozzle (3) replaced with the first lid (2) to be attached to the opening end (11) of the body (1) in a freely detachable manner and the second lid (4) attached to the nozzle (3) in a freely detachable manner and the body (1) has an internal dimension sufficient to house the swab (5). The side wall (13) adjacent to the closing end (12) of the body (1) is preferably made thin by making the side wall (13) thinner than the side wall (14) adjacent to the opening end (11) of the body (1).
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种容器，用于提取能够通过简单操作将使用棉签取样的样本提取到提取溶剂中并且能够在使用后能够被安全地丢弃的样本。解决方案：用于提取试样的容器由具有开口端（11）和封闭端（12）相对的管状体（1）组成，第一盖（2）附接到开口端（11））以可拆卸的方式安装在主体（1）的开口端（11）上，喷嘴（3）以第一盖（2）代替，以可自由拆卸的方式安装在主体（1）的开口端（11）上，（4）以可自由拆卸的方式附接到喷嘴（3），并且主体（1）具有足以容纳棉签（5）的内部尺寸。优选地，通过使侧壁（13）比靠近所述主体（1）的开口端（11）的侧壁（14）更薄，邻近主体（1）的闭合端（12）的侧壁（13）身体（1）。版权所有（C）2006，JPO＆NCIPI

6. 发明专利

JP2006067979A Immunity detecting method for influenza a type virus 审中-公开
标题翻译：流感病毒类型的免疫检测方法
公开(公告)号：JP2006067979A
公开(公告)日：2006-03-16
申请号：JP2004258880
申请日：2004-09-06
申请人： Bl:Kk , 株式会社ビーエル
发明人： KIDA HIROSHI , SAKOTA YOSHIHIRO , NANBA YASUHARU , MOCHIZUKI TAKESHI
IPC分类号： C12N15/09 , C07K14/11 , C07K16/10 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/02 , C12P21/08 , G01N33/543 , G01N33/553 , G01N33/569 , G01N33/577
摘要： PROBLEM TO BE SOLVED: To provide a method for quickly and easily detecting a wide range of influenza A type viruses, and to provide an apparatus for the same. SOLUTION: A recombinant NS1 protein and a monoclonal antibody to the same are obtained by cloning a fraction of a gene encoding NS1 protein which is a non structural protein common in various kinds of influenza A type viruses. This invention provides an immunoassay method using an antibody against the NS1 protein of the influenza A type viruses, especially a sandwich type immunoassay method using a first antibody and a second antibody against the NS1 protein, in particular, the invention provides an immunochromatography method and a testing split for immunochromatography. At least one of the first antibody and the second antibody is preferably the monoclonal-antibody. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种快速且容易地检测大范围的甲型流感病毒的方法，并提供用于其的装置。解决方案：通过克隆编码作为各种甲型流感病毒类型中常见的非结构蛋白质的NS1蛋白的基因的一部分获得重组NS1蛋白及其单克隆抗体。本发明提供了使用针对A型流感病毒的NS1蛋白的抗体的免疫测定方法，特别是使用第一抗体和针对NS1蛋白的第二抗体的夹心型免疫测定方法，特别是本发明提供免疫色谱法和用于免疫层析的检测。第一抗体和第二抗体中的至少一种优选为单克隆抗体。版权所有（C）2006，JPO＆NCIPI

7. 发明专利

JP2008058208A Immuno-chromatography method using single-chain variant-part antibody 审中-公开
标题翻译：使用单链变体部分抗体的免疫色谱法
公开(公告)号：JP2008058208A
公开(公告)日：2008-03-13
申请号：JP2006237181
申请日：2006-09-01
申请人： Bl:Kk , Shizuoka Prefecture , 株式会社ビーエル , 静岡県
发明人： OTA TOSHIYA , IIZUKA CHIKAYO , YAMADA SHINYA , MOCHIZUKI TAKESHI , NANBA YASUHARU
IPC分类号： G01N33/543 , C07K16/00 , C12N15/09 , C12P19/34 , C40B40/08 , G01N33/531
摘要： PROBLEM TO BE SOLVED: To provide a sandwich type immunoassay using recombination protein having a bonding property to an antigen, especially an immuno-chromatography method, and recombination protein suitable for use for this. SOLUTION: In the sandwich type immunoassay using a first bonding material and a second bonding material to antigen to be measured, at least one of the first bonding material and second bonding material is made of recombination protein having a heavy chain variant-part and light chain variant-part of the antibody to the antigen. Preferably, the recombination protein is single-chain variant-part fragment type antibody (scFv antibody) obtained by a phage displaying method. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：使用具有与抗原结合特性的重组蛋白质，特别是免疫色谱法，以及适用于此的重组蛋白质提供夹层型免疫测定法。解决方案：在使用第一接合材料和第二接合材料对要测量的抗原的夹心型免疫测定中，第一接合材料和第二接合材料中的至少一个由具有重链变体部分的重组蛋白质和轻链变体部分抗原的抗体。优选地，重组蛋白是通过噬菌体展示法获得的单链变体部分片段型抗体（scFv抗体）。版权所有（C）2008，JPO＆INPIT

8. 发明专利

JP2007218593A Immuno-chromatography measuring method for bio-pilin detection, and its device 有权
标题翻译：用于生物皮检测的免疫色谱测量方法及其装置
公开(公告)号：JP2007218593A
公开(公告)日：2007-08-30
申请号：JP2006036202
申请日：2006-02-14
申请人： Bl:Kk , 株式会社ビーエル
发明人： NANBA YASUHARU , YAMAGUCHI TOKIO
IPC分类号： G01N33/53 , C07K16/18 , G01N33/543 , G01N33/577
摘要： PROBLEM TO BE SOLVED: To provide a method and device for measuring bio-pilin usable for easy and rapid diagnosis in a clinical case without requiring a special instrument and expert technology. SOLUTION: In the immuno-chromatography measuring method and device for bio-pilin detection, a film carrier 3 having a capture part 41 formed by previously fixing an anti-bilirubin antibody to a predetermined position and an indicator body indicating a conjugate of the bio-pilin and high molecular compound with an indicator material are prepared. Mixed liquid of the indicator body and a tested material is chromato-developed by the film carrier toward the capture part. The indicator body and the bio-pilin in the tested material are captured by the capture part competitively. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供用于在临床情况下容易且快速诊断的生物分析仪的测量方法和装置，而不需要专门的仪器和专家技术。解决方案：在免疫色谱测量方法和用于生物匹林检测的装置中，具有通过预先将抗胆红素抗体固定到预定位置而形成的捕获部分41的薄膜载体3和指示体制备具有指示剂材料的生物分子和高分子化合物。指示体和被测材料的混合液体由胶片载体向捕获部分进行色谱显影。测试材料中的指示体和生物皮林被捕获部分竞争地捕获。版权所有（C）2007，JPO＆INPIT

9. 发明专利

JP2004166564A Monoclonal antibody and method for diagnosing tuberculosis 审中-公开
公开(公告)号：JP2004166564A
公开(公告)日：2004-06-17
申请号：JP2002334886
申请日：2002-11-19
申请人： Biodynamics Laboratory Inc , Bl:Kk , 株式会社バイオダイナミクス研究所 , 株式会社ビーエル
发明人： SUZUKI TAKASHI , OGAWA MASAYO , NAGAHORA HITOSHI , ONDA MASAAKI , NANBA YASUHARU
IPC分类号： G01N33/543 , A61K49/00 , C07K14/35 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/08 , G01N33/569 , G01N33/577
摘要： PROBLEM TO BE SOLVED: To provide a method for diagnosing tuberculosis, having higher precision, by obtaining a monoclonal antibody which induces widely immune reaction with various kinds protein MPT64 and protein MPB64 secreted from various kinds of human tubercule bacilli and bovine tubercule bacilli. SOLUTION: The monoclonal antibody against two kinds of peptides comprises a specific amino acid sequence derived from Mycobacterium. The method for diagnosing tuberculosis comprises a sandwich type immunoassay method using the two kinds of monoclonal antibodies. The immuno-chromatographic assay method comprises preparing a membrane carrier equipped with a catching part formed by previously immobilizing either of the two kinds of the monoclonal antibodies to a predetermined position, mixing the other monoclonal antibody and a fixed amount of a sample to be examined with a developing solvent, carrying out chromatographic development toward the catching part by the membrane carrier and catching tubercule bacillus-derived protein contained in the sample to be tested in the catching part. COPYRIGHT: (C)2004,JPO

10. 发明专利

JP2014095720A Immunodetection method of influenza virus h5 subtype 有权
标题翻译：流感病毒H5亚型的免疫检测方法
公开(公告)号：JP2014095720A
公开(公告)日：2014-05-22
申请号：JP2014004593
申请日：2014-01-14
申请人： Bl:Kk , 株式会社ビーエル
发明人： KIDA HIROSHI , SAKOTA YOSHIHIRO , NANBA YASUHARU
IPC分类号： G01N33/569 , C07K16/10 , C12P21/08 , G01N33/543 , G01N33/548
CPC分类号： C07K16/1018 , G01N33/56994 , G01N2333/11
摘要： PROBLEM TO BE SOLVED: To provide a method and a measuring instrument that can specifically detect influenza virus H5 subtype rapidly and easily.SOLUTION: An antibody, especially a monoclonal antibody, specifically reacting to a hemagglutinin protein of influenza virus H5 subtype, and an immunoassay with the antibody, especially a sandwich type immunoassay using a first antibody and a second antibody for the hemagglutinin protein, particularly an immuno chromatography assay and an immuno chromatography method test strip, are provided. At least one of the first antibody and the second antibody is the monoclonal antibody.
摘要翻译：要解决的问题：提供可以快速，容易地特异性检测流感病毒H5亚型的方法和测量仪器。解决方案：特异性地对流感病毒H5亚型的血凝素蛋白进行反应的抗体，特别是单克隆抗体，以及免疫测定使用抗体，特别是使用第一抗体和用于血凝素蛋白的第二抗体的三明治型免疫测定法，特别是免疫色谱法和免疫色谱法测试条。第一抗体和第二抗体中的至少一个是单克隆抗体。

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